Abstract: The disclosure provides compounds useful for treating alpha-1 antitrypsin deficiency (AATD), according to formula (I): tautomers thereof, pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable salts of the tautomers, deuterated derivatives of the compounds, deuterated derivatives of the tautomers, and deuterated derivatives of the salts, solid forms of those compounds and processes for making those compounds.

Abstract: A temperature modulation assembly for a motor vehicle's passenger compartment includes an assembly panel having a single or a plurality of solar panels which convert sunlight into electricity and an assembly housing which includes an internal thermoelectric Peltier cooler having a heat sink on its cool side and a heat sink on its hot side and an internal fluid distribution module which draws air into the assembly housing, causes some of the air to be cooled by passing through the cool side heat sink and directed back into the passenger compartment and the rest of the air to be heated by passing through the hot side heat sink and directed back into the passenger compartment. The components of the assembly housing utilize electricity that originates at the assembly panel, and the assembly housing is structured to distribute cooled towards near the passenger seating and heated air towards the windshield.

Abstract: Systems, devices, and methods for providing a sheet product dispenser with automated product level tracking functionality are provided herein. Various product level sensors are disclosed herein including a product level sensor configured to emit a signal toward an outer circumference of a sheet product roll on a spindle extending along a longitudinal axis and to receive a reflected signal. The product level sensor is positioned a radial distance away from the spindle and aimed to emit the signal in a direction that is not parallel and not perpendicular to the longitudinal axis. The product level sensor detects a parameter of the reflected signal corresponding to the distance between the product level sensor and the sheet product roll. Other example embodiments include mechanical product level sensors. Various communication protocols may be employed to limit transmission of data to conserve battery life while still maintaining desired communication functionality.

Abstract: A traffic light assembly and method for controlling a set of heating elements for the traffic light assembly. A traffic signal with a lens and a visor, the visor having an inner surface and extending from the lens. A sensor mounted to the traffic signal and in direct communication with an environment surrounding the traffic light assembly. A control module located within the traffic signal, the control module comprising a controller for implementing a primary loop that continuously checks environmental conditions via the sensor to determine if a predetermined condition is met.

Abstract: A surgical tool including a socket having a housing and an aperture within the housing, the socket configured to receive a ball and a pin at least partially in the aperture. The ball is positioned at least partially in the socket and configured to rotate within the socket, the ball comprising an elongated opening extending through the ball. The pin is coupled to the socket and disposed at least partially in the socket on opposite sides of the socket, the pin including a first longitudinal axis and extending through the elongated opening of the ball between opposite sides of the socket. The ball is configured to partially rotate about the first longitudinal axis of the pin, and partially rotate, about a second axis perpendicular to the first longitudinal axis of the pin, in a plane aligned with the elongated opening.

Abstract: A system for automatically acquiring focus of remote flying objects (RFOs) includes an interface and processor. The interface is configured to receive a radar data and a lens temperature data. The processor is configured to determine a focal setting for a lens system based at least in part on the radar data and the lens temperature data; and provide the focal setting for the lens system.

Abstract: A method optimizes questions to retain engagement. The method includes generating, using a machine learning model, a churn risk from user interaction data. The method includes selecting, when the churn risk satisfies a threshold, a field, from multiple fields, using multiple prediction confidences corresponding to multiple prediction values generated for the multiple fields. The method includes obtaining a prediction value for the field and obtaining a question, corresponding to the field, using the prediction value. The method includes presenting the question and receiving a user input in response to the question.

Abstract: A ground support tractor for providing ground support services at an airport has a cab forward configuration and a cab aft configuration. The ground support tractor includes a common chassis having a forward mounting location and an aft mounting location. A seat assembly, a battery system and a plurality of body panels are coupled to the common chassis. In the cab forward configuration of the ground support tractor, the seat assembly is coupled to the forward mounting location, the battery system is coupled to the aft mounting location and the body panels are positioned in a cab forward orientation. In the cab aft configuration of the ground support tractor, the seat assembly is coupled to the aft mounting location, the battery system is coupled to the forward mounting location and the body panels are positioned in a cab aft orientation.

Abstract: The present invention relates to methods of treating and dosing regimens using Mevidalen, also described as 2-(2,6-dichlorophenyl)-1-[(1S,3R)-3-(hydroxymethyl)-5-(3-hydroxy-3-methylbutyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl]ethanone, and/or pharmaceutical compositions thereof, for treatment of hallucinations and/or psychosis, including dementia-related psychosis.

Abstract: Systems, apparatuses, and methods to seal a container are provided. An apparatus for securing a film to a container includes a body portion to house film and a sealing portion. The sealing portion includes a loading zone to receive a portion of film from the body portion and an aperture to receive a top portion of the container and the portion of the film therethrough to enable positioning within a sealing volume. A plurality of near-infrared light emitting diodes (NIR LEDs) face toward and at least partially surround the top portion of the container when positioned within the sealing volume. A controller is configured to receive sensor input from a sensor indicating that the top portion of the container is within the sealing volume and cause, in response thereto, activation of the plurality of NIR LEDs to secure the portion of the film to the top portion of the container.

Abstract: A system for providing a personalized assistant within a network-based communication session includes a processor and a memory storage device storing instructions. The system determines when a first communication session participant joins the network-based communication session after a threshold duration of time subsequent to the start time of the session. Upon determining the first participant has joined, the system obtains content associated with the session and creates request data for a pre-trained generative language model. The request data includes an instruction requesting a predetermined number of suggested utterances not present in the content, each utterance relating to one or more topics corresponding to the content. The system transforms the request data to a command based on a command template and provides the command to the generative language model.

