Abstract: An ultrasound phased array integrated in flexible CMOS technology is provided. The CMOS IC chip is fabricated through various chip-thinning techniques, resulting in mechanical flexibility, robustness, and minimized mechanical loading for the piezoelectric transducers. The ultrasound phased array CMOS patch can allow for the generation of high intensity focal regions for maximum penetration in regions of interest.

Abstract: An exemplary system and method can be provided, e.g., for detecting a molecular size and charge. The exemplary system can comprise a cavity, nanopores separated by the cavity, and electrolyte reservoirs. Each of the reservoirs can be provided on a side of a respective nanopore, and within the cavity. A plurality of such systems can be integrated in a surface of a complementary metal-oxide-semiconductor (CMOS) integrated circuit, which can comprise transimpedance amplifiers configured to measure a conductance through the nanopores. Further an exemplary device can be provided for protein sequencing, and can comprise a first compartment with a first electrode, a second compartment with a second electrode, and a channel between the first and second compartments. Each of the compartments can be fluidly coupled to the channel using a nanopore.

Abstract: A fully implanted integrated, wireless, flexible CMOS chip for long-term recording and stimulation of the brain in vivo and methods of manufacturing thereof are provided. The chip is an entire biocompatible system and can include the dense surface electrode array, the underlying CMOS integrated circuit architecture, integrated wireless powering and telemetry. Furthermore, miniaturization through manufacturing, permits implantation of the chip under the skull and other regions of interest with no wires or connections. Furthermore, these devices and systems can operate under a dual modality such as to be able to record and stimulate the surface of the brain and/or tissue in which they have been implanted.

Abstract: The present disclosure provides devices, systems, and methods for detection of nucleic acids based on CRISPR-Cas editing systems, for example for use in biosurveillance. Disclosed herein are systems and methods utilizing two devices: 1) a point of—need disposable “FET Strip” (enzymatic), and 2) an instrument-operated “FET Multiplexor” (electronic), to provide detection of a nucleic acid for biosurveillance.

Abstract: Systems and methods for performing non-destructive sensing of a cell or tissue, in vivo or in culture, are provided. The disclosed systems and methods include fabricating and powering one or more implantable integrated circuit (IC) chips that include a network of Photovoltaic (PV) cells for energy harvesting from an optical energy source, an optical modulator integrating Quantum Dot capacitors (QD-caps) for optical data transfer using fluorescence modulation, and sensing circuitry. The IC chip disclosed herein can measure a thickness of around 10 ?m, allowing injection into small cells and diffusion through tissue, it is powered and imaged under a microscope and communicates using fluorescence modulation imaged under a microscope.

Abstract: Systems and methods for performing non-destructive sensing of a cell or tissue, in vivo or in culture, are provided. The disclosed systems and methods include fabricating and powering one or more implantable integrated circuit (IC) chips that include a network of Photovoltaic (PV) cells for energy harvesting from an optical energy source, an optical modulator integrating Quantum Dot capacitors (QD-caps) for optical data transfer using fluorescence modulation, and sensing circuitry. The IC chip disclosed herein can measure a thickness of around 10 ?m, allowing injection into small cells and diffusion through tissue, it is powered and imaged under a microscope and communicates using fluorescence modulation imaged under a microscope.

Abstract: An exemplary ultrasound (US) apparatus, can include, for example, a flexible substrate, a plurality of ultrasound transducers coupled to the flexible substrate, and an integrated circuit(s) (IC(s)) mounted on the substrate to drive and control the transducer array, where the IC(s) can be configured to control an excitation phase of the ultrasound transducers based at least in part on a shape of the flexible substrate. The ultrasound transducers can be an array of bulk piezoelectric transducers. The substrate can be a flexible printed circuit board. The IC(s) can be configured to separately control (i) a transmission of ultrasound energy from each of the transducers, (ii) a magnitude, or a (iii) phase, where the IC(s) can be configured to use the phase to focus the transmitted energy compensating for a curvature of the ultrasound apparatus.

Abstract: A fully implanted integrated, wireless, flexible CMOS chip for long-term recording and stimulation of the brain in vivo and methods of manufacturing thereof are provided. The chip is an entire biocompatible system and can include the dense surface electrode array, the underlying CMOS integrated circuit architecture, integrated wireless powering and telemetry. Furthermore, miniaturization through manufacturing, permits implantation of the chip under the skull and other regions of interest with no wires or connections. Furthermore, these devices and systems can operate under a dual modality such as to be able to record and stimulate the surface of the brain and/or tissue in which they have been implanted.

