Abstract: The present invention provides methods for the treatment of non-alcoholic steatohepatitis (NASH) including advanced fibrotic and/or cirrhotic stages of NASH. The methods include administration of a compound comprising a double stranded RNAi (dsRNAi) oligonucleotide, or a pharmaceutically acceptable salt thereof, to the patient. The dsRNAi oligonucleotide optionally contains an antisense strand and a sense strand, wherein the antisense strand and the sense strand form a duplex region, and wherein the antisense strand comprises a region of complementarity to a KHK mRNA target sequence.

Abstract: dsRNAi oligonucleotides can be used in methods for the treatment of NASH, preferably the advanced fibrotic and/or cirrhotic stages thereof, using dosage regimens comprising a loading phase followed by a maintenance phase.

Abstract: A method of preparing an antibody therapeutic is provided comprising: (a) providing a dissociated cell sample from at least one solid tumor sample obtained from a patient; (b) loading the dissociated cell sample into a microfluidic device having a flow region and at least one isolation region fluidically connected to the flow region; (c) moving at least one B cell from the dissociated cell sample into at least one isolation region in the microfluidic device, thereby obtaining at least one isolated B cell; and (d) using the microfluidic device to identify at least one B cell that produces antibodies capable of binding to cancer cells. The cancer cells can be the patient's own cancer cells. Also provided are methods of treating patients, methods of labeling or detecting cancer, engineered T or NK cells comprising antibodies or fragments thereof, and engineered antibody constructs.

Abstract: A prosthetic foot includes a foot portion and a switching adapter. The switching adapter includes a first member coupled to the foot portion, a second member, a third member interposed between the first member and the second member, and a locking mechanism. The third member has a first side wall and a second side wall larger in length than the first side wall. The third member is configured to rotate relative to the first member and the second member towards a first position, thereby placing the prosthetic device in a walking mode. The third member is further configured to rotate relative to the first member and the second member towards a second position, thereby placing the prosthetic device in a running mode. The locking mechanism is configured to rotate with the third member in response to rotation of the third member.

Abstract: An artificial intelligence-based system and method for automatically generating and adjusting tags associated with one or more UI/UX related components or features is provided. Analysis may be performed on the data collected by the one or more tags so that design change recommendations can be dynamically recommended and/or implemented. When design changes are implemented, the system may automatically reconfigure or adjust all relevant tags. The AI-based system may be a standalone platform or may be incorporated into existing UI/UX programs.

Abstract: A computing platform is configured to: (i) receive, from a first client station, (a) data related to the first client station and (b) a first image associated with a target location; (ii) based on the received data related to the first client station, determine a location signature associated with the first image; (iii) determine that the location signature associated with the first image has a threshold level of similarity to a location signature associated with a second image that is associated with the target location; (iv) evaluate at least the first image to determine progression of a construction-related activity at the target location; (v) based on the evaluation of at least the first image, determine that the construction-related activity at the target location has progressed a threshold amount; and (vi) transmit, to a second client station, a communication related to progression of the construction-related activity.

Abstract: Components for valve treatment systems are disclosed. Valve treatment systems can include a delivery system for an implantable device. The delivery system can include one or more of clasp control components slidably disposed on a catheter handle, a control element for opening and closing the implantable device, a catheter assembly with features to reduce friction with another catheter assembly, grips for attaching catheter assemblies to clamps, catheter assemblies with features that stiffen or provide variable stiffness, and catheter assemblies with one or more steering control lumens incorporated into a reinforcement layer.

Abstract: An intelligence platform determines that a package was delivered to a location, and receives real-time information associated with the package or location. The real-time information includes sensor data received from one or more sensor devices disposed proximate to the package, or third party data received from one or more third party devices associated with a geographic region that includes the location to which the package was delivered. The intelligence platform determines, using a machine learning model, a score for the package based on the real-time information, where the score predicts a measure of vulnerability of the package, and determines whether to retrieve or protect the package based on the score. The intelligence platform selects an unmanned vehicle (UV) to retrieve or protect the package based on vehicular data, and transmits instructions to the UV to cause the UV to navigate to the package and retrieve or protect the package.

Abstract: A network-connected security device is communicatively coupled to an audio/video (A/V) recording and communication device having a camera and a speaker. A method receives video data captured by the camera, and performs an object recognition algorithm upon the received video data to identify an object therein. The method performs a table lookup using the identified object, into a data structure that associates objects with at least one description of a predefined voice message. The method selects a description of a predefined voice message associated with the identified object, and transmits the selected description's predefined voice message to the A/V recording and communication device for output through the speaker.

Abstract: An intelligence platform determines that a package was delivered to a location, and receives real-time information associated with the package or location. The real-time information includes sensor data received from one or more sensor devices disposed proximate to the package, or third party data received from one or more third party devices associated with a geographic region that includes the location to which the package was delivered. The intelligence platform determines, using a machine learning model, a score for the package based on the real-time information, where the score predicts a measure of vulnerability of the package, and determines whether to retrieve or protect the package based on the score. The intelligence platform selects an unmanned vehicle (UV) to retrieve or protect the package based on vehicular data, and transmits instructions to the UV to cause the UV to navigate to the package and retrieve or protect the package.

