Abstract: A tissue support device is provided for managing access through tissue. The tissue support device engages the tissue proximate an opening in the tissue and biases the tissue support device to bring the engaged tissue together.

Abstract: A method for charging a deformable intraocular lens into a receptacle through a slit or opening in the receptacle periphery, the lens in un-deformed state includes a roughly disc shaped optic part configured to act as a lens when inserted into an eye and at least two elongated haptic legs, each leg having an inner end attached to the optic part, an outer end being free and intermediate points in between the inner end and the free end, each leg being curved in unstressed state and being flexible to at least a less curved configuration under stress. Steps include stretching the legs to align the legs along a substantially straight line, aligning or maintaining the substantially straight line over and substantially parallel with the slit or opening of the receptacle, and transferring at least the two legs through the slit or opening into the receptacle.

Abstract: The present invention relates to balloon catheters for treating a luminal system of a patient. Specifically, the invention relates to catheters having a flexible membrane positioned at a distal portion of the catheter, the flexible membrane retained in a substantially unexposed conformation prior to deployment. Preferably the flexible membrane is capable of delivering a therapeutic agent to a localized environment when deployed to an exposed conformation.

Abstract: The present invention relates to balloon catheters for treating a luminal system of a patient. Specifically, the invention relates to catheters having a flexible membrane positioned at a distal portion of the catheter, the flexible membrane retained in a substantially unexposed conformation prior to deployment. Preferably the flexible membrane is capable of delivering a therapeutic agent to a localized environment when deployed to an exposed conformation.

Abstract: Stent delivery system comprising a catheter shaft having a proximal end portion and a distal end portion and an expandable member provided at the distal end portion of the shaft, the expandable member having a delivery condition and a deployed condition and formed at least in part from a matrix of fiber elements to define a continuous surface substantially free of openings when in the delivery condition.

Abstract: This device for stretching the haptics of an intraocular lens has at least two haptic guiding surfaces, a seat arranged with respect to the guiding surfaces so as to allow contact between a first point on each haptic and its corresponding guiding surface, and a lens guiding arrangement operable to allow the lens positioned in the seat to be moved along a path in the optic axis direction to bring at least a second point on each haptic into contact with, or closer to, its corresponding guiding surface and to orient each haptic in a less curved state, wherein the guiding surfaces extend in opposite directions from a channel operable to receive the lens.

Abstract: A catheter for delivering an agent to an injection site in a wall of a patient's body lumen, with an elongated shaft having a needle-through lumen slidably containing a needle therein, and an expandable member on the distal shaft section which has a collapsed configuration and a radially expanded configuration. In the radially expanded configuration, the expandable member supports the shaft in a position spaced away from the body lumen wall, and the needle slidably exits the needle-through lumen in the extended configuration through the port spaced away from the body lumen wall as a portion of the expandable member maintains the position of the port section of the shaft in the body lumen. The expandable member typically has an open-walled, helical, or lobed configuration providing a perfusion path along the expandable member.

Abstract: A pre-assembled kit for administering ischemic postconditioning comprising a catheter and a handle having a fluid circuit to control and modulate flow of inflation fluid to and from a balloon wherein the catheter is free from additional assembly and preparation procedures such that it is ready-to-use within a variety of vessel sizes.

Abstract: Devices and methods for treating veins and venous conditions, such as chronic cerebrospinal venous insufficiency, are provided. In one aspect, the disclosed subject matter provides an intraluminal scaffold having a generally tubular body with a lumen defined therethrough, the tubular body having a compressed condition for delivery and an expanded condition for implant within a vessel having a distended portion, at least a length of the tubular body configured to form an enlarged portion in the expanded condition to engage a wall of the distended portion of the vessel. Methods for fabricating and using the scaffold, methods for remodeling a vein, and methods of deploying a medical device in a vessel without negatively impacting the function of a valve of the vessel, are also provided.

Abstract: The present invention provides an intraluminal stent delivery catheter device having improved stent retention. Particularly, the present invention is directed to a catheter having an expandable member and a fibrous matrix positioned over the expandable member and a stent mounted on the outer surface of the fibrous matrix. The fibrous matrix provides mechanical interface for improved stent retention, delivery and deployment.

Abstract: A method for charging a deformable intraocular lens into a receptacle through a slit or opening in the receptacle periphery, the lens in un-deformed state comprising a) a roughly disc shaped optic part configured to act as a lens when inserted into an eye and b) at least two elongated haptic legs, each leg having an inner end attached to the optic part, an outer end being free and intermediate points in between the inner end and the free end, each leg being curved in unstressed state and being flexible to at least a less curved configuration under stress. The method comprises the steps of i) stretching the legs to align the legs along a substantially straight line, ii) aligning or maintaining the substantially straight line over and substantially parallel with the slit or opening of the receptacle, and iii) transferring at least the two legs through the slit or opening into the receptacle.

