Abstract: In one aspect, the disclosure relates to substituted N-(2-(2,6-dioxopiperidinyl-3-yl)-1,3-dioxoisoindolin-5-yl)arylsulfonamide analogs that useful as modulators of cereblon (CRBN) activity, methods of making same, pharmaceutical compositions comprising same, and methods of treating various clinical conditions and disorders using same, e.g., a disorder of uncontrolled cellular proliferation, such as a cancer, which may be associated with cereblon protein dysfunction and/or a GSPT1 dysfunction. In various further aspects, the disclosed compounds can selectively modulate the degradation of GSPT1 protein, i.e., the disclosed compounds can act as GSPT1 degraders. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: A quantum bit array is disclosed. In an embodiment, the quantum bit array includes a control gate coupled to a qubit and at least one pass gate coupled between the qubit and an adjacent qubit to control operation of the qubit of the quantum bit array, a bit line, and a first transistor channel that connects the bit line to the control gate. The array further comprises at least one word line coupled to the first transistor channel. The at least one word line selectively controls charge flow through the first transistor channel. The array further comprises a capacitor coupled to selectively store charge in the first transistor channel.

Abstract: In one embodiment, a susceptor for thermal processing is provided. The susceptor includes an outer rim surrounding and coupled to an inner dish, the outer rim having an inner edge and an outer edge. The susceptor further includes one or more structures for reducing a contacting surface area between a substrate and the susceptor when the substrate is supported by the susceptor. At least one of the one or more structures is coupled to the inner dish proximate the inner edge of the outer rim.

Abstract: A tissue box comprising front and rear surfaces including horizontal fold lines; a left end surface including a horizontal fold line and a vertical perforation line; a right end surface including a horizontal fold line and a vertical perforation line; a top surface including a tissue pull-out-port; a bottom surface including a horizontal perforation line at the center of said bottom surface and vertical perforation lines at either end; lock keys form in said bottom surface so that said left end surface and right end surface can tuck in said lock keys; and said front surface, rear surface, left end surface, right end surface, top surface, and bottom surface all foldably connect to form a rectangular box. By its construction, said tissue box height can be reduced to prevent the termination of the cascade pulling mechanism when the remaining number of tissues in the box becomes half or less.

Abstract: A tissue box comprising front and rear surfaces including horizontal fold lines; a left end surface including a horizontal fold line and a vertical perforation line; a right end surface including a horizontal fold line and a vertical perforation line; a top surface including a tissue pull-out-port; a bottom surface including a horizontal perforation line at the center of said bottom surface and vertical perforation lines at either end; lock keys form in said bottom surface so that said left end surface and right end surface can tuck in said lock keys; and said front surface, rear surface, left end surface, right end surface, top surface, and bottom surface all foldably connect to form a rectangular box. By its construction, said tissue box height can be reduced to prevent the termination of the cascade pulling mechanism when the remaining number of tissues in the box becomes half or less.

Abstract: A heart rate monitor may include a strap and a heart rate monitoring pod releasably coupled to the strap. A securement element may be disposed in the strap to selectively secure the pod to the strap. The pod may be selectively removable from the securement element and include one or more charger contacts. The pod may include one or more LEDs and/or vibrating elements to provide a light animation feedback and/or a haptic feedback to a user. A charger may be provided to charge the pod. The charger and pod may have complementary shapes to align the pod on the charger. For example, placement of the pod on the charger may align the charger contacts of the pod with one or more charging elements (e.g., pins) disposed in the charger.

Abstract: A data processing system may generate a plurality of probability distributions, each probability distribution corresponding to a different profile characteristic regarding transactions performed by an entity. The data processing system may receive a first profile characteristic configuration for each of the plurality of probability distributions and a corresponding first start time. The data processing system may adjust each of the plurality of probability distributions according to the first profile characteristic configuration for the probability distribution and the first start time to generate a first set of adjusted probability distributions. The data processing system may sample each of the first set of adjusted probability distributions to generate transaction data for one or more first transactions. The data processing system may generate a record comprising the generated transaction data.

Abstract: A method of plugging channels of a honeycomb body and a honeycomb body including plugged channels. The method includes applying a shear force to a plugging mixture including a plurality of inorganic particles, clay, and a liquid vehicle to alter the viscosity of the plugging mixture from a first viscosity prior to the vibrating to a second viscosity which is less than the first viscosity. A honeycomb body is placed into contact with the plugging mixture such that a portion of the plugging mixture having the second viscosity flows into the plurality of channels. Application of the shear force is stopped or reduced to increase the viscosity of the portion of the plugging mixture in the plurality of channels to greater than the first viscosity.

Abstract: A method of manufacturing a semiconductor device includes forming a gate trench over a semiconductor substrate, depositing a gate dielectric layer and a work function layer in the gate trench, depositing a capping layer over the work function layer, passivating a surface portion of the capping layer to form a passivation layer, removing the passivation layer, depositing a fill layer in the gate trench, recessing the fill layer and the capping layer, and forming a contact metal layer above the capping layer in the gate trench.

