Abstract: The present disclosure relates to certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof), that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.

Abstract: The present invention relates to the use of cannabidiol (CBD) for the treatment of seizures associated with rare epilepsy syndromes. In particular the seizures associated with rare epilepsy syndromes that are treated are those which are experienced inpatients diagnosed with congenital disorder of glycosylation 1P. In a further embodiment the types of seizures include tonic and myoclonic seizures. Preferably the dose of CBD is between 5 mg/kg/day to 50 mg/kg/day.

Abstract: The present invention relates to the use of cannabidiol (CBD) for the treatment of seizures associated with rare epilepsy syndromes. In particular the seizures associated with rare epilepsy syndromes that are treated are those which are experienced inpatients with ZDHHC9 gene mutation. In a further embodiment the types of seizures include tonic-clonic and atonic seizures. Preferably the dose of CBD is between 5 mg/kg/day to 50 mg/kg/day.

Abstract: The present invention relates to the use of cannabidiol (CBD) for the treatment of seizures associated with rare epilepsy syndromes. In particular the seizures associated with rare epilepsy syndromes that are treated are those which are experienced inpatients with CHRNA4 gene mutation. In a further embodiment the types of seizures include tonic-clonic, atonic, myoclonic and absence seizures. Preferably the dose of CBD is between 5 mg/kg/day to 50 mg/kg/day.

Abstract: The present invention relates to the use of cannabidiol (CBD) for the treatment of seizures associated with rare epilepsy syndromes. In particular the seizures associated with rare epilepsy syndromes that are treated are those which are experienced inpatients with CLCN4 gene mutation. In a further embodiment the types of seizures include tonic seizures. Preferably the dose of CBD is between 5 mg/kg/day to 50 mg/kg/day.

Abstract: This invention relates generally to pharmaceutical compositions and preparations of curons and uses thereof.

Abstract: Novel compounds, compositions, and methods of using and preparing the same, which may be useful for treating alpha-1 antitrypsin deficiency (AATD).

Abstract: Techniques are described herein for optimizing the presentation of content through obtaining viewership metrics, generating multiple renditions of presentations of content, and selecting optimized renditions of content. One aspect includes associating a request for viewership metrics with a presentation of content, publishing the presentation of content, and receiving information of the viewership metrics associated with the presentation. Another aspect includes copying a presentation of a content item, creating a second presentation of the content item for publishing over one or more channels, and linking the presentation of the content item to the second presentation of the content item, such that a change to one propagates to the other of the presentation of the content item or the second presentation of the content item. In yet another aspect, a content rendition may be selected for presentation based on performance of the rendition out of multiple renditions in an auction.

Abstract: There is disclosed a patient restraint assembly including a head restraint configured to extend around the patient's head, at least one securement member (4) extending from the first end of the head restraint, and at least one securement member (5) extending from the second end of the head restraint, said securement members (4, 5) being configured to releasably secure said head restraint to a support table, an adjustment unit (15) to adjust the tension in the securement member(s) (4, 5), wherein adjustment of the adjustment unit (15) applies the same force simultaneously to the securement member(s) (4) at the first end and the securement member(s) (5) at the second end of the head restraint.

Abstract: An air filter assembly includes a filter element having at least one variable dimension, and a frame for engaging and supporting the filter element. The frame may include a plurality of linear segments forming a rectangular configuration, and a plurality of clips for connecting the linear segments together at corners thereof. The linear segments may be L-channel segments, C-channel segments, or may be of other form. Clips may be used for connecting the linear segments together at the corners. The filter element may have a pattern of creases or fold lines to facilitate folding thereof from an expanded configuration to a reduced configuration. A grate may be included for spanning an area bounded by the frame to support the filter element. The grate may have multiple arms and a central hub. An edge treatment may form a seal between the filter element and the frame.

