Abstract: Methods, composition, and intermediates are disclosed that are useful for making 4-Tetrazolyl-4-phenylpiperidine Compounds according to Formula I, where Ar1 is —C3-C8 cycloalkyl, phenyl, naphthyl, anthryl, phenanthryl or -(5-7-membered) heteroaryl, each being unsubstituted or substituted with one or more R2 groups; Ar2 is phenyl, naphthyl, anthryl, phenanthryl or -(5-7-membered) heteroaryl, each being unsubstituted or substituted with one or more R2 groups; Z1 and Z2 are each independently a —(C1-C4 alkyl) group; R1 is —(CH2)nC(O)N(R3)(R4) where R3 and R4 are each independently H or —(C1-C4 alkyl); R2 is halogen, —C1-C3 alkyl, —O—(C1-C3 alkyl), —NH(C1-C3 alkyl) or —N(C1-C3 alkyl)2; n is an integer ranging from 1 to 4; m is an integer ranging from 0 to 4; and, in certain embodiments, the phenyl moiety attached to the 4-position of the piperidine ring of a compound according to Formula I can be optionally substituted with one or more R2 groups.

Abstract: The present invention therefore provides a method for the analysis of radiographic images, comprising the steps of acquiring a plurality of projection images of a patient, acquiring a surrogate signal indicative of the location of a target structure in the patient, reconstructing a plurality of volumetric images of the patient from the projection images, each volumetric image being reconstructed from projection images having a like breathing phase, identifying the position of the target structure such as a tumour in each volumetric image, associating a surrogate signal with each of the projection images, and determining a relationship between the surrogate signal and the position of the target structure. Multiple projection images having a like breathing phase can be grouped for reconstruction, to provide sufficient numbers for reconstruction. The analysis of the multiple values of the surrogate associated with each breathing phase can be used to determine the mean surrogate value and its variation.

Abstract: The invention allows data originating according to a first communications standard to be transmitted over a physical layer using a second communications standard. According to an embodiment of the invention, a data stream is received from a physical transmission medium that uses particular first communications standard. Next, a data type identification (DTID) is appended to each byte in the data stream, thereby creating a technology independent data stream having a particular bit rate. This bit rate is then matched to a different bit rate that corresponds to a second communications standard. The technology independent data stream is then transmitted over a physical transmission medium that uses the second communications standard.

Abstract: Aspects of a method and system for a connector with integrated power over Ethernet functionality are provided. In this regard, one or more circuits and/or processors that reside within and/or on a connector may be operable to manage a supply power that is delivered over a cable based on characteristics of the connector and/or characteristics of the cable. The cable may carry the supply power while concurrently carrying data communications. The one or more circuits and/or processors may be operable to source and sink the supply power. The one or more circuits and/or processors may be operable to control which one or more conductors of the cable are utilized for conveying the supply power.

Abstract: The present invention describes a communications system having a first link partner and a second link partner that are connected by a communications link having at least four pairs of conductors. According to IEEE Standard 802.3 (e.g. Ethernet) for 1000Base-T, a data link is maintained (in a period absent data transmission) by sending idle signals over four pairs of conductors of the cable to maintain a logical connection. This idle signal scheme is replaced with an alternate idle signaling scheme that uses only two pairs of conductors to maintain a logical connection and therefore can operate with using lower power. The other two pairs of conductors of the four pairs of conductors are unused to maintain a logical connection absent data transfer, and therefore can be used to implement a Suspend Mode of operation. During Suspend Mode, the physical layer of each link partner powers down unnecessary circuitry so as to operate in a low power environment.

Abstract: The disclosure relates to erythroid progenitor cells and methods for producing parvovirus B 19 in the cells. The invention includes transformed and/or immortalized CD36+ erythroid progenitor cells permissive for B19 infection and methods for producing useful quantities of B 19 in the cells described herein. Infectious virus produced by the cells of the disclosure is useful for identifying and developing therapeutically effective compositions for treatment and/or prevention of human parvovirus B 19 infections.