Abstract: A promotion offering system and method is disclosed. The promotion offering system and method selects consumers for a test promotion that has one or more attributes, and is configured to generate test data for multiple consumer groupings. The promotion offering system and method may use the test data in analyzing whether to send a promotion to a consumer. For example, the promotion offering system and method may use one algorithm to generate a list of ranked promotions, and may use the test data in order to adjust the list of ranked promotions (such as replacing a highest ranked promotion with another promotion).

Abstract: Implementations of conductive energy weapons (CEWs) may include a shock generating circuit configured to couple to a power source, two electrodes operatively coupled to the shock generating circuit, and a safety circuit operatively coupled to the shock generating circuit. The shock generating circuit may be configured to generate a first pulse train and deliver the first pulse train to a target, and may be configured to generate at least a second pulse train and deliver the at least second pulse train to a target. The safety circuit may be configured to prevent the CEW from applying pulse trains to the target after a predetermined number of pulse trains. The first pulse train may include two or more pulses having waveforms substantially identical with each other, each of the waveforms of the two or more pulses having both a positive voltage segment and a negative voltage segment.

Abstract: An entity search method, a related device, and a computer storage medium are provided. The method includes: determining a first classifier and a second classifier that are included in query information; determining, based on a first entity library and the first classifier and the second classifier that are included in the query information, s correlations corresponding to each of w candidate entities, wherein information about the candidate entity includes a third classifier and a fourth classifier, and the correlation indicates a correlation between the classifiers in the query information and the classifiers in the candidate entity; and determining, based on the s correlations corresponding to each of the w candidate entities, information about a target entity corresponding to the query information, wherein the target entity is an entity in the w candidate entities.

Abstract: A system and method for throttling communications with consumer devices is disclosed. The consumer devices are associated with consumers and consumers are associated with preferred types of electronic correspondence. The system and method transmits to a first set of the consumer devices a first electronic correspondence including a deal from a deal program comprising an offer and an expiration date. The system and method receive responses to the first electronic correspondence and based on the responses and expiration of outstanding offers at the expiration date generates an indicator used to determine to communicate with one or more additional consumers through their consumer devices. The system and method generate additional electronic correspondence of the preferred type and transmit the additional electronic correspondence to the additional consumers. In this way, additional electronic correspondence may be throttled upward or downward.

Abstract: The present invention relates to an ergonomic bidirectional self-locking mechanism for endoscope angulation control knob operation, which allows for easier access to the endoscope control knobs, reduced muscle exertion for knob operation, and real-time locking of the position of the knobs when turned, as disclosed herein. The invention has benefits for the operator thereof from ergonomic and patient safety perspectives.

Abstract: Implementations of conductive energy weapons (CEWs) may include a shock generating circuit configured to couple to a power source, two electrodes operatively coupled to the shock generating circuit, and a safety circuit operatively coupled to the shock generating circuit. The shock generating circuit may be configured to generate a first pulse train and deliver the first pulse train to a target, and may be configured to generate at least a second pulse train and deliver the at least second pulse train to a target. The safety circuit may be configured to prevent the CEW from applying pulse trains to the target after a predetermined number of pulse trains. The first pulse train may include two or more pulses having waveforms substantially identical with each other, each of the waveforms of the two or more pulses having both a positive voltage segment and a negative voltage segment.

Abstract: A promotion program analytical system and method is disclosed. The promotion program analytical system and method selects a promotion program to offer to a consumer. Selection of the promotion program to present to the consumer includes determining a probability that the consumer will accept the promotion program. The probability of acceptance may be determined based on past performance data of similar promotion programs, and also past performance data on the promotion program itself when it is available.

Abstract: Systems, methods and techniques disclosed herein provide dynamic time-based adjustment of predictive modeling data.

Abstract: A sensor device includes a carrier, a force feedback sensor, and a probe containing a spin defect, the probe being connected to the force feedback sensor either directly or indirectly via a handle structure. In order to couple the spin defect to a microwave field in an efficient and robust manner, the sensor device includes an integrated microwave antenna arranged at a distance of less than 500 micrometers from the spin defect. The sensor device can be configured as a self-contained exchangeable cartridge that can easily be mounted in a sensor mount of a scanning probe microscope.

Abstract: The present invention relates to an ergonomic bidirectional self-locking mechanism for endoscope angulation control knob operation, which allows for easier access to the endoscope control knobs, reduced muscle exertion for knob operation, and real-time locking of the position of the knobs when turned, as disclosed herein. The invention has benefits for the operator thereof from ergonomic and patient safety perspectives.

Abstract: A promotion program analytical system and method is disclosed. The promotion program analytical system and method selects a promotion program to offer to a consumer. Selection of the promotion program to present to the consumer includes determining a probability that the consumer will accept the promotion program. The probability of acceptance may be determined based on past performance data of similar promotion programs, and also past performance data on the promotion program itself when it is available.