Abstract: The present invention provides a vector system comprising a nucleotide sequence coding for an antibody. In particular, the present invention relates to the use of such a vector system in a subject, where the nucleotide sequence is expressed in vivo to produce said antibody.

Abstract: An inflation valve for use with an inflatable emergency evacuation slide includes a thermally actuated gas relief valve having an exhaust port the effective size of which increases with increasing temperature. The exhaust port is metered by a valve member. The valve member position is controlled by a thermal actuator that lengthens with increasing temperature. At high ambient temperatures, the valve member moves to uncover the exhaust port thereby increasing the effective size of the port so that a large percentage of the inflation gas is vented. At low ambient temperatures the valve member moves to cover the exhaust port, thereby decreasing effective size of the exhaust port so that little or no inflation gas is vented.

Abstract: The use of an ScFv Ab (ScFv Ab) capable of recognising a disease associated molecule (DAM) in the manufacture of a medicament for the prevention and/or treatment of a disease condition associated with a DAM is described. The ScFv Ab has therapeutic, diagnostic and prognostic applications.

Abstract: The present invention provides 5T4 tumour-associated antigen (TAA) for use in a method of immunotherapy of tumours. The invention also relates to a recombinant poxvirus vector from which at least one immune evasion gene has been deleted, which comprises a nucleic acid sequence encoding a 5T4 TAA and the use thereof in vaccinating against and in treating tumours.

Abstract: An inflatable aircraft evacuation slide system includes a primary valve, a bust disk and a valve leakage trap operatively disposed between the primary valve and the burst disk. The valve leakage trap comprises a small exhaust vent opening into a flow restriction orifice in the gas path between the primary valve and the burst disk. In operation, when the aircraft emergency exit is opened in the armed condition, the primary valve opens and pressurizes the chamber until the burst disk ruptures allowing inflation gases to pass through the flow restriction orifice to inflate the inflatable evacuation slide. Because there is a substantial pressure drop across the flow restriction orifice, the presence of the valve leakage safety vent in the orifice does not result in significant loss of inflation gas needed for inflating the inflatable evacuation slide. In the event of leakage past the primary valve, however, the valve leakage trap safely vents the leakage pressure to the atmosphere.

Abstract: The present invention provides 5T4 tumour-associated antigen (TAA) for use in a method of immunotherapy of tumours. The invention also relates to a recombinant poxvirus vector from which at least one immune evasion gene has been deleted, which comprises a nucleic acid sequence encoding a 5T4 TAA and the use thereof in vaccinating against and in treating tumours.

Abstract: A vector comprising a nucleotide sequence of interest (“NOI”) encoding a product of interest (“POI”) is described. The NOI and/or the POI is capable of recognizing a tumor, such that in use the vector is capable of delivering the NOI and/or the POI to the tumor.

Abstract: A fuel-water separator for diesel engines has a coalescing media and baffle plates through which diesel fuel and water pass upwardly, separation thereof being effected by reducing emulsification of water with fuel, and by passing of heavy particulates to the bottom of the separator.

Abstract: The use of an ScFv Ab (ScFv Ab) capable of recognising a disease associated molecule (DAM) in the manufacture of a medicament for the prevention and/or treatment of a disease condition associated with a DAM is described. The ScFv Ab has therapeutic, diagnostic and prognostic applications.

Abstract: A vector comprising a nucleotide sequence of interest (“NOI”) encoding a product of interest (“POI”) is described. The NOI and/or the POI is capable of recognizing a tumor, such that in use of the vector is capable of delivering the NOI and/or the POI to the tumor.

Abstract: Canine and feline 5T4 polypeptide sequences and nucleotide sequences encoding them are provided. A vector system comprising a nucleic acid encoding 5T4 and a 5T4-specific agent are also provided.

Abstract: The present invention provides a vector system comprising a nucleotide sequence coding for an antibody. In particular, the present invention relates to the use of such a vector system in a subject, where the nucleotide sequence is expressed in vivo to produce said antibody.