Abstract: A laser frame for holding a plurality of optical components includes a first flexure structure for adjustably holding a first one of the optical components, and a first cellular structure for supporting and cooling a second one of the optical components. The first flexure structure and the first cellular structure are each a unitary structure formed by additive manufacturing. Also, a laser frame for holding an optical component includes a passive cooling cellular structure for supporting and cooling the optical component. The passive cooling cellular structure has a non-uniform density, and the laser frame is a unitary structure formed by additive manufacturing.

Abstract: In one embodiment, the present disclosure provides an engineered cell having a first chimeric antigen receptor polypeptide including a first antigen recognition domain, a first signal peptide, a first hinge region, a first transmembrane domain, a first costimulatory domain, and a first signaling domain; and a second chimeric antigen receptor polypeptide including a second antigen recognition domain, a second signal peptide, a second hinge region, a second transmembrane domain, a second co-stimulatory domain, and a second signaling domain; wherein the first antigen recognition domain is different than the second antigen recognition domain.

Abstract: A processor includes a prediction table, a prediction logic circuit, and a prediction verification circuit. The prediction table has a plurality of sets, each of the sets has a hot way number, at least one warm way number, and at least one confidence value corresponding to the at least one warm way number. The prediction logic circuit generates a prediction result by predicting if the at least one warm way number is an opened way. The prediction verification circuit generates a correct/incorrect information according to the prediction result, and generates an update information according to the correct/incorrect information. The prediction verification circuit updates the hot way number, the at least one warm way number and the at least one confidence value of the at least one warm way number according to the update information.

Abstract: The present disclosure relates to compositions and methods relating to chimeric antigen receptor (CAR) polypeptides and methods relating thereto. In one embodiment, the present disclosure relates to engineered cells having chimeric antigen receptor polypeptides directed to at least two targets. In another embodiment, the present disclosure relates to engineered cells having chimeric antigen receptor polypeptides and an enhancer moiety.

Abstract: The present invention is directed to an oral pharmaceutical dosage form comprising a capsule containing at least two tablets, each tablet containing at least one different pharmaceutically active ingredient

Abstract: A dual air flow rebuildable dripping atomizer for use with electronic cigarettes which uses a sleeve lock that allows the user to adjust and direct the air flow is provided. The adjustable air flow sleeve also allows the sleeve to be locked in place preventing the e-liquid from leaking out. Rotating the adjustable air flow sleeve in a clockwise or counter-clockwise direction allows not only the direction of the air flow to be determined but how much air enters an inner air chamber of the atomizer. As a result, a user can determine, for example, the size of the vapor cloud and the intensity of the flavor. Additionally, the adjustable air flow sleeve may be adjusted to block air holes located on an inner edge surface of the adjustable air flow sleeve preventing the e-liquid from leaking.

Abstract: Systems and methods for data aggregation and processing are provided in manner that is decentralized and preserves privacy. A data aggregation and computation system may include an interface, a controller, and one or more clusters of computation nodes. The interface may receive an inquiry from a requesting entity for computing information regarding an individual based on pieces of information held by a plurality of entities. The controller may communicate an identifier for the individual to a processor system associated with each of the entities based on the inquiry. The clusters of computation nodes may each receive encrypted data fragments from each of the processor systems, the data fragments comprising unrecognizable fragments that no individual processor system can re-assemble to recover the information, perform secure, multi-party computations based on the data fragments, and generate a result based on the secure, multi-party computations for the individual.

Abstract: The present disclosure provides chimeric antigen receptors, compostions, and methods thereof. In one embodiment the present disclosure provides a method of treating autoimmune diseases, asthma, and preventing or mediating organ rejection in a subject.

Abstract: A multi-beam phased antenna structure and a controlling method are provided. The multi-beam phased antenna structure includes a main antenna array and a passive beam forming circuit. The main antenna array includes a plurality of first main antennas and a plurality of second main antennas. The first main antennas are spaced out a predetermined distance. The predetermined distance is related to a coverage of the multi-beam phased antenna structure. The first main antennas and the second main antennas are interleaved. The second main antennas are spaced out the predetermined distance. The passive beam forming circuit includes a plurality of main phase shifters. The main phase shifters are electrically coupled to the second main antennas, such that a difference between a first phase of each of the first main antennas and a second phase of each of the second main antennas is substantially 180°.

