Patents by Inventor Kevan M. Shokat

Kevan M. Shokat has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted pyrazolo[3,4-D]pyrimidines and uses thereof
    Patent number: 9321772
    Abstract: Presented herein are novel therapeutic compounds and methods of using the same for the treatment of cancers.
    Type: Grant
    Filed: February 25, 2014
    Date of Patent: April 26, 2016
    Assignees: The Regents of the University of California, Icahn School of Medicine at Mount Sinai
    Inventors: Arvin C. Dar, Tirtha K. Das, Martin Sos, Trever G. Bivona, Kevan M. Shokat, Ross L. Cagan
  • COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASES AND CARDIOMYOPATHY
    Publication number: 20160108044
    Abstract: Disclosed herein inter alia are compositions and methods useful in the treatment neurodegenerative diseases and cardiomyopathy, and for modulating the activity of PINK1.
    Type: Application
    Filed: August 11, 2015
    Publication date: April 21, 2016
    Inventors: Nicholas T. Hertz, Kevan M. Shokat, Robert DeVita
  • MTOR MODULATORS AND USES THEREOF
    Publication number: 20160000789
    Abstract: The present invention provides methods and compositions for selective modulation of certain protein kinases, and especially mTor complexes. The methods and compositions are particularly useful in inhibiting mTor selectively for therapeutic applications.
    Type: Application
    Filed: June 5, 2015
    Publication date: January 7, 2016
    Inventors: Kevan M. Shokat, David Fruman, Pingda Ren, Troy Edward Wilson, Liansheng Li, Andrew Hsieh, Morris Feldman, Beth Apsel, Yi Liu, Christian Rommel, Katrina Chan, Davide Ruggero, David Pearce, Matthew Janes
  • COMPOSITIONS AND METHODS FOR TREATING CANCER
    Publication number: 20150087628
    Abstract: K-Ras is the most frequently mutated oncogene in human cancer. Disclosed herein are compositions and methods for modulating K-Ras and treating cancer.
    Type: Application
    Filed: April 10, 2013
    Publication date: March 26, 2015
    Inventors: Jonathan Ostrem, Ulf Peters, Kevan M. Shokat
  • PYRAZOLO PYRIMIDINE DERIVATIVES AND METHODS OF USE THEREOF
    Publication number: 20150031881
    Abstract: This invention generally relates to pyrazolo pyrimidine derivatives useful as, inter alia, inhibitors of short chain dehydrogenase/reductase (SDR) family of NAD(P)(H) dependent oxido-reductases. More specifically, the invention relates to pyrazolo pyrimidine derivatives, including derivatives and analogs of SDR inhibitors, pharmaceutical compositions containing derivatives and analogs of SDR inhibitors, methods of making derivatives and analogs of SDR inhibitors and methods of use thereof.
    Type: Application
    Filed: February 21, 2014
    Publication date: January 29, 2015
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Masahiro Tanaka, Chao Zhang, Kevan M. Shokat, Alma L. Burlingame, Kirk Hansen, Raynard L. Bateman, Stephen G. DiMagno
  • METHODS AND COMPOSITIONS FOR MODULATING IRE1, SRC, AND ABL ACTIVITY
    Publication number: 20150011575
    Abstract: Disclosed herein are, inter alia, compositions for modulating Ire1, Src, or Abl, methods for identifying modulating activity in test compounds, and methods for treating diseases caused by the activity or inactivity of Ire1, Src, or Abl.
    Type: Application
    Filed: July 2, 2014
    Publication date: January 8, 2015
    Inventors: Peter Walter, Alexei Korennykh, Kevan M. Shokat, Chao Zhang, Janet Finer-Moore, Robert Stroud, Pascal Egea, Andrei Korostelev, Arvin Dar, Sebastian Bernales
  • USE OF TRANSLATIONAL PROFILING TO IDENTIFY TARGET MOLECULES FOR THERAPEUTIC TREATMENT
    Publication number: 20140288097
    Abstract: The present invention provides methods of identifying an agent or drug candidate molecule, validating a target, and identifying normalizing therapeutics that modulates translation, such as in an oncogenic signaling pathway, in a biological sample as determined by translational profiling of one or more genes in the biological sample. The present invention also provides diagnostic and therapeutic methods using the translational profiling methods described herein.
