Abstract: Methods, systems, and products monitor a person's regimen for medicinal and dietary restrictions. When the person's regimen requires a liquid medication or supplement, an oral instrument is commanded to dispense a dosage of fluid. The oral instrument stores a reservoir of the fluid. If the oral instrument is a spoon, for example, the spoon may automatically dispense cough syrup or other medicine. A toothbrush, likewise, may automatically dispense mouthwash. A sensor may confirm presence of the oral instrument in the person's mouth, thus ensuring the dosage of fluid is ingested.

Abstract: Provided are small molecule inhibitors of the KRAS(G12D) mutant oncoprotein having the structural formula: and pharmaceutically acceptable salts and compositions thereof, which are useful for treating cancers and related conditions.

Abstract: Multiple circuits in a computing device can share one or more conductive elements. The use of the conductive element can vary by circuit, such as an antenna radiator for a radio frequency (RF) circuit or an electrode for an electrocardiography (ECG) circuit. The circuitry sharing a conductive element can utilize signals obtained over different frequency ranges. Those ranges can be used to select decoupling circuitry, or elements, that can enable the respective circuits to obtain signals over a respective frequency range, excluding signals over one or more other frequency ranges corresponding to other circuitry sharing the circuit. Such an approach allows for concurrent independent operation of the circuitry sharing a conductive element.

Abstract: In one embodiment, a susceptor for thermal processing is provided. The susceptor includes an outer rim surrounding and coupled to an inner dish, the outer rim having an inner edge and an outer edge. The susceptor further includes one or more structures for reducing a contacting surface area between a substrate and the susceptor when the substrate is supported by the susceptor. At least one of the one or more structures is coupled to the inner dish proximate the inner edge of the outer rim.

Abstract: Technologies for a field effect transistor (FET) with a ferroelectric gate dielectric are disclosed. In an illustrative embodiment, a perovskite stack is grown on a buffer layer as part of manufacturing a transistor. The perovskite stack includes one or more doped semiconductor layers alternating with other lattice-matched layers, such as undoped semiconductor layers. Growing the doped semiconductor layers on lattice-matched layers can improve the quality of the doped semiconductor layers. The lattice-matched layers can be preferentially etched away, leaving the doped semiconductor layers as fins for a ribbon FET. In another embodiment, an interlayer can be deposited on top of a semiconductor layer, and a ferroelectric layer can be deposited on the interlayer. The interlayer can bridge a gap in lattice parameters between the semiconductor layer and the ferroelectric layer.

Abstract: A network computer system receives request data from computing devices of requesting users in a sub-region of a service area. The system further receives location data from computing devices of drivers operating in the sub-region. Based on the request data and the location data, the system determines a service condition for the sub-region. Based on the service condition indicating that the sub-region is in a driver oversupply state, the system transmits a service instruction to computing devices of a plurality of drivers within the sub-region, the service instruction being associated with a target outside the sub-region and a set of progress conditions. The system then periodically determines, for each driver of the plurality of drivers, an estimated time of arrival (ETA) to the target from a current position of the driver to determine whether the driver is satisfying the set of progress conditions of the service instruction.

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Human Respiratory Syncytial Virus (HRSV) or Human Metapneumovirus (HMPV) inhibitors. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HRSV or HMPV infection. The invention also relates to methods of treating an HRSV or HMPV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Abstract: Electrochemical sensors have great promise for point-of-care and in vivo measurement of medically relevant molecules. However, the need for calibrating individual sensors limits the practical applicability of these sensing platforms. The invention provides a novel method of operating electrochemical sensors which obviates the need to calibrate individual sensors against a sample of known concentration. The invention exploits the frequency dependence of electrochemical output signals and the dependence of output signals on the inherent electron transfer kinetics of a selected sensor design. By use of signals generated at a nonresponsive frequency, a normalizing output value is generated that accounts for sensor-to-sensor variation and which enables an accurate calculation of target concentration. The scope of the invention also includes pre-calibrated sensors that may be utilized without calibration steps.

Abstract: A substrate processing apparatus includes a vacuum chamber with upper and lower electrodes and a processing zone for processing a substrate using plasma. The upper electrode includes a surface that is substantially parallel to a surface of the substrate when the substrate is positioned in the chamber. The apparatus includes at least one magnetic field source configured to generate one or more active magnetic fields through the processing zone, and a controller coupled to the at least one magnetic field source and the upper electrode. The controller is configured to apply RF power between the upper and lower electrodes to generate the plasma using a process gas. The controller controls the current through the at least one magnetic field source during the processing of the substrate, where the current is based on a target value corresponding to at least one characteristic of the one or more active magnetic fields.

Abstract: Systems and methods are described for generating record clusters. The methods comprise receiving a plurality of records from data sources and providing at least a subset of the records to a scoring model that determines scores for various pairings of the records, a score for a given pair of the records representing a probability that the given pair of records contain data elements about the same entity. The method further comprises generating a graph data structure that includes a plurality of nodes, individual nodes representing a different record from the records. The method also comprises assigning a different unique identifier to individual clusters of the final clusters and responding to a request for data regarding a given entity by providing aggregated data elements from those records of the records associated with a cluster of the final clusters having an identifier that represents the given entity.

