Abstract: An intramedullary nail system includes an insertion handle for insertion of an intramedullary nail into a medullary canal of a bone and an aiming arm to releasably couplable to the insertion handle. The arm includes a connecting hole and a plurality of openings extending therethrough, the connecting hole configured to slidably receive a distal portion of the insertion handle therethrough. A locking mechanism is configured to lock the arm in a desired orientation relative to the insertion handle and includes a pin movable between a locked configuration, in which a tip thereof extends into the connecting hole and one of the plurality of recesses of the insertion handle to lock the arm in the desired orientation relative to the insertion handle, and an unlocked configuration, in which the tip of the pin does not extend into the connecting hole so that the arm is rotatable thereabout.

Abstract: An orthopedic fixation system includes a fastener configured to secure a first bone with a second bone whereby the fastener stabilizes the first bone relative to the second bone. The fastener includes an elastic component that provides the fastener with the ability to accommodate relative motion between the first bone relative to the second bone.

Abstract: An intramedullary nailing system has an intramedullary nail, an inserter, and a deployment instrument. The nail has an elongate body housing a spring and a shuttle that is joined with the spring and defining an aperture for receiving a locking member for affixing the shuttle to bone. The inserter has a leading end for coupling with the nail, a trailing end, and a cannulation extending forwardly from the trailing to leading end. The instrument has an elongate body having trailing, intermediate, and leading portions. The leading portion is configured to extend through the cannulation and couple with the shuttle. An actuator defines transmission formations for engaging complementary structures of the intermediate portion. The actuator is manipulatable to cause the transmission formations to engage the complementary structures for translating the instrument body and shuttle rearwardly together, thereby loading a forward spring force in the spring.

Abstract: An orthopedic fixation system includes a fastener configured to secure a first bone with a second bone whereby the fastener stabilizes the first bone relative to the second bone. The fastener includes an elastic component that provides the fastener with the ability to accommodate relative motion between the first bone relative to the second bone.

Abstract: A bone correction system is configured to attach to the medial cuneiform and the first metatarsal of a patient's foot in a deformed configuration. An articulation joint is configured to rotate and angulate the first metatarsal with respect to the medial cuneiform. A translation assembly is configured to cause the first metatarsal to travel toward and/or against the medial cuneiform. Thus, the bone correction system is configured to iterate the patient's foot from the deformed configuration to a corrected configuration. A bone plate can permanently fix the medial cuneiform and the first metatarsal in the corrected configuration.

Abstract: A system includes an intramedullary nail, a pin, a spindle, and a compression device including a pair of arms having distal and proximal ends. The nail is inserted through a medullary canal of a bone, extends longitudinally from a proximal end to a distal end and includes slotted opening extending transversely through a proximal portion of the nail and elongated along a length of the nail. The pin extends longitudinally from proximal to distal ends and is inserted through the opening. The spindle is releasably coupled to an insertion handle facilitating implantation of the nail. The distal ends connected to one another via a distal block releasably engaging the spindle. The proximal ends include engaging members mounted over the pin, so that moving the spindle distally with respect to the handle correspondingly moves the pin through the opening in a distal direction relative to the nail.

Abstract: A drill guide, including: a handle; and a base connected to the handle, the base further including: a body; a lip on an outer surface of the body, the lip configured to interface an upper surface of a bone plate; a guide hole extending through the body from a first surface of the body to a second surface of the body; and a relief surface extending between the first surface of the body and the second surface of the body.

Abstract: A drill guide, including: a handle; and a base connected to the handle, the base further including: a body; a lip on an outer surface of the body, the lip configured to interface an upper surface of a bone plate; a guide hole extending through the body from a first surface of the body to a second surface of the body; and a relief surface extending between the first surface of the base and the second surface of the body.

Abstract: A fixation apparatus may be attached to first and second anatomical structure segments. Images of the fixation apparatus and the attached anatomical structure segments may then be captured. In some examples, the images need not necessarily be orthogonal with respect to one another. Configuration information associated with the fixation apparatus may then be received. Additionally, first image information may be received, for example including indications of one or more locations, within the images, of at least part of one or more elements of the fixation apparatus. Additionally, second image information may be received, for example including indications of one or more locations, within the images, of at least part of the first and the second anatomical structure segments. Manipulations to the fixation apparatus for correction of the anatomical structure deformity may then be determined, and indications of the determined manipulations may then be provided to one or more users.

Abstract: Methods are provided for treating disorders associated with default mode network (DMN) dysfunction in a patient, where the methods include administering alpha-frequency transcranial alternating current stimulation (?-tACS) to the brain of the patient via at least one electrode, and where the ?-tACS is effective to regulate DMN dysfunction and treat disorders associated therewith. Diseases and disorders associated with DMN dysfunction include normal or abnormal aging, cognitive impairment, or neuropsychiatric disorders such as Alzheimer's disease, schizophrenia, autism, or posttraumatic stress disorder (PTSD).

Abstract: A method for syndesmosis fixation including at least one suture anchor configured to be implanted into bone and at least one suture assembly configured to extend from the suture anchor and about at least a portion of a fibula when the suture anchor is implanted in a tibia on either side of a fibular notch of the tibia. The suture assembly is selectively adjustable from a non-tensioned condition to a tensioned condition to stabilize and reduce the fibula relative to the tibia.

