Abstract: A skip fire engine controller and method of control is described wherein during transitions from a first firing density to a second firing density, a firing density and a pumping density are separately set so as to balance the conflicting demands of (a) torque control, (b) Noise, Vibration and Harshness (NVH), (c) air flow through the engine and (d) air-fuel ratio.

Abstract: In this board game, players take turns being the Chief and rating their level of agreement with prompts such as: “For $1000, I would be willing to wear the same underwear for a week without washing it.” The opinions are guessed using a scale from 1 (“Frostbite!—Completely Disagree”) to 10 (“All Ablaze!—Completely Agree”). Before the Chief reveals his/her rating, all of the other players guess the Chief's response using secret voting tokens, and all the votes are revealed simultaneously. At the end of the round, the closest matches score victory points. With over 700 cards already written, the prompts cover an enormous range of topics from intimate to hilarious, from every-day to fantastical, from family-oriented to party-friendly. Since the point system requires collecting points of all colors in order to win, you cannot win simply by knowing one other player extremely well.

Abstract: A variety of methods and arrangements for controlling the exhaust gas temperature of a lean burn, skip fire controlled internal combustion engine are described. In one aspect, an engine controller includes an aftertreatment system monitor and a firing timing determination unit. The aftertreatment monitor obtains data relating to a temperature of one or more aftertreatment elements, such as a catalytic converter. Based at least partly on this data, the firing timing determination unit generates a firing sequence for operating the engine in a skip fire manner such that the temperature of the aftertreatment element is controlled within its effective operating range.

Abstract: The present disclosure provides chimeric antigen receptor polypeptides having antigen recognition domains for CD2, CD3, CD4, CD5, CD7, CD8, and CD52 antigens, and polynucleotides encoding for the same. The present disclosure also provides for engineered cells expressing the polynucleotide or polypeptides. In some embodiments, the disclosure provides methods for treating diseases associated with CD2, CD3, CD4, CD5, CD7, CD8, and CD52 antigens.

Abstract: The present invention discloses methods for producing a covalently attached antioxidant coating using a multi-step coating process consisting of (1) exposing the substrate surface to plasma polymerization to produce a surface containing functional groups; (2) contacting the surface containing functional groups with crosslinking agents to produce a reactive surface; (3) contacting the reactive surface with a solution of one or more antioxidant compounds or a solution of one or more antioxidant-containing polymers. Alternatively, the third step is replaced by (3) contacting the reactive surface with a solution of one or more polymers to produce a polymer coated surface and (4) covalently attaching one or more antioxidant compounds to the polymer coated surface.

Abstract: The separating television provided in the present invention relates to the field of television and through independently configuring the master control module and the screen terminal module in the television, the screen terminal module is mainly used to play the audio and video data and control the playing, and the master control module is mainly used to receive and process the audio and video data; the master control module and the screen terminal module are independently configured in physical structure, thus allows users to carry out the operations like repair, maintenance, upgrade and replacement on them independently; especially for the extreme unmatched upgrade speed between the screen terminal device and the master control device in the field of the television, the separating television disclosed in the present application can upgrade each separate unit according to individual requirements, thus effectively reduces the upgrading cost of televisions.

Abstract: The present disclosure relates to compositions and methods relating to chimeric antigen receptor (CAR) polypeptides and methods relating thereto. In one embodiment, the present disclosure relates to engineered cells having chimeric antigen receptor polypeptides directed to at least two targets. In another embodiment, the present disclosure relates to engineered cells having chimeric antigen receptor polypeptides and an enhancer moiety.

Abstract: An intermediate server synchronizes reporting data between a requestor computing device and an effector computing device. The server stores a plurality of event identifiers, and a plurality of reporting templates. Each template has a template identifier, and a mapping between a subset of the event identifiers and a set of reporting stages. The server, responsive to a production task request from the requestor device, obtains a selected templated identifier and generates a reporting data record for the production task request. The reporting data record includes fields for each stage defined by the selected template. After relaying the production task request to the effector device, the server receives reporting data from the effector device, containing values corresponding for a reported subset of the events. The server stores a portion of the values in the reporting data record according to the template; and transmits the reporting data record to the requestor device.

Abstract: Embodiments relate generally to systems and methods for calibrating a gas detector. Some embodiments may include a gas detector comprising one or more sensing elements operable to detect volatile organic compounds (VOC), and a probe operable to provide air flow into the gas detector, wherein the probe comprises: a housing operable to attach to a main body of the gas detector and operable to hold a calibration tube during calibration of the gas detector; a cap operable to attach to the housing and operable to fit over and cover the calibration tube; and one or more inlets, wherein when a calibration tube is inserted into the probe, the air flows through the calibration tube. In some embodiments of the gas detector, the calibration tube inserted into the probe comprises activated carbon fiber (ACF) filter material.

