Patents by Inventor Kevan M. Shokat

Kevan M. Shokat has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR TREATING PARASITIC DISEASES
    Publication number: 20200291030
    Abstract: Disclosed herein, inter alia, are compositions and methods for treating parasitic diseases.
    Type: Application
    Filed: March 17, 2017
    Publication date: September 17, 2020
    Inventors: Florentine Rutaganira, Kevan M. Shokat, Laurence David Sibley, James W. Janetka
  • COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASES AND CARDIOMYOPATHY
    Publication number: 20200283442
    Abstract: Disclosed herein inter alia are compositions and methods useful in the treatment neurodegenerative diseases and cardiomyopathy, and for modulating the activity of PINK 1.
    Type: Application
    Filed: May 26, 2020
    Publication date: September 10, 2020
    Inventors: Nicholas T. Hertz, Kevan M. Shokat, Robert DeVita
  • COMPOSITIONS AND METHODS FOR TREATING CANCER
    Publication number: 20200255446
    Abstract: K-Ras is the most frequently mutated oncogene in human cancer. Disclosed herein are compositions and methods for modulating K-Ras and treating cancer.
    Type: Application
    Filed: December 19, 2019
    Publication date: August 13, 2020
    Inventors: Jonathan Ostrem, Ulf Peters, Kevan M. Shokat
  • Compositions and methods for treating neurodegenerative diseases and cardiomyopathy
    Patent number: 10723737
    Abstract: Disclosed herein inter alia are compositions and methods useful in the treatment neurodegenerative diseases and cardiomyopathy, and for modulating the activity of PINK1.
    Type: Grant
    Filed: February 21, 2017
    Date of Patent: July 28, 2020
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, MITOKININ LLC
    Inventors: Nicholas T. Hertz, Kevan M. Shokat, Robert DeVita
  • COMPOSITIONS AND METHODS FOR TREATING CANCER
    Publication number: 20200131135
    Abstract: Disclosed herein, inter alia, are compositions and methods for modulating Ras and treating cancer.
    Type: Application
    Filed: December 15, 2017
    Publication date: April 30, 2020
    Inventors: Kevan M. Shokat, Daniel Gentile, Steven Moss
  • USE OF TRANSLATIONAL PROFILING TO IDENTIFY TARGET MOLECULES FOR THERAPEUTIC TREATMENT
    Publication number: 20190136321
    Abstract: The present invention provides methods of identifying an agent or drug candidate molecule, validating a target, and identifying normalizing therapeutics that modulates translation, such as in an oncogenic signaling pathway, in a biological sample as determined by translational profiling of one or more genes in the biological sample. The present invention also provides diagnostic and therapeutic methods using the translational profiling methods described herein.
    Type: Application
    Filed: October 15, 2018
    Publication date: May 9, 2019
    Inventors: Davide Ruggero, Andrew Hsieh, Merritt Edlind, Kevan M. Shokat, James Appleman, Steve Worland
  • ErbB Inhibitors and Uses Thereof
    Publication number: 20190119284
    Abstract: Described herein, inter alia, are compositions of ErbB modulators and methods of using the same.
    Type: Application
    Filed: April 19, 2017
    Publication date: April 25, 2019
    Inventors: Christopher Novotny, Kevan M. Shokat, Weijun Shen
  • COMPOSITIONS AND METHODS FOR TREATING CANCER
    Publication number: 20190119295
    Abstract: K-Ras is the most frequently mutated oncogene in human cancer. Disclosed herein are compositions and methods for modulating K-Ras and treating cancer.
    Type: Application
    Filed: June 20, 2018
    Publication date: April 25, 2019
    Inventors: Jonathan Ostrem, Ulf Peters, Kevan M. Shokat
  • Compositions and methods for treating cancer
    Patent number: 10023588
    Abstract: K-Ras is the most frequently mutated oncogene in human cancer. Disclosed herein are compositions and methods for modulating K-Ras and treating cancer.
    Type: Grant
    Filed: November 6, 2015
    Date of Patent: July 17, 2018
    Assignee: The Regents of the University of California
    Inventors: Jonathan Ostrem, Ulf Peters, Kevan M. Shokat
  • COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASES AND CARDIOMYOPATHY
    Publication number: 20180072731
    Abstract: Disclosed herein inter alia are compositions and methods useful in the treatment neurodegenerative diseases and cardiomyopathy, and for modulating the activity of PINK1.
    Type: Application
    Filed: February 21, 2017
    Publication date: March 15, 2018
    Inventors: Nicholas T. Hertz, Kevan M. Shokat, Robert DeVita
  • Substituted pyrazolo[3,4-D]pyrimidines and uses thereof
    Patent number: 9895373
    Abstract: Presented herein are novel therapeutic compounds and methods of using the same for the treatment of cancers.
    Type: Grant
    Filed: March 23, 2016
    Date of Patent: February 20, 2018
    Assignees: The Regents of the University of California, Icahn School of Medicine at Mount Sinai
    Inventors: Arvin C. Dar, Tirtha K. Das, Martin Sos, Trever G. Bivona, Kevan M. Shokat, Ross L. Cagan
  • MTOR modulators and uses thereof
    Patent number: 9629843
    Abstract: The present invention provides methods and compositions for selective modulation of certain protein kinases, and especially mTor complexes. The methods and compositions are particularly useful in inhibiting mTor selectively for therapeutic applications.
