Patents by Inventor Kenneth S. Rehder

Kenneth S. Rehder has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heterocyclic apelin receptor (APJ) agonists and uses thereof
    Patent number: 11926612
    Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) with heterocyclic cores and uses of such agonists.
    Type: Grant
    Filed: October 11, 2017
    Date of Patent: March 12, 2024
    Assignee: RESEARCH TRIANGLE INSTITUTE
    Inventors: Scott P. Runyon, Rangan Maitra, Sanju Narayanan, Kenneth S. Rehder
  • Apelin receptor (APJ) agonists and uses thereof
    Patent number: 11535630
    Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
    Type: Grant
    Filed: October 28, 2020
    Date of Patent: December 27, 2022
    Assignee: RESEARCH TRIANGLE INSTITUTE
    Inventors: Scott P. Runyon, Rangan Maitra, Sanju Narayanan, James Barnwell Thomas, Kenneth S. Rehder, Srinivas Olepu
  • METHODS AND USES FOR APELIN RECEPTOR AGONISTS
    Publication number: 20220280483
    Abstract: The present disclosure provides a method for treating idiopathic pulmonary fibrosis in a patient in need thereof comprising administering a therapeutically effective amount of an apelin receptor agonist.
    Type: Application
    Filed: August 28, 2020
    Publication date: September 8, 2022
    Inventors: Rangan MAITRA, Sanju NARAYANAN, Kenneth S. REHDER, Scott P. RUNYON
  • Apelin receptor (APJ) agonists and uses thereof
    Patent number: 10954247
    Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
    Type: Grant
    Filed: May 18, 2018
    Date of Patent: March 23, 2021
    Assignee: Research Triangle Institute
    Inventors: Scott P. Runyon, Rangan Maitra, Sanju Narayanan, James Barnwell Thomas, Kenneth S. Rehder, Srinivas Olepu
  • APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF
    Publication number: 20210070767
    Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
    Type: Application
    Filed: October 28, 2020
    Publication date: March 11, 2021
    Inventors: Scott P. RUNYON, Rangan MAITRA, Sanju NARAYANAN, James Barnwell THOMAS, Kenneth S. REHDER, Srinivas OLEPU
  • HETEROCYCLIC APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF
    Publication number: 20190322644
    Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) with heterocyclic cores and uses of such agonists.
    Type: Application
    Filed: October 11, 2017
    Publication date: October 24, 2019
    Inventors: Scott P. RUNYON, Rangan MAITRA, Sanju NARAYANAN, Kenneth S. REHDER
  • Apelin receptor (APJ) agonists and uses thereof
    Patent number: 10100059
    Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: October 16, 2018
    Assignee: Research Triangle Institute
    Inventors: Scott P. Runyon, Rangan Maitra, Sanju Narayanan, James Barnwell Thomas, Kenneth S. Rehder, Srinivas Olepu
  • APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF
    Publication number: 20180265518
    Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
    Type: Application
    Filed: May 18, 2018
    Publication date: September 20, 2018
    Inventors: Scott P. RUNYON, Rangan MAITRA, Sanju NARAYANAN, James Barnwell THOMAS, Kenneth S. REHDER, Srinivas OLEPU
  • APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF
    Publication number: 20170166577
    Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
    Type: Application
    Filed: December 9, 2016
    Publication date: June 15, 2017
    Inventors: Scott P. Runyon, Rangan Maitra, Sanju Narayanan, James Barnwell Thomas, Kenneth S. Rehder, Srinivas Olepu
  • Prenylation inhibitors and methods of their synthesis and use
    Patent number: 7501446
    Abstract: The present invention is directed to compounds useful in the treatment of diseases associated with prenylation of proteins and pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising same, and to methods for inhibiting protein prenylation in an organism using the same.
    Type: Grant
    Filed: January 1, 2007
    Date of Patent: March 10, 2009
    Assignee: PPD Discovery, Inc.
    Inventors: Francine Feirong Li, Kenneth S. Rehder, Michael Gordon Campbell, Celeste Patrice Viscardi, Jon-Paul Strachan, Zhengming Guo
  • Prenylation inhibitors and methods of their synthesis and use
    Patent number: 7501444
    Abstract: The present invention is directed to compounds useful in the treatment of diseases associated with prenylation of proteins and pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising same, and to methods for inhibiting protein prenylation in an organism using the same.
    Type: Grant
    Filed: July 14, 2006
    Date of Patent: March 10, 2009
    Assignee: PPD Discovery, Inc.
