Patents by Inventor Kenneth Hillan

Kenneth Hillan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DIAGNOSIS AND TREATMENT OF HEPATIC DISORDERS
    Publication number: 20070059738
    Abstract: The present invention encompasses methods and compositions useful in diagnosing and treating hepatic disorders, especially those characterized by inflammation. The method comprises administration of an agent which prevents the interaction of MAdCAM with a MAdCAM binding partner or ligand. These compositions are useful in treating diseases or disorders involving ?4?7/MAdCAM blockade, as well as inhibiting a primary event in the inflammatory response such as blocking interactions between intercellular adhesion molecules and their ligands. Disorders treatable using the methods disclosed herein include infections, especially viral infections, iatrogenic disorders, cholestatic disorders, hereditary disorders, sarcoidosis, organ transplant, and the like. The diagnostic methods of the invention can be employed to detect the presence of a disorder or to monitor the course of therapy used to treat the disorder.
    Type: Application
    Filed: July 14, 2006
    Publication date: March 15, 2007
    Applicant: GENENTECH, INC.
    Inventors: Sherman Fong, Kenneth Hillan
  • COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF TUMOR
    Publication number: 20070053835
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Application
    Filed: October 4, 2006
    Publication date: March 8, 2007
    Applicant: Genentech, Inc.
    Inventors: Frederic DeSauvage, Gretchen Frantz, Kenneth Hillan, Paul Polakis, Andrew Polson, Victoria Smith, Susan Spencer, Thomas Wu, Zemin Zhang
  • Compositions and Methods for the Diagnosis and Treatment of Tumor
    Publication number: 20070048218
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Application
    Filed: October 4, 2006
    Publication date: March 1, 2007
    Applicant: Genentech, Inc.
    Inventors: Gretchen Frantz, Kenneth Hillan, Heidi Phillips, Paul Polakis, Susan Spencer, P. Williams, Thomas Wu, Zemin Zhang
  • Compositions and Methods for the Diagnosis and Treatment of Tumor
    Publication number: 20070048326
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Application
    Filed: October 4, 2006
    Publication date: March 1, 2007
    Applicant: Genentech, Inc.
    Inventors: Belinda Cairns, Ruihuan Chen, Gretchen Frantz, Kenneth Hillan, Hartmut Koeppen, Heidi Phillips, Paul Polakis, Susan Spencer, Victoria Smith, P. Williams, Thomas Wu, Zemin Zhang
  • Fibroblast growth factor-19 (FGF-19) nucleic acids and polypeptides and methods of use for the treatment of obesity
    Publication number: 20070042395
    Abstract: The present invention is directed to novel polypeptides belonging to the fibroblast growth factor family and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Furthermore, methods of treating obesity are provided.
    Type: Application
    Filed: January 25, 2006
    Publication date: February 22, 2007
    Applicant: Genentech, Inc.
    Inventors: David Botstein, Audrey Goddard, Austin Gurney, Kenneth Hillan, David Lawrence, Margaret Roy
  • WISP polypeptides and nucleic acids encoding same
    Publication number: 20070041964
    Abstract: Wnt-1-Induced Secreted Proteins (WISPs) are provided, whose genes are induced at least by Wnt-1. Also provided are nucleic acid molecules encoding those polypeptides, as well as vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides, and methods for producing the polypeptides.
    Type: Application
    Filed: July 17, 2006
    Publication date: February 22, 2007
    Inventors: David Botstein, Robert Cohen, Audrey Goddard, Austin Gurney, Kenneth Hillan, David Lawrence, Arnold Levine, Diane Pennica, Margaret Roy, William Wood
  • Interleukin-8 homologous polypeptides and therapeutic uses thereof
    Publication number: 20070025962
    Abstract: The present invention is directed to novel polypeptides having structural homology to IL-8 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treatment and diagnosis of inflammatory diseases.
    Type: Application
    Filed: September 28, 2006
    Publication date: February 1, 2007
    Inventors: Dan Eaton, Dorothy French, J. Grimaldi, Kenneth Hillan, Maria Pisabarro, Kerstin Schmidt, Victoria Smith, Daniel Tumas, Richard Vandlen, Colin Watanabe, P. Williams, William Wood
  • IL-17 homologous polypeptides and therapeutic uses thereof
    Publication number: 20070020735
    Abstract: The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
    Type: Application
    Filed: September 29, 2006
    Publication date: January 25, 2007
    Inventors: Jian Chen, Ellen Filvaroff, Sherman Fong, Dorothy French, Audrey Goddard, Paul Godowski, J. Grimaldi, Austin Gumey, Kenneth Hillan, Sarah Hymowitz, Hanzhong Li, James Pan, Melissa Starovasnik, Daniel Tumas, Menno Lookeren, Richard Vandlen, Colin Watanabe, P. Williams, William Wood, Daniel Yansura
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20060275864
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: October 20, 2004
    Publication date: December 7, 2006
    Applicant: GENENTECH, INC.
