Abstract: A method of treating or inhibiting degeneration of a retina of a subject in need thereof comprising administering an effective amount of a compound of metipranolol, or a metabolite thereof, to an organ, a tissue, or the subject, wherein the degeneration of the retina is caused by an ocular disease. In some embodiments, the compound, or a metabolite thereof, is administered topically, orally, or parenterally. In some embodiments, a drug delivery vehicle comprising a dosage of the compound, or the metabolite of, is delivered parenterally via intravitreal injection. In further embodiments, the dosage may range from 0.5 ?g/day-15 ?g/day.

Abstract: A method of treating or inhibiting degeneration of a retina of a subject in need thereof comprising administering an effective amount of a compound of metipranolol, or a metabolite thereof, to an organ, a tissue, or the subject, wherein the degeneration of the retina is caused by an ocular disease. In some embodiments, the compound, or a metabolite thereof, is administered topically, orally, or parenterally. In some embodiments, a drug delivery vehicle comprising a dosage of the compound, or the metabolite of, is delivered parenterally via intravitreal injection. In further embodiments, the dosage may range from 0.5 ?g/day-15 ?g/day.

Abstract: A method, including: obtaining an initial model of a subsurface property; simulating synthetic data from the initial model; obtaining recorded borehole seismic data, wherein the recorded borehole seismic data was obtained with a seismic source or receiver located in a well; and inverting, with a computer, the recorded borehole seismic data by full wavefield inversion, wherein the full wavefield inversion includes comparing the synthetic data to the recorded borehole seismic data, and computing a cost function, obtaining a gradient function from the cost function, wherein the gradient function is related to a change in the objective function with an incremental change in model parameters, using the initial model to compute an illumination function or a resolution function for seismic sources and receivers, and obtaining a conditioned gradient function by conditioning the gradient function with the illumination function or the resolution function.

Abstract: Systems and methods which provide electromagnetic subsurface mapping to derive information with respect to subsurface features whose sizes are near to or below the resolution of electromagnetic data characterizing the subsurface are shown. Embodiments operate to identify a region of interest (203) in a resistivity image generated (202) using electromagnetic data (201). One or more scenarios may be identified for the areas of interest, wherein the various scenarios comprise representations of features whose sizes are near to or below the resolution of the electromagnetic data (204). According to embodiments, the scenarios are evaluated (205), such as using forward or inverse modeling, to determine each scenarios' fit to the available data and further to determine their geologic reasonableness (206). Resulting scenarios may be utilized in a number of ways, such as to be substituted in a resistivity image for a corresponding region of anomalous resistivity for enhancing the resistivity image (207).

Abstract: A method for designing a controlled-source electromagnetic survey that will discriminate between a defined deep marginal-interest reservoir (2) and specified false positive resistivity structures of concern (3, 4, 5). A reservoir model and a false positive model are constructed for each false positive scenario. The resistivity of the false positive model may be tuned to give electromagnetic data similar enough to the reservoir model when forward modeled that any differences fall in the model null space. A null-space discriminating ratio (“NSDR”) is defined, for example as the peak normalized difference of the two related modeled electromagnetic field data sets. An area coverage display of NSDR values (6) allows determination of such additional data as may be needed to distinguish the false positive body, and a survey design is developed accordingly (7). Reduction of the number of variables affecting the area coverage displays is a key feature of the method.

Abstract: Ophthalmic compositions are provided that comprise or consist essentially of (a) ketotifen or a ketotifen salt, (b) a non-ionic tonicity agent, and (c) water. The concentration of ketotifen or the ketotifen salt is preferably from 0.01% to 0.05%. The non-ionic tonicity agent is preferably glycerol and the concentration of the glycerol is preferably from 4% to 7%. The compositions preferably have an osmolality of from 400 to 875 milliosmoles/Kg. The compositions may also contain an anti-redness agent. Methods of treating allergic conjunctivitis using the ophthalmic compositions and methods of treating dry eye disease using the ophthalmic compositions are also provided.

Abstract: Method for generating a three-dimensional resistivity data volume for a subsurface region from an initial resistivity model and measured electromagnetic field data from an electromagnetic survey of the region, where the initial resistivity model is preferably obtained by performing multiple ID inversions of the measured data [100]. The resulting resistivity depth profiles are then registered at proper 3D positions [102]. The 3D electromagnetic response is simulated [106] assuming the resistivity structure is given by the initial resistivity model. The measured electromagnetic field data volume is scaled by the simulated results [108] and the ratios are registered at proper 3D positions [110] producing a ratio data volume [112]. A 3D resistivity volume is then generated by multiplying the initial resistivity volume by the ratio data volume (or some function of it), location-by location [114]. A related method emphasizes deeper resistive anomalies over masking effects of shallow anomalies.

Abstract: Systems and methods which provide electromagnetic subsurface mapping to derive information with respect to subsurface features whose sizes are near to or below the resolution of electromagnetic data characterizing the subsurface are shown. Embodiments operate to identify a region of interest (203) in a resistivity image generated (202) using electromagnetic data (201). One or more scenarios may be identified for the areas of interest, wherein the various scenarios comprise representations of features whose sizes are near to or below the resolution of the electromagnetic data (204). According to embodiments, the scenarios are evaluated (205), such as using forward or inverse modeling, to determine each scenarios' fit to the available data and further to determine their geologic reasonableness (206). Resulting scenarios may be utilized in a number of ways, such as to be substituted in a resistivity image for a corresponding region of anomalous resistivity for enhancing the resistivity image (207).

