Abstract: The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems.

Abstract: The present invention provides polymeric fiber scaffolds, methods and devices suitable for fabricating such polymeric fiber scaffolds, and uses thereof for wound healing.

Abstract: Some embodiments provide method of forming a three-dimensional tissue scaffold that includes extruding a bioink material through a nozzle onto a support while moving the nozzle relative to the support or moving the support relative to the nozzle to form a three-dimensional structure of the bioink material. The bioink material includes a plurality of polymeric fibers, each polymeric fiber having a diameter on a range of 0.1 ?m to 20 ?m, and each polymeric fiber comprising one or more biocompatible polymers, and a carrier. The method also includes cross-linking or heat fusing at least some of plurality of polymeric fibers in the three-dimensional structure of the bioink material.

Abstract: Exemplary embodiments provide systems, devices and methods for the fabrication of three-dimensional polymeric fibers having micron, submicron and nanometer dimensions, as well as methods of use of the polymeric fibers.

Abstract: The present invention provides high throughput assays for identifying compounds that modulate a contractile function, as well as devices suitable for use in these assays.

Abstract: The present invention provides methods and systems which accommodate 3-dimensional adipocyte expansion to produce, e.g., mature adipocytes and synthetic adipose tissue with cellular properties of mature adult organisms, including cell size and cytoarchitecture, and the use of such methods and systems for, e.g., in vitro drug screening and/or toxicity assays, disease modeling, and therapeutic applications.

Abstract: The present invention provides high throughput assays for identifying compounds that modulate a contractile function, as well as devices suitable for use in these assays.

Abstract: Photosensitive cardiac rhythm modulation structures and systems are described. A genetically-engineered tissue comprising a population of pacing cells expressing a photosensitive membrane transport mechanism that is responsive to light of a particular wavelength(s) combined with one or more of a light source, a power generator, and a sensor provides pacemaker and/or defibrillator function to a subject. The systems further provide in vitro model systems for electrophysiological studies.

Abstract: Embodiments described herein are directed to devices for supporting growth of anisotropic muscle tissue layers and in vitro readout and quantification of force generated by the tissue layers using one or more strain-sensing elements integrated into the device. Embodiments also include multiplexed apparatuses of multiple independent devices, methods of fabricating the devices and apparatuses, and methods of using the devices and apparatuses.

Abstract: Photosensitive cardiac rhythm modulation structures and systems are described. A genetically-engineered tissue comprising a population of pacing cells expressing a photosensitive membrane transport mechanism that is responsive to light of a particular wavelength(s) combined with one or more of a light source, a power generator, and a sensor provides pacemaker and/or defibrillator function to a subject. The systems further provide in vitro model systems for electrophysiological studies.

Abstract: Exemplary embodiments provide systems, devices and methods for the fabrication of three-dimensional polymeric fibers having micron, submicron and nanometer dimensions, as well as methods of use of the polymeric fibers.

Abstract: The present disclosure provides materials and articles of clothing including a plurality of nanocapsules, each nanocapsule including a polymeric shell surrounding at least one fluid, and a plurality of polymeric fibers co-spun with the plurality of nanocapsules. The nanocapsules can be made by miniemulsion polymerization. The encapsulated at least one fluid can include at least one essential oil. In some embodiments, the materials are deodorizing, antifungal, and/or antibacterial. Methods of manufacturing the materials and articles of clothing are also provided.

Abstract: The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems.

Abstract: Disclosed herein are organ chips that can be individually used or integrated together to form different microphysiological systems, e.g., for use in cell culturing, drug screening, toxicity assays, personalized therapeutic treatment, scaffolding in tissue repair and/or replacement, and/or pharmacokinetic or pharmacodynamics studies.

Abstract: The present invention provides devices, constructs, and methods of use of polymeric fiber-scaffolded engineered tissues and assays for identifying compounds that modulate a contractile function, using such devices and constructs.

Abstract: Exemplary embodiments provide systems, devices and methods for simultaneously measuring mechanical and electrophysiological tissue responses (e.g., contractile function, or the like).

Abstract: Microfluidic systems including a housing configured to receive a cartridge, the cartridge including a plurality of wells for receiving one or more biological cells are described herein. The microfluidic systems include a structure with channels for introducing a medium into the housing and through channels the cartridge. Microfluidic systems including a housing configured to receive a cartridge, the housing including channels for loading one or more biological cells within wells of the cartridge are described herein. Three-dimensional scaffolds, devices, and systems comprising such scaffolds that mimic the in vivo structure, physical properties, and protein composition of extracellular matrix surrounding pancreatic islet cells and adipocytes, and the use of such compositions, devices and systems for, e.g., in vitro drug screening and/or toxicity assays, disease modeling, and therapeutic applications are also described herein.

Abstract: Disclosed herein are organ chips that can be individually used or integrated together to form different microphysiological systems, e.g., for use in cell culturing, drug screening, toxicity assays, personalized therapeutic treatment, scaffolding in tissue repair and/or replacement, and/or pharmacokinetic or pharmacodynamics studies.

Abstract: The present invention fluidic devices incorporating functional muscle tissues, methods of making the fluidic devices and methods of use of the fluidic devices.

Abstract: The present invention provides high throughput assays for identifying compounds that modulate a contractile function, as well as devices suitable for use in these assays.