Patents by Inventor Kenneth Walsh

Kenneth Walsh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6689807
    Abstract: This invention relates to methods and compositions for the treatment of conditions associated with vascular insufficiency, and to methods and compositions for screening assays to select agents that are useful for this purpose. In particular the invention relates to HMG CoA reductase inhibitors and their use in promoting angiogenesis in vivo and in activating Akt in vascular endothelial cells in vitro and in vivo.
    Type: Grant
    Filed: June 8, 2000
    Date of Patent: February 10, 2004
    Assignee: Caritas St. Elizabeth's Medical Center of Boston, Inc.
    Inventor: Kenneth Walsh
  • Publication number: 20030212266
    Abstract: A novel growth arrest homeobox gene has been discovered and the nucleotide sequences have been determined in both the rat and the human. The expression of the novel homeobox gene inhibits vascular smooth muscle cell growth. The growth arrest homeobox gene hereinafter referred to as the “Gax gene” and its corresponding proteins are useful in the study of vascular smooth muscle cell proliferation and in the treatment of blood vessel diseases that result from excessive smooth muscle cell proliferation, particularly after balloon angioplasty.
    Type: Application
    Filed: June 17, 2003
    Publication date: November 13, 2003
    Inventors: David H. Gorski, Kenneth Walsh
  • Publication number: 20030199067
    Abstract: A novel growth arrest homeobox gene has been discovered and the nucleotide sequences have been determined in both the rat and the human. The expression of the novel homeobox gene inhibits vascular smooth muscle cell growth. The growth arrest homeobox gene hereinafter referred to as the “Gax gene” and its corresponding proteins are useful in the study of vascular smooth muscle cell proliferation and in the treatment of blood vessel diseases that result from excessive smooth muscle cell proliferation, particularly after balloon angioplasty.
    Type: Application
    Filed: August 27, 2001
    Publication date: October 23, 2003
    Inventors: David H. Gorski, Kenneth Walsh
  • Publication number: 20030114382
    Abstract: This invention relates to methods and compositions for modulating endothelial cell viability, endothelial cell migration, and angiogenesis. In particular the invention relates to GSK3 molecules, agents that modify the kinase activity of these molecules, and use of the foregoing in modulating the endothelial cell viability, endothelial cell migration, and angiogenesis.
    Type: Application
    Filed: October 23, 2002
    Publication date: June 19, 2003
    Inventor: Kenneth Walsh
  • Patent number: 6369039
    Abstract: A method of site-specifically delivering a therapeutic agent to a target location within a body cavity, vasculature or tissue. The method comprises the steps of providing a medical device having a substantially saturated solution of therapeutic agent associated therewith; introducing the medical device into the body cavity, vasculature or tissue; releasing a volume of the solution of therapeutic agent from the medical device at the target location at a pressure of from about 0 to about 5 atmospheres for a time of up to about 5 minutes; and withdrawing the medical device from the body cavity, vasculature or tissue. In another aspect, the present invention includes a system for delivering a therapeutic agent to a body cavity, vasculature or tissue, comprising a medical device having a substantially saturated solution of the therapeutic agent associated therewith.
    Type: Grant
    Filed: December 3, 1998
    Date of Patent: April 9, 2002
    Assignee: Scimed Life Sytems, Inc.
    Inventors: Maria Palasis, Kenneth Walsh
  • Patent number: 6280969
    Abstract: A novel growth arrest homeobox gene has been discovered and the nucleotide sequences have been determined in both the rat and the human. The expression of the novel homeobox gene inhibits vascular smooth muscle cell growth. The growth arrest homeobox gene hereinafter referred to as the “Gax gene” and its corresponding proteins are useful in the study of vascular smooth muscle cell proliferation and in the treatment of blood vessel diseases that result from excessive smooth muscle cell proliferation, particularly after balloon angioplasty.
    Type: Grant
    Filed: May 14, 1998
    Date of Patent: August 28, 2001
    Assignee: Case Western Reserve University
    Inventors: David H. Gorski, Kenneth Walsh
  • Patent number: 5990092
    Abstract: Methods and compositions for reducing or preventing the proliferation of vascular smooth muscle cells are provided. The method involves the step of administering an isolated GATA-6 molecule to a subject to prevent or reduce vascular smooth muscle cell proliferation. The isolated GATA-6 molecule can be a GATA-6 nucleic acid or a GATA-6 protein.
    Type: Grant
    Filed: August 27, 1997
    Date of Patent: November 23, 1999
    Assignee: St. Elizabeth's Medical Center
    Inventor: Kenneth Walsh
  • Patent number: 5858990
    Abstract: A method for treating vascular injury, particularly vascular injury resulting from restenosis following angioplasty, and vascular remodeling is provided. The method involves administering to subjects in need of such treatment an effective amount of a Fas ligand molecule.
    Type: Grant
    Filed: March 4, 1997
    Date of Patent: January 12, 1999
    Assignee: St. Elizabeth's Medical Center
    Inventor: Kenneth Walsh
  • Patent number: 5856121
    Abstract: A novel growth arrest homeobox gene has been discovered and the nucleotide sequences have been determined in both the rat and the human. The expression of the novel homeobox gene inhibits vascular smooth muscle cell growth. The growth arrest homeobox gene hereinafter referred to as the "Gax gene" and its corresponding proteins are useful in the study of vascular smooth muscle cell proliferation and in the treatment of blood vessel diseases that result from excessive smooth muscle cell proliferation, particularly after balloon angioplasty.
    Type: Grant
    Filed: February 24, 1994
    Date of Patent: January 5, 1999
    Assignee: Case Western Reserve University
    Inventors: David H. Gorski, Kenneth Walsh
  • Patent number: 5851521
    Abstract: The present invention relates to replication defective recombinant viruses which contain at least one inserted gene encoding all or part of the protein GAX or of a variant of this protein, and to their therapeutic use, in particular for treating post-angioplastic restenosis.
    Type: Grant
    Filed: September 30, 1996
    Date of Patent: December 22, 1998
    Assignee: Case Western Reserve University
    Inventors: Didier Branellec, Kenneth Walsh, Jeffrey M. Isner, Patrice Denefle
  • Patent number: RE37933
    Abstract: The present invention relates to replication defective recombinant viruses which contain at least one inserted gene encoding all or part of the protein GAX or of a variant of this protein, and to their therapeutic use, in particular for treating post-angioplastic restenosis.
    Type: Grant
    Filed: December 21, 2000
    Date of Patent: December 10, 2002
    Assignee: Case Western Reserve University
    Inventors: Didier Branellec, Kenneth Walsh, Jeffrey M. Isner, Patrice Denefle