Abstract: Compositions and methods are provided herein for treating intestinal glycocalyx dysfunction. The composition can comprise a chito-oligosaccharide (COS), and optionally a human milk oligosaccharide (hMO) in an amount sufficient to maintain an intestinal glycocalyx and a pharmaceutically acceptable carrier. The composition can be formulated as an oral dosage form or a parenteral dosage form. The method can comprise identifying intestinal glycocalyx dysfunction in the subject. The method can further comprise administering to the subject a COS in an amount and at a frequency sufficient to prevent, stabilize and reverse damage in the intestinal glycocalyx.

Abstract: A mobility platform is configured to execute one or more tasks in a worksite including a first passive landmark and a second passive landmark. The mobility platform may include a chassis, a drive system supporting the chassis, a first laser rangefinder disposed on the chassis at a first location, a second laser rangefinder disposed on the chassis at a second location, and at least one processor. The at least one processor may be configured to determine a position and orientation of the chassis based on a first distance measured by the first laser rangefinder between the first location and a first known landmark position, a second distance measured by the second laser rangefinder between the second location and a second known landmark position, and yaw angle information from at least one of the first and second laser rangefinders.

Abstract: A shrink-expand fit system for mounting a panel within an existing window frame. The system includes an elongated shrinkable-expandable elastic portion and an elongated groove portion. The groove portion is configurated to securely receive and hold the panel. The shrinkable portion can be sealed to create an airtight space. The shrinkable portion includes a vacuum seal valve and can shrink under vacuum and expand under atmospheric pressure to tightly hold the panel against the window frame.

Abstract: Described herein are embodiments of a positioning device for positioning a target in an environment for use by a system in localization in the environment. The positioning device comprises a base, a rod extending along a longitudinal axis of the base, an alignment spike attached to a first end of the rod, and at least three legs connected to the base. The alignment spike comprises a tip for contacting a point on a surface that the positioning device is placed upon. Each of the legs is configured to extend radially from the base and retract radially towards the base.

Abstract: A method of treating a vulnerable atherosclerotic plaque can include identifying the vulnerable atherosclerotic plaque and administering a sulfated polysaccharide, or a pharmaceutically acceptable salt thereof, to a subject in an amount and at a frequency sufficient to stabilize and reverse a vulnerable atherosclerotic plaque.

Abstract: An article of footwear, such as a shoe or boot, includes a sole, an upper, and one or more guides that are coupled or attached with the upper. The one or more guides are configured and arranged to route or direct a tension member along a path about the footwear. The footwear also includes a panel having a fixed end that is attached to a first side of the upper and a free end that is positioned opposite the fixed end. The panel extends from the first side of the upper toward a second side of the upper. The panel is positionable over at least one guide of the one or more guides to cover and conceal the at least one guide from external view.

Abstract: A mobility platform is configured to execute one or more tasks in a worksite including a first passive landmark and a second passive landmark. The mobility platform may include a chassis, a drive system supporting the chassis, a first laser rangefinder disposed on the chassis at a first location, a second laser rangefinder disposed on the chassis at a second location, and at least one processor. The at least one processor may be configured to determine a position and orientation of the chassis based on a first distance measured by the first laser rangefinder between the first location and a first known landmark position, a second distance measured by the second laser rangefinder between the second location and a second known landmark position, and yaw angle information from at least one of the first and second laser rangefinders.

Abstract: A computer system is disclosed that provides classification-based access controls at the dataset row-level. The system may perform operations including: ingesting a dataset, wherein the dataset comprises a table of rows and columns; determining a column of the table that includes permissions information; applying parsing rules to the column to determine, for each row of the table, a list of permissions markings; receiving, from a user, a request to access the dataset; and in response to receiving the request: determining a permissions policy associated with the user; determining an evaluated policy associated with the user based on the permissions policy; filtering the table based on applying the evaluated policy associated with the user to the permissions markings of each row of the table; and providing the user access to the filtered table.

Abstract: Provided is a defect detection method and device, computer equipment and a storage medium. The method includes: acquiring an RGB image, a depth image and a sample label of a detection object sample; performing feature map extraction and feature map fusion on the RGB image and the depth image by a feature extraction network of the defect detection model, to obtain a fused feature map; performing defect detection based on the fused feature map by a feature reconstruction network of the defect detection model, to obtain a defect score map, wherein the defect score map being obtained by fusing a global defect score map which is generated based on a global defect detection network with a local defect score map which is generated by a local defect detection network; and updating parameters of the defect detection model based on the defect score map and the sample label.

Abstract: Techniques for performing an emissions demand response event are described. In an example, a power control server system receives an emissions rate forecast for a predefined future time period. Using the emissions rate forecast, an emissions rate event is identified during the predefined future time period. Based on the plurality of emissions rate event, an emissions demand response event is generated during the predefined future time period. The power control server system then causes a power controller to modify an energy consumption by an electronic device in accordance with the generated emissions demand response event.