    Inventors: Avi Ashkenazi, David Botstein, Luc Desnoyers, Dan Eaton, Napoleone Ferrara, Ellen Filvaroff, Sherman Fong, Wei-Qiang Gao, Hanspeter Gerber, Mary Gerritsen, Audrey Goddard, Paul Godowski, Christopher Grimaldi, Austin Gurney, Kenneth Hillan, Ivar Kljavin, Jennie Mather, James Pan, Nicholas Paoni, Margaret Roy, Timothy Stewart, Daniel Tumas, P. Williams, William Wood
  • Interleukin-8 homologous polypeptides and therapeutic uses thereof
    Publication number: 20060210991
    Abstract: The present invention is directed to novel polypeptides having structural homology to IL-8 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treatment and diagnosis of inflammatory diseases.
    Type: Application
    Filed: March 9, 2004
    Publication date: September 21, 2006
    Inventors: Dan Eaton, Dorothy French, J. Grimaldi, Kenneth Hillan, Maria Pisabarro, Kerstin Schmidt, Victoria Smith, Daniel Tumas, Richard Vandlen, Colin Watanabe, P. Williams, William Wood
  • Compositions and methods for the diagnosis and treatment of tumor
    Publication number: 20060160997
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Application
    Filed: October 11, 2005
    Publication date: July 20, 2006
    Applicant: Genentech, Inc.
    Inventors: Belinda Cairns, Ruihuan Chen, Gretchen Frantz, Kenneth Hillan, Hartmut Koeppen, Heidi Phillips, Paul Polakis, Susan Spencer, Victoria Smith, P. Williams, Thomas Wu, Zemin Zhang
  • Compositions and methods for the diagnosis and treatment of tumor
    Publication number: 20060147374
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Application
    Filed: January 18, 2006
    Publication date: July 6, 2006
    Applicant: Genentech, Inc.
    Inventors: Gretchen Frantz, Kenneth Hillan, Paul Polakis, Beni Wolf, Thomas Wu, Zemin Zhang
  • Compositions and methods for the diagnosis and treatment of tumor
    Publication number: 20060147373
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Application
    Filed: September 13, 2005
    Publication date: July 6, 2006
    Inventors: Belinda Cairns, Ruihuan Chen, Gretchen Frantz, Kenneth Hillan, Hartmut Koeppen, Heidi Phillips, Paul Polakis, Susan Spencer, Victoria Smith, P. Williams, Thomas Wu, Zemin Zhang
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20060148076
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: February 13, 2006
    Publication date: July 6, 2006
    Inventors: David Botstein, Audrey Goddard, Austin Gurney, Paul Godowski, Kenneth Hillan, Margaret Roy, William Wood
  • Compositions and methods for the diagnosis and treatment of tumor
    Publication number: 20060140961
    Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
    Type: Application
    Filed: January 23, 2006
    Publication date: June 29, 2006
    Applicant: Genentech, Inc.
    Inventors: Gretchen Frantz, Kenneth Hillan, Paul Polakis, Beni Wolf, Thomas Wu, Zemin Zhang
  • IL-17 homologous polypeptides and therapeutic uses thereof
    Publication number: 20060134755
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: December 20, 2005
    Publication date: June 22, 2006
    Inventors: Jian Chen, Ellen Filvaroff, Sherman Fong, Audrey Goddard, Paul Godowski, Christopher Grimaldi, Austin Gurney, Hanzhong Li, Kenneth Hillan, Daniel Tumas, Menno VanLookeren, Richard Vandlen, Colin Watanabe, P. Williams, William Wood, Daniel Yansura
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20060127983
    Abstract: The present invention is directed to secreted and transmembrane polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: December 6, 2005
    Publication date: June 15, 2006
    Inventors: Kevin Baker, David Botstein, Dan Eaton, Napoleone Ferrara, Ellen Filvaroff, Mary Gerritsen, Audrey Goddard, Paul Godowski, J. Grimaldi, Austin Gurney, Kenneth Hillan, Ivar Kljavin, Mary Napier, Margaret Roy, Daniel Tumas, William Wood
  • Secreted and transmembrane polypeptides and nucleic acids encoding the same
    Publication number: 20060105427
    Abstract: The present invention is directed to secreted and transmembrane polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: December 6, 2005
    Publication date: May 18, 2006
    Inventors: Kevin Baker, David Botstein, Dan Eaton, Napoleone Ferrara, Ellen Filvaroff, Mary Gerritsen, Audrey Goddard, Paul Godowski, J. Grimaldi, Austin Gurney, Kenneth Hillan, Ivar Kljavin, Mary Napier, Margaret Roy, Daniel Tumas, William Wood
  • IL-17 homologous polypeptides and therapeutic uses thereof
    Publication number: 20060088917
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: December 20, 2005
    Publication date: April 27, 2006
    Inventors: Jian Chen, Ellen Filvaroff, Sherman Fong, Audrey Goddard, Paul Godowski, Christopher Grimaldi, Austin Gurney, Hanzhong Li, Kenneth Hillan, Daniel Tumas, Menno VanLookeren, Richard Vandlen, Colin Watanabe, P. Williams, William Wood, Daniel Yansura
  • IL-17 homologous polypeptides and therapeutic uses thereof
    Publication number: 20060088916
    Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
    Type: Application
    Filed: December 20, 2005
    Publication date: April 27, 2006
    Inventors: Jian Chen, Ellen Filvaroff, Sherman Fong, Audrey Goddard, Paul Godowski, Christopher Grimaldi, Austin Gurney, Hanzhong Li, Kenneth Hillan, Daniel Tumas, Menno VanLookeren, Richard Vandlen, Colin Watanabe, P. Williams, William Wood, Daniel Yansura