Abstract: Systems and methods for performing non-destructive sensing of a cell or tissue, in vivo or in culture, are provided. The disclosed systems and methods include fabricating and powering one or more implantable integrated circuit (IC) chips that include a network of Photovoltaic (PV) cells for energy harvesting from an optical energy source, an optical modulator integrating Quantum Dot capacitors (QD-caps) for optical data transfer using fluorescence modulation, and sensing circuitry. The IC chip disclosed herein can measure a thickness of around 10 ?m, allowing injection into small cells and diffusion through tissue, it is powered and imaged under a microscope and communicates using fluorescence modulation imaged under a microscope.

Abstract: A method for single-molecule detection is provided and uses a carbon nanotube having a probe entity attached thereto to define a first state of the carbon nanotube. The carbon nanotube is introduced to a target entity to define a second state of the carbon nanotube. The electrical conductance of the carbon nanotube in the first and second states is compared to detect the presence of a biomolecular entity. A system for single-molecule detection including a carbon nanotube is also provided.

Abstract: A method for single-molecule detection is provided and uses a carbon nanotube having a probe entity attached thereto to define a first state of the carbon nanotube. The carbon nanotube is introduced to a target entity to define a second state of the carbon nanotube. The electrical conductance of the carbon nanotube in the first and second states is compared to detect the presence of a biomolecular entity. A system for single-molecule detection including a carbon nanotube is also provided.

Abstract: A method for single-molecule detection is provided and uses a carbon nanotube having a probe entity attached thereto to define a first state of the carbon nanotube. The carbon nanotube is introduced to a target entity to define a second state of the carbon nanotube. The electrical conductance of the carbon nanotube in the first and second states is compared to detect the presence of a biomolecular entity. A system for single-molecule detection including a carbon nanotube is also provided.

Abstract: A shifter assembly for changing gears in a vehicle transmission, including a housing and a shift rod rotatably supported in the housing. The shift rod is selectively movable between a plurality of radial positions. A disc is in rotational communication with the shift rod for concurrent movement between the radial positions. The disc defines a plurality of gates each having respective first and second ends. A plurality of solenoids are disposed in the housing adjacent the disc. Each of the solenoids has a plunger selectively movable between a first position spaced from the disc and a second position disposed within one of the gates. The gates are spaced equally from each other and are radially aligned about a common reference circle. Rotation of the shift rod is selectively limited by at least one of the plungers in the second position engaging at least one of the ends of the gates.

Abstract: Methods of forming and resulting devices are described that include graphene devices on boron nitride. Selected methods of forming and resulting devices include graphene field effect transistors (GFETs) including boron nitride.

Abstract: A method for single-molecule detection is provided and uses a carbon nanotube having a probe entity attached thereto to define a first state of the carbon nanotube. The carbon nanotube is introduced to a target entity to define a second state of the carbon nanotube. The electrical conductance of the carbon nanotube in the first and second states is compared to detect the presence of a biomolecular entity. A system for single-molecule detection including a carbon nanotube is also provided.

Abstract: A shifter assembly for changing gears in a vehicle transmission, including a housing and a shift rod rotatably supported in the housing. The shift rod is selectively movable between a plurality of radial positions. A disc is in rotational communication with the shift rod for concurrent movement between the radial positions. The disc defines a plurality of gates each having respective first and second ends. A plurality of solenoids are disposed in the housing adjacent the disc. Each of the solenoids has a plunger selectively movable between a first position spaced from the disc and a second position disposed within one of the gates. The gates are spaced equally from each other and are radially aligned about a common reference circle. Rotation of the shift rod is selectively limited by at least one of the plungers in the second position engaging at least one of the ends of the gates.

Abstract: Methods of forming and resulting devices are described that include graphene devices on boron nitride. Selected methods of forming and resulting devices include graphene field effect transistors (GFETs) including boron nitride.

Abstract: An apparatus and method for detecting functional cellular activity within a volume of a tissue. The method includes inserting a three-dimensional array of optical emitters and optical detectors into a volume of a tissue, where the tissue volume includes one or more cells labeled with an optical reporter of cellular activity; illuminating the one or more cells with photons from the optical emitters of the three-dimensional array to generate optical signals from the optical reporter that labels the one or more cells; and detecting the optical signals using the optical detectors of the three-dimensional array, where the illumination includes one-photon excitation of the optical reporter.

Abstract: Methods of forming and resulting devices are described that include graphene devices on boron nitride. Selected methods of forming and resulting devices include graphene field effect transistors (GFETs) including boron nitride.

Abstract: An apparatus comprises a thin-film bulk acoustic resonator such as including an acoustic mirror, a piezoelectric region acoustically coupled to the acoustic mirror, and first and second conductors electrically coupled to the piezoelectric region. In an example, an integrated circuit substrate can include an interface circuit connected to the first and second conductors of the resonator, the integrated circuit substrate configured to mechanically support the resonator. An example can include an array of such resonators co-integrated with the interface circuit and configured to detect a mass change associated with one or more of a specified protein binding, a specified antibody-antigen coupling, a specified hybridization of a DNA oligomer, or an adsorption of specified gas molecules.