Abstract: A stent and a system comprising a stent and a stent deployment catheter are disclosed. The stent comprises an elongated tubular body defining a longitudinal axis and including a proximal end, a distal end, and a central lumen extending between the proximal end and the distal end. The central lumen is configured for passage of a guide wire therethrough. The stent further comprises a tapered and/or frustoconical distal tip portion disposed at the distal end of the elongated tubular body, wherein the distal tip portion comprises one or more spiral threads. The stent deployment catheter comprises an inner sheath configured to be slidably disposed within the central lumen of the elongated tubular body; and an outer sheath configured to be slidably disposed over the inner sheath. The stent and stent deployment catheter can be configured for placement of the stent within a pancreaticobiliary duct.

Abstract: Aspects of the present disclosure relate to systems and methods for generating a composite image. This can include a western blot imager with a real time camera. One aspect of the present disclosure relates to an imaging system. The imaging system includes a sample plane that can receive and hold a sample, a photon resolving camera, and a lens attached to the photon resolving camera, the photon resolving camera and the lens positioned to image the sample plane.

Abstract: Methods and compositions useful in papermaking and tissuemaking applications are provided. Some embodiments of the methods and compositions include a polyaminoamide polymer functionalized with an acrylamidophenyl boronic acid and a crosslinked polyaminoamide functionalized with an acrylamidophenyl boronic acid. The methods and compositions provide useful properties for creping that include good adhesion even under excessively wet conditions, improved film uniformity, and good film durability, while maintaining good film softness and rewettability necessary for efficient runnability of the tissue machine.

Abstract: Methods and compositions for improving performance of flocculants in an industrial production process. Methods include pH triggered cross-linking reaction between a flocculating agent, such as dextran, and a composition comprising a boronic acid-containing polymer. The pH trigger can be provided by a fluid having a pH of 8 or more. The production process can be a Bayer Process and the fluid is caustic liquor or slurry in the fluid circuit of the Bayer, wherein the reaction time is reduced over conventional methods and the cross-linked dextran composition effectuates improved flocculation of the trihydrate particles.

Abstract: An imaging system including an illuminator apparatus or an epi-illumination apparatus that has LEDs for illuminations is provided for stain-free gel activation and fluorescent sample visualization. The illuminator apparatus includes a housing, a light source array disposed on at least one side surface of the housing and including at least one plurality of LEDs having each LED individually operable to output light of a predetermined color within a range of wavelengths, and a controller for controlling ranges of operational parameters of the at least one plurality of LEDs. The light emitted from the light source array incidents upon a sample having a gel that includes a product of UV light induced reaction between tryptophan and a haloalkane and the light emitted from the light source array includes ultraviolet (UV) light to excite a fluorescent response of the sample.

Abstract: A transitional treatment composition and methods of treating coal refuse are provided. The transitional treatment composition comprises an anionic acrylate-acrylamide copolymer having from about 30 mole percent to about 50 mole percent (meth)acrylate, from about 50 mole percent to about 70 mole percent (meth)acrylamide, and a reduced specific viscosity of from about 18 dL/g to about 30 dL/g. The transitional treatment composition can be made down in an aqueous liquid.

Abstract: A computing device-implemented method for automated tracking and optimization of global manufacturing and supply based on impacts of post-approval changes (PACs) is discussed. An exemplary method includes retrieving data from data sources including at least an inventory database, a regulatory database, and a PAC information database. The method further includes analyzing the retrieved data to identify one or more impacts of at least one PAC on one or more drug products or drug substances using a predefined ruleset for determining which changes were implemented for each lot. The method also includes generating a list of the identified one or more impacts on the one or more drug products or drug substances.

Abstract: Papermaking additives that include various polymers and/or micropolymers are disclosed. The micropolymers may have a network structure that can be created by crosslinking or other means. The micropolymer may be an acrylamide based polymer having a boronic acid moiety. The weight average molecular weight of the micropolymer may be greater than 1,000,000.

Abstract: Methods and compositions useful in papermaking and tissuemaking applications are provided. Some embodiments of the methods and compositions include a polyaminoamide polymer functionalized with an acrylamidophenyl boronic acid and a crosslinked polyaminoamide functionalized with an acrylamidophenyl boronic acid. The methods and compositions provide useful properties for creping that include good adhesion even under excessively wet conditions, improved film uniformity, and good film durability, while maintaining good film softness and rewettability necessary for efficient runnability of the tissue machine.

Abstract: Methods and compositions useful in papermaking and tissuemaking applications are provided. Some embodiments of the methods and compositions comprise a polyaminoamide (“PAA”) polymer functionalized with an acrylamidophenyl boronic acid and a crosslinked polyaminoamide functionalized with an acrylamidophenyl boronic acid. The methods and compositions provide useful properties for creping that include good adhesion even under excessively wet conditions, improved film uniformity, and good film durability, while maintaining good film softness and rewettability necessary for efficient runnability of the tissue machine.

