Abstract: Disclosed herein are compounds of the general Formula (I), and methods of synthesizing a substituted bicyclo[1.1.1]pentane using a Group VII or Group IX transition metal compound.

Abstract: Disclosed herein are spirocyclic compounds, together with pharmaceutical compositions and methods of ameliorating and/or treating a cancer described herein with one or more of the compounds described herein.

Abstract: Disclosed herein are nitrogen-containing bicyclic compounds, together with pharmaceutical compositions and methods of ameliorating and/or treating a cancer described herein with one or more of the compounds described herein.

Abstract: Described herein are compounds that are autotaxin inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with autotaxin activity.

Abstract: An apparatus and method for a fluid leak detection and shutdown for a fluid distribution system having a total system flow rate. The apparatus includes a solenoid shutoff valve having a normally open state and an activated closed state with a flow capacity matched to the total fluid distribution system flow rate. The apparatus also has a primary fluid flow line and a smaller capacity secondary fluid flow line. The apparatus includes a flow sensor in fluid communication with the secondary fluid flow line, wherein the flow sensor has a perceptible output and a flow rate capacity less than the solenoid shutoff flow capacity. Operationally, the flow sensor receives a portion of the solenoid shutoff valve flow capacity in priority over the primary fluid flow line, allowing the flow sensor to detect minimal flow rates and using the perceptible output to activate the solenoid shutoff valve into the closed state.

Abstract: Analgesic compounds for treatment of pain or fever that include a bicyclopentane moiety linked to an amine, combinations of the compounds with opioid analgesic drugs, and methods for treating pain or fever by administering a compound described herein.

Abstract: Disclosed herein are nitrogen-containing bicyclic compounds, together with pharmaceutical compositions and methods of ameliorating and/or treating a cancer described herein with one or more of the compounds described herein.

Abstract: A stowage bin assembly is configured to be positioned above at least a portion of one or more seats within a vehicle. The stowage bin assembly may include a pivot bin including a forward end panel, an aft end panel that is opposed to the forward end panel, a front panel extending between the forward and aft end panels, and a closeout bracket secured to the forward end panel, the aft end panel, and the front panel. A baggage retaining chamber is defined between the forward end panel, the aft end panel, and the front panel. The closeout bracket spans between the forward end panel and the aft end panel.

Abstract: A stowage bin assembly is configured to be positioned above at least a portion of one or more seats within a vehicle. The stowage bin assembly may include a pivot bin including a forward end panel, an aft end panel that is opposed to the forward end panel, a front panel extending between the forward and aft end panels, and a closeout bracket secured to the forward end panel, the aft end panel, and the front panel. A baggage retaining chamber is defined between the forward end panel, the aft end panel, and the front panel. The closeout bracket spans between the forward end panel and the aft end panel.

Abstract: Analgesic compounds for treatment of pain or fever that include a bicyclopentane moiety linked to an amine, combinations of the compounds with opioid analgesic drugs, and methods for treating pain or fever by administering a compound described herein.

Abstract: Analgesic compounds for treatment of pain or fever, comprising a bicyclopentane moiety linked to an amine, combinations of the compounds with opioid analgesic drugs, and methods for treating pain or fever by administering the compounds.

Abstract: Disclosed herein are compounds of the general Formula (I), and methods of synthesizing substituted bicyclo[1.1.1 jpentanes. The synthetic methods described herein use a [1.1.1]propellane, a Group VIII transition metal compound, a hydride source and a reagent that can contribute a substituent to form a substituted bicyclo[1.1.1]pentane, such as a compound of the general Formula (I).

Abstract: Analgesic compounds for treatment of pain or fever that include a bicyclopentane moiety linked to an amine, combinations of the compounds with opioid analgesic drugs, and methods for treating pain or fever by administering a compound described herein.

Abstract: Analgesic compounds for treatment of pain or fever, comprising a bicyclopentane moiety linked to an amine, combinations of the compounds with opioid analgesic drugs, and methods for treating pain or fever by administering the compounds.

Abstract: A section divider system is configured to separate sections within an internal cabin of a vehicle. The section divider system may include a first rail secured to a fixed panel within the internal cabin. A closeout panel may be secured to the fixed panel. The closeout panel extends between the fixed panel and a passenger service unit (PSU) within the internal cabin. A clearance space is formed between a portion of the closeout panel and the PSU. The closeout panel is configured to prevent access to an interior of the PSU. A bracket is secured to the first rail. One or more connecting beams extend from the bracket through the clearance space. A section divider assembly is connected to the connecting beam(s).

Abstract: Disclosed herein are compounds of the general Formula (I), and methods of synthesizing a substituted bicyclo[1.1.1]pentane using a Group VII or Group IX transition metal compound.

Abstract: A stowage bin assembly is configured to be positioned above at least a portion of one or more seats within a vehicle. The stowage bin assembly may include a pivot bin including a forward end panel, an aft end panel that is opposed to the forward end panel, a front panel extending between the forward and aft end panels, and a closeout bracket secured to the forward end panel, the aft end panel, and the front panel. A baggage retaining chamber is defined between the forward end panel, the aft end panel, and the front panel. The closeout bracket spans between the forward end panel and the aft end panel.

Abstract: A section divider system is configured to separate sections within an internal cabin of a vehicle. The section divider system may include a first rail secured to a fixed panel within the internal cabin. A closeout panel may be secured to the fixed panel. The closeout panel extends between the fixed panel and a passenger service unit (PSU) within the internal cabin. A clearance space is formed between a portion of the closeout panel and the PSU. The closeout panel is configured to prevent access to an interior of the PSU. A bracket is secured to the first rail. One or more connecting beams extend from the bracket through the clearance space. A section divider assembly is connected to the connecting beam(s).

Abstract: An apparatus and method for a fluid leak detection and shutdown for a fluid distribution system having a total system flow rate. The apparatus includes a solenoid shutoff valve having a normally open state and an activated closed state with a flow capacity matched to the total fluid distribution system flow rate. The apparatus also has a primary fluid flow line and a smaller capacity secondary fluid flow line. The apparatus includes a flow sensor in fluid communication with the secondary fluid flow line, wherein the flow sensor has a perceptible output and a flow rate capacity less than the solenoid shutoff flow capacity. Operationally, the flow sensor receives a portion of the solenoid shutoff valve flow capacity in priority over the primary fluid flow line, allowing the flow sensor to detect minimal flow rates and using the perceptible output to activate the solenoid shutoff valve into the closed state.

Abstract: Analgesic compounds for treatment of pain or fever that include a bicyclopentane moiety linked to an amine, combinations of the compounds with opioid analgesic drugs, and methods for treating pain or fever by administering a compound described herein.