Abstract: An ischemic postconditioning system and related method comprising a catheter including a plurality of lumens and at least one expandable member with at least one chamber including a moveable plunger and a return mechanism operatively engaged with the plunger. The moveable plunger divides the at least one chamber into first and second volumes. A first pressure source is provided having a first fluid at a first pressure and is disposed in fluid communication with the first volume of the chamber. Further, a second pressure source is provided having a second fluid at a second pressure and is disposed in fluid communication with the second volume of the chamber. Similarly, the at least one expandable member is disposed in fluid communication with the second volume of the chamber. The first fluid supplied by the first pressure source displaces the plunger in a first direction delivering at least a portion of the second fluid into the at least one expandable member.

Abstract: A device and method is disclosed for reducing turbulent blood flow over stent struts of an intravascular stent implanted in, for example, a coronary artery. An abrasive slurry is passed over the struts of an intravascular stent in order to remove a portion of the stent struts to form an airfoil shape. When the stent having airfoil-shaped struts is implanted in an artery, the flow of blood over the airfoil shape will reduce the likelihood of turbulent blood flow and thereby will reduce the likelihood of turbulent blood flow and thereby reduce the likelihood of a buildup in plaque or injury to the vessel wall.

Abstract: The present invention relates to balloon catheters for treating a luminal system of a patient. Specifically, the invention relates to catheters having a flexible membrane positioned at a distal portion of the catheter, the flexible membrane retained in a substantially unexposed conformation prior to deployment. Preferably the flexible membrane is capable of delivering a therapeutic agent to a localized environment when deployed to an exposed conformation.

Abstract: A catheter tubing is disclosed having a cross-sectional profile that takes the characteristics of a structural beam, such as an “I”-beam, and in so doing possesses the bending moment and stiffness of the beam profile. The tubing can be made from existing polymers and existing manufacturing techniques, and multi-lumen configurations are possible. In the example of the I-beam profile, the catheter tubing will have two lumens while a double I-beam configuration will possess four lumens.

Abstract: Expandable intraluminal scaffold defining a longitudinal axis is provided, wherein the scaffold includes at least two filaments extending from a head portion disposed along the longitudinal axis at a first longitudinal end, each of the at least two filaments including a free end portion at a second longitudinal end opposite the head portion. The at least two filaments converge toward each other at a juncture disposed proximate the longitudinal axis between the first longitudinal end and the second longitudinal end. A system including a delivery system and the intraluminal scaffold, as well as a method of delivering the scaffold, is also provided.

Abstract: Intraluminal scaffold assembly implantable in a body lumen of a patient to manipulate a valve of the lumen is provided. The intraluminal scaffold assembly includes an intraluminal scaffold, an elongated core member coupled with the intraluminal scaffold having a length sufficient to traverse a valve in a body lumen with the intraluminal scaffold positioned proximate the valve. The intraluminal scaffold assembly can further include one or more additional intraluminal scaffolds, a weighted element or an active element that is coupled with the elongated core member. A system including a delivery system and the intraluminal scaffold assembly, as well as methods of delivering the intraluminal scaffold assembly and using the intraluminal scaffold assembly to manipulate a valve in a body lumen, is also provided.

Abstract: A tissue support device is provided for managing access through tissue. The tissue support device engages the tissue proximate an opening in the tissue and biases the tissue support device to bring the engaged tissue together.

Abstract: A catheter for delivering an agent to an injection site in a wall of a patient's body lumen, with an elongated shaft having a needle-through lumen slidably containing a needle therein, and an expandable member on the distal shaft section which has a collapsed configuration and a radially expanded configuration. In the radially expanded configuration, the expandable member supports the shaft in a position spaced away from the body lumen wall, and the needle slidably exits the needle-through lumen in the extended configuration through the port spaced away from the body lumen wall as a portion of the expandable member maintains the position of the port section of the shaft in the body lumen. The expandable member typically has an open-walled, helical, or lobed configuration providing a perfusion path along the expandable member.

Abstract: A delivery catheter for delivery, then photo-activation of photo sensitive material has a photo-sensitive substance-delivery part and an activation part. The catheter delivers substances such as biomaterials to a target site, followed by illumination of the target using optics located at the distal tip of the catheter which are optically coupled to an extracorporeal light source. In another aspect a deployable light-delivery catheter is disclosed that can illuminate a large area of tissue.