Abstract: The present disclosure relates to extracellular vesicles comprising one or more antigens from a coronavirus (e.g., SARS-CoV-1 or SARS-CoV-2) and optionally an adjuvant. Also provided herein are methods for producing the EVs and methods for using the EVs to treat and/or prevent diseases or disorders, e.g., infectious diseases.

Abstract: Various techniques and mechanisms for sharing remote resources among a trusted group are disclosed. A credential management agent utilizes a resource credential for a first user to access a secure resource corresponding to the first user for a second user by at least validating a second user and validating a consent of the first user to allow the second user to access the secure resource using the resource credential for the first user. The secure resource resides on a remote server system accessible via one or more application program interfaces (APIs). A platform management agent provides an interface for shared resource-agnostic credential sharing. The platform management agent validates credentials for the second user as belonging to a trusted group and forwards a request for access to the secure resource for the second user to the credential management agent.

Abstract: The subject of this disclosure includes an ablation system for visually supporting a tissue ablation procedure, including a display comprising a user interface; and at least one processor in communication with the display, the at least one processor configured to control one or more of a plurality of electrodes of a radiofrequency balloon catheter to ablate organ tissues of one or more targeted pulmonary veins; determine a characteristic, based on ablation parameters of the radiofrequency balloon catheter, of pulmonary vein isolation (PVI) success rate; and present, on the display, visual information corresponding to each electrode for an indication, based on the characteristic, for PVI success rate.

Abstract: The present disclosure relates to systems, methods, and non-transitory computer-readable media that implements related image search and image modification processes using various search engines and a consolidated graphical user interface. For instance, in one or more embodiments, the disclosed systems receive an input digital image and search input and further modify the input digital image using the image search results retrieved in response to the search input. In some cases, the search input includes a multi-modal search input having multiple queries (e.g., an image query and a text query), and the disclosed systems retrieve the image search results utilizing a weighted combination of the queries. In some implementations, the disclosed systems generate an input embedding for the search input (e.g., the multi-modal search input) and retrieve the image search results using the input embedding.

Abstract: Integrated circuit structures having internal spacers for 2D channel materials, and methods of fabricating integrated circuit structures having internal spacers for 2D channel materials, are described. For example, an integrated circuit structure includes a stack of two-dimensional (2D) material nanowires. A gate structure is vertically around the stack of 2D material nanowires. Internal gate spacers are between vertically adjacent ones of the stack of 2D material nanowires and laterally adjacent to the gate structure. The 2D material nanowires are recessed relative to the internal gate spacers. Conductive contact structures are at corresponding ends of the stack of 2D material nanowires, the conductive contact structures adjacent to the internal gate spacers and vertically overlapping with the internal gate spacers.

Abstract: This disclosure relates to a curable composition that includes at least one poly(arylene ether) copolymer, at least one phosphorus-containing flame retardant, and at least one radical initiator. This disclosure also relates to using the composition to form a film, a laminate, a prepreg, and/or a circuit board.

Abstract: The present invention discloses populations of T cells expressing a chimeric antigen receptor (CAR), wherein said T cells are placental T cells derived from cord blood, placental perfusate, or a mixture thereof. Such populations of cells are shown to be improved in a number of aspects over alternative populations of cells such as those derived from peripheral blood mononuclear cell T cells. It also discloses methods of treating cancer, such as a hematologic cancer, e.g., a B cell cancer, or a symptom thereof in a patient in need thereof. These methods comprise administering to the patient an amount of the population of T cells of any one of the invention effective to alleviate the cancer or symptom thereof in the patient.

Abstract: The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of PI3K? enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with PI3K? signaling with the compounds and compositions of the disclosure.

Abstract: An integrated electro-optic frequency comb generator based on ultralow loss integrated, e.g. thin-film lithium niobate, platform, which enables low power consumption comb generation spanning over a wider range of optical frequencies. The comb generator includes an intensity modulator, and at least one phase modulator, which provides a powerful technique to generate a broad high power comb, without using an optical resonator. A compact integrated electro-optic modulator based frequency comb generator, provides the benefits of integrated, e.g. lithium niobate, platform including low waveguide loss, high electro-optic modulation efficiency, small bending radius and flexible microwave design.

Abstract: Techniques for modifying data within a virtual space are discussed herein. A communication platform may receive a request from a user profile associated with a virtual space. The request may include instruction(s) for the communication platform to perform a modifying operation on data within a virtual space. Based on receiving the request, the communication platform may identify the data on which the operation is to be performed. The communication platform may input the data to one or more machine-learning models trained to output data that is a modified version of the data input to the machine-learning model (e.g., modified data). In such cases, the modified data may be modified consistent with the requested operation. The communication platform may receive the modified data from the machine-learning model and cause the modified data to be displayed via a user interface associated with the user profile.

