Abstract: Disclosed herein are compounds of formula I: or a pharmaceutically acceptable salt thereof, where the variables are as defined herein. These compounds are useful in treating RET associated cancers. Formulations containing the compounds of formula I and methods of making the compounds of formula I are also disclosed.

Abstract: Suspension systems for recreational vehicles are disclosed. The suspension systems may include at least one adjustable member coupling a sway bar to respective suspensions. The suspension systems may include a torque actuator associated with a sway bar.

Abstract: Provided herein are RET kinase inhibitors according to the formula: pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods for their use in the treatment of diseases that can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders. A, R1, n, X1, X2, X3, X4, and R2 have the meanings given in the specification.

Abstract: Illumination articles are described. More specifically, illumination articles that include a wearable device configured for wearing on the head of a wearer, a lightguide and light sources for emitting light into the lightguide are described. The illumination articles allow for wearable devices that uniformly illuminate a working area at high brightness without providing excessive glare to observers.

Abstract: Illumination articles are described. More specifically, illumination articles that include a wearable device configured for wearing on the head of a wearer, a lightguide and light sources for emitting light into the lightguide are described. The illumination articles allow for wearable devices that uniformly illuminate a working area at high brightness without providing excessive glare to observers. The disclosed illumination article comprises: a wearable device configured for wearing on the head of a wearer, a lightguide disposed on the wearable device, wherein the lightguide is elongated and has a first end and a second end opposite the first end, and a first light source positioned at the first end, for emitting light into the lightguide.

Abstract: One aspect of the present invention relates to ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in various transition-metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming reactions. The subject methods provide improvements in many features of the transition-metal-catalyzed reactions, including the range of suitable substrates, number of catalyst turnovers, reaction conditions, and efficiency. For example, improvements have been realized in transition metal-catalyzed: aryl amination reactions; aryl amidation reactions; Suzuki couplings; and Sonogashira couplings. In certain embodiments, the invention relates to catalysts and methods of using them that operate in aqueous solvent systems.

Abstract: Disclosed are folded configurations in coiled sheets enabling formation of masking sheet rolls for improved dispensing and unfolding, in combination, with adhesive tape securable to a walled surface.

Abstract: One aspect of the present invention relates to ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in various transition-metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming reactions. The subject methods provide improvements in many features of the transition-metal-catalyzed reactions, including the range of suitable substrates, number of catalyst turnovers, reaction conditions, and efficiency. For example, improvements have been realized in transition metal-catalyzed: aryl amination reactions; aryl amidation reactions; Suzuki couplings; and Sonogashira couplings. In certain embodiments, the invention relates to catalysts and methods of using them that operate in aqueous solvent systems.

Abstract: The present invention relates to compounds according to formula 1, which exhibit cytotoxic activity. The compounds may be used in the treatment of cancer.

Abstract: Catheter having a first elongate tubular body having a lumen, a second elongate tubular body having a lumen, and an elongate member. The elongate member joins the first and second elongate tubular bodies. The first tubular body is fixedly attached on the distal portion of the elongate member, and the second elongate tubular body is disposed on the elongate member is slidable along a portion of the elongate member. The second elongate tubular body can be in a first position so that the first and second tubular bodies are not adjacent to each other and can be in a second position so that the first and second tubular bodies are adjacent to each other. The catheter may have a locking mechanism that can lock the first and second elongate tubular bodies to each other so that the lumens of the first and second elongate tubular bodies form one continuous lumen.

Abstract: The present invention relates to compounds according to formula 1, which exhibit cytotoxic activity. The compounds may be used in the treatment of cancer.

Abstract: Disclosed are folded configurations in coiled sheets enabling formation of masking sheet rolls for improved dispensing and unfolding, in combination, with adhesive tape securable to a walled surface.

Abstract: Disclosed is a folded configuration in a coiled sheet that enables formation of masking sheet rolls that enable improved dispensing of the sheet roll in combination with an adhesive tape.

Abstract: One aspect of the present invention relates to ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in various transition-metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming reactions. The subject methods provide improvements in many features of the transition-metal-catalyzed reactions, including the range of suitable substrates, number of catalyst turnovers, reaction conditions, and efficiency. For example, improvements have been realized in transition metal-catalyzed: aryl amination reactions; aryl amidation reactions; Suzuki couplings; and Sonogashira couplings. In certain embodiments, the invention relates to catalysts and methods of using them that operate in aqueous solvent systems.

Abstract: One aspect of the present invention relates to ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in various transition-metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming reactions. The subject methods provide improvements in many features of the transition-metal-catalyzed reactions, including the range of suitable substrates, number of catalyst turnovers, reaction conditions, and efficiency. For example, improvements have been realized in transition metal-catalyzed: aryl amination reactions; aryl amidation reactions; Suzuki couplings; and Sonogashira couplings. In certain embodiments, the invention relates to catalysts and methods of using them that operate in aqueous solvent systems.

Abstract: A bioprocess for producing carboxylic acids, alcohols and aldehydes is provided by culturing Candida sp. in a fermentation medium containing various defined substrates.

Abstract: A bioprocess for producing carboxylic acids, alcohols and aldehydes is provided by culturing Candida sp. in a fermentation medium containing various defined substrates.

Abstract: A bioprocess for producing carboxylic acids, alcohols and aldehydes is provided by culturing Candida sp. in a fermentation medium containing various defined substrates.

Abstract: Catheter having a first elongate tubular body having a lumen, a second elongate tubular body having a lumen, and an elongate member. The elongate member joins the first and second elongate tubular bodies. The first tubular body is fixedly attached on the distal portion of the elongate member, and the second elongate tubular body is disposed on the elongate member is slidable along a portion of the elongate member. The second elongate tubular body can be in a first position so that the first and second tubular bodies are not adjacent to each other and can be in a second position so that the first and second tubular bodies are adjacent to each other. The catheter may have a locking mechanism that can lock the first and second elongate tubular bodies to each other so that the lumens of the first and second elongate tubular bodies form one continuous lumen.

Abstract: A process for forming a color and odor stable polycarboxylic acid or polyhydroxy acid is provided. The process is carried out by fermenting a mixture containing a substrate which can be converted by fermentation into a polycarboxylic acid or a polyhydroxy acid, an organism capable of transforming the substrate by fermentation in a fermentation medium containing a source of carbon and energy, a source of inorganic nitrogen, a source of phosphate, a metal, a biotin which is substantially free of particulate matter and bacteria.