Abstract: A method of making an optical fiber sensor device for distributed sensing includes generating a laser beam comprising a plurality of ultrafast pulses, and focusing the laser beam into a core of an optical fiber to form a nanograting structure within the core, wherein the nanograting structure includes a plurality of spaced nanograting elements each extending substantially parallel to a longitudinal axis of optical fiber. Also, an optical fiber sensor device for distributed sensing includes an optical fiber having a longitudinal axis, a core, and a nanograting structure within the core, wherein the nanograting structure includes a plurality of spaced nanograting elements each extending substantially parallel to the longitudinal axis of the optical fiber. Also, a distributed sensing method and system and an energy production system that employs such an optical fiber sensor device.

Abstract: Features are described for efficiently and accurately identifying a user of an electronic device with limited user interaction. The features include receiving a mobile device identifier from the mobile device. The features include transmitting the mobile device identifier to a service provider associated with the mobile device. The features include receiving information identifying the user from the service provider. The features include identifying a set of candidates associated with at least a portion of the information. The features include generating a metric for the candidates included in the set of candidates. An individual metric indicates a degree of relatedness between a value for the user for the at least one data field and a value for a candidate for the at least one data field. The features include identifying the user as a specific candidate included in the set of candidates based on the metric corresponding to a threshold.

Abstract: A method of making an optical fiber sensor device for distributed sensing includes generating a laser beam comprising a plurality of ultrafast pulses, and focusing the laser beam into a core of an optical fiber to form a nanograting structure within the core, wherein the nanograting structure includes a plurality of spaced nanograting elements each extending substantially parallel to a longitudinal axis of optical fiber. Also, an optical fiber sensor device for distributed sensing includes an optical fiber having a longitudinal axis, a core, and a nanograting structure within the core, wherein the nanograting structure includes a plurality of spaced nanograting elements each extending substantially parallel to the longitudinal axis of the optical fiber. Also, a distributed sensing method and system and an energy production system that employs such an optical fiber sensor device.

Abstract: A lightguide is configured to transmit a scanned and/or focused processing beam to a target. The processing beam has a wavefront amplitude and phase set by a spatial light modulator. Suitable wavefront characteristics are obtained based on portions of the processing beam returned to a detector through the lightguide. A beam path can be detected at a first, reduced power, and processing along the beam path performed at a second, higher optical power.

Abstract: A variety of methods and arrangements for controlling the exhaust gas temperature of a lean burn, skip fire controlled internal combustion engine are described. In one aspect, an engine controller includes an aftertreatment system monitor and a firing timing determination unit. The aftertreatment monitor obtains data relating to a temperature of one or more aftertreatment elements, such as a catalytic converter. Based at least partly on this data, the firing timing determination unit generates a firing sequence for operating the engine in a skip fire manner such that the temperature of the aftertreatment element is controlled within its effective operating range.

Abstract: The present disclosure provides chimeric antigen receptors, compostions, and methods thereof. In one embodiment the present disclosure provides a method of treating autoimmune diseases, asthma, and preventing or mediating organ rejection in a subject.

Abstract: A skip fire engine controller and method of control is described wherein during transitions from a first firing density to a second firing density, a firing density and a pumping density are separately set so as to balance the conflicting demands of (a) torque control, (b) Noise, Vibration and Harshness (NVH), (c) air flow through the engine and (d) air-fuel ratio.

Abstract: In this board game, players take turns being the Chief and rating their level of agreement with prompts such as: “For $1000, I would be willing to wear the same underwear for a week without washing it.” The opinions are guessed using a scale from 1 (“Frostbite!—Completely Disagree”) to 10 (“All Ablaze!—Completely Agree”). Before the Chief reveals his/her rating, all of the other players guess the Chief's response using secret voting tokens, and all the votes are revealed simultaneously. At the end of the round, the closest matches score victory points. With over 700 cards already written, the prompts cover an enormous range of topics from intimate to hilarious, from every-day to fantastical, from family-oriented to party-friendly. Since the point system requires collecting points of all colors in order to win, you cannot win simply by knowing one other player extremely well.

Abstract: A variety of methods and arrangements for controlling the exhaust gas temperature of a lean burn, skip fire controlled internal combustion engine are described. In one aspect, an engine controller includes an aftertreatment system monitor and a firing timing determination unit. The aftertreatment monitor obtains data relating to a temperature of one or more aftertreatment elements, such as a catalytic converter. Based at least partly on this data, the firing timing determination unit generates a firing sequence for operating the engine in a skip fire manner such that the temperature of the aftertreatment element is controlled within its effective operating range.