Abstract: The invention provides pyrazolylsulfonamide compounds, pharmaceutical compositions, their use for inhibiting mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), and their use in the treatment of a disease or condition, such as a proliferative disorder, inflammatory disorder, or autoimmune disorder.

Abstract: The invention provides pyridinylsulfonamide compounds, pharmaceutical compositions, their use for inhibiting mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), and their use in the treatment of a disease or condition, such as a proliferative disorder, inflammatory disorder, or autoimmune disorder.

Abstract: A method of modifying a time to collision threshold includes receiving data and images of an object from image capturing devices and non-visual sensors within an automobile, from infrastructure cameras, and from image capturing devices within other automobiles, determining ambient light levels and color of the object, comparing ambient light levels to a pre-determined ambient light level threshold, determining a standard time to collision threshold, and sending the standard time to collision threshold to the collision avoidance system when ambient light levels are at least the pre-determined ambient light level, and, determining a standard time to collision threshold, a lighting coefficient, a color coefficient, applying the lighting and color coefficients to the standard time to collision threshold, calculating a modified time to collision threshold, sending the modified time to collision threshold to the collision avoidance system, when the ambient light levels are less than the pre-determined ambient light

Abstract: A system for dynamically calculating collision avoidance metric thresholds for a vehicle includes a vehicle sensor, a passenger position tracking device, and a controller. The controller is in electrical communication with the vehicle sensor and the passenger position tracking device. The controller is programmed to determine a collision avoidance metric using the vehicle sensor, determine an offset to a collision avoidance metric threshold using the passenger position tracking device, and adjust the collision avoidance metric threshold based on the offset. The controller is also programed to compare the collision avoidance metric to the collision avoidance metric threshold and perform an action in response to determining that the collision avoidance metric is less than or equal to the collision avoidance metric threshold.

Abstract: A system for detecting and mitigating window condensation for a vehicle includes an interior camera and a heating, ventilation, and air conditioning (HVAC) system. The system also includes a controller in electrical communication with the interior camera and the HVAC system. The controller is programmed to determine an opacity of a first window of the vehicle using the interior camera, compare the opacity of the first window to an opacity threshold, and adjust the HVAC system to decrease the opacity of the first window of the vehicle in response to determining that the opacity of the first window is greater than or equal to the opacity threshold.

Abstract: The present disclosure is directed to an electric vehicle cordset and system for identifying faults in an electric vehicle cordset. The electric vehicle cordset and system include a cordset controller. The cordset controller includes a cordset processor, a plurality of fault detection circuits connected to the cordset processor, and a first status light connected to the cordset processor. The cordset processor is configured to execute a set of instructions including identify a fault in one of the fault detection circuits, terminate power in the cordset, turn on the first status light indicating the fault is present, and encode the fault in the first status light through modulating the first status light.

Abstract: The present invention relates methods of treating cytokine storm syndrome comprising administering to a patient in need thereof a therapeutically effective amount of an adenosine A2A receptor agonist.

Abstract: Composite laminates fabricated from one or more respective laminae of composite material (e.g., fiber-reinforced polymers) may be pre-formed and fully cured, yet configured to be selectively conformable to a desired radius of curvature. To repair a damaged composite structure, a plurality of such composite laminates may be bonded together to form a repair part that may be bolted to or otherwise secured to the damaged composite structure, thereby repairing the structure using repair parts that may match the parent material of the damaged composite structure. Methods of forming said repair parts from a plurality of such composite laminates may provide advantages in costs and lead time, over conventional techniques. Kits may include a plurality of such pre-formed and cured composite laminates that may be stacked and combined together in a plurality of different arrangements to create a customizable repair part for a given damaged composite structure.

Abstract: Composite laminates fabricated from one or more respective laminae of composite material (e.g., fiber-reinforced polymers) may be pre-formed and fully cured, yet configured to be selectively conformable to a desired radius of curvature. To repair a damaged composite structure, a plurality of such composite laminates may be bonded together to form a repair part that may be bolted to or otherwise secured to the damaged composite structure, thereby repairing the structure using repair parts that may match the parent material of the damaged composite structure. Methods of forming said repair parts from a plurality of such composite laminates may provide advantages in costs and lead time, over conventional techniques. Kits may include a plurality of such pre-formed and cured composite laminates that may be stacked and combined together in a plurality of different arrangements to create a customizable repair part for a given damaged composite structure.