Abstract: Provided are flexible interconnect circuit assemblies and methods of fabricating thereof. In some examples, a flexible interconnect circuit comprises multiple circuit portions, which are monolithically integrated. During the fabrication, some of these circuit portions are folded relative to other portions, forming a stack in each fold. For example, the initial orientation of these portions can be selected such that smaller sheets can be used for circuit fabrication. The portions are then unfolded into the final design configuration. In some examples, the assembly also comprises a bonding film and a temporary support film attached to the bonding film such that the two circuit portions at least partially overlap with the bonding film and are positioned between the bonding film and temporary support film. In some examples, at least some circuit portions extend past the boundary of the bonding film and are coupled to connectors.

Abstract: A system for providing a personalized assistant within a network-based communication service includes one or more processors and a memory storage device storing instructions thereon. During a network-based communication session, the system receives a query from a computing device of a first communication session participant and processes the query by determining that a second communication session participant has shared content via a content sharing feature of the network-based communication service. In response, the system provides the query and at least a portion of the shared content as input to a model, which dynamically constructs a prompt for use as input with a generative language model. The system then presents the prompt as input to the generative language model, receives a response as output from the generative language model, and causes presentation of the response to be presented to the communication session participant.

Abstract: A computer server includes processor and memory hardware. The processor hardware executes instructions including parsing a hypertext transfer protocol (HTTP) request from a first user agent to identify a first data object matching a set of characteristics and generating a new data element based on the HTTP request. The instructions include, in response to the first data object being present: extracting a first set of serialized data elements and serializing them with the new data element to generate a second data object. The instructions include, in response to the first data object being absent and a user associated with the first user agent being identifiable: determining a second set of serialized data elements based on an identity of the user, and serializing them with the new data element to generate the second data object. The instructions include transmitting an HTTP response including the second data object.

Abstract: In one embodiment, a method is provided. The method includes receiving a registration message from a network device. The registration request indicates that a first computing device has connected to the computing devices. The method also includes determining a category for the first computing device based on the registration message. The method further includes determining a set of rules for the computing device based on the category. The method further includes transmitting the set of rules to the network device. The set of rules indicates permissions for the first computing device. Each network of the set of networks is initially isolated from other networks of the set of networks when the network is created. Each network of the set of networks comprises a respective computing device of the set of computing devices.

Abstract: A method of forming a flexible interconnect circuit is described. A method may involve laminating a substrate to a conductive layer followed by patterning the conductive layer. This patterning operation forms individual conductive portions, which may be also referred to as traces or conductive islands. The substrate supports these portions relative to each other during and after patterning. After patterning, an insulator may be laminated to the exposed surface of the patterned conductive layer. At this point, the conductive layer portions are also supported by the insulator, and the substrate may optionally be removed, e.g., together with undesirable portions of the conductive layer. Alternatively, the substrate may be retained as a component of the circuit and the undesirable portions of the patterned conductive layer may be removed separately. These approaches allow using new patterning techniques as well as new materials for substrates and/or insulators.

Abstract: Systems and methods or determining tax recommendations for a taxpayer by using a tax calculation graph to identify tax variables that a taxpayer can control and modify, including a recommendation engine configured to analyze a tax calculation graph which is calculated using tax data of the taxpayer. An identified tax variable can be analyzed by determining nodes of the graph affecting a value of the identified tax variable, providing a user interface enabling at least one modification to the nodes, and determining an effect on the identified tax variable due to the at least one modification.

Abstract: A computing system running a host operating system and a virtual machine (VM). The computing system includes at least one device that is directly assigned to the VM. The computing system is configured to execute one or more first VM components and one or more second VM components. The one or more first VM components are configured to manage the one or more second VM components via one or more identification pointers. While the one or more second VM components remain loaded in a system memory, and the directly assigned device remains attached to the VM and remains configured to communicate with the one or more second VM component, the one or more first VM components are shut down and restored.

Abstract: Provided are flexible hybrid interconnect circuits and methods of forming thereof. A flexible hybrid interconnect circuit comprises multiple conductive layers, stacked and spaced apart along the thickness of the circuit. Each conductive layer comprises one or more conductive elements, one of which is operable as a high frequency (HF) signal line. Other conductive elements, in the same and other conductive layers, form an electromagnetic shield around the HF signal line. Some conductive elements in the same circuit are used for electrical power transmission. All conductive elements are supported by one or more inner dielectric layers and enclosed by outer dielectric layers. The overall stack is thin and flexible and may be conformally attached to a non-planar surface. Each conductive layer may be formed by patterning the same metallic sheet. Multiple pattern sheets are laminated together with inner and outer dielectric layers to form a flexible hybrid interconnect circuit.

Abstract: A stator vane for a turbomachine is provided. The stator vane includes an airfoil that has a nominal suction-side profile substantially in accordance with suction-side Cartesian coordinate values of X, Y, and Z set forth in TABLE I. The Cartesian coordinate values of X, Y, and Z are defined relative to a point data origin at a base of the airfoil. The Cartesian coordinate values of X, Y, and Z are non-dimensional values that are convertible to dimensional distances expressed in a unit of distance by multiplying the Cartesian coordinate values of X, Y, and Z by a scaling factor of the airfoil in the unit of distance. The X and Y values are connected by smooth continuing arcs to define suction-side profile sections at each Z value. The suction-side profile sections at the Z values are joined smoothly with one another to form a complete airfoil suction-side shape.