Patents by Inventor Kenneth W. Busch
Kenneth W. Busch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8189188Abstract: A new strategy for the quantitative determination of enantiomeric purity that combines guest-host complexation, spectroscopy, and chemometric modeling. Spectral data for samples of known enantiomeric composition is subjected to a type of multivariate regression modeling known as partial least squares (“PLS-1”) regression. The PLS-1 regression produces a mathematical model that can be used to predict the enantiomeric composition of a set of samples of unknown enantiomeric purity. In this strategy, the concentration of the chiral compound does not have to be fixed or known.Type: GrantFiled: October 6, 2006Date of Patent: May 29, 2012Assignee: Baylor UniversityInventors: Kenneth W. Busch, Jemina Rose Ingle, Marianna Busch
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Patent number: 8190551Abstract: A method for classifying textile samples and unknown fabrics into known categories using spectroscopy, chemometric modeling, and soft independent modeling of class analogies (“SIMCA”). The method involves collecting spectral data, preferably diffuse near infrared reflectance data, for a library of known fabric samples, creating a database of principal component analyses for each type of fabric, and using SIMCA to classify an unknown fabric sample according to the database.Type: GrantFiled: October 11, 2006Date of Patent: May 29, 2012Assignee: Baylor UniversityInventors: Kenneth W. Busch, Christopher B. Davis, Marianna Busch
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Patent number: 8026483Abstract: A method for determining sugar concentration using spectropolarimetry and multivariate regression modeling A set of fixed polarizers are used in association with a spectrometer, which enables the measurement of optical rotation as absorbance values over a range of wavelengths. The adverse effects of color within the samples is corrected by measuring a background level of absorbance that is not due to optical rotation and using this as a baseline. A regression model is then developed for predicting sugar concentration in unknown samples. This method is effective even if the sample is colored.Type: GrantFiled: October 11, 2006Date of Patent: September 27, 2011Assignee: Baylor UniversityInventors: Kenneth W. Busch, Carlos Calleja-Amador, Dennis H. Rabbe, Marianna Busch
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Patent number: 7911608Abstract: A new method and strategy for the quantitative determination of enantiomeric purity that combines polarimetry, spectroscopy, and chemometric modeling. Spectral data is collected after a light beam is passed through a first polarimeter, a sample of a chiral compound, and a second polarimeter oriented at a 45 degree angle relative to the first polarimeter. The spectral data for samples of known enantiomeric composition is subjected to a type of multivariate regression modeling known as partial least squares (“PLS-1”) regression. The PLS-1 regression produces a mathematical model that can be used to predict the enantiomeric composition of a set of samples of unknown enantiomeric purity.Type: GrantFiled: September 30, 2005Date of Patent: March 22, 2011Assignee: Baylor UniversityInventors: Kenneth W. Busch, Dennis H. Rabbe
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Publication number: 20110045598Abstract: A strategy, or method, for the quantitative determination of enantiomeric purity that combines lin situ enantiomer diastereomerization', spectroscopy, and chemometric modeling. Spectral data for samples of known enantiomeric composition is subjected to a type of multivariate regression modeling known as partial least squares (“PLS-I”) regression. The PLS-I regression produces a mathematical model that can be used to predict the enantiomeric composition of a set of samples of unknown enantiomeric purity. In this strategy, the guest-host complexation utilizes improved chiral selector molecules, including chiral amines and chiral alcohols such as phenylethylamine and 1,2-propanediol, that form ion pairs or covalent bonds with the chiral analytes.Type: ApplicationFiled: October 17, 2008Publication date: February 24, 2011Inventors: Kenneth W. Busch, Selorm Modzabi, Marianna Busch
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Publication number: 20100045969Abstract: A new strategy for the quantitative determination of enantiomeric purity that combines guest-host complexation, spectroscopy, and chemometric modeling. Spectral data for samples of known enantiomeric composition is subjected to a type of multivariate regression modeling known as partial least squares (“PLS-1”) regression. The PLS-1 regression produces a mathematical model that can be used to predict the enantiomeric composition of a set of samples of unknown enantiomeric purity. In this strategy, the concentration of the chiral compound does not have to be fixed or known.Type: ApplicationFiled: October 6, 2006Publication date: February 25, 2010Applicant: BAYLOR UNIVERSITYInventors: Kenneth W. Busch, Jemina Rose Ingle, Marianna Busch
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Publication number: 20100036795Abstract: A method for classifying textile samples and unknown fabrics into known categories using spectroscopy, chemometric modeling, and soft independent modeling of class analogies (“SIMCA”). The method involves collecting spectral data, preferably diffuse near infrared reflectance data, for a library of known fabric samples, creating a database of principal component analyses for each type of fabric, and using SIMCA to classify an unknown fabric sample according to the database.Type: ApplicationFiled: October 11, 2006Publication date: February 11, 2010Inventors: Kenneth W. Busch, Christopher B. Davis, Marianna Busch