Abstract: Example methods and apparatus for presenting location-based food movement notifications in connection with cook programs of grills are disclosed. An example grill includes a cookbox, a lid, a cooking chamber, a controller, and a lighting module. The cooking chamber is defined by the cookbox and the lid. The controller implements a cook program to cook an item of food within the cooking chamber. The cook program includes a food movement step requiring the item of food to be added to the cooking chamber, to be removed from the cooking chamber, or to be moved within the cooking chamber. In response to determining that the cook program has advanced to the food movement step, the controller causes the lighting module to present a location-based food movement notification indicating a location within the cooking chamber at which the food movement step is to be performed.

Abstract: Systems, methods, and devices are described herein for placing secondary content into a break of unknown duration in a stream of primary content. In one aspect, the described techniques may include streaming a segment of primary content, for example, by a reduce capability client device, such as a mobile device or tablet. The device may receive information indicative of a break in the streaming of the primary content. The device may play secondary content based on receiving the information indicative of the break. The device may determine when a next segment of the primary content is available, and begin streaming the next segment of the primary content upon detecting that the second segment of the primary content is available.

Abstract: The disclosure provides novel solid state forms of Compound I selected from ethanol solvate Form A, ethanol solvate Form B, citric acid cocrystal Form A, and Form B, compositions comprising the same, and methods of making and using the same, including use in treating APOL1 mediated kidney disease. (I).

Abstract: The present disclosure relates to certain (2S)—N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof), that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.

Abstract: Systems, methods, and computer-readable media for identifying a main group of people in an image via social relation recognition. The main group of people is identified within an image by identifying social relationships between people visible in the image. The identification of social relationships is performed by a Social Relation Recognition Network (SRRN) trained using deep learning. The SRRN combines two techniques for group identification, First Glance and Graph Reasoning, and fuses their outputs to generate a prediction of group membership. A group refinement module improves and filters the group membership after identification of an initial main group.

Abstract: In one aspect, there is disclosed a solenoid having a bobbin with a core wire positioned about the bobbin to form a coil. A power supply wire is connected an end of the core wire and a frame is connected to the bobbin. An overmolded housing surrounds the core wire, the frame and a portion of the power supply wire.

Abstract: Systems, methods and computer readable storage media provide a flexible and variability-accommodating instrument cluster for display on an in-vehicle screen and a user experience interaction model for providing dynamic driving-context-relevant information via the instrument cluster. The instrument cluster may be shown in a contextual content view, wherein the contextual content view may include a one or more gauges and/or messaging that are determined to be relevant to a determined contextual state of the vehicle. The contextual state of the vehicle may be determined based on signaling data provided by a plurality of data sources, wherein the signaling data may indicate one or a combination of conditions associated with the contextual state. The instrument cluster may be dynamically updated to display the driving-context-relevant information when the contextual state is detected.

Abstract: One embodiment of the present disclosure provides a system and associated processes for sharing cardholder data (CHD) between a merchant that utilizes tokenization and a second merchant that may or may not utilize tokenization. In one embodiment, the merchant, or an employee of the merchant, can use the system and associated processes to reacquire CHD from a tokenization provider system. In one embodiment, the merchant identifies to the tokenization provider system a desire to share CHD, which is associated with a token, with a second merchant. The merchant and/or the tokenization provider system can then invite the second merchant to register with the tokenization provider system. Once registered with the tokenization provider system, the second merchant can access any CHD that the merchant associated with the second merchant.

Abstract: In one embodiment, a computing system may access an image to be displayed by a display. The system may determine one or more first characteristics associated with a content of the image. The one or more first characteristics may include a contrast level of the content of the image with respect to a background of the image. The system may determine a first display persistence time period for the display to display the image based on the one or more first characteristics associated with the content of the image. The system may configure the display to display the image using the first display persistence time period.

Abstract: A food processor includes a bowl with a removable lid. Food items are advanced into the bowl through a feed tube formed in the lid where they are cut by a blade assembly. A rotating disk is adjustable relative to the blade assembly to vary the thickness of the food items cut by the blade assembly.