Abstract: A hybrid guide RNA (hgRNA) comprising a proximal spacer, a distal spacer, a type II CRISPR-Cas tracrRNA, and a type V CRISPR-Cas direct repeat. Also provided herein are further multiplexed hgRNAs comprising additional direct repeats and spacers as well as methods of making and using thereof. Libraries comprising said hgRNAs or components thereof, cells, kits and reagents employed in the making or use thereof are also provided.

Abstract: The present invention relates to a wire gripper to aid in wire pulling and method of use, A gripper is inserted into an interior cavity. A base comprises an interior cavity and a threaded attachment. The gripper comprises more than one flexible finger. A wire receptacle is formed between the flexible fingers. The gripper slides into the interior cavity of the base. A collar is open at both the top and bottom end. A wire passes through the top end of the collar and slides into the wire receptacle. The wire is retained within the wire receptacle by fastening the base to the collar causing the flexible finger to apply retaining pressure to the wire preventing the wire from being removed from the wire grabber. A pulling tension is applied by an installer person to the wire grabber to pull the wire from a starting location to a destination location.

Abstract: One or more embodiments relates to a system and method for storing information in a storage ring. One embodiment relates to an architecture including at least one laser adapted to target and process at least one qubit in the storage ring; and an optical pathway in optical communication with the at least one laser, enabling the laser to process the at least one qubit.

Abstract: A radiotherapy device, a method and a computer readable medium are disclosed. The radiotherapy device includes a radiation source and a controller. The radiation source is configured to apply radiation to a subject. The controller is configured to determine an overlap between a defined volume of the subject and an isodose surface and to instruct the radiation source to halt application of the radiation based on the determination.

Abstract: Disclosed herein is a method for producing a calibrated pseudo-CT image of at least part of a patient for radiation treatment planning. The method comprises obtaining radiation intensity data indicative of attenuation properties of tissues within the patient and calibrating a first pseudo-CT image of at least part of the patient using the radiation intensity data to produce the calibrated pseudo-CT image.

Abstract: The present invention is directed to generating an n-dimensional map using the results of a query for compounds enumerated within a collection of documents describing a particular biological target of interest and a curated set of sequences, such as but not limited to, protein or nucleotide sequences not enumerated in the collection of documents. Both sets of sequences (document coded and curated coded) are converted into coded forms and placed in the n-dimensional map. One or more processors are configured to evaluate the distance between the curated coded forms and the closest cluster of document coded forms. Based on the distance between a coded form and the document coded forms, the curated coded forms can be ranked regarding the likelihood of interacting with the particular biological target.

Abstract: Embodiments of the present disclosure relate to water effect play structures for use in playgrounds, splash pads, and water parks. The play structures comprise a plurality of water tanks maintained at an elevation above a play surface. Each of the plurality of water tanks fills with water and then releases the water contained therein, splashing children in the vicinity. Each of the plurality of water tanks may be configured to release the water contained therein at different times. Further, in some embodiments, the water tanks may be enclosed, such as by being connected to a water transport system that fills the tanks internally and by having a movable cover over the opening(s) through which the water is released.

Abstract: The present invention is directed to generating an n-dimensional map using the results of a query for compounds enumerated within a collection of documents describing a particular biological target of interest and a curated set of compounds not enumerated in the collection of documents. Both sets of compounds (document coded and curated coded) are converted into coded forms and placed in the n-dimensional map. One or more processors are configured to evaluate the distance between the curated coded forms and the closest cluster of document coded forms. Based on the distance between a coded form and the document coded forms, the curated coded forms can be ranked regarding the likelihood of interacting with the particular biological target.

Abstract: Embodiments of the present disclosure relate to water effect play structures for use in playgrounds, splash pads, and water parks. The play structures comprise a plurality of water tanks maintained at an elevation above a play surface. Each of the plurality of water tanks fills with water and then releases the water contained therein, splashing children in the vicinity. Each of the plurality of water tanks may be configured to release the water contained therein at different times. Further, in some embodiments, the water tanks may be enclosed, such as by being connected to a water transport system that fills the tanks internally and by having a movable cover over the opening(s) through which the water is released.

Abstract: A system and method for storing information in a quantum computer using a quantum storage ring. The method comprises cooling ions in the quantum storage ring to a low temperature; and binding the ions into a lattice structure, forming an ion Coulomb crystal.