Abstract: The present disclosure provides a method of manufacturing an electrode using a continuous coating line for applying an electrode coating layer on a substrate surface of a substrate, the continuous coating line comprising a coating apparatus comprising a coating head and a coating fluid supply system, and at least one oven comprising a heating element, and a substrate carrier for carrying the substrate, the method comprising continuously carrying the substrate through the continuous coating line using the substrate carrier; continuously applying a battery electrode slurry composition from the coating head to the substrate surface to form a wet coated substrate, wherein the battery electrode slurry composition is continuously fed into the coating head by the coating fluid supply system; and heating the wet coated substrate in the oven to form a dried coating on the substrate.

Abstract: Compositions and methods are provided herein for treating intestinal glycocalyx dysfunction. The composition can comprise a chito-oligosaccharide (COS), and optionally a human milk oligosaccharide (hMO) in an amount sufficient to maintain an intestinal glycocalyx and a pharmaceutically acceptable carrier. The composition can be formulated as an oral dosage form or a parenteral dosage form. The method can comprise identifying intestinal glycocalyx dysfunction in the subject. The method can further comprise administering to the subject a COS in an amount and at a frequency sufficient to prevent, stabilize and reverse damage in the intestinal glycocalyx.

Abstract: Systems and methods for image dense field based view calibration are provided. In one embodiment, an input image is applied to a dense field machine learning model that generates a vertical vector dense field (VVF) and a latitude dense field (LDF) from the input image. The VVF comprises a vertical vector of a projected vanishing point direction for each of the pixels of the input image. The latitude dense field (LDF) comprises a projected latitude value for the pixels of the input image. A dense field map for the input image comprising the VVF and the LDF can be directly or indirectly used for a variety of image processing manipulations. The VVF and LDF can be optionally used to derive traditional camera calibration parameters from uncontrolled images that have undergone undocumented or unknown manipulations.

Abstract: Described herein are fire-resistant one-component polyurethane spray foam compositions. Also described herein are methods of making and using fire-resistant one-component polyurethane spray foam compositions. Also described herein are dispensers for dispensing the fire-resistant one-component polyurethane spray foam compositions. Compositions and methods in accordance with the present disclosure are useful in a wide variety of applications, and particularly useful in meeting building codes for construction applications.

Abstract: Crystalline forms of Compound I: pharmaceutically acceptable salts thereof, and solvates and hydrates thereof are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.

Abstract: A surgical robot system includes a robot having a robot base and a robot arm coupled to the robot base, and a surgical retractor. The surgical retractor includes a retractor frame, a coupler, blades, a force and/or torque sensor, and a force and/or torque feedback determination unit. The retractor frame includes arms that are translatably and/or pivotably connected to the retractor frame. The coupler releasably attaches the retractor frame to the robot arm. The blades are each coupled to and extend away from a distal end of one of the arms. The force and/or torque sensor is connected to the blades and indicates an amount of force and/or torque being applied to the blades from contact with material of a surgical site. The force and/or torque feedback determination unit determines the amount of force and/or torque being applied to the blades based on the indication.

Abstract: A device implementing a system for multipath connection management may include first and second local communication interfaces, and a processor configured to establish a primary connection for communicating between the first local communication interface and a first remote communication interface of an other device, and a secondary connection for communicating between the second local communication interface and a second remote communication interface. The processor may be configured to transmit application and control data over the primary connection and concurrently transmit a copy of control data over the secondary connection. The processor may be configured to determine that a degradation of the quality of the primary connection is attributable to the other device. The processor may be configured to switch the secondary connection to the first local communication interface and the second remote communication interface.

Abstract: A system and method for reviewing a tomosynthesis image data set comprising volumetric image data of a breast, the method comprising, in one embodiment, causing an image or a series of images from the data set to be displayed on a display monitor and selecting or indicating through a user interface an object or region of interest in a presently displayed image of the data set, thereby causing an image from the data set having a best focus measure of the user selected or indicated object or region of interest to be automatically displayed on the display monitor.

Abstract: A head-mounted device may have an inner display that displays images for a user and an outer display that informs nearby people of the status of the user and inner display. For example, the outer display may display an image of a face, an abstract layer, or both, depending on whether the inner display is operating in passthrough mode, mixed reality mode, or virtual reality mode. An ambient light sensor in the head-mounted device may be used to measure the brightness and color of ambient light. The white point of the face layer on the outer display may be adapted to the color of ambient light, whereas the white point of the abstract layer on the outer display may remain fixed. The white point of a display may be a correlated color temperature setting (e.g., measured in degrees Kelvin) that determines the warmth or coolness of displayed colors.

Abstract: A unimodal ethylene-co-1-butene copolymer that, when in melted form at 190 degrees Celsius, is characterized by a unique melt property space defined by combination of shear thinning and melt elasticity properties. A blown film consisting essentially of the unimodal ethylene-co-1-butene copolymer. A method of synthesizing the unimodal ethylene-co-1-butene copolymer. A method of making the blown film. A manufactured article comprising the unimodal ethylene-co-1-butene copolymer.