Abstract: In one embodiment, a transistor device includes a gate material layer on a substrate, a ferroelectric (FE) material layer on the gate material, a semiconductor channel material layer on the FE material layer, a first source/drain material on the FE material layer and adjacent the semiconductor channel material layer, and a second source/drain material on the FE material layer and adjacent the semiconductor channel material layer and on an opposite side of the semiconductor channel material layer from the first source/drain material. A first portion of the FE material layer is directly between the gate material and the first source/drain material, and a second portion of the FE material layer is directly between the gate material and the second source/drain material.

Abstract: A wearable computing device is provided. The wearable computing device includes a, conductive housing and a printed circuit board at least partially disposed within the conductive housing. The wearable computing device further includes a slot antenna defined by a gap between the conductive housing and the printed circuit board. The wearable computing device includes a display screen electrically coupled to the printed circuit board. The wearable computing device includes a cover positioned on the display screen. The cover includes a top surface and a bottom surface. The wearable computing device includes a biometric sensor electrode positioned partially on the top surface of the cover. The biometric sensor at least partially wraps around a periphery of the cover.

Abstract: A storage console includes a housing with a storage chamber, two closure members connected to the housing, an actuator movably arranged in the housing and a latch mechanism rotatably connected to the housing. The two closure members can be rotated to open or close the storage chamber. The latch mechanism includes two latch members and a synchronizer connected between the two latch members. The movement of the actuator actuates the two latch members to rotate to a lock position in which the two latch members engage with the two closure members or a release position in which the two latch members are separated from the two closure members. The two closure members of the storage console can be opened synchronously by use of the actuator and closed independently of each other.

Abstract: The instant disclosure is directed to a heterogeneous fiber fluid reservoir for holding and delivering fluid. A reservoir may comprise a rod having a core component and a surrounding component. Each of the core component and the surrounding component may comprise fibers. The core component may have a first property, and the surrounding component may have a second property different from the first property, or the core component and the surrounding component may each have a different value or range of values for the same property. Alternatively, a reservoir may comprise a rod that includes fibers and has a cross-sectional diameter. At least one property of the rod may vary in value along the cross-sectional diameter of the rod. The property may include, for example, fiber bulk density, fiber diameter, fiber material, fiber morphology, fiber surface tension, capillary force, fluid absorption capacity, color, or combinations thereof.

Abstract: Various systems and methods for non-destructive testing (NDT) devices are provided. In one embodiment, an NDT can include a tubular housing including a proximal end and a distal end. The tubular housing can include a head section arranged at the distal end, and a bendable articulation section secured to the head section and arranged proximal to the head section. A sensor can be arranged within the head section, and include a first output terminal having an output signal cable extending along the tubular housing to a control unit arranged at the proximal end of the tubular housing, and a second output terminal grounded within the tubular housing.

Abstract: The online concierge system generates task units based on orders and assigns batches of task units to pickers. The online concierge system generates task units based on received orders. The online concierge system generates permutations of these task units to generate candidate sets of task batches. The online concierge system scores each of these candidate sets, and selects a set of task batches to assign to pickers based on the scores. Additionally, to determine which task UI to display to the picker, the picker client device uses a UI state machine. The UI state machine is a state machine where each state corresponds to a task UI to display on the picker client device. The state transitions between the UI states of the UI state machine indicate which UI state to transition to from a current UI state based on the next task unit in the received task batch.

Abstract: A self-lifting toilet seat system includes a toilet seat configured to be sat upon by a user. The system has a hinge configured to rotatably couple the toilet seat and a toilet bowl. The hinge is configured so that the toilet seat is transitionable from an up position to a down position. A lifting system is configured to raise the toilet seat towards the up position. A sealed hinge housing has at least a portion of a delay system therein. The delay system is configured to cause a time delay before the lifting system causes the toilet seat to self-lift towards the up position. The delay system is configured so that the time delay begins after removal of a threshold downward force on the toilet seat.

Abstract: The present disclosure relates to a film formed with a metal precursor and an organic precursor, as well as methods for forming and employing such films. The film can be employed as a photopatternable film or a radiation-sensitive film. In particular embodiments, the film includes alternating layers of metal-containing layers and organic layers. In other embodiments, the film includes a matrix of deposited metal and organic constituents.

Abstract: A nanocrystalline magnetic conductive sheet for wireless charging and a preparation method therefor are provided. The nanocrystalline magnetic conductive sheet includes a composition of Fe(100-x-y-z-?-?-?)MxCuyM?zSi?B?X?, saturation magnetic induction is greater than or equal to 1.25T. The preparation method includes preparing an alloy with a preset composition of into an alloy strip with an initial state of amorphousness by a single roll rapid quenching method, annealing an amorphous alloy strip according to a preset annealing process, to obtain a nanocrystalline strip, performing a magnetic fragmentation process on the nanocrystalline strip, to obtain the nanocrystalline magnetic conductive sheet for wireless charging.