    Inventors: Bradley B. Brown, Kenneth S. Rehder
  • Prenylation inhibitors and methods of their synthesis and use
    Patent number: 7166619
    Abstract: The present invention is directed to compounds useful in the treatment of diseases associated with prenylation of proteins and pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising same, and to methods for inhibiting protein prenylation in an organism using the same.
    Type: Grant
    Filed: August 6, 2003
    Date of Patent: January 23, 2007
    Assignee: PPD Discovery , Inc.
    Inventors: Francine Feirong Li, Kenneth S. Rehder, Michael Gordon Campbell, Celeste Patrice Viscardi, Jon-Paul Strachan, Zhengming Guo
  • Prenylation inhibitors and methods of their synthesis and use
    Patent number: 7112596
    Abstract: The present invention is directed to compounds useful in the treatment of diseases associated with prenylation of proteins and pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising same, and to methods for inhibiting protein prenylation in an organism using the same.
    Type: Grant
    Filed: September 27, 2005
    Date of Patent: September 26, 2006
    Assignee: PPD Discovery, Inc.
    Inventors: Bradley B. Brown, Kenneth S. Rehder
  • Substituted heterocyclic compounds
    Patent number: 7056924
    Abstract: Disclosed are novel heterocyclic derivatives, useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction. The compounds are also useful in the treatment of diabetes, and for increasing HDL plasma levels in mammals.
    Type: Grant
    Filed: January 16, 2004
    Date of Patent: June 6, 2006
    Assignee: CV Therapeutics, Inc.
    Inventors: Prabha Ibrahim, Kevin Shenk, Elfatih Elzein, Venkata Palle, Jeff Zablocki, Kenneth S. Rehder
  • Substituted heterocyclic compounds
    Patent number: 7001909
    Abstract: Disclosed are novel heterocyclic derivatives, useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction. The compounds are also useful in the treatment of diabetes, and for increasing HDL plasma levels in mammals.
    Type: Grant
    Filed: January 17, 2003
    Date of Patent: February 21, 2006
    Assignee: CV Therapeutics, Inc.
    Inventors: Prabha Ibrahim, Kevin Shenk, Elfatih Elzein, Venkata Palle, Jeff Zablocki, Kenneth S. Rehder
  • Prenylation inhibitors and methods of their synthesis and use
    Patent number: 6960603
    Abstract: The present invention is directed to compounds useful in the treatment of diseases associated with prenylation of proteins and pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising same, and to methods for inhibiting protein prenylation in an organism using the same.
    Type: Grant
    Filed: August 22, 2003
    Date of Patent: November 1, 2005
    Assignee: PPD Discovery, Inc.
    Inventors: Bradley B. Brown, Kenneth S. Rehder
  • Substituted heterocyclic compounds
    Patent number: 6930111
    Abstract: Disclosed are novel heterocyclic derivatives, useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction. The compounds are also useful in the treatment of diabetes, and for increasing HDL plasma levels in mammals.
    Type: Grant
    Filed: July 18, 2002
    Date of Patent: August 16, 2005
    Assignee: CV Therapeutics, Inc.
    Inventors: Prabha Ibrahim, Kevin Shenk, Elfatih Elzein, Venkata Palle, Jeff Zablocki, Kenneth S. Rehder
  • Substituted heterocyclic compounds
    Publication number: 20040176383
    Abstract: Disclosed are novel heterocyclic derivatives, useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction. The compounds are also useful in the treatment of diabetes, and for increasing HDL plasma levels in mammals.
    Type: Application
    Filed: January 16, 2004
    Publication date: September 9, 2004
    Inventors: Prabha Ibrahim, Kevin Shenk, Elfatih Elzein, Venkata Palle, Jeff Zablocki, Kenneth S. Rehder
  • Prenylation inhibitors and methods of their synthesis and use
    Publication number: 20040116425
    Abstract: The present invention is directed to compounds useful in the treatment of diseases associated with prenylation of proteins and pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising same, and to methods for inhibiting protein prenylation in an organism using the same.
    Type: Application
    Filed: August 6, 2003
    Publication date: June 17, 2004
    Inventors: Francine Feirong Li, Kenneth S. Rehder, Michael Gordon Campbell, Celeste Patrice Viscardi, Jon-Paul Strachan, Zhengming Guo
  • Apelin receptor (APJ) agonists and uses thereof
    Patent number: RE49594
    Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
    Type: Grant
    Filed: May 4, 2020
    Date of Patent: August 1, 2023
    Assignee: RESEARCH TRIANGLE INSTITUTE
    Inventors: Scott P. Runyon, Rangan Maitra, Sanju Narayanan, James Barnwell Thomas, Kenneth S. Rehder, Srinivas Olepu