    Type: Application
    Filed: February 7, 2014
    Publication date: September 25, 2014
    Applicant: The Regents of The University of California
    Inventors: Davide Ruggero, Andrew Hsieh, Merritt Edlind, Kevan M. Shokat, James Appleman, Steve Worland
  • P13 KINASE ANTAGONISTS
    Publication number: 20140288096
    Abstract: The present invention provides novel PI3-Kinase antagonists and methods of use thereof.
    Type: Application
    Filed: October 18, 2013
    Publication date: September 25, 2014
    Applicant: The Regents of the University of California
    Inventors: Zachary A. Knight, Olusegun Williams, Kevan M. Shokat
  • SUBSTITUTED PYRAZOLO[3,4-D]PYRIMIDINES AND USES THEREOF
    Publication number: 20140243357
    Abstract: Presented herein are novel therapeutic compounds and methods of using the same for the treatment of cancers.
    Type: Application
    Filed: February 25, 2014
    Publication date: August 28, 2014
    Applicants: Mount Sinai School of Medicine, The Regents of the University of California
    Inventors: Arvin C. Dar, Tirtha K. Das, Martin Sos, Trever G. Bivona, Kevan M. Shokat, Ross L. Cagan
  • Methods and compositions for modulating IRE1, SRC, and ABL activity
    Patent number: 8815885
    Abstract: Disclosed herein are, inter alia, compositions for modulating Ire1, Src, or Abl, methods for identifying modulating activity in test compounds, and methods for treating diseases caused by the activity or inactivity of Ire1, Src, or Abl.
    Type: Grant
    Filed: September 15, 2009
    Date of Patent: August 26, 2014
    Assignee: The Regents of the University of California
    Inventors: Peter Walter, Alexei Korennykh, Kevan M. Shokat, Chao Zhang, Janet Finer-Moore, Robert Stroud, Pascal Egea, Andrei Korostelev, Arvin Dar, Sebastian Bernales
  • Fused ring heteroaryl kinase inhibitors
    Patent number: 8697709
    Abstract: Provided herein are fused ring heteroaryl compounds useful in a variety of methods, including reducing the activity of certain kinases and treating certain disease states.
    Type: Grant
    Filed: October 16, 2009
    Date of Patent: April 15, 2014
    Assignee: The Regents of the University of California
    Inventors: Arvin Dar, Kevan M Shokat
  • Substituted pyrazolo[3,2-d]pyrimidines as anti-cancer agents
    Patent number: 8642604
    Abstract: The present invention provides novel compounds that are antagonists of PI3 kinase, PI3 kinase and tyrosine kinase, PI3 kinase and mTOR, or PI33 kinase, mTOR and tyrosine kinase.
    Type: Grant
    Filed: July 24, 2009
    Date of Patent: February 4, 2014
    Assignee: The Regents of the University of California
    Inventors: Zachary A. Knight, Beth Apsel, Kevan M. Shokat
  • Pyrazolo Pyrimidine Derivatives and Methods of Use Thereof
    Publication number: 20120065154
    Abstract: This invention generally relates to pyrazolo pyrimidine derivatives useful as, inter alia, inhibitors of short chain dehydrogenase/reductase (SDR) family of NAD(P)(H) dependent oxido-reductases. More specifically, the invention relates to pyrazolo pyrimidine derivatives, including derivatives and analogs of SDR inhibitors, pharmaceutical compositions containing derivatives and analogs of SDR inhibitors, methods of making derivatives and analogs of SDR inhibitors and methods of use thereof.
