Abstract: Devices and methods provided for joint arthroscopy contemplate and enable the provision of patient specific instruments (PSI). The devices and anatomical features of a patient are rendered adjustable by the provision of guide elements and feature to account for and enable repositioning of the anatomical features during surgery. Where the joint arthroscopy involves ankle arthroplasty, a PSI system includes a tibial PSI operable to be coupled to a tibia and a talar PSI operable to be coupled to a talus. Pins pass through the tibial PSI into the tibia and through the talar PSI into the talus. The tibia and talus are aligned based on the tibial PSI, the talar PSI, the pins, and optionally a connection guide operable to receive, or be coupled to, the pins. The tibial PSI and the talar PSI allow for the transfer of pre-operative planning to intra-operative procedures.

Abstract: A folded solid-state battery cell stack and a method of making the same are disclosed. The folded battery cell stack includes a flexible substrate and solid-state battery cells thereon. Each battery cell includes a cathode on or over the substrate, a solid-state electrolyte on the cathode, an anode current collector (ACC) on the solid-state electrolyte, an insulator layer on the ACC and having a sidewall portion, and a conductive redistribution layer on the insulator layer, including the sidewall portion, in ohmic contact with the ACC. The substrate includes a bend between adjacent solid-state battery cells, and the redistribution layer along the sidewall portion of each solid-state battery cell is aligned with other redistribution layers along other sidewall portions in the stack. The method includes forming the cells on the substrate and folding the substrate at a gap between adjacent solid-state battery cells.

Abstract: A stackable solid-state battery cell, a packaged solid-state battery including the same, and a method of making the same are disclosed. The battery cell includes a substrate, a cathode on or over the substrate, a solid-state electrolyte on the cathode, an anode current collector (ACC) on the solid-state electrolyte, an insulator layer on the ACC having a sidewall portion, a conductive redistribution layer on the insulator layer, including the sidewall portion, in electrical contact with the ACC, and a printed adhesive on a major surface of the cell. The packaged solid-state battery includes a plurality of the stackable solid-state battery cells and battery terminals in electrical contact with an active layer of each cell. The method includes printing the adhesive on the major surface, which can be the outermost surface of the redistribution layer and the insulator layer, or the substrate surface opposite from the cathode.

Abstract: A solid-state battery cell and a method of making the same are disclosed. The battery cell includes a substrate, a cathode on or over the substrate, a solid-state electrolyte on the cathode, an anode current collector (ACC) on the solid-state electrolyte, a conductive bump on the ACC, an insulator layer on the ACC and having a sidewall portion, and a conductive redistribution layer in ohmic contact with the conductive bump and on the insulator layer, including the sidewall portion. The insulator layer surrounds the conductive bump and exposes a surface of the conductive bump. The method includes printing the conductive bump on the ACC, printing the insulator layer on the ACC and a sidewall of the ACC, solid-state electrolyte, cathode and substrate, and forming the conductive redistribution layer on the exposed conductive bump and the insulator layer, including the sidewall portion.

Abstract: A determination is made that anomaly analysis is to be performed with respect to an application. An anomaly score of the application is generated with respect to observed values of a plurality of metrics of the application. Generation of the anomaly score comprises computing an anomaly score contribution associated with an analysis of a correlation between values of a pair of metrics of the application. In response to a detection that the anomaly score exceeds a threshold, an anomaly response operation is initiated.

Abstract: A method of making a lithium metal oxide film is disclosed. The method includes blanket-depositing a cathode material, a solid-state electrolyte, and an anode current collector (ACC) material on a substrate, laser-patterning the ACC material to define the solid-state battery cells and form an ACC in each of the cells, and cutting or dicing the solid-state battery cells through the electrolyte and the cathode material to form a cathode in each of the solid-state battery cells. The method avoids issues related to topography and wet patterning when making the cathode, electrolyte and ACC layers. The method also avoids the need to fabricate a physical mask, thereby enabling greater patterning flexibility, higher throughput and lower costs than photolithography.

Abstract: A vacuum pad may include a first layer, a top layer that at least partially forms a top surface of the vacuum pad, a plurality of holes extending through the top layer into an interior space located between at least a portion of the first layer and at least a portion of the top layer, an outlet tube in fluid communication with the interior space, a raised barrier that surrounds the plurality of holes, a plurality of dividers located in the interior space that extend along the first layer from a first end of the respective divider located adjacent to the outlet tube, and at least one spacer located in the interior space that has a different shape than the plurality of dividers. The vacuum pad may include at least one channel and at least one collection area located in the interior space.

Abstract: A cylindrical solid-state battery and methods of making the same are disclosed. The battery includes a solid-state battery cell wound, wrapped or rolled around a core or itself, first and second terminals on opposite ends of the battery, and packaging between the first and second terminals, sealing the cell therein. The cell comprises a cathode current collector (CCC), a cathode on the CCC, a solid-state electrolyte on the cathode, an anode current collector (ACC) on the electrolyte, an insulation film on the ACC with an opening therein exposing the ACC, and a conductive redistribution layer in the opening and on the insulation film and a first sidewall of the cell. One of the terminals is electrically connected to the ACC through the redistribution layer, and the other terminal is electrically connected to the cathode or CCC on the opposite end of the battery.

Abstract: A solid-state battery and methods of making the same are disclosed. The battery includes a plurality of cells and first and second terminals on opposite sides/edges of the battery. Each cell includes a cathode current collector (CCC), a cathode thereon, a solid-state electrolyte, an anode current collector (ACC), a barrier/insulation film, a via/opening in the barrier/insulation film exposing the ACC, and a conductive redistribution layer on the ACC in the via/opening, on the barrier/insulation film, and on a first sidewall of each cell. The barrier/insulation film encapsulates the CCC, the cathode, the solid-state electrolyte and the ACC. The first sidewall of each cell is on one of the sides/edges of the battery. One terminal is electrically connected to each ACC through the redistribution layer, and the other is electrically connected to each cathode or CCC.

Abstract: A method for asset routing including receiving a digital asset, determining a set of print partners for the digital asset, determining a set of candidate batches for the digital asset, selecting a print partner for the digital asset, optionally determining a print partner for an unmatched digital asset, and routing the digital asset to the print partner.

Abstract: Described herein are compositions and methods for stabilizing RNA and protein antigens for long-term storage and use in transdermal microneedle patches, methods for filling microneedles, and methods of use. A stabilized RNA vaccine composition comprises: a complex of RNA with one or more cationic polymers; and one or more cationic lipid entities. A method for stabilizing RNA comprises: forming a complex comprising the RNA with one or more cationic polymers; mixing the complex with one or more cationic lipid entities comprising liposomes or lipid nanoparticles to form a lipid mixture; and drying the lipid mixture