Abstract: Systems, methods, and computer readable medium to provide patterned layer deposition of liquid types to a plate surface in layers organized in layouts with sites of patterns aligned to a plate origin of the plate surface. At least one layer includes a layout defining a geometric layout of the plate surface.

Abstract: A fluid ejection system, in an example, includes at least one nozzle of at least one die from which a fluid is ejected and at least one nanowell at which the at least one nozzle ejects an amount of fluid. A method of dispensing a fluid, in an example, includes addressing at least one nanowell with at least one nozzle of at least one die, and depositing a fluid in the nanowell with the at least one nozzle.

Abstract: This disclosure teaches the concept, and method of creating, a dual use device intended for persons who take insulin. In one embodiment, the novel device is an insulin delivery cannula, the outer wall of which contains electrodes, chemical compounds and electrical interconnects that allow continuous glucose sensing and delivery of data to a remote device. Heretofore, the main problem in attempting to sense glucose at the site of insulin delivery has been the high current resulting from oxidation by the sensor of the preservatives in the insulin formulations. One means of eliminating these interferences is to poise the indicating electrode(s) of the sensor at a bias sufficiently low to avoid the signal from oxidation of the preservatives. One way of obtaining a glucose signal at a low bias is to use an osmium-ligand-polymer complex instead of conventional hydrogen peroxide sensing.

Abstract: This disclosure teaches the concept, and method of creating, a dual use device intended for persons who take insulin. In one embodiment, the novel device is an insulin delivery cannula, the outer wall of which contains electrodes, chemical compounds and electrical interconnects that allow continuous glucose sensing and delivery of data to a remote device. Heretofore, the main problem in attempting to sense glucose at the site of insulin delivery has been the high current resulting from oxidation by the sensor of the preservatives in the insulin formulations. One means of eliminating these interferences is to poise the indicating electrode(s) of the sensor at a bias sufficiently low to avoid the signal from oxidation of the preservatives. One way of obtaining a glucose signal at a low bias is to use an osmium-ligand-polymer complex instead of conventional hydrogen peroxide sensing.

Abstract: Optical readers are disclosed in examples herein. An example optical reader including a light source to emit a light beam; and a spot pattern generator to receive the light beam and to generate a two-dimensional spot array from the light beam, the two-dimensional spot array to be directed toward a substrate having nanostructures, the two-dimensional spot array to be sensed to detect a presence or an absence of a substance of interest on the substrate.

Abstract: In example implementations, a method is provided. The method may be executed by a processor of a fluid dispensing apparatus. The method includes dispensing a fluid onto a surface from a dispenser during an alignment procedure. The surface is ejected for alignment verification. The surface is then received for re-execution of the alignment procedure after the alignment verification. The dispenser is re-used to dispense fluid onto the surface during re-execution of the alignment procedure.

Abstract: In example implementations, a method is provided. The method may be executed by a processor of a fluid dispensing apparatus. The method includes storing a correction factor for an unqualified fluid. A request to dispense the unqualified fluid is received. A dispense parameter is adjusted in accordance with the correction factor. Then, the unqualified fluid is dispensed in accordance with the dispense parameter that is adjusted.

Abstract: Optical readers are disclosed in examples herein. An example optical reader including a light source to emit a light beam; and a spot pattern generator to receive the light beam and to generate a two-dimensional spot array from the light beam, the two-dimensional spot array to be directed toward a substrate having nanostructures, the two-dimensional spot array to be sensed to detect a presence or an absence of a substance of interest on the substrate.

Abstract: The present invention relates to novel genetic markers associated with endometriosis and risk of developing endometriosis, and methods and materials for determining whether a human subject has endometriosis or is at risk of developing endometriosis and the use of such risk information in selectively administering a treatment that at least partially prevents or compensates for an endometriosis related symptom.

Abstract: Disclosed herein are methods of using genetic markers associated with endometriosis, for example via a computer-implemented program to predict risk of developing endometriosis, and methods of preventing or treating endometriosis or a symptom thereof. For example, the present disclosure provides a method of testing for endometriosis and treating a subject having at least one genetic mutation in at least one gene of UGT2B28, USP17L2 (alias DUBS), and METTL11B such that the subject is prevented from developing endometriosis or such that endometriosis in the subject is prevented from progressing. The treatment may be a surgical intervention, a hormone treatment, a pharmaceutical treating, or a combination thereof.

