Abstract: Antibody-based binding agents derived from human and camelid immunoglobulins are described, as well as strains of yeast engineered to secrete the binding agents, and methods of treating and preventing Clostridium difficile infections using the engineered strains of yeast. These binding agents recognize and bind with specificity to Clostridium difficile toxin A and/or toxin B and in some cases exhibit toxin neutralizing activity. The binding agents include camelid VHH peptide monomers, linked groups of VHH peptide monomers, VHH peptide monomers joined to antibody Fc domains, and VHH peptide monomers joined to IgG antibodies.

Abstract: The present invention is directed to a pharmaceutical composition comprising a pharmaceutically effective amount of guaifenesin, naproxen and at least one further active which is selected to be an antitussive, a decongestant or an antihistamine.

Abstract: Techniques for performing an emissions demand response event are described. In an example, a power control server system receives an emissions rate forecast for a predefined future time period. Using the emissions rate forecast, an emissions rate event is identified during the predefined future time period. Based on the plurality of emissions rate event, an emissions demand response event is generated during the predefined future time period. The power control server system then causes a power controller to modify an energy consumption by an electronic device in accordance with the generated emissions demand response event.

Abstract: The present invention is directed to a pharmaceutical composition comprising a pharmaceutically effective amount of guaifenesin, naproxen and at least one further active which is selected to be an antitussive, a decongestant or an antihistamine.

Abstract: The present disclosure recites systems and methods for generating record clusters. For example, a computer-implemented method comprises receiving a plurality of records from data sources and providing at least a subset of the records to a scoring model that determines scores for various pairings of the records, a score for a given pair of the records representing a probability that the given pair of records contain data elements about the same entity. The method further comprises generating a graph data structure that includes a plurality of nodes, individual nodes representing a different record from the records. The method also comprises assigning a different unique identifier to individual clusters of the final clusters and responding to a request for data regarding a given entity by providing aggregated data elements from those records of the records associated with a cluster of the final clusters having an identifier that represents the given entity.

Abstract: A computer includes a processor and a memory, and the memory stores instructions executable by the processor to detect static environmental features in a camera image from a camera of a vehicle, generate a distance transform image of the static environmental features as detected in the camera image, and determine a pose of the vehicle based on a comparison of map data indicating the static environmental features with the distance transform image. Pixel values of respective pixels in the distance transform image indicate respective pixel distances of the respective pixels from the static environmental features in the distance transform image.

Abstract: The present disclosure provides chimeric antigen receptors, compostions, and methods thereof. In one embodiment the present disclosure provides a method of treating autoimmune diseases, asthma, and preventing or mediating organ rejection in a subject.

Abstract: Embodiments described herein relate to an optical device and methods of forming an optical device. The optical device includes a substrate, an illumination source, a capping layer, an encapsulation layer, and a passivation layer. The encapsulation layer includes a first atomic layer deposition (ALD) layer, a chemical vapor deposition (CVD) layer, and a second ALD layer. The method includes disposing a capping layer over an illumination layer, the illumination layer disposed over a substrate in a processing chamber; disposing a first atomic layer deposition (ALD) layer over the capping layer; disposing a chemical vapor deposition (CVD) layer over the first ALD layer; disposing a second ALD layer over the CVD layer; and disposing a passivation layer over the second ALD layer.

Abstract: The application describes method of modifying an image. The method may include a step of receiving, via an user interface of a service, a reference image and an input including text associated with the reference image. The method may also include a step of determining, via a trained machine learning (ML) model, one or more features of the reference image. The method may further include a step of modifying, via one or more trained latent diffusion models (LDMs), the reference image based upon the determined features and the received input. Any one or more of a background of the reference image, an area of the reference image or a style of the reference image may be modified. The method may even further include a step of causing to display, via the user interface of the service, the modified image.

Abstract: A formulation for oral administration comprises an expectorant, an analgesic, and at least one additional active ingredient having a modified release providing a therapeutic effect for each of the active ingredients for up to 12 hours.

Abstract: Techniques are described for a computing device to provide security-related information by (a) receiving a plurality of documents that relate to a plurality of security-related features provided by a service provider (SP) external to the device; (b) receiving instructions from the SP indicating a first selection of which of the plurality of documents to include in a report page and a second selection of which of the plurality of security-related features to monitor; (c) monitoring the SP for the features indicated by the second selection, and storing monitoring results; (d) receiving a request to report security-related information about the SP; (e) in response to receiving the request, creating a link for accessing the plurality of documents indicated by the first selection and the monitoring results; and (f) generating a report page that includes hyperlinks to the documents indicated by the first selection and a summary of the monitoring results.