Abstract: A thrust bearing having an inner cage having inner cage pockets, with inner rollers in the inner cage pockets, and a first outer cage having a larger diameter than the inner cage and having first outer cage pockets, with first outer rollers in the first outer cage pockets. The inner cage and the first outer cage are axially and radially aligned. A radially extending rim is provided on one circumferential side of one of the inner cage or the first outer cage that faces a facing circumferential side of the other of the inner cage or the first outer cage. First and second radially extending side tabs are provided on the facing circumferential side of the other of the inner cage or the first outer cage that define a circumferentially extending channel therebetween that receives the radially extending rim to connect the cages together.

Abstract: A thrust bearing having an inner cage having inner cage pockets, with inner rollers in the inner cage pockets, and a first outer cage having a larger diameter than the inner cage and having first outer cage pockets, with first outer rollers in the first outer cage pockets. The inner cage and the first outer cage are axially and radially aligned. A radially extending rim is provided on one circumferential side of one of the inner cage or the first outer cage that faces a facing circumferential side of the other of the inner cage or the first outer cage. First and second radially extending side tabs are provided on the facing circumferential side of the other of the inner cage or the first outer cage that define a circumferentially extending channel therebetween that receives the radially extending rim to connect the cages together.

Abstract: A method for electromagnetic imaging of containers receives uncalibrated first data corresponding to signals of a first plurality of different frequencies associated with an antenna array residing in a container having contents. The method estimates of a second data based on a computer model and simulation of signals of a second plurality of different frequencies associated with the antenna array, the second plurality of different frequencies including a subset of the first plurality of different frequencies. The method compares magnitudes, without corresponding phase comparisons, of the first and second data at each frequency of the second plurality of different frequencies. The method updates the second data based on the comparing. The method provides information about the contents within the container based on the updated second data.

Abstract: Disclosed herein are apparatus, assemblies, and methods for mitigating thermal bow in the rotor of an engine at start-up. One apparatus includes a control module that facilitates operating the rotor prior to starting the engine and an acceleration module that facilitates accelerating the rotor to at least a threshold speed prior to starting the engine. An assembly includes a start-up device coupleable to the rotor and configured to start the rotor and a start-up module coupled to the start-up device in which the start-up device and the start-up module are configured to coordinate operations to accelerate the rotor to at least a threshold speed prior to starting the aircraft engine. One method includes transmitting a control signal to control the rotor prior to starting the engine and commanding the start-up device to accelerate the rotor to at least a threshold speed prior to starting the engine.

Abstract: The present invention provides a combined radiotherapy and MRI system in which an imaging coil is mounted on a mechanical arm. The position of the imaging coil is thus known and in embodiments can be controlled to prevent collisions with the patient and unfavourable interactions between the imaging coil and the radiation beam.

Abstract: A method, computer system, and computer program product may include the steps of processing at least a part of the technical document to extract a term denoting a given element of the software program product, performing a respective check on whether the extracted term is correspondingly recorded in at least one of an accessible ontology and an accessible synonym database, whereby each ontology entry comprises a corresponding preferred term in respect of the given element of the software program product, and the accessible synonym database comprises respective entries of the corresponding preferred term, and a synonym corresponding to the corresponding preferred term, in respect of the given element of the software program product, and updating an accessible notification database according to a given check performed against at least one of the accessible ontology database and the accessible synonym database.

Abstract: The present invention provides a combined radiotherapy and MRI system in which an imaging coil is mounted on a mechanical arm. The position of the imaging coil is thus known and in embodiments can be controlled to prevent collisions with the patient and unfavourable interactions between the imaging coil and the radiation beam.

Abstract: A system and method include identification of a plurality of sub-volumes of an image volume, each of the plurality of sub-volumes of the image volume associated with a respective one of a plurality of vertebra, registration of each of the plurality of sub-volumes of the image volume to one of a plurality of reference sub-volumes associated with a same respective vertebra, input of the registered sub-volumes and the image volume to a trained neural network, reception of an output image volume from the trained neural network, the output image volume labeled to associate voxels with respective vertebra, and display of the output image volume.

Abstract: The present disclosure is directed to a triazine-modified ionic liquid compound, the synthesis thereof and an electrochemical cell electrolyte containing the triazine-modified ionic liquid compound.

Abstract: A method for electromagnetic imaging of containers receives uncalibrated first data corresponding to signals of a first plurality of different frequencies associated with an antenna array residing in a container having contents. The method estimates of a second data based on a computer model and simulation of signals of a second plurality of different frequencies associated with the antenna array, the second plurality of different frequencies including a subset of the first plurality of different frequencies. The method compares magnitudes, without corresponding phase comparisons, of the first and second data at each frequency of the second plurality of different frequencies. The method updates the second data based on the comparing. The method provides information about the contents within the container based on the updated second data.