Abstract: It is desirable to achieve a co-incident investigative kV source for a therapeutic MV source—a so-called “beams-eye-view” source. It has been suggested that bremsstrahlung radiation from an electron window be employed; we propose a practical structure for achieving this which can switch easily between a therapeutic beam and a beam-eye-view diagnostic beam capable of offering good image resolution. Such a radiation source comprises an electron gun, a pair of targets locatable in the path of a beam produced by the electron gun, one target of the pair being of a material with a lower atomic number than the other, and an electron absorber insertable into and withdrawable from the path of the beam. In a preferred form, the electron gun is within a vacuum chamber, and the pair of targets are located at a boundary of the vacuum chamber. The lower atomic number target can be Nickel and the higher atomic number target Copper and/or Tungsten.

Abstract: A radiotherapeutic apparatus comprises a source able to emit a beam of therapeutic radiation along a beam axis, a multi-leaf collimator arranged to collimate the beam to a desired shape, wherein the source is rotatable about a rotation axis that is substantially orthogonal and intersects with the beam axis thereby to describe an arc around that axis, and further comprises a control means able to control the dose/time rate of the source, the rotation speed of the source, and the multi-leaf collimator position. The control means is arranged to control the source in accordance with a treatment plan over first and second arc-segments such that at least the multi-leaf collimator changes shape at a different rate per degree in the second arc-segment as to the first arc-segment.

Abstract: A method for coating a metallic surface with an aqueous composition for pretreating before applying another coating or for treating said metallic surfaces. The method is characterized in that the composition contains, in addition to water; a) at least one hydrolyzable or at least partially hydrolyzed fluorine-free silane, and; b) at least one hydrolyzable or at least partially hydrolyzed fluorine-containing silane. The invention also relates to corresponding compositions.

Abstract: For Respiration Correlated Cone Beam CT scanning, we have observed that improvements in the frame rate are in fact undesirable. We therefore propose a radiographic apparatus comprising a beam of radiation and a detector therefor, adapted to obtain a two dimensional image of the beam after passing through a cyclically varying object to be investigated, a processor adapted to review the images and select images at like points in the cycle, and a control means for the beam of radiation adapted to activate the beam periodically. The control means can activate the beam at a frequency of between 0.5 and 5 Hertz, more preferably between 1 and 3 Hertz, which corresponds (roughly) to a frequency that is between 6 and 10 times the frequency of the cyclical variation. It will assist if the selected point of the cycle is an extremity thereof, as the rate of change in these areas is at a minimum. Thus, slight mismatches between the two cycles will then have only a small effect.

Abstract: A document comprises a body having at least one defined portion therein, each defined portion being represented in the body of the document as a body object, each of the document and each body object therein being rights-managed as protected content based on license terms specified in a digital license. A recipient of the document can render the protected content of each of the document and each body object therein by acquiring the digital license and satisfying the license terms set forth in the digital license.

Abstract: A communication system includes a first device and a second device that can advertise multiple capabilities using communication links. A first type of auto-negotiation between the first and second devices is performed using a first communication link between the devices. A second communication link between the devices is used to facilitate a second type of auto-negotiation. For example, the first communication link can include pairs A and B of an IEEE Std. 802.3 four twisted pair cable. The second communication link can include pairs C and D of the cable.

Abstract: The invention relates to an axial bearing arrangement (1) and a method for the manufacture thereof, with a first bearing ring (3) forming a structural unit (16) with a radially inwardly directed axial projection (11) with a radially outwardly directed resilient element (13) and a first running surface (5), and a second bearing ring (2) with a radially outwardly arranged axial projection (10) with a radially inwardly directed resilient element (12), with a second running surface (4), and a single-piece rolling body cage (6) which receives distributed over the circumference rolling bodies (8) which roll on the running surfaces (4, 5), wherein the rolling body cage (6) radially engages over the two resilient elements (12, 13).

