Abstract: Described herein are compounds of Formula I: I and their pharmaceutically acceptable salts, wherein R1, R2, R3, R4, R7, RF, t1, Y1, and Y2 are defined herein; their use as MC4R antagonists; pharmaceutical compositions containing such compounds and salts; the use of such compounds and salts to treat, for example, cachexia, anorexia, or anorexia nervosa; and intermediates and processes for preparing such compounds and salts.

Abstract: A handheld surgical instrument and a bridge for a handheld surgical instrument, through which bridge a plurality of working instruments can be inserted in an ideal manner into a shaft of the handheld surgical instrument. This is achieved by the fact that a bridge for a handheld surgical instrument has a channel-like guide bore for an optical unit. This bore extends through the entire bridge, specifically from a proximal end to a distal end. The guide bore is segmented from the proximal end to the distal end of the bridge and that the segments have longitudinal axes offset with respect to one another.

Abstract: Described herein is a crystalline form of (2R)-2-(5-fluoro-2-methoxypyridin-4-yl)-1-[(2S)-7-methyl-6-(pyrimidin-2-yl)-3,4-dihydro-1H-spiro[1,8-naphthyridine-2,3-pyrrolidin]-1-yl]propan-1-one having a powder X-ray diffraction pattern comprising at least one characteristic peak, in terms of 2? at a copper wavelength, selected from 8.7±0.2, 11.1±0.2, and 13.3±0.2.

Abstract: Described is a system and method for routing output information to one or more of a plurality of output devices. In one implementation, output information that includes information to be presented and a location information identifying where the output information is to be presented may be generated by an output host. The output information is received by an output router that determines, based on the location information, an output device and routes the output information to the output device for presentation.

Abstract: The invention relates to a method (100) for an automated generation of synthetic scenes (175), comprising the following steps: providing (101) scene data (110) representing a plurality of template scenes (120), providing (102) object data (115) specifying various objects (125) for insertion into the synthetic scene (175), providing (103) at least one scene parameter (130) for the template scenes (120), which describes at least one characteristic of the template scenes (120), generating (106) intermediate representations (140) for the synthetic scenes (175), wherein, regarding the intermediate representations (140), at least one selected object (125) is in each case inserted into a selected template scene (120), wherein the insertion of the at least one selected object (125) is parametrized based on the provided scene parameter (130) in order to account for physical plausibility in the respective intermediate representation (140), determining (107) conditioning data (150) from the generated intermediate rep

Abstract: An apparatus for preventing deployment failure or damage of a movable portion of a treatment device via a force limiting element in the treatment device.

Abstract: A system and associated method for manipulating tissues and anatomical or other structures in medical applications for the purpose of treating diseases or disorders or other purposes. In one aspect, the system includes an expandable structure for enhancing engagement with median lobe prostate tissue.

Abstract: Apparatus and computer-implemented method for generating an anomaly. A first representation of a digital input, including a digital time series, a digital audio signal, or a digital image, preferably a video image, a radar image, a LiDAR image, an ultrasound image, an image from a motion sensor, or an infrared image, in a state space is mapped onto the digital input using a first model which is configured to map the first representation onto the digital input. The digital input is mapped onto a prediction for a content contained in the digital input using a second model which is configured to map the digital input onto the prediction. A second representation in the state space which degrades the prediction is determined based on a measure that characterizes a quality of the prediction. The anomaly is generated based on the second representation.

Abstract: Vapor phase transport systems and methods of depositing perovskite films are described. In an embodiment, a deposition method includes feeding a perovskite solution or constituent powder to a vaporizer, followed by vaporization and depositing the constituent vapor as a perovskite film. In an embodiment, a deposition system and method includes vaporizing different perovskite precursors in different vaporization zones at different temperatures, followed by mixing the vaporized precursors to form a constituent vapor, and depositing the constituent vapor as a perovskite film.

Abstract: A device and computer-implemented method for determining a data set for use in training a machine learning system. A first and second data set are combined to form the data set for use in training. The first data set includes a first digital image identified by at least one label from a first set of labels. The second data set includes a second digital image identified by at least one label from a second set of labels. The two sets of labels differ by at least one label. A first encoding for identifying the first digital image is determined with labels from both sets of labels. The first encoding is mapped to a first representation in a state space. The data set for use in training includes the first digital image and the first representation.

