Abstract: Example methods and apparatus for automating startup processes of gas grills are disclosed. An example grill includes a first burner, a second burner, a first burner valve operatively positioned between the first burner and a manifold of the grill, a second burner valve operatively positioned between the second burner and the manifold, a first ignitor operatively positioned relative to the first burner, and a second ignitor operatively positioned relative to the second burner. The example grill further includes a controller operatively coupled to the first burner valve, the second burner valve, the first ignitor, and the second ignitor. In response to determining that a user-based startup request has been received at the grill, the controller is to instruct the first burner valve and the second burner valve to open, and instruct the first ignitor and the second ignitor to ignite corresponding ones of the first burner and the second burner.

Abstract: Example methods and apparatus for automating shutdown processes of gas grills are disclosed. An example grill includes a first burner, a second burner, a first burner valve operatively positioned between the first burner and a manifold of the grill, and a second burner valve operatively positioned between the second burner and the manifold. The example grill further includes a controller operatively coupled to the first burner valve and the second burner valve. In response to determining that a shutdown request has been received at the grill, the controller is to instruct the first burner valve and the second burner valve to close.

Abstract: Apparatuses, systems and methods are provided for treating pulmonary tissues via delivery of energy, generally characterized by high voltage pulses, to target tissue using a pulmonary tissue modification system (e.g., an energy delivery catheter system). Example pulmonary tissues include, without limitation, the epithelium (the goblet cells, ciliated pseudostratified columnar epithelial cells, and basal cells), lamina propria, submucosa, submucosal glands, basement membrane, smooth muscle, cartilage, nerves, pathogens resident near or within the tissue, or a combination of any of these. The system may be used to treat a variety of pulmonary diseases or disorders such as or associated with COPD (e.g., chronic bronchitis, emphysema), asthma, interstitial pulmonary fibrosis, cystic fibrosis, bronchiectasis, primary ciliary dyskinesia (PCD), acute bronchitis and/or other pulmonary diseases or disorders.

Abstract: A system for paving a bridge comprising a screed rail configured to support a concrete paver and a plurality of adjustable width barrier brackets to support the screed rail with a bridge barrier, where each adjustable width barrier brackets comprise a rail support bracket and an “L” barrier bracket which allows for width adjustment by translation of the rail support bracket through the “L” barrier bracket.

Abstract: The present disclosure relates to certain (2S)—N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof), that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.

Abstract: The present disclosure relates to certain (2S)—N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof), that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.

Abstract: A mat assembly including a planar mat body formed to cover a preselected area of a surface region. The preselected area partially defines a volume of ground to be broken by explosion therein. The mat body includes one or more layer elements. The mat body has an engagement surface for engagement with the preselected area. The mat assembly includes a skirt element connected with the mat body having an external portion extending from the mat body, for at least partially restraining matter ejected from the volume of ground upon initiation of the explosion.

Abstract: This invention relates generally to anellosomes and compositions and uses thereof.

Abstract: A hierarchical resource management system for a building includes one or more processors. The processors implement a plurality of agents that each monitor sensed values, and generate operating scenarios based on the sensed values for corresponding resources. The processors also implement a coordinator that filters the operating scenarios to remove the operating scenarios that violate internal laws of the agents to form an aggregate validated set of operating scenarios. The processors further implement a supervisor that, responsive to receipt of target conditions for the zones and the aggregate validated set of operating scenarios from the coordinator, selects a combination of the operating scenarios from the aggregate validated set of operating scenarios that achieves target conditions and minimizes overall energy consumption by the resources such that some of the operating scenarios of the combination do not minimize energy consumption of the resources corresponding to the some of the operating scenarios.

Abstract: A device for treating a tissue opening includes a proximal portion including an elongated flexible member, a capsule releasably coupled to a distal end of the flexible member and including a lumen extending therethrough and a clip including a pair of arms movably housed within the capsule. A suture extending along a first one of the pair of arms and including a loop at a distal end thereof extending across an opening extending through the first one of the pair of arms. A suture grabbing element extending laterally from a second one of the pair of arms and including a hook so that, when the pair of arms are moved toward a closed configuration, the hook extends through the opening to grab the loop and draw the distal end of the suture from the first one of the pair of arms toward the second one of the pair of arms.

Abstract: Systems, methods, and non-transitory computer-readable media are disclosed for selectively rendering augmented reality content based on predictions regarding a user's ability to visually process the augmented reality content. For instance, the disclosed systems can identify eye tracking information for a user at an initial time. Moreover, the disclosed systems can predict a change in an ability of the user to visually process an augmented reality element at a future time based on the eye tracking information. Additionally, the disclosed systems can selectively render the augmented reality element at the future time based on the predicted change in the ability of the user to visually process the augmented reality element.

Abstract: Head-mounted display systems may include an eye-tracking subsystem and a fixation distance prediction subsystem. The eye-tracking subsystem may be configured to determine at least a gaze direction of a user's eyes and an eye movement speed of the user's eyes. The fixation distance prediction subsystem may be configured to predict, based on the eye movement speed and the gaze direction of the user's eyes, a fixation distance at which the user's eyes will become fixated prior to the user's eyes reaching a fixation state associated with the predicted fixation distance. Additional methods, systems, and devices are also disclosed.

Abstract: The present disclosure relates to certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof), that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD) , to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.

Abstract: The present disclosure relates to certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof), that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.

Abstract: The present disclosure relates to certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof), that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.

Abstract: According to one aspect, a medical system may include an instrument including an end effector for acting as a monopolar electrode. The end effector may be configured to be positioned in a body of a subject and emit radiofrequency energy towards a target area in the body. The medical system may further include a return electrode. The return electrode may be deliverable within the body proximate the target area and separately from the instrument and the monopolar electrode. The return electrode may be configured to contact tissue in the body proximate the target area and receive radiofrequency energy emitted from the end effector.

Abstract: Systems and methods for operating a mobile platform. The methods comprise, by a computing device: obtaining a LiDAR point cloud; using the LiDAR point cloud to generate a track for a given object in accordance with a particle filter algorithm by generating states of a given object over time (each state has a score indicating a likelihood that a cuboid would be created given an acceleration value and an angular velocity value); using the track to train a machine learning algorithm to detect and classify objects based on sensor data; and/or causing the machine learning algorithm to be used for controlling movement of the mobile platform.

Abstract: Pulsed electric fields (PEFs) are transmitted to a body lumen or passageway in a manner which provides focal therapy. In some embodiments, PEFs are delivered through independent electrically active electrodes of an energy delivery body, typically in a monopolar fashion. Such delivery concentrates the electrical energy over a smaller surface area, resulting in stronger effects than delivery through an electrode extending circumferentially around the lumen or passageway. It also forces the electrical energy to be delivered in a staged regional approach, mitigating the effect of preferential current pathways through the surrounding tissue. Focal delivery of PEFs can provide increased tissue lethality by employing precise timing and sequencing of energy delivery to the electrodes.

Abstract: Described herein are compounds of Formula I, wherein R1, R2, and R3 are defined herein, their use as branched-chain alpha keto acid dehydrogenase kinase inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to treat, for example, diabetes, NASH and heart failure.