Abstract: The micromixer with overlapping-crisscross entrance incorporated with the grooved microchannel, is used effectively for mixing two or more fluid streams. The X-shape overlapping-crisscross inlet ports wherein two microfluidic channels contact over a small area, allow the fluid streams flow through and create the tumbling inside the micromixer. Then merging with some patterned grooves on the walls also induces swirling motion. As a result, the folding and stretching effects of the flow are augmented to amplify the fluid mixing of two or more streams of the inlet fluids within a relative short distance in the micromixer. All of the flow streams are actuated with either pressure driven by a syringe pump or capillary electrophoresis. The present invention is applicable for micro total analysis systems and drug delivery systems.

Abstract: The present invention discloses a novel micro valve device, comprising a micro fluidic channel, which is formed by combining two hydrophobic plates, and the micro/nano structure on the wall surfaces of the channel are used to manipulate the mobility of the fluid in the channel. The function of the micro/nano structure mentioned above is to alter the micro or nano surface pattern on the wall surfaces of the channel. According to the relation between the surface pattern and the surface tension, the textured areas on the wall surfaces can change the mobility of the fluid in the channel. This effect is used as a switch in new types of micro valve devices for biomedical tests. Methods of making the micro valve device are described and include generating a micro/nano structure on the surfaces of the channel. The temporal control of different valve resistances can be achieved with different lengths, shapes, depths and materials of the micro/nano structures.

Abstract: A fluidic oscillator includes an oscillator body having two attachment walls defining an oscillating chamber therebetween, an inlet duct communicatively extended from the oscillating chamber for guiding a flow of fluid entering into the oscillating chamber, an outlet duct communicatively extended from the oscillating chamber for guiding the flow of fluid exiting from the oscillating chamber, a flow splitter provided at the outlet duct to communicate with the oscillating chamber, and two feedback channels communicating with the oscillating chamber. Each of the attachment walls has an upstream portion and a downstream portion integrally extended therefrom as a step shouldering manner to form a modulating shoulder for modulating an oscillation of the flow within the oscillation chamber so as to stabilize the flow of the fluid to pass through the oscillator body.

Abstract: A gene gun is described wherein the contour design of the spray nozzle of the gene gun modifies the operation of the gene gun. A low pressure gas is used to accelerate the micro-particles that are coated with nucleic acid of a foreign gene into cytoplasma or nuclei of an animal or plant cell to express the special protein and to generate the new biological function.