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Publication number: 20090302207Abstract: A new method and strategy for the quantitative determination of enantiomeric purity that combines polarimetry, spectroscopy, and chemometric modeling. Spectral data is collected after a light beam is passed through a first polarimeter, a sample of a chiral compound, and a second polarimeter oriented at a 45 degree angle relative to the first polarimeter. The spectral data for samples of known enantiomeric composition is subjected to a type of multivariate regression modeling known as partial least squares (“PLS-1”) regression. The PLS-1 regression produces a mathematical model that can be used to predict the enantiomeric composition of a set of samples of unknown enantiomeric purity.Type: ApplicationFiled: September 30, 2005Publication date: December 10, 2009Inventors: Kenneth W. Busch, Dennis H. Rabbe
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Publication number: 20090201491Abstract: A method for determining sugar concentration using spectropolarimetry and multivariate regression modeling A set of fixed polarizers are used in association with a spectrometer, which enables the measurement of optical rotation as absorbance values over a range of wavelengths. The adverse effects of color within the samples is corrected by measuring a background level of absorbance that is not due to optical rotation and using this as a baseline. A regression model is then developed for predicting sugar concentration in unknown samples. This method is effective even if the sample is colored.Type: ApplicationFiled: October 11, 2006Publication date: August 13, 2009Inventors: Kenneth W. Busch, Carlos Calleja-Amador, Denis H. Rabbe, Marianna Busch
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Publication number: 20080204712Abstract: The present invention is a dispersive, diffraction grating, NIR spectrometer that automatically calibrates the wavelength scale of the instrument without the need for external wavelength calibration materials. The invention results from the novel combination of: 1) a low power He—Ne laser at right angles to the source beam of the spectrometer; 2) a folding mirror to redirect the collimated laser beam so that it is parallel to the source beam; 3) the tendency of diffraction gratings to produce overlapping spectra of higher orders; 4) a “polka dot” beam splitter to redirect the majority of the laser beam toward the reference detector; 5) PbS detectors and 6) a software routine written in Lab VIEW that automatically corrects the wavelength scale of the instrument from the positions of the 632.8 nm laser line in the spectrum.Type: ApplicationFiled: April 28, 2008Publication date: August 28, 2008Inventors: Kenneth W. Busch, Dennis H. Rabbe
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Patent number: 7365328Abstract: A dispersive, diffraction grating, NIR spectrometer that automatically calibrates the wavelength scale of the instrument without the need for external wavelength calibration materials is shown. The device shows: 1) a low power He—Ne laser at right angles to the source beam of the spectrometer; 2) a folding mirror to redirect the collimated laser beam so that it is parallel to the source beam; 3) the tendency of diffraction gratings to produce overlapping spectra of higher orders; 4) a “polka dot” beam splitter to redirect the majority of the laser beam toward the reference detector; 5) PbS detectors and 6) a software routine written in Lab VIEW that automatically corrects the wavelength scale of the instrument from the positions of the 632.8 nm laser line in the spectrum.Type: GrantFiled: July 14, 2004Date of Patent: April 29, 2008Inventors: Kenneth W. Busch, Dennis H. Rabbe
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Patent number: 7191070Abstract: A new strategy for the quantitative determination of enantiomeric purity that combines guest-host complexation, spectroscopy, and chemometric modeling. Spectral data for samples of known enantiomeric composition is subjected to a type of multivariate regression modeling known as partial least squares (“PLS-1”) regression. The PLS-1 regression produces a mathematical model that can be used to predict the enantiomeric composition of a set of samples of unknown enantiomeric purity.Type: GrantFiled: December 3, 2004Date of Patent: March 13, 2007Assignee: Baylor UniversityInventors: Kenneth W. Busch, Isabel Maya P. Swamidoss, Sayo Fakayode, Marianna Busch
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Patent number: 6774368Abstract: The present invention is a dispersive, diffraction grating, NIR spectrometer that automatically calibrates the wavelength scale of the instrument without the need for external wavelength calibration materials. The invention results from the novel combination of: 1) a low power He—Ne laser at right angles to the source beam of the spectrometer; 2) a folding mirror to redirect the collimated laser beam so that it is parallel to the source beam; 3) the tendency of diffraction gratings to produce overlapping spectra of higher orders; 4) a “polka dot” beam splitter to redirect the majority of the laser beam toward the reference detector; 5) PbS detectors and 6) a software routine written in Lab VIEW that automatically corrects the wavelength scale of the instrument from the positions of the 632.8 nm laser line in the spectrum.Type: GrantFiled: March 8, 2002Date of Patent: August 10, 2004Assignee: Baylor UniversityInventors: Kenneth W. Busch, Dennis H. Rabbe