Abstract: Systems and methods for searching data management systems. Administrative users may define rules for hashtags, and then the rules are dynamically applied on the fly when an end user searches customer data. Hashtags are used to filter records for specific data, so as to improve data search accuracy and efficiency.

Abstract: Compositions and methods are provided herein for treating intestinal glycocalyx dysfunction. The composition can comprise a chito-oligosaccharide (COS), and optionally a human milk oligosaccharide (hMO) in an amount sufficient to maintain an intestinal glycocalyx and a pharmaceutically acceptable carrier. The composition can be formulated as an oral dosage form or a parenteral dosage form. The method can comprise identifying intestinal glycocalyx dysfunction in the subject. The method can further comprise administering to the subject a COS in an amount and at a frequency sufficient to prevent, stabilize and reverse damage in the intestinal glycocalyx.

Abstract: Embodiments are directed to systems and techniques to provide smart access control devices with legacy access control systems.

Abstract: A method includes receiving a first image, receiving a motion dataset, determining a motion level, determining an initialization state, and determining a tracking level. In a first condition, the method includes generating a first image pyramid, detecting a plurality of features in the first image pyramid using a first detector threshold, and generating a first set of detected keypoints from the plurality of features. In a second condition, the method includes generating a second image pyramid, detecting the plurality of features in the second image pyramid using a second detector threshold, the second detector threshold being less restrictive than the first detector threshold, and generating a second set of detected keypoints. In a third condition, the method includes detecting the plurality of features in the first image according to the first detector threshold and generating a third set of detected keypoint.

Abstract: Sub-pixel circuits and methods of forming sub-pixel circuits that may be utilized in a display, such as an organic light-emitting diode (OLED) display, are provided. In one example, a sub-pixel includes a substrate, adjacent overhang structures, an anode, an OLED material, a cathode, an encapsulation layer stack. The encapsulation layer stack includes a first layer, a second layer disposed over the first layer, and a third layer. The first layer and the second layer have a first portion disposed over the cathode, a second portion disposed over a sidewall of each overhang structure, and a third portion disposed under an underside surface of an extension of each overhang structure. A gap is defined by contact of the first portion of the second layer and the third portion of the second layer. The third layer is disposed over the second layer outside of the gap.

Abstract: In one embodiment, the present disclosure provides an engineered cell having a first chimeric antigen receptor polypeptide including a first antigen recognition domain, a first signal peptide, a first hinge region, a first transmembrane domain, a first co-stimulatory domain, and a first signaling domain; and a second chimeric antigen receptor polypeptide including a second antigen recognition domain, a second signal peptide, a second hinge region, a second transmembrane domain, a second co-stimulatory domain, and a second signaling domain; wherein the first antigen recognition domain is different than the second antigen recognition domain.

Abstract: Techniques are described for a computing system to provide security-related information by (a) storing, by the computing system, security-related documents about a service provider; (b) monitoring, by the computing system, services provided by the service provider for a plurality of security-related features, and storing monitoring results; (c) receiving, by the computing system, a request to report security-related information about the service provider; (d) in response to receiving the request, creating a link for accessing the security-related documents and the monitoring results; and (e) in response to a user accessing the link, providing, by the computing system, the user with access to the security-related documents and monitoring results. A system, apparatus, and computer program product for performing this method and similar methods are also described.

Abstract: A mobility platform is configured to execute one or more tasks in a worksite including a passive landmark. A mobility platform may include a first laser rangefinder and at least one processor configured to sweep the first passive landmark with the first laser rangefinder to collect a first plurality of distance measurements for a first plurality of yaw angles, fit a first shape to the first plurality of distance measurements based on a predetermined shape of the first passive landmark, and determine a position of a geometric center of the first passive landmark relative to the first location of the first laser rangefinder based on the fit first shape.

Abstract: Compositions, systems, and methods are disclosed for preparing and utilizing arrays, such as single-analyte arrays containing a plurality of fiducial elements with random spatial distributions. Arrays may be prepared with pluralities of fiducial elements comprising optically active or passive moieties. Arrays containing random spatial distributions of fiducial elements may be utilized for various array-based processes that require spatial information.