Abstract: An artificial intelligence-based system and method for automatically generating and adjusting tags associated with one or more UI/UX related components or features is provided. Analysis may be performed on the data collected by the one or more tags so that design change recommendations can be dynamically recommended and/or implemented. When design changes are implemented, the system may automatically reconfigure or adjust all relevant tags. The AI-based system may be a standalone platform or may be incorporated into existing UI/UX programs.

Abstract: An artificial intelligence-based system and method for automatically generating and adjusting tags associated with one or more UI/UX related components or features is provided. Analysis may be performed on the data collected by the one or more tags so that design change recommendations can be dynamically recommended and/or implemented. When design changes are implemented, the system may automatically reconfigure or adjust all relevant tags. The AI-based system may be a standalone platform or may be incorporated into existing UI/UX programs.

Abstract: A system and method are disclosed in which cash deposits may be made at merchant locations who support such deposits. Using a mobile phone or other hand-held device, a bank customer requests a cash deposit from a banking app, receives a barcode on the mobile device, the barcode containing embedded information indicating the cash deposit amount, and presents the barcode to the merchant, along with the cash to be deposited. Once the transaction with the merchant is complete, the account of the bank customer's account is credited with the cash amount. The bank uses behavioral and historical data of the bank customer to customize a cash deposit limit for the customer.

Abstract: A dunnage conversion machine converts a sheet stock material into a dunnage product that is relatively thicker and less dense than the stock material. The conversion machine includes a conversion assembly that draws the sheet stock material therethrough and randomly crumples at least a portion of the sheet stock material. Before severing a discrete dunnage product of a desired length from the substantially continuous length of sheet stock material, the random crumpling is minimized or eliminated in an area to be cut to reduce or eliminate the production of scrap shards of sheet stock material during the cutting operation.

Abstract: Disclosed are systems and methods for validating institutional or individual credentials and generating public facing electronic insignias representative of the validated credentials. Financial institutions maintain vast amounts of data regarding customers, and in particular data relating to financial history and performance. The disclosed systems and methods provide a novel framework for leveraging such data in order to generate and/or validate credential data. In some embodiments, an immutable ledger maintained at one or more databases in communication with financial institutions may store electronic credential records regarding an institution or individual that can be analyzed and accessed in order to assign an entity to a specific accreditation tier.

Abstract: A network-connected security device is communicatively coupled to an audio/video (A/V) recording and communication device having a camera and a speaker. A method receives video data captured by the camera, and performs an object recognition algorithm upon the received video data to identify an object therein. The method performs a table lookup using the identified object, into a data structure that associates objects with at least one description of a predefined voice message. The method selects a description of a predefined voice message associated with the identified object, and transmits the selected description's predefined voice message to the A/V recording and communication device for output through the speaker.

Abstract: An intelligence platform determines that a package was delivered to a location, and receives real-time information associated with the package or location. The real-time information includes sensor data received from one or more sensor devices disposed proximate to the package, or third party data received from one or more third party devices associated with a geographic region that includes the location to which the package was delivered. The intelligence platform determines, using a machine learning model, a score for the package based on the real-time information, where the score predicts a measure of vulnerability of the package, and determines whether to retrieve or protect the package based on the score. The intelligence platform selects an unmanned vehicle (UV) to retrieve or protect the package based on vehicular data, and transmits instructions to the UV to cause the UV to navigate to the package and retrieve or protect the package.

Abstract: An intelligence platform determines that a package was delivered to a location, and receives real-time information associated with the package or location. The real-time information includes sensor data received from one or more sensor devices disposed proximate to the package, or third party data received from one or more third party devices associated with a geographic region that includes the location to which the package was delivered. The intelligence platform determines, using a machine learning model, a score for the package based on the real-time information, where the score predicts a measure of vulnerability of the package, and determines whether to retrieve or protect the package based on the score. The intelligence platform selects an unmanned vehicle (UV) to retrieve or protect the package based on vehicular data, and transmits instructions to the UV to cause the UV to navigate to the package and retrieve or protect the package.

Abstract: A system and method are disclosed in which cash deposits may be made at merchant locations who support such deposits. Using a mobile phone or other hand-held device, a bank customer requests a cash deposit from a banking app, receives a barcode on the mobile device, the barcode containing embedded information indicating the cash deposit amount, and presents the barcode to the merchant, along with the cash to be deposited. Once the transaction with the merchant is complete, the account of the bank customer's account is credited with the cash amount. The bank uses behavioral and historical data of the bank customer to customize a cash deposit limit for the customer.

Abstract: An artificial intelligence-based system and method for automatically generating and adjusting tags associated with one or more UI/UX related components or features is provided. Analysis may be performed on the data collected by the one or more tags so that design change recommendations can be dynamically recommended and/or implemented. When design changes are implemented, the system may automatically reconfigure or adjust all relevant tags. The AI-based system may be a standalone platform or may be incorporated into existing UI/UX programs.