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Publication number: 20020175287Abstract: The present invention is a dispersive, diffraction grating, NIR spectrometer that automatically calibrates the wavelength scale of the instrument without the need for external wavelength calibration materials. The invention results from the novel combination of: 1) a low power He—Ne laser at right angles to the source beam of the spectrometer; 2) a folding mirror to redirect the collimated laser beam so that it is parallel to the source beam; 3) the tendency of diffraction gratings to produce overlapping spectra of higher orders; 4) a “polka dot” beam splitter to redirect the majority of the laser beam toward the reference detector; 5) PbS detectors and 6) a software routine written in Lab VIEW that automatically corrects the wavelength scale of the instrument from the positions of the 632.8 nm laser line in the spectrum.Type: ApplicationFiled: March 8, 2002Publication date: November 28, 2002Inventors: Kenneth W. Busch, Dennis H. Rabbe
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Patent number: 5696378Abstract: A method and apparatus for quantitatively determining chlorine content and fractional abundance of chlorine isotopes in unknown samples. When using this method and apparatus to determine chlorine content, isotope dilution principles may be employed. Chlorine isotopes used for diluting an unknown sample may be .sup.35 Cl or .sup.37 Cl, and relative isotope content in the diluted mixture may be measured using infrared spectrometry.Type: GrantFiled: March 20, 1996Date of Patent: December 9, 1997Assignee: Baylor UniversityInventors: Kenneth W. Busch, Arvie J. Kuehn, Marianna A. Busch
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Patent number: 5473162Abstract: Apparatus and method for qualitatively and quantitatively analyzing infrared emission from excited molecules in the determination of, for example, total inorganic carbon, chloride and available chlorine in aqueous samples. Methods of exciting the gas-phase, infrared-active molecules to emit radiation include flame excitation, furnace excitation, excitation by electron impact in a gas discharge or excitation by collisions with a vibrationally excited diatomic molecule. The detector is optimized by use of dual beam system with background subtraction capabilities thereby eliminating background noise and fluctuations therein.Type: GrantFiled: September 20, 1993Date of Patent: December 5, 1995Assignee: Baylor UniversityInventors: Kenneth W. Busch, M. Keith Hudson, Marianna A. Busch, Sidney W. Kubala, Jr., David C. Tilotta, Christopher K. Y. Lam, Ravishankar Srinivasan, Yunke Zhand
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Patent number: 5246868Abstract: Apparatus and method for qualitatively and quantitatively analyzing infrared emission from excited molecules in samples of interest is disclosed. Over the wavelength interval from 1 to 5 um, two strong emission bands are observed with a PbSe detector when organic compounds are introduced into an hydrogen/air flame. The band at 4.3 um (2326 cm.sup.-1 is due to the asymmetric stretch of carbon dioxide while the band at 2.7 um is due to both water and carbon dioxide emission. The carbon dioxide emission at 4.3 um is most intense at the tip of the flame, and increases with the amount of organic compound introduced into the flame. For chromatographic application, an optical filter can be used to isolate the 4.3 um emission band. The infrared emission detection system finds application in the determination of total inorganic carbon, chloride and available chlorine in aqueous samples.Type: GrantFiled: September 29, 1989Date of Patent: September 21, 1993Assignee: Research Corporation Technologies, Inc.Inventors: Kenneth W. Busch, M. Keith Hudson, Marianna A. Busch, Sidney W. Kubala, Jr., David C. Tilotta, Christopher K. Y. Lam, Ravishankar Srinivasan
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Patent number: 4494872Abstract: A dispersive optical spectrometer is disclosed which comprises light detection means, dispersion means for separating light radiation into spectral components and for directing the spectral components toward the light detection means, means for admitting light radiation into the entrance focal plane and for directing the light radiation toward the dispersion means, the light radiation admitting means including a plurality of spaced-apart apertures, and light transmission means for transmitting light radiation from a light source to one or more of the apertures. In a preferred embodiment, the apertures form a two-dimensional, rectilinear array for producing non-overlapping spectra.Type: GrantFiled: March 24, 1982Date of Patent: January 22, 1985Assignee: Baylor UniversityInventor: Kenneth W. Busch
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Patent number: 4375919Abstract: A dispersive optical spectrometer is disclosed which comprises light detection means, dispersion means for separating light radiation into spectral components and for directing the spectral components toward the light detection means, means for admitting light radiation into the entrance focal plane and for directing the light radiation toward the dispersion means, the light radiation admitting means including a plurality of spaced-apart apertures, and light transmission means for transmitting light radiation from a light source to one or more of the apertures.Type: GrantFiled: October 7, 1980Date of Patent: March 8, 1983Assignee: Baylor UniversityInventor: Kenneth W. Busch