Abstract: Methods and compositions for improving performance of flocculants in an industrial production process. Methods include pH triggered cross-linking reaction between a flocculating agent, such as dextran, and a composition comprising a boronic acid-containing polymer. The pH trigger can be provided by a fluid having a pH of 8 or more. The production process can be a Bayer Process and the fluid is caustic liquor or slurry in the fluid circuit of the Bayer, wherein the reaction time is reduced over conventional methods and the cross-linked dextran composition effectuates improved flocculation of the trihydrate particles.

Abstract: Disclosed herein are methods of protein quantification and normalization using haloalkylated tryptophan fluorescence. Complex protein samples, i.e., samples that each contain 1,000 or more distinct proteins, from diverse sources that do not have common protein profiles are treated with a halo-substituted organic compound (i.e. haloalkane) that reacts with tryptophan residues to form fluorescent products. Irradiation of the samples with ultraviolet light and the detection and quantification of the resultant fluorescent emissions from all proteins in each sample are then used to obtain comparative values for total protein content among the various samples.

Abstract: Methods and compositions for improving performance of flocculants in an industrial production process. Methods include pH triggered cross-linking reaction between a flocculating agent, such as dextran, and a composition comprising a boronic acid-containing polymer. The pH trigger can be provided by a fluid having a pH of 8 or more. The production process can be a Bayer Process and the fluid is caustic liquor or slurry in the fluid circuit of the Bayer, wherein the reaction time is reduced over conventional methods and the cross-linked dextran composition effectuates improved flocculation of the trihydrate particles.

Abstract: Disclosed herein are methods of protein quantification and normalization using haloalkylated tryptophan fluorescence. Complex protein samples, i.e., samples that each contain 1,000 or more distinct proteins, from diverse sources that do not have common protein profiles are treated with a halo-substituted organic compound (i.e. haloalkane) that reacts with tryptophan residues to form fluorescent products. Irradiation of the samples with ultraviolet light and the detection and quantification of the resultant fluorescent emissions from all proteins in each sample are then used to obtain comparative values for total protein content among the various samples.

Abstract: An optical signal module including a driver and an optical signal module. The driver includes a differential pair configured to receive and process an input signal to create a drive signal. A modulation current source provides a modulation current to the differential pair. One or more termination resistors connected to the differential pair for impedance matching. A first switch, responsive to a first control signal, maintains charge on a charge storage device. The optical signal module includes an optical signal generator arranged between a supply voltage node and a bias current node. The optical signal generator receives the drive signal and generates an optical signal representing the input signal. A second switch is between a supply voltage node the bias current node. The second switch, responsive to second control signal, selectively establishes a short between the supply voltage node the bias current node.

Abstract: Methods and compositions useful in papermaking and tissuemaking applications are provided. Some embodiments of the methods and compositions comprise a polyaminoamide (“PAA”) polymer functionalized with an acrylamidophenyl boronic acid and a crosslinked polyaminoamide functionalized with an acrylamidophenyl boronic acid. The methods and compositions provide useful properties for creping that include good adhesion even under excessively wet conditions, improved film uniformity, and good film durability, while maintaining good film softness and rewettability necessary for efficient runnability of the tissue machine.

Abstract: Papermaking additives that include various polymers and/or micropolymers are disclosed. The micropolymers may have a network structure that can be created by crosslinking or other means. The micropolymer may be an acrylamide based polymer having a boronic acid moiety. The weight average molecular weight of the micropolymer may be greater than 1,000,000.

Abstract: Disclosed herein are methods of protein quantification and normalization using haloalkylated tryptophan fluorescence. Complex protein samples, i.e., samples that each contain 1,000 or more distinct proteins, from diverse sources that do not have common protein profiles are treated with a halo-substituted organic compound (i.e. haloalkane) that reacts with tryptophan residues to form fluorescent products. Irradiation of the samples with ultraviolet light and the detection and quantification of the resultant fluorescent emissions from all proteins in each sample are then used to obtain comparative values for total protein content among the various samples.

Abstract: An optical signal module including a driver and an optical signal module. The driver includes a differential pair configured to receive and process an input signal to create a drive signal. A modulation current source provides a modulation current to the differential pair. One or more termination resistors connected to the differential pair for impedance matching. A first switch, responsive to a first control signal, maintains charge on a charge storage device. The optical signal module includes an optical signal generator arranged between a supply voltage node and a bias current node. The optical signal generator receives the drive signal and generates an optical signal representing the input signal. A second switch is between a supply voltage node the bias current node. The second switch, responsive to second control signal, selectively establishes a short between the supply voltage node the bias current node.

Abstract: The present disclosure concerns synthesis and anion binding features of poly-cyanostilbene macrocycles of Formula (I):