Abstract: The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the ALAS1 gene, and methods of using such dsRNA compositions to alter (e.g., inhibit) expression of ALAS1.

Abstract: The invention provides novel inhibitors of ROCK1 and/or ROCK2. Also provided are methods of treating diseases and disorders involving inhibiting ROCK1 and/or ROCK2. The present invention includes pharmaceutical compositions comprising the compounds of the invention and a pharmaceutically acceptable carrier and/or diluents. The present invention includes compositions comprising a substantially pure compound of the invention and a pharmaceutically acceptable salt, steroisomer, or hydrate thereof: and a pharmaceutically acceptable excipient and/or diluents.

Abstract: A computing system causes a plurality of display devices to display user interfaces containing portions of a canvas shared by a plurality of users. The canvas is a graphical space containing discrete graphical elements located at arbitrary locations within the canvas. Each of the discrete graphical elements graphically represents a discrete resource. When a user interacts with a resource in the set of resources, the computing system modifies the canvas to include an interaction element indicating that the user is interacting with the resource. The computer system then causes the display devices to update the user interfaces such that the user interfaces reflect a substantially current state of the canvas. In this way, the users may be able to understand which ones of the users are interacting with which ones of the resources.

Abstract: A biopsy system with a grid plate used as either a lateral or medial compression plate of a localization fixture used with a breast coil includes a rotatable guide cube that may be inserted into a desired rectangular recess in the grid plate after rotating to position a selected guide hole in the desired spatial orientation. Versions of a guide cube include those rotatable in two axes to provide additional hole positions, angled holes, enlarged circular holes that function with a rotating guide to support a noncircular biopsy instrument cannula (e.g., trocar/sleeve combination, core biopsy probe of a biopsy device) for rotation. A rotating guide may have an unlocked state for easily sliding to a selected longitudinal position thereon. Thereafter, the rotating guide is locked to serve as a positive depth stop (e.g., quarter turn locking elastomeric rings, triangular and scissor clips, and shutter depth stops).

Abstract: A compressor for a gas turbine engine includes a stator and a rotor. The stator includes first and second stator vanes attached to first and second vane platforms, respectively. The rotor includes a plurality of rotor blades that rotate with respect to the stator. An inner stator casing supports the first and second vane platforms and encloses the stator and the rotor. An outer stator casing encloses the inner stator casing, and a bleed cavity is disposed therebetween. At least one diffuser is disposed between the first vane platform and the second vane platform, and is configured to allow air communication between the inner stator casing and the bleed cavity. An exit opening of the diffuser is disposed within the bleed cavity at a location separate from the inner stator casing and the outer stator casing.

Abstract: In recent years, a great deal of attention has been drawn to the issue of water contamination, particularly in developing countries, where an inexpensive, effective method of reducing waterborne pathogens and contaminants is needed. Experiments performed with mucilage extracted from the Opuntia ficus-indica cactus show that this mucilage is an effective tool for clearing contaminants from water supplies, including the removal of Escherichia coli and Bacillus cereus bacteria, and the reduction of arsenic concentrations with very low mucilage concentrations (5 mg/L and 10 mg/L). Results for Bacillus and E. coli show settling to be complete in approximately five to ten minutes with removal rates of up to 97%, when CaCl2 is co-applied. Arsenic is removed at between 35% to 85% by increasing the contact time between the mucilage and the arsenic solutions depending on the pH and mucilage concentration.

Abstract: An ink cartridge is disclosed that includes a single cast reservoir portion of a first polymer configuration, the reservoir portion including raised walls that extend up to a top edge, the raised walls including a back wall. A latch handle protrudes from the back wall. A single cast lid is attached to the top edge. The lid is of a second polymer configuration that is stronger than the first polymer configuration.

Abstract: Implantable medical devices, implantable medical device systems that include such implantable medical devices, and implantable medical device batteries, as well as methods of making. Such devices can include a battery of relatively small volume but of relatively high power (reported as therapeutic power) and relatively high capacity (reported as capacity density).