Abstract: A fixation apparatus may be attached to first and second anatomical structure segments. Images of the fixation apparatus and the attached anatomical structure segments may then be captured. In some examples, the images need not necessarily be orthogonal with respect to one another. Configuration information associated with the fixation apparatus may then be received. Additionally, first image information may be received, for example including indications of one or more locations, within the images, of at least part of one or more elements of the fixation apparatus. Additionally, second image information may be received, for example including indications of one or more locations, within the images, of at least part of the first and the second anatomical structure segments. Manipulations to the fixation apparatus for correction of the anatomical structure deformity may then be determined, and indications of the determined manipulations may then be provided to one or more users.

Abstract: A fixation apparatus may be attached to first and second anatomical structure segments. Images of the fixation apparatus and the attached anatomical structure segments may then be captured. In some examples, the images need not necessarily be orthogonal with respect to one another. Configuration information associated with the fixation apparatus may then be received. Additionally, first image information may be received, for example including indications of one or more locations, within the images, of at least part of one or more elements of the fixation apparatus. Additionally, second image information may be received, for example including indications of one or more locations, within the images, of at least part of the first and the second anatomical structure segments. Manipulations to the fixation apparatus for correction of the anatomical structure deformity may then be determined, and indications of the determined manipulations may then be provided to one or more users.

Abstract: A method for syndesmosis fixation including at least one suture anchor configured to be implanted into bone and at least one suture assembly configured to extend from the suture anchor and about at least a portion of a fibula when the suture anchor is implanted in a tibia on either side of a fibular notch of the tibia. The suture assembly is selectively adjustable from a non-tensioned condition to a tensioned condition to stabilize and reduce the fibula relative to the tibia.

Abstract: A fixation apparatus may be attached to first and second anatomical structure segments. Images of the fixation apparatus and the attached anatomical structure segments may then be captured. In some examples, the images need not necessarily be orthogonal with respect to one another. Configuration information associated with the fixation apparatus may then be received. Additionally, first image information may be received, for example including indications of one or more locations, within the images, of at least part of one or more elements of the fixation apparatus. Additionally, second image information may be received, for example including indications of one or more locations, within the images, of at least part of the first and the second anatomical structure segments. Manipulations to the fixation apparatus for correction of the anatomical structure deformity may then be determined, and indications of the determined manipulations may then be provided to one or more users.

Abstract: An on board diagnostic (OBD) device having a radio modem is provided. An antenna of the radio modem is connected to a printed circuit board (PCB) housed within a plastic housing, where the PCB has a ground plane which is extended by a conductive extension. The conductive extension lengthens an effective length of a counterpoise of the antenna without necessitating an increase in size of the OBD device/plastic housing, resulting in maintaining a small form factor for the OBD device, while increasing antenna efficiency and/or bandwidth.

Abstract: An on board diagnostic (OBD) device having a radio modem is provided. An antenna of the radio modem is connected to a printed circuit board (PCB) housed within a plastic housing, where the PCB has a ground plane which is extended by a conductive extension. The conductive extension lengthens an effective length of a counterpoise of the antenna without necessitating an increase in size of the OBD device/plastic housing, resulting in maintaining a small form factor for the OBD device, while increasing antenna efficiency and/or bandwidth.

Abstract: Embodiments describe computer systems and computer programs for implementing BioCAD methods comprising one or more data models and one or more BioCAD tools, wherein the BioCAD tools enable users to design or refactor a biomolecule or to conduct a biological experiment in silico by user input of one or more components selected by the user from a database populated with information on components and scientific data of existing biomolecules and experiments. Data models of the programs are operable to manage development of the new biomolecule or experiment based on information in the databases. Computer programs also provide an output with information that enables the users to determine in silico if the newly designed or refactored molecule or biological experiment is satisfactory or not for its intended purpose in vitro and also provides the user the capability to re-design the biomolecule or experiment till it is satisfactory.

Abstract: Embodiments describe a non-transitory computer-readable storage medium encoded with instructions, executable by a processor, comprising instructions for a method for performing a biological workflow in silico comprising: presenting to a user a plurality of subroutines listed in a sequential order of the workflow, wherein at least two subroutines comprise two steps; providing the user ability to navigate to any subroutine and/or step, to select a subroutine, to view, set, or change one or more parameters associated with step/subroutine; providing option to display biomolecule(s) resulting from execution of the subroutines/steps; and providing an option to navigate to a prior subroutine and change a parameter of a step of the prior subroutine and execute the step of the prior subroutine, if the user is not satisfied with the displayed biomolecule(s). Computer systems and methods for performing a biological workflow in silico are also described.

Abstract: Embodiments describe a non-transitory computer-readable storage medium encoded with instructions, executable by a processor, comprising instructions for a method for performing a biological workflow in silico comprising: presenting to a user a plurality of subroutines listed in a sequential order of the workflow, wherein at least two subroutines comprise two steps; providing the user ability to navigate to any subroutine and/or step, to select a subroutine, to view, set, or change one or more parameters associated with step/subroutine; providing option to display biomolecule(s) resulting from execution of the subroutines/steps; and providing an option to navigate to a prior subroutine and change a parameter of a step of the prior subroutine and execute the step of the prior subroutine, if the user is not satisfied with the displayed biomolecule(s). Computer systems and methods for performing a biological workflow in silico are also described.