Abstract: The present invention relates to variant antibodies and methods of generating said antibodies with a reduced level of binding to process impurities. In particular, the invention describes variant IgG4 antibodies which have been modified in the heavy chain constant region at any one or a combination of amino acids in the region between Kabat residues 203 and 256, wherein the variant IgG4 antibody has a reduced level of binding to host cell protein (HCP), compared to an unmodified IgG4 antibody. The invention also relates to compositions comprising said variant IgG4 antibodies.

Abstract: The present invention relates to a recombinant signal sequence derived from E. coli. The invention also relates to a fusion protein comprising the signal sequence, a recombinant protein and methods of producing the recombinant protein. The recombinant signal sequence can be used to provide a method for controlling the viscosity of the fermentation, and/or controlling basal (pre-induction) expression of the recombinant protein.

Abstract: A containment case assembly, including a tray and closing lid, comprises an upper frame that is configured to support from one to a plurality of removable screw decks is described. The screw decks have a column of first openings into which removable silicon plugs or inserts are positioned. The removable inserts include indicia or labels that indicate to a user the size of a surgical screw that is positioned in a row of second openings that are aligned in the screw deck immediately adjacent to one of the first openings. The upper frame of the containment case also has an inlet provided with a series of adjacent indicia or labels that are spaced at regular millimeter intervals for use in verifying the length of a surgical screw. The upper frame is further provided with a series of regularly spaced openings that have progressively larger sizes. These openings enable a user to verify the diameter of a surgical screw.

Abstract: The present invention relates to variant antibodies and methods of generating said antibodies with a reduced level of binding to process impurities. In particular, the invention describes variant IgG4 antibodies which have been modified in the heavy chain constant region at any one or a combination of amino acids in the region between Kabat residues 203 and 256, wherein the variant IgG4 antibody has a reduced level of binding to host cell protein (HCP), compared to an unmodified IgG4 antibody. The invention also relates to compositions comprising said variant IgG4 antibodies.

Abstract: The present invention relates to a recombinant signal sequence derived from E. coli. The invention also relates to a fusion protein comprising the signal sequence, a recombinant protein and methods of producing the recombinant protein. The recombinant signal sequence can be used to provide a method for controlling the viscosity of the fermentation, and/or controlling basal (pre-induction) expression of the recombinant protein.

Abstract: Composite laminates fabricated from one or more respective laminae of composite material (e.g., fiber-reinforced polymers) may be pre-formed and fully cured, yet configured to be selectively conformable to a desired radius of curvature. To repair a damaged composite structure, a plurality of such composite laminates may be bonded together to form a repair part that may be bolted to or otherwise secured to the damaged composite structure, thereby repairing the structure using repair parts that may match the parent material of the damaged composite structure. Methods of forming said repair parts from a plurality of such composite laminates may provide advantages in costs and lead time, over conventional techniques. Kits may include a plurality of such pre-formed and cured composite laminates that may be stacked and combined together in a plurality of different arrangements to create a customizable repair part for a given damaged composite structure.

Abstract: A containment case assembly, including a tray and closing lid, comprises an upper frame that is configured to support from one to a plurality of removable screw decks is described. The screw decks have a column of first openings into which removable silicon plugs or inserts are positioned. The removable inserts include indicia or labels that indicate to a user the size of a surgical screw that is positioned in a row of second openings that are aligned in the screw deck immediately adjacent to one of the first openings. The upper frame of the containment case also has an inlet provided with a series of adjacent indicia or labels that are spaced at regular millimeter intervals for use in verifying the length of a surgical screw. The upper frame is further provided with a series of regularly spaced openings that have progressively larger sizes. These openings enable a user to verify the diameter of a surgical screw.

Abstract: A portable lighting system including a ring shaped body having a top surface, a bottom surface, an outside wall and an inside wall, the ring shaped body defining a body perimeter, a rim secured to the body and extending away from the outside wall, a plurality of lights secured about the body perimeter, and a power source operatively connected to the plurality of lights. The power source may be a battery or other power source and can power the lights in addition to a controller, camera, transceiver, or sensor. One or more of the lights may be flexibly secured to the body and the body may be secured in place through a variety of ways. A safety ring and/or accessory bracket may be secured atop the portable lighting system.

Abstract: The motorcycle transparent globe toy device provides a transparent globe within which at least one model motorcycle with rider is magnetically attracted to an interior surface via a plurality of ferrous particles. A remote controller for each motorcycle with rider dictates a speed of each. A plurality of arrangements of ferrous particles in the interior surface provides any number of patterns of a track system within the globe.

Abstract: A method of providing high integrity communication in a high integrity processing system having at least two redundant application processors in a non-lockstep configuration where the redundant application processors are running the same application and where the redundant application processors are connected to at least one input/output processor by a communication channel.