Abstract: Techniques are disclosed relating to spectrum sharing between different radio access technologies. In some embodiments, a broadcast base station is configured to wirelessly broadcast audio and video data to a plurality of broadcast receiver devices using a particular frequency band. In these embodiments, the broadcast base station is configured to discontinue broadcasting in the particular frequency band during a scheduled time interval, to enable one or more cellular base stations to perform bi-directional packet-switched wireless data communications using the particular frequency band.

Abstract: The invention relates to an apparatus and methods for operation in relatively high radiation fields to remotely switch signal devices through a shared single main umbilical signal cable. The invention is particularly suitable for use in a nuclear reactor, such as a boiling water reactor, and in difficult to access areas in the reactor pressure vessel. One or more main umbilical cables connect a control station to an enclosure housing a signal switching device. The signal switching device allows several signal generating/receiving devices, such as cameras and ultrasonic probes, to be controlled by the one or more main umbilical cables.

Abstract: A load sense passage in a load sense hydraulic system may be vented by allowing flow from the load sense passage to a reservoir via a drain passage when a first flow control valve is in a neutral position. This venting may be prevented by preventing flow from the load sense passage to a reservoir via the drain passage when the first flow control valve is in a flow-allowing position.

Abstract: A part, such as an automotive part, is provided. The part includes at least two work pieces of steel which are joined together at a weld seam which includes at least one of nickel and iron and is substantially entirely free of silicate islands. The part also includes a painted, phosphated or electrocoated coating which is bonded with at least a portion of the substantially entirely silicate island free weld seam.

Abstract: Thermoplastic elastomer compositions, in particular derived from one or more styrenic block copolymers wherein at least one styrenic block copolymer comprises a controlled distribution copolymer block including a conjugated diene and a mono alkenyl arene, a plurality of biorenewable materials, preferably a softener and one or more synergistic additives such as a polar polymer; a synergistic block copolymer such as a relatively high molecular weight styrenic block copolymer; and/or filler. Numerous desirable articles can be formed from the compositions. Processes for preparing the compositions and articles are disclosed.

Abstract: Method and system for protecting induction motors from stalled start conditions provide a motor overload protection device that includes a stalled start detector capable of differentiating long start from stalled start conditions. This helps the motor overload protection device identify a stalled start condition right away and trip immediately rather than allowing the motor to continue drawing locked rotor current for the duration of the startup interval. Such a motor overload protection device may be used with any suitable multiphase induction motors, including two-phase motors, three phase motors, and the like. And because only the motor phase currents are used to detect the stalled start condition, the motor overload protection device disclosed herein does not require voltage phase shift information and/or motor speed measurements, thereby simplifying overall management of the motor.

Abstract: A field effect transistor is provided which includes a plurality of fins, at least a portion of a given fin including a respective source region, and a raised source disposed at least partially on the fins and including III-V material. The field effect transistor further includes a diffusion barrier disposed at least partially on the raised source and including transition metal bonded with silicon or germanium, and a gate stack capacitively coupled at least to the respective source regions of the fins.

Abstract: A sensor including electrodes, a control module and a physical layer module. The electrodes are configured to (i) attach to a patient, and (ii) receive a first electromyographic signal from the patient. The control module is connected to the electrodes. The control module is configured to (i) detect the first electromyographic signal, and (ii) generate a first voltage signal. The physical layer module is configured to: receive a payload request from a console interface module or a nerve integrity monitoring device; and based on the payload request, (i) upconvert the first voltage signal to a first radio frequency signal, and (ii) wirelessly transmit the first radio frequency signal from the sensor to the console interface module or the nerve integrity monitoring device.

Abstract: The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compounds, and methods for using these compounds in the treatment of HIV infection.

Abstract: This application generally relates to systems and methods for generating and rendering visualizations of an object or environment using 2D and 3D image data of the object or the environment captured by a mobile device. In one embodiment, a method includes providing, by the system, a representation of a 3D model of an environment from a first perspective of the virtual camera relative to the 3D model, receiving, by the system, input requesting movement of the virtual camera relative to the 3D model, and selecting, by the system, a first 2D image from a plurality of two dimensional images associated with different capture positions and orientations relative to the 3D model based on association of a capture position and orientation of the first 2D image with a second perspective of the virtual camera relative to the 3D model determined based on the movement.