Abstract: A formulation for oral administration comprises an expectorant, an analgesic, and at least one additional active ingredient having a modified release providing a therapeutic effect for each of the active ingredients for up to 12 hours.

Abstract: Protective equipment for protecting a portion of a user's body (such as an articulating leg guard for protecting part of a user's leg) may include a knee guard assembly for covering at least a portion of a user's anterior knee region, a thigh guard assembly for covering at least a portion of a user's anterior thigh region, and at least two connection elements positioned to connect the knee guard assembly to the thigh guard assembly. The connection elements may be rotatably attached to the knee guard assembly at a first rotation axis and rotatably attached to the thigh guard assembly at a second rotation axis that is spaced apart from the first rotation axis. The leg guard may further include a floating knee guard assembly for covering at least a portion of a user's leg when a gap forms between the knee guard assembly and the thigh guard assembly.

Abstract: A computer system is disclosed that provides classification-based access controls at the dataset row-level. The system may perform operations including: ingesting a dataset, wherein the dataset comprises a table of rows and columns; determining a column of the table that includes permissions information; applying parsing rules to the column to determine, for each row of the table, a list of permissions markings; receiving, from a user, a request to access the dataset; and in response to receiving the request: determining a permissions policy associated with the user; determining an evaluated policy associated with the user based on the permissions policy; filtering the table based on applying the evaluated policy associated with the user to the permissions markings of each row of the table; and providing the user access to the filtered table.

Abstract: This disclosure relates to a fluid filtration apparatus, and to methods of making and using a fluid filtration apparatus of this disclosure. Fluid filtration apparatus includes a frame having a porous member secured thereto, and the frame is rotatably supported within a housing. Fluid, and particulates therein, are introduced via an inlet and components of the fluid may be filtered through the porous member to yield a filtrate (and particulates having passed through the porous member) and a retentate (and particulates not having passed through the porous member). Methods of manufacturing (and assembling) and methods of using a fluid filtration apparatus of this disclosure are also described.

Abstract: Protective equipment for protecting a portion of a user's body (such as an articulating leg guard for protecting part of a user's leg) may include a knee guard assembly for covering at least a portion of a user's anterior knee region, a thigh guard assembly for covering at least a portion of a user's anterior thigh region, and at least two connection elements positioned to connect the knee guard assembly to the thigh guard assembly. The connection elements may be rotatably attached to the knee guard assembly at a first rotation axis and rotatably attached to the thigh guard assembly at a second rotation axis that is spaced apart from the first rotation axis. The leg guard may further include a floating knee guard assembly for covering at least a portion of a user's leg when a gap forms between the knee guard assembly and the thigh guard assembly.

Abstract: Antibody-based binding agents derived from human and camelid immunoglobulins are described, as well as strains of yeast engineered to secrete the binding agents, and methods of treating and preventing Clostridium difficile infections using the engineered strains of yeast. These binding agents recognize and bind with specificity to Clostridium difficile toxin A and/or toxin B and in some cases exhibit toxin neutralizing activity. The binding agents include camelid VHH peptide monomers, linked groups of VHH peptide monomers, VHH peptide monomers joined to antibody Fc domains, and VHH peptide monomers joined to IgG antibodies.

Abstract: The present invention is directed to a pharmaceutical composition comprising a pharmaceutically effective amount of guaifenesin, naproxen and at least one further active which is selected to be an antitussive, a decongestant or an antihistamine.

Abstract: Techniques for performing an emissions demand response event are described. In an example, a power control server system receives an emissions rate forecast for a predefined future time period. Using the emissions rate forecast, an emissions rate event is identified during the predefined future time period. Based on the plurality of emissions rate event, an emissions demand response event is generated during the predefined future time period. The power control server system then causes a power controller to modify an energy consumption by an electronic device in accordance with the generated emissions demand response event.

Abstract: The present invention is directed to a pharmaceutical composition comprising a pharmaceutically effective amount of guaifenesin, naproxen and at least one further active which is selected to be an antitussive, a decongestant or an antihistamine.

Abstract: The present disclosure recites systems and methods for generating record clusters. For example, a computer-implemented method comprises receiving a plurality of records from data sources and providing at least a subset of the records to a scoring model that determines scores for various pairings of the records, a score for a given pair of the records representing a probability that the given pair of records contain data elements about the same entity. The method further comprises generating a graph data structure that includes a plurality of nodes, individual nodes representing a different record from the records. The method also comprises assigning a different unique identifier to individual clusters of the final clusters and responding to a request for data regarding a given entity by providing aggregated data elements from those records of the records associated with a cluster of the final clusters having an identifier that represents the given entity.