Abstract: The invention relates to a first bearing arrangement (1) and a method for the manufacture thereof, with a first bearing ring (3) forming a structural unit (16) with a radially inwardly directed axial projection (11) with a radially outwardly directed resilient element (13) and a first running surface (5), and a second bearing ring (2) with a radially outwardly arranged axial projection (10) with a radially inwardly directed resilient element (12), with a second running surface (4), and a single-piece rolling body cage (6) which receives distributed over the circumference rolling bodies (8) which roll on the running surfaces (4, 5), wherein the rolling body cage (6) radially engages over the two resilient elements (12, 13).

Abstract: An email comprises a body having at least one related and previously sent email, where each previously sent email is represented in the body of the email as a body object. Each of the email and each body object therein is rights-managed as protected content, whereby a recipient of the email can render the protected content of each of the email and each body object therein with a corresponding license if the recipient satisfies terms set forth in the license.

Abstract: A radiotherapeutic apparatus comprises a source able to emit a beam of therapeutic radiation along a beam axis, a multi-leaf collimator arranged to collimate the beam to a desired shape, wherein the source is rotateable about a rotation axis that is substantially orthogonal and intersects with the beam axis thereby to describe an arc around that axis, and further comprises a control means able to control the dose/time rate of the source, the rotation speed of the source, and the multi-leaf collimator position. The control means is arranged to receive a treatment plan in which the arc is divided into a plurality of notional arc-segments, and specifying the total dose for the arc-segment and a Start and end MLC position.

Abstract: Flat panel images obtained during concurrent radiotherapy typically suffer from artefacts that relate to the pulses of MV energy. For a radiotherapeutic apparatus comprising a pulsed source of therapeutic radiation, a detector comprising control circuitry, an array of pixel elements, each having a signal output and an ‘enable’ input and being arranged to release a signal via the signal output upon being triggered by the enable input, and an interpreter arranged to receive the signal outputs of the pixel elements, the interpreter having a reset control, there are advantages in the control circuitry being adapted to reset the interpreter after a pulse of therapeutic radiation, prior to enabling at least one pixel of the array. Alternatively, the control circuitry can prompt a plurality of pulses by the pulsed source and then enable a plurality of pixels of the array. In effect, the therapeutic pulses are grouped into a short flurry of pulses.

Abstract: Realtime beam shape adjustment in response to (for example) online CT scanning of a patient during treatment is assisted by the radiotherapy apparatus comprising a source adapted to emit a beam of therapeutic radiation, a collimator for delimiting the radiation beam, the collimator comprising a plurality of leaves arranged alongside each other and be moveable longitudinally so that the tips of the leaves define a variable edge of the collimator, the leaves being mounted on a support that is moveable laterally with respect to the leaves. In this way, movements of the tumour that are perpendicular to the direction of leaf motion can be accommodated by simply moving the collimator bodily so as to accommodate this. It is preferred that the apparatus also includes a control means adapted to receive information as to the location of the target volume, and, on the basis of that information, control the longitudinal positions of the leaves and the lateral position of the support.

Abstract: A method of forming an orifice plate for a fluid ejection device includes depositing and patterning a mask material on a conductive surface, forming a first layer on the conductive surface, forming a second layer on the first layer, and removing the first layer and the second layer from the conductive surface, wherein the first layer includes a metallic material and the second layer includes a polymer material.

Abstract: The present invention describes a communications system having a first link partner and a second link partner that are connected by a communications link having at least four pairs of conductors. According to IEEE Standard 802.3 (e.g. Ethernet) for 1000Base-T, a data link is maintained (in a period absent data transmission) by sending idle signals over four pairs of conductors of the cable to maintain a logical connection. This idle signal scheme is replaced with an alternate idle signaling scheme that uses only two pairs of conductors to maintain a logical connection and therefore can operate with using lower power. The other two pairs of conductors of the four pairs of conductors are unused to maintain a logical connection absent data transfer, and therefore can be used to implement a Suspend Mode of operation. During Suspend Mode, the physical layer of each link partner powers down unnecessary circuitry so as to operate in a low power environment.