Abstract: Method for generating a three-dimensional resistivity data volume for a subsurface region from an initial resistivity model and measured electromagnetic field data from an electromagnetic survey of the region, where the initial resistivity model is preferably obtained by performing multiple ID inversions of the measured data [100]. The resulting resistivity depth profiles are then registered at proper 3D positions [102]. The 3D electromagnetic response is simulated [106] assuming the resistivity structure is given by the initial resistivity model. The measured electromagnetic field data volume is scaled by the simulated results [108] and the ratios are registered at proper 3D positions [110] producing a ratio data volume [112]. A 3D resistivity volume is then generated by multiplying the initial resistivity volume by the ratio data volume (or some function of it), location-by location [114]. A related method emphasizes deeper resistive anomalies over masking effects of shallow anomalies.

Abstract: Disclosed herein are methods for decreasing or attenuating an increase in capillary permeability in the retina in a subject in need of such treatment, comprising administering a composition comprising an amount of a phthalazine derivative or a salt thereof to a subject suffering from excessive or pathological capillary permeability in the retina, the amount of phthalazine derivative or salt thereof being effective to decrease the permeability of capillaries in the retina of the subject.

Abstract: A method for designing a controlled-source electromagnetic survey that will discriminate between a defined deep marginal-interest reservoir (2) and specified false positive resistivity structures of concern (3, 4, 5). A reservoir model and a false positive model are constructed for each false positive scenario. The resistivity of the false positive model may be tuned to give electromagnetic data similar enough to the reservoir model when forward modeled that any differences fall in the model null space. A null-space discriminating ratio (“NSDR”) is defined, for example as the peak normalized difference of the two related modeled electromagnetic field data sets. An area coverage display of NSDR values (6) allows determination of such additional data as may be needed to distinguish the false positive body, and a survey design is developed accordingly (7). Reduction of the number of variables affecting the area coverage displays is a key feature of the method.

Abstract: Disclosed are methods for decreasing or attenuating an increase in capillary permeability in the retina in a subject in need of such treatment, comprising administering a composition comprising an amount of a staurosporine derivative or a salt thereof to a subject suffering from excessive or pathological capillary permeability in the retina, the amount of staurosporine derivative or salt thereof being effective to decrease the permeability of capillaries in the retina of the subject.

Abstract: The present invention relates to a refractory shield for protecting a superheater tube against fluid attack comprising first and second partial-tubes (2, 8), each partial-tube having a C-shaped cross section, the C-shaped cross section defining first (3, 9) and second (4, 10) ends; wherein the ends of the partial-tubes are opposably engaged, and wherein the partial-tubes comprise means (5) for preventing radial movement of the first partial-tube relative to the second partial-tube.

Abstract: The present invention relates to a refractory shield for protecting a superheater tube against fluid attack comprising first and second partial-tubes, each partial-tube having a C-shaped cross-section, the C-shaped cross section defining first and second ends; wherein the ends of the partial-tubes are opposably engaged, and wherein the partial-tubes comprise means for preventing radial movement of the first partial-tube relative to the second partial-tube.

Abstract: The present invention relates to a washer fluid heater for operative connection to a coolant line of the engine cooling system of a vehicle, having a housing formed of a material of low to medium thermal conductivity, which together with end walls positioned in sealing relation thereto, at longitudinally opposite ends thereof, form a washer fluid chamber. Each of the end walls has a central opening of circular cross section. A central heating conduit, formed from a material of high thermal conductivity passes through the washer fluid chamber and through each of the central openings and is adapted for connection into the coolant line of a water cooled automobile engine. A first and a second annular grommets, each formed from a resilient material, are in sealing contact with a respective one of the central openings of the respective end walls. Each grommet has an inner opening dimmensioned to sealingly receive the heating conduit in throughpassing relation.

Abstract: The invention is an improved process for the large scale production of acetic acid, (dimethoxyphosphinyl) [[1,1-dimethylethyl)dimethylsilyl]oxy]-, (4-nitrophenyl)methyl ester.

Abstract: A method for producing a transparent polycrystalline magnesia-alumina spinel body having high ultraviolet transmissivity and high strength and hardness characteristics is provided. A closed porosity body is formed from a spinel powder preferably having at least minimum purity characteristics. The closed porosity body can be formed by techniques including hot pressing and pressureless sintering. The closed porosity body is subjected to a hot isostatic pressure treatment to reduce residual porosity. The resulting body has high transmissivity of electro-magnetic radiation in the range between about 0.2 microns and about 6 microns and is resistant to abrasion or erosion, has high strength, and does not substantially deteriorate after exposure to ultraviolet light.

Abstract: A process for the preparation of 2' and 3'-(halo-substituted)-2',3'-dideoxy nucleosides by reacting a protected anhydrothymidine compound with a halogenating composition containing a transition metal or lanthanide compound.

Abstract: An improved process for the preparation of 2' and 3'-(halo-substituted)-2',3'-dideoxy nucleosides by reacting a protected anhydrothymidine compound with a halogenating composition containing a substituted organoaluminum compound which exhibits greater solubility in conventional solvents than AlF.sub.3.

Abstract: Phospocholine derivatives having the formula: ##STR1## in which W, Z, Q and R are described in the specification are disclosed as useful for inhibiting the enzyme phospholipase A.sub.2. Methods of making and using the compounds are also disclosed.