Abstract: A device and method for delivering a device such as a sensor or fluid transport structure or a fluid transport structure sensor combination into, for example, mammalian skin. Such a device allows a sensor to penetrate mammalian skin without the use of an introducer device such as a needle. A device in accordance with embodiments of the present disclosure includes a housing for attachment to mammalian skin including an exit port for receiving the distal end of a biosensor and an injection activation device including a mechanism for forcing the sensing device from a first position within the housing, through the exit port to a second position, with sufficiently high velocity to partially penetrate the mammalian skin.

Abstract: It is desirable to have audio and/or video systems and processing tools that can automatically record audio/video and analyze such recordings to capture material that may be relevant to a user. In one or more embodiments disclosed herein, a recording may be condensed by using one or more tools, including but not limited to, converting speech to text and searching for relevant content, keywords, and the like; detecting and sorting speakers and/or content (e.g., events in a conversation); removing non-substantive content (e.g., silences and other irrelevant content); adjusting the audio for increased playback speed; using prosodic and other indicia in the audio to identify areas of interest; performing diarization; using pseudo-random or random sample to select content; and other methods to extract information to provide a summary or representation of recorded content for review by a user.

Abstract: A device and method for delivering a device such as a sensor or fluid transport structure or a fluid transport structure sensor combination into, for example, mammalian skin. Such a device allows a sensor to penetrate mammalian skin without the use of an introducer device such as a needle. A device in accordance with embodiments of the present disclosure includes a housing for attachment to mammalian skin including an exit port for receiving the distal end of a biosensor and an injection activation device including a mechanism for forcing the sensing device from a first position within the housing, through the exit port to a second position, with sufficiently high velocity to partially penetrate the mammalian skin.

Abstract: A microplate lid is disclosed. An electronics board includes a plurality of board throughholes corresponding to well locations of a microplate. A cover plate includes a plurality of plate throughholes corresponding to respective board throughholes to define a plurality of plate-board throughhole pairs. The cover plate is located atop the electronics board. A plurality of directing lumens is at least partially defined by the cover plate. Each directing lumen corresponds to a respective plate throughhole. A plurality of user-perceptible array indicators is provided to the electronics board. Each array indicator is associated with a different plate-board throughhole pair than every other array indicator.

Abstract: An apparatus includes a pipette dispenser to control dispensing of a volume to a dispensing location. A tip is operatively coupled to the pipette dispenser. The tip includes an electromechanical print head to dispense the volume from the pipette dispenser to the dispensing location based on a command from the pipette dispenser that indicates an amount of the volume to be dispensed from the print head.

Abstract: According to an example, a microfluidic apparatus may include a channel, a foyer, in which the foyer is in fluid communication with the channel and in which the channel has a smaller width than the foyer, a sensor to sense a property of a fluid passing through the channel, a nozzle in fluid communication with the foyer, and an actuator positioned in line with the nozzle. The microfluidic apparatus may also include a controller to determine whether the sensed property of the fluid meets a predetermined condition and to perform a predefined action in response to the sensed property of the fluid meeting the predetermined condition.

Abstract: According to an example, a microfluidic apparatus may include a fluid slot, a foyer in fluid communication with the fluid slot via a channel having a relatively smaller width than the foyer, a sensor to detect a presence of a particle of interest in a fluid passing through the channel, a nozzle in fluid communication with the foyer, and an actuator positioned in line with the nozzle. The microfluidic apparatus may also include a controller to receive information from the sensor, determine, from the received information, whether a particle of interest has passed through the channel, and control the actuator to expel fluid in the foyer through the nozzle based upon the determination.

Abstract: A digital dispense apparatus comprising a plurality of fluid dispense devices, at least one reservoir connected to the plurality of fluid dispense devices to deliver fluid to the plurality of fluid dispense devices, at least one contact pad array, and a single monolithic carrier structure.

Abstract: A digital dispense apparatus includes at least one fluid dispense device, at least one reservoir fluidically connected to the at least one fluid dispense device, a monolithic carrier structure carrying the at least one fluid dispense device and reservoir, the monolithic carrier forming fluid routing between the reservoir and the fluid dispense device.

Abstract: The present invention relates to novel genetic markers associated with preeclampsia and risk of developing preeclampsia, and methods and materials for determining whether a human subject has preeclampsia or is at risk of developing preeclampsia and the use of such risk information in selectively administering a treatment that at least partially prevents or compensates for an preeclampsia related condition.