Abstract: An apparatus includes a catheter, an introducer, and an actuator. A distal end portion of the introducer is configured to couple to an indwelling peripheral intravenous line. The actuator is movably coupled to the introducer and is configured to move the catheter between a first position, in which the catheter is disposed within the introducer, and a second position, in which a distal end portion of the catheter is distal to the introducer. A first portion of the actuator is disposed outside of the introducer and in contact with an outer surface of the introducer such that (1) a longitudinal axis defined by a second portion of the actuator is nonparallel to a longitudinal axis defined by the introducer and (2) the second portion of the actuator exerts a force on a proximal end portion of the catheter operable to increase an internal stress within a portion of the catheter.

Abstract: A tissue support device is provided for managing access through tissue. The tissue support device engages the tissue proximate an opening in the tissue and biases the tissue support device to bring the engaged tissue together.

Abstract: An apparatus includes an introducer defining a lumen and a catheter movably disposed in the lumen. The introducer has a distal end portion configured to operably couple to an indwelling peripheral intravenous line at least partially disposed in a vein. The catheter is configured to be moved between a first position, in which the catheter is proximal to the peripheral intravenous line when the introducer is operably coupled thereto, and a second position, in which a distal surface of the catheter is distal to the introducer and disposed at a predetermined distance from a distal tip of the peripheral intravenous line. The predetermined distance defined between the distal surface of the catheter and the distal tip of the peripheral intravenous line is based at least in part on a venous anatomy associated with the vein.

Abstract: An apparatus includes an introducer defining a lumen and a catheter movably disposed in the lumen. The introducer has a distal end portion configured to operably couple to an indwelling peripheral intravenous line at least partially disposed in a vein. The catheter is configured to be moved between a first position, in which the catheter is proximal to the peripheral intravenous line when the introducer is operably coupled thereto, and a second position, in which a distal surface of the catheter is distal to the introducer and disposed at a predetermined distance from a distal tip of the peripheral intravenous line. The predetermined distance defined between the distal surface of the catheter and the distal tip of the peripheral intravenous line is based at least in part on a venous anatomy associated with the vein.

Abstract: Stent delivery system comprising a catheter shaft having a proximal end portion and a distal end portion and an expandable member provided at the distal end portion of the shaft, the expandable member having a delivery condition and a deployed condition and formed at least in part from a matrix of fiber elements to define a continuous surface substantially free of openings when in the delivery condition.

Abstract: An apparatus includes a catheter, an introducer, and an actuator. A distal end portion of the introducer is configured to be coupled to a peripheral intravenous line. The introducer defines an inner volume having a first portion that defines an axis parallel to and offset from an axis defined by a second portion. A first portion of the actuator is movably disposed in the first portion of the inner volume. A second portion of the actuator is movably disposed in the second portion of the inner volume and coupled to the catheter movably disposed in the second portion of the inner volume. The actuator moves the catheter between a first position, in which the catheter is disposed within the introducer, and a second position, in which at least a portion of the catheter is disposed within the peripheral intravenous line.

Abstract: A tissue support device is provided for managing access through tissue. The tissue support device engages the tissue proximate an opening in the tissue and biases the tissue support device to bring the engaged tissue together.

Abstract: Stent delivery system comprising a catheter shaft having a proximal end portion and a distal end portion and an expandable member provided at the distal end portion of the shaft, the expandable member having a delivery condition and a deployed condition and formed at least in part from a matrix of fiber elements to define a continuous surface substantially free of openings when in the delivery condition.

Abstract: A tissue support device is provided for managing access through tissue. The tissue support device engages the tissue proximate an opening in the tissue and biases the tissue support device to bring the engaged tissue together.

Abstract: Catheter-based systems for in-vivo targeted light therapy include a first type of catheter configured for photo-activating photosensitive substances in tissue, and a second type of catheter configured for photo-degrading photosensitive substances in tissue. The catheters may be configured to produce light using a variety of light sources, such as light emitting diodes (LEDs) and fiber optics. The light transmission is directed to tissue in such a way that only portions of tissue in a treatment area are exposed to light, depending upon whether the tissue is diseased or healthy.

Abstract: A catheter capable of rapid inflation and deflation and operation by one individual.

Abstract: A system including a catheter and an expandable member. The catheter includes an independent inflation lumen and an separate independent deflation lumen capable of sequential inflation and deflation of an expandable member in rapid succession, such as less than five seconds.

Abstract: A tissue support device is provided for managing access through tissue. The tissue support device engages the tissue proximate an opening in the tissue and biases the tissue support device to bring the engaged tissue together.

Abstract: Systems and methods for electropolishing devices are disclosed. The electropolishing system includes electropolishing fixtures configured to reposition the devices during the electropolishing process.

Abstract: A catheter having a fluid circuit to control and modulate flow of inflation fluid to and from a balloon.

Abstract: Catheter-based systems for in-vivo targeted light therapy include a first type of catheter configured for photo-activating photosensitive substances in tissue, and a second type of catheter configured for photo-degrading photosensitive substances in tissue. The catheters may be configured to produce light using a variety of light sources, such as light emitting diodes (LEDs) and fiber optics. The light transmission is directed to tissue in such a way that only portions of tissue in a treatment area are exposed to light, depending upon whether the tissue is diseased or healthy.

Abstract: A catheter for delivering an agent to an injection site in a wall of a patient's body lumen, with an elongated shaft having a needle-through lumen slidably containing a needle therein, and an expandable member on the distal shaft section which has a collapsed configuration and a radially expanded configuration. In the radially expanded configuration, the expandable member supports the shaft in a position spaced away from the body lumen wall, and the needle slidably exits the needle-through lumen in the extended configuration through the port spaced away from the body lumen wall as a portion of the expandable member maintains the position of the port section of the shaft in the body lumen. The expandable member typically has an open-walled, helical, or lobed configuration providing a perfusion path along the expandable member.

Abstract: A method for synergistic mitigation of reperfusion injury after an ischemia event in a subject.

Abstract: The present invention relates to balloon catheters for treating a luminal system of a patient. Specifically, the invention relates to catheters having a flexible membrane positioned at a distal portion of the catheter, the flexible membrane retained in a substantially unexposed conformation prior to deployment. Preferably the flexible membrane is capable of delivering a therapeutic agent to a localized environment when deployed to an exposed conformation.

Abstract: Systems and methods for electropolishing devices are disclosed. The electropolishing system includes electropolishing fixtures configured to reposition the devices during the electropolishing process.