Abstract: Described herein are methods of treating MC4R-related conditions, diseases, or disorders by administering compounds of Formula I: or their pharmaceutically acceptable salts, wherein R1, R2, R3, X1, Y1, Y2, Y3, Y4 and Y5 are defined herein. Such conditions, diseases, or disorders include cachexia, anorexia, or anorexia nervosa.

Abstract: An apparatus for transferring mechanical energy in a handle to a cartridge to manipulate tissue or anatomical structures within the body of a human or animal subject for the purpose of treating diseases or disorders.

Abstract: Albarran modules have an Albarran lever at a distal end of a shaft. The Albarran lever is actuatable via a toggle on a main body of the Albarran module. For this purpose, the lever is coupled mechanically to the toggle by pull wires along the shaft. In known Albarran modules, the fitting and bracing of these pull wires proves complicated and laborious. Exemplary embodiments include an Albarran module (10), a drive body (17), and a method for bracing a pull wire (21), by which method at least one pull wire (21) can be braced in a particularly simple and reliable manner. This is achieved by the fact that a tensioning means for bracing the at least one pull wire (21) is connectable to a drive body (17) of the Albarran module (10) parallel to a longitudinal axis of a shaft (12).

Abstract: Embodiments disclosed herein are directed to assemblies for forming polycrystalline diamond compacts and methods for forming the polycrystalline diamond compacts with the assemblies. An example assembly includes a substrate and a diamond material positioned adjacent to an interfacial surface of the substrate. The assembly also includes an enclosure defining a chamber. The substrate and the diamond material are disposed in the chamber. In an embodiment, the assembly includes a sealant and the sealant includes at least one of cobalt or a copper-nickel alloy. In an embodiment, the substrate includes a concave bottom surface that is opposite the interfacial surface.

Abstract: A system and associated method for manipulating tissues and anatomical or other structures in medical applications for the purpose of treating diseases or disorders or other purposes. In one aspect, the system includes an expandable structure for enhancing engagement with median lobe prostate tissue.

Abstract: A semiconductor-superconductor hybrid device comprises a semiconductor component configured to host a 2DEG or a 2DHG; a superconductor component for inducing superconductivity in a channel of the semiconductor component; and a set of depletion gates. The superconductor component comprises a grounded strip of superconductor. The depletion gates comprise a first outer gate for defining a first outer segment; a second outer gate for defining a second outer segment, and an inner gate for defining an inner segment of the channel. The device further comprises a first junction comprising a space between the first outer gate and the inner gate, and a helper gate for gating the first space; and a second junction comprising a space between the second outer gate and the inner gate, and a helper gate for gating the second space. The helper gates are operable to connect the channel to leads.

Abstract: An Albarran module, a drive body, and a method for bracing a pull wire, by which method at least one pull wire can be braced in a simple and reliable manner by a tensioning means for bracing the at least one pull wire is connectable to a drive body of the Albarran module parallel to a longitudinal axis of a shaft. The Albarran module has an Albarran lever at a distal end of a shaft. The Albarran lever is actuatable via a toggle on a main body of the Albarran module. For this purpose, the lever is coupled mechanically to the toggle by pull wires along the shaft. In known Albarran modules, the fitting and bracing of these pull wires proves complicated and laborious.

Abstract: Solar cell interconnect with bypass diodes are described. In an embodiment, a semiconductor-based bypass layer is formed over a top electrode layer of a solar cell and spans over a vertical interconnect providing vertical interconnection between the bottom electrode layer and top electrode layer of serial solar cells. A bypass electrode layer is formed over the semiconductor-based bypass layer and in contact with the top electrode layer for one of the solar cells.

Abstract: An implant that can be used for the treatment of the urinary tract in a manner which is more efficient and gentler on the body. This is achieved by virtue of the fact that an implant for expanding a urethra of a person by applying a local ischemic pressure to the tissue of the urethra has a pressure means structure. This pressure means structure has at least two pressure means, wherein the implant can be introduced into the urethra with a distal end in front. In this case, each of the pressure means has a spreading element and two bracing elements, namely a proximal and a distal bracing element, and wherein the bracing elements are each articulated movably at a first end to the spreading element and movably at a second end to a central bracing means.