    Type: Application
    Filed: January 28, 2011
    Publication date: March 15, 2012
    Applicant: The Regents of the University of California
    Inventors: Masahiro Tanaka, Chao Zhang, Kevan M. Shokat, Alma L. Burlingame, Kirk Hansen, Raynard L. Bateman, Stephen G. DiMagno
  • Methods and Compositions for Modulating IRE1, SRC, and ABL Activity
    Publication number: 20110319436
    Abstract: Disclosed herein are, inter alia, compositions for modulating Ire1, Src, or Abl, methods for identifying modulating activity in test compounds, and methods for treating diseases caused by the activity or inactivity of Ire1, Src, or Abl.
    Type: Application
    Filed: September 15, 2009
    Publication date: December 29, 2011
    Applicant: The Regents of the University of California
    Inventors: Peter Walter, Alexei Korennykh, Kevan M. Shokat, Chao Zhang, Janet Finer-Moore, Robert Stroud, Pascal Egea, Andrei Korostelev, Arvin Dar, Sebastian Bernales
  • Kinase Antagonists
    Publication number: 20110301144
    Abstract: The present invention provides novel compounds that are antagonists of PI3 kinase, PI3 kinase and tyrosine kinase, PI3 kinase and mTOR, or PI33 kinase, mTOR and tyrosine kinase.
    Type: Application
    Filed: January 29, 2011
    Publication date: December 8, 2011
    Applicant: The Regents of the University of California
    Inventors: Zachary A. Knight, Beth Apsel, Kevan M. Shokat
  • FUSED RING HETEROARYL KINASE INHIBITORS
    Publication number: 20110275651
    Abstract: Provided herein are fused ring heteroaryl compounds useful in a variety of methods, including reducing the activity of certain kinases and treating certain disease states.
    Type: Application
    Filed: October 16, 2009
    Publication date: November 10, 2011
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Arvin Dar, Kevan M. Shokat
  • MTOR Modulators and Uses Thereof
    Publication number: 20110224223
    Abstract: The present invention provides methods and compositions for selective modulation of certain protein kinases, and especially mTor complexes. The methods and compositions are particularly useful in inhibiting mTor selectively for therapeutic applications.
    Type: Application
    Filed: July 8, 2009
    Publication date: September 15, 2011
    Applicants: The Regents of the University of California, a California corporation, Intellikine, Inc.
    Inventors: Kevan M. Shokat, David Fruman, Pingda Ren, Troy Edward Wilson, Liansheng Li, Andrew Hsieh, Morris Feldman, Beth Apsel, Yi Liu, Christian Rommel, Katrina Chan, Davide Ruggero, David Pearce, Matthew Janes
  • Anti-Inflammatory Pyrazolopyrimndines
    Publication number: 20110144134
    Abstract: The present invention provides anti-inflammatory compounds useful in the treatment of diseases and conditions in which inflammation is involved in disease progression or the manifestation of symptoms of the disease or condition.
    Type: Application
    Filed: January 31, 2011
    Publication date: June 16, 2011
    Applicant: The Regents of the University of California
    Inventors: Kevan M. Shokat, Nikolai Sepetov, Chao Zhang, Heinz W. Gschwend, Eric J. Kunkel
  • KINASE ANTAGONISTS
    Publication number: 20100009963
    Abstract: The present invention provides novel compounds that are antagonists of PI3 kinase, PI3 kinase and tyrosine kinase, PI3 kinase and mTOR, or PI33 kinase, mTOR and tyrosine kinase.
    Type: Application
    Filed: July 24, 2009
    Publication date: January 14, 2010
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: ZACHARY A. KNIGHT, BETH APSEL, KEVAN M. SHOKAT
  • P13 Kinase Antagonists
    Publication number: 20090270426
    Abstract: The present invention provides novel PI3-Kinase antagonists and methods of use thereof.
    Type: Application
    Filed: July 1, 2009
    Publication date: October 29, 2009
    Applicant: Regents of the University of California
    Inventors: Zachary A. Knight, Olusegun Williams, Kevan M. Shokat