Abstract: Data transformation in a distributed system of applications and data repositories is described. The subsystems for the overall framework are distributed, thereby allowing for customization to require only isolated changes to one or more subsystems. In one embodiment, a source code repository is used to receive and store source code. A build subsystem can retrieve source code from the source code repository and build it, using one or more criteria. By building the source code, the build subsystem can generate an artifact, which is executable code, such as a JAR or SQL file. Likewise, by building the source code, the build subsystem can generate one or more job specifications for executing the executable code. In one embodiment, the artifact and job specification may be used to launch an application server in a cluster. The application server can then receive data transformation instructions and execute the data transformation instructions.

Abstract: A system for treating a patient suffering from obstructive sleep apnea or snoring is diclsoed. The system includes an air flow generator configured to deliver an air flow at a positive therapeutic pressure during the treatment, and an expiratory valve with an open pressure connected air flow generator. The open pressure is dependent on the therapeutic pressure from the air flow generator. The expiratory valve further exerts a back pressure upon each exhalation from the patient sufficient to create a pneumatic splint in the patient's respiratory tract. The exhalation from the patient has a first half followed by a second half and the back pressure is varied such that during the start of the first half the back pressure is between 0 and 50% of a peak back pressure and increases to a peak back pressure in the second half.

Abstract: A skip fire control that relies on a combination of a torque request, exhaust temperature, and air-fuel ratio in determining firing density is described. Also, skipped firing opportunities may either pump or not pump air into an exhaust system, allowing an exhaust gas temperature in the exhaust system to be controlled or modulated. The present invention is also related to Dynamic Skip Fire (DSF), where a decision to either fire or skip cylinders is made every firing opportunity.

Abstract: A method of treating a vulnerable atherosclerotic plaque can include identifying the vulnerable atherosclerotic plaque and administering a sulfated polysaccharide, or a pharmaceutically acceptable salt thereof, to a subject in an amount and at a frequency sufficient to stabilize and reverse a vulnerable atherosclerotic plaque.

Abstract: A variety of methods and arrangements for controlling the exhaust gas temperature of a lean burn, skip fire controlled internal combustion engine are described. In one aspect, an engine controller includes an aftertreatment system monitor and a firing timing determination unit. The aftertreatment monitor obtains data relating to a temperature of one or more aftertreatment elements, such as a catalytic converter. Based at least partly on this data, the firing timing determination unit generates a firing sequence for operating the engine in a skip fire manner such that the temperature of the aftertreatment element is controlled within its effective operating range.

Abstract: Embodiments relate generally to systems and methods for calibrating a gas detector. Some embodiments may include a gas detector comprising one or more sensing elements operable to detect volatile organic compounds (VOC), and a probe operable to provide air flow into the gas detector, wherein the probe comprises: a housing operable to attach to a main body of the gas detector and operable to hold a calibration tube during calibration of the gas detector; a cap operable to attach to the housing and operable to fit over and cover the calibration tube; and one or more inlets, wherein when a calibration tube is inserted into the probe, the air flows through the calibration tube. In some embodiments of the gas detector, the calibration tube inserted into the probe comprises activated carbon fiber (ACF) filter material.

Abstract: Using machine learning for misfire detection in a Dynamic firing level modulation controlled internal combustion engine is described. A neural network is used to calculate expected crank acceleration from various inputs, including the dynamically defined cylinder skip fire sequence. The output of the neural network is then compared to a signal indicative of the measured crank acceleration. Based the comparison, a prediction is made if a misfire has occurred or not. In alternative embodiment, the neural network is expanded to include the measured crank acceleration as an additional input. With the latter embodiment, the neural network is arranged to directly predict misfire events.

Abstract: In one embodiment, the present disclosure provides an engineered cell having a first chimeric antigen receptor polypeptide including a first antigen recognition domain, a first signal peptide, a first hinge region, a first transmembrane domain, a first co-stimulatory domain, and a first signaling domain; and a second chimeric antigen receptor polypeptide including a second antigen recognition domain, a second signal peptide, a second hinge region, a second transmembrane domain, a second co-stimulatory domain, and a second signaling domain; wherein the first antigen recognition domain is different than the second antigen recognition domain.

Abstract: The present disclosure provides chimeric antigen receptor polypeptides having antigen recognition domains for CD2, CD3, CD4, CD5, CD7, CD8, and CD52 antigens, and polynucleotides encoding for the same. The present disclosure also provides for engineered cells expressing the polynucleotide or polypeptides. In some embodiments, the disclosure provides methods for treating diseases associated with CD2, CD3, CD4, CD5, CD7, CD8, and CD52 antigens.