    Type: Grant
    Filed: June 5, 2015
    Date of Patent: April 25, 2017
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, INTELLIKINE, INC.
    Inventors: Kevan M. Shokat, David Fruman, Pingda Ren, Troy Edward Wilson, Liansheng Li, Andrew Hsieh, Morris Feldman, Beth Apsel, Yi Liu, Christian Rommel, Katrina Chan, Davide Ruggero, David Pearce, Matthew Janes
  • COMPOSITIONS AND METHODS FOR TREATING CANCER
    Publication number: 20160368930
    Abstract: K-Ras is the most frequently mutated oncogene in human cancer. Disclosed herein are compositions and methods for modulating K-Ras and treating cancer.
    Type: Application
    Filed: November 6, 2015
    Publication date: December 22, 2016
    Inventors: Jonathan Ostrem, Ulf Peters, Kevan M. Shokat
  • SUBSTITUTED PYRAZOLO[3,4-D]PYRIMIDINES AND USES THEREOF
    Publication number: 20160354377
    Abstract: Presented herein are novel therapeutic compounds and methods of using the same for the treatment of cancers.
    Type: Application
    Filed: March 23, 2016
    Publication date: December 8, 2016
    Inventors: Arvin C. Dar, Tirtha K. Das, Martin Sos, Trever G. Bivona, Kevan M. Shokat, Ross L. Cagan
  • Substituted pyrazolo[3.4-D] pyrimidines as anti-inflammatory agents
    Patent number: 9512125
    Abstract: The present invention provides anti-inflammatory compounds useful in the treatment of diseases and conditions in which inflammation is involved in disease progression or the manifestation of symptoms of the disease or condition.
    Type: Grant
    Filed: November 21, 2005
    Date of Patent: December 6, 2016
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Kevan M. Shokat, Nikolai Sepetov, Chao Zhang, Heinz W. Gschwend, Eric J. Kunkel
  • PI3 kinase antagonists
    Patent number: 9493467
    Abstract: The present invention provides novel PI3-Kinase antagonists having the formula: and methods of use thereof.
    Type: Grant
    Filed: October 18, 2013
    Date of Patent: November 15, 2016
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Zachary A. Knight, Olusegun Williams, Kevan M. Shokat
  • AURORA KINASE INHIBITORS
    Publication number: 20160250211
    Abstract: Disclosed herein inter alia are compositions and methods useful in the treatment of cancer and for modulating the activity of Aurora A kinase and/or a Myc family protein.
    Type: Application
    Filed: November 20, 2015
    Publication date: September 1, 2016
    Inventors: Justin Gabriel Meyerowitz, William Clay Gustafson, William A. Weiss, Nicholas T. Hertz, Kevan M. Shokat
  • Methods and compositions for modulating Ire1, SRC and ABL activity
    Patent number: 9382230
    Abstract: Disclosed herein are, inter alia, compositions for modulating Ire1, Src, or Abl, methods for identifying modulating activity in test compounds, and methods for treating diseases caused by the activity or inactivity of Ire1, Src, or Abl.
    Type: Grant
    Filed: July 2, 2014
    Date of Patent: July 5, 2016
    Assignee: The Regents of the University of California
    Inventors: Peter Walter, Alexei Korennykh, Kevan M. Shokat, Chao Zhang, Janet Finer-Moore, Robert Stroud, Pascal Egea, Andrei Korostelev, Arvin Dar, Sebastian Bernales
  • PYRAZOLO PYRIMIDINE DERIVATIVES AND METHODS OF USE THEREOF
    Publication number: 20160168151
    Abstract: This invention generally relates to pyrazolo pyrimidine derivatives useful as, inter alia, inhibitors of short chain dehydrogenase/reductase (SDR) family of NAD(P)(H) dependent oxido-reductases. More specifically, the invention relates to pyrazolo pyrimidine derivatives, including derivatives and analogs of SDR inhibitors, pharmaceutical compositions containing derivatives and analogs of SDR inhibitors, methods of making derivatives and analogs of SDR inhibitors and methods of use thereof.
    Type: Application
    Filed: September 24, 2015
    Publication date: June 16, 2016
    Inventors: Masahiro Tanaka, Chao Zhang, Kevan M. Shokat, Alma L. Burlingame, Kirk Hansen, Raynard L. Bateman, Stephen G. DiMagno
  • Methods and compositions for kinase inhibition
    Patent number: 9353116
    Abstract: The present invention sets forth a new chemical genetic approach for engineering kinase enzymes with a cysteine gatekeeper residue as well as for developing electrophilic inhibitors thereto. The present invention also provides a Src proto-oncogenic tyrosine kinase with a cysteine gatekeeper that recapitulates wild type activity and can be irreversibly inhibited both in vitro and in cells. The present invention also provides methods and compositions for modulating kinases and for treating kinase-associate diseases.
    Type: Grant
    Filed: November 30, 2012
    Date of Patent: May 31, 2016
    Assignee: The Regents of the University of California
    Inventors: Adam L. Garske, Kevan M. Shokat