Abstract: The present disclosure relates to methods, compositions, and kits for treating target nucleic acids, including methods and compositions for fragmenting and tagging nucleic acid (e.g., DNA) using transposome complexes bound to a solid support.

Abstract: The invention provides humanized anti-human Tau(pS422) antibodies and methods of using the same.

Abstract: A reader mechanism and method for interfacing with an information chip on a build material container are provided. The reader mechanism includes a reading head configured to read the information chip. A platform includes an actuator to move the reading head relative to the information chip. A brake holds the build material container in place while the reading head contacts the information chip.

Abstract: A battery maintenance device for performing maintenance on a battery pack of an automotive vehicle powered by the battery pack includes communication circuitry configured to retrieve information related to condition of batteries/cells of the battery pack obtained using sensors in the battery pack. Measurement circuitry couples to batteries/cells of the battery pack and obtains measurement information related to a measured condition of batteries/cells of the battery pack. A controller verifies operation of the sensors in the battery pack by comparing the retrieved information with the measurement and provides a comparison output. Output circuitry outputs an indication of a failing sensor in the battery pack based upon the comparison output.

Abstract: A rolling diaphragm syringe has a proximal end having an end wall, a distal end, and a sidewall extending between the proximal end and the distal end. The rolling diaphragm syringe further has a piston engagement portion protruding proximally from a central portion of the end wall, the piston engagement portion having a central axis, and a plurality of grooves recessed inward relative to an outer surface of the piston engagement portion. The grooves are spaced apart from each other in a direction about the central axis.

Abstract: A multi-tenant system performs custom configuration of a tenant-specific chatbot to process and act upon natural language requests. The multi-tenant system configures the tenant-specific chatbots without requiring tenant-specific training. The multi-tenant system providing a user interface for configuring a tenant-specific set of permitted actions. The multi-tenant system determines a set of example phrases for each of the selected permitted actions. The multi-tenant system receives a natural language request from a user and identifies the action that the user wants to perform. The multi-tenant system uses a neural network to compare the natural language request with example phrases to identify an example phrase that matches the natural language request. The multi-tenant system performs the action corresponding to the matching example phrase.

Abstract: A gauge assembly includes a gauge surface including at least one graphic, which may be a plurality of graphics defining a scale in a generally circular pattern on the gauge surface. A light guide has a main body portion disposed adjacent to the gauge surface and corresponding to the shape of the gauge surface. The light guide has a plurality of raised tick marks extending from the main body portion. The light guide is configured to provide illumination to the illuminable graphic(s) and the plurality of tick marks. A light housing disposed a light housing disposed adjacent to the light guide, the light housing having at least one light housing opening disposed adjacent to at least one of the plurality of raised tick marks.

Abstract: A sensor device includes a carrier, a force feedback sensor, and a probe containing a spin defect, the probe being connected to the force feedback sensor either directly or indirectly via a handle structure. In order to couple the spin defect to a microwave field in an efficient and robust manner, the sensor device includes an integrated microwave antenna arranged at a distance of less than 500 micrometers from the spin defect. The sensor device can be configured as a self-contained exchangeable cartridge that can easily be mounted in a sensor mount of a scanning probe microscope.

Abstract: A vaporizer device and associated methodology for providing accurate sampling through substantially efficient, complete and uniform single pass vaporization of a liquid sample by avoiding liquid pre-vaporization and downtime attributable to system damage from incomplete vaporization, particularly in the distribution, transportation, and custody transfer of natural gas. The vaporizer device includes at least one input port for receiving a liquid sample, a channel for directing the liquid to a vaporizer core and a heating assembly within the vaporizer core configured to flash vaporize the liquid sample. The vaporized sample can then be passed to an outlet for sample analysis.

Abstract: The disclosed embodiments provide an improved monitoring and security system to identify the presence of persons within a premises, to track the relative location of the person as he or she traverse the premises, and to generate an alert and optionally enter a lockdown mode if the person does not possess a pre-registered computing device or wireless transceiver. In the lockdown mode, doors optionally can be shut and locked through remote or local control or automatically if the distance between the person and the particular door falls below a predetermined threshold.

Abstract: Control information for configuring an audiovisual device to present multimedia content according to a first service type may be generated. A method may include generating first control information for configuring an audiovisual device to decode a multimedia stream, generating first data that indicates a structure of the first control information, and transmitting the first data and the first control information. The first control information may be generated according to a first protocol version. Second data and second control information may be similarly generated and transmitted according to a second protocol version. Disclosed techniques may facilitate receiving devices to determine whether they support received wireless transmissions and decode the transmissions based on the control information.

Abstract: An additive manufacturing system comprises a build plane and an energy source configured to direct energy onto a work region of the build plane. An optical detector is configured to receive one or more optical signals from the work region. An optical filter is positioned between the work region and the optical detector, wherein the optical filter includes a first partially transmissive polarized filter having a first polarization axis and a second partially transmissive polarized filter having a second polarization axis. The first polarization axis is rotationally offset from the second polarization axis approximately 90 degrees. The optical filter improves the signal to noise ratio of the optical sensors.

Abstract: Fluid management systems are disclosed that include software-controlled, electro-mechanical devices used in combination with single-use or multi-use tubing sets. Functions of the fluid management systems can include fluid pressurization, fluid warming, fluid deficit monitoring (including flow-based and weight-based), suction, fluid collection, and fluid evacuation (including indirect-to-drain and direct-to-drain options). The systems can be configured based on the surgical environment (e.g., operating room or physician office) as well as other user needs and/or preferences.

Abstract: An example mobile system is disclosed. The system comprises a transparent display screen, and a scanner head to scan an area seen through the transparent display. Position of the scanner is adjustable with respect to the transparent display. The scanner comprises at least one camera and at least one light source. The mobile system further comprises an outer frame, a cover to house the scanner head along with electronic components.

Abstract: A system for checking references is disclosed that can be initiated by an individual for self-verification in anticipation of applying for a position, or a potential employer or user. The system may generate a survey that is distributed to references who can provide feedback based on the survey prompts. The survey may be drafted using parameters input by the individual, or the survey may be drafted using employment related information gathered from another source, for instance third-party website that collects employment data, such as O*NET. Based on received survey responses, a reference report is generated. The reference checking system also comprises an adverse action process and monitoring system that enables FCRA compliance in the event the reference report results in an adverse action. Also, the reference checking system provides a structured database for storing and retrieving reference reports designed to help reduce repeat requests for feedback from reference providers.

Abstract: Provided herein are novel lipase inhibitors and methods for using the same to treat inflammation, multisystem organ failure, necrotic pancreatic acinar cell death, acute pancreatitis, sepsis (e.g., culture negative sepsis), burns, and acne. For example, provided herein are two novel lipase inhibitors useful in the methods described herein: or a pharmaceutically acceptable salt thereof.

Abstract: The present invention discloses a papermaking fabric having a both machine direction (MD) and cross-machine direction (CD) oriented protuberances for molding and structuring a nascent paper web, particularly tissue paper webs. The MD oriented protuberances are spaced apart from one another in the fabric cross-machine direction and may be continuous and parallel to one another. The CD oriented protuberances are preferably discrete and comprise less than 15 percent of the web contacting surface of the fabric. In certain instances the MD oriented protuberances are formed from interwoven filaments and the CD oriented protuberances are nonwoven and may be applied to the woven fabric substrate by printing.

Abstract: Systems, devices, and methods for operating in an unlicensed band are disclosed herein. In one example, a device may receive configuration information that includes a maximum channel occupancy time (MCOT) and a plurality of parameters including a plurality of transmission opportunity windows (TOWs). Based on the configuration information, the device may split a transmission into a plurality of bursts that may be grouped into sets of bursts based on how many bursts fit within a TOW. The number of bursts in a set of bursts may be less than or equal to the MCOT. The device may perform a clear channel assessment (CCA) to determine if the channel is busy and to determine a start time within the TOW for the bursts. The device may then transmit the set of bursts for that TOW, where each burst may have a burst indicator (BI).

Abstract: The present invention discloses tissue products, specifically rolled paper towel products, such as one, two or three ply tissue products having a basis weight greater than about 35 gsm and a GMT greater than about 1,500 g/3?. The products have a three-dimensional surface, typically the air contacting surface, comprising substantially continuous machine direction (MD) oriented elements, discrete cross-machine direction (CD) oriented elements and discrete MD oriented valleys having valley sidewalls formed by the MD oriented elements and valley endwalls formed by the CD oriented elements. The discrete valleys generally have a length greater than about 10.0 mm. The CD oriented elements comprise a relatively small percentage of the tissue surface area, such as less than about 15 percent, yet the tissue products display good anti-nesting properties when spirally wound into rolls, such as a Roll Structure greater than about 1.75.

Abstract: A system for de-plugging ground engaging tools of an agricultural implement includes a ground engaging tool. A fluid nozzle is in fluid communication with a pressurized fluid source such that pressurized fluid from the pressurized fluid source is flowable to the fluid nozzle. The fluid nozzle is oriented towards the ground engaging tool. Thus, pressurized fluid from the fluid nozzle is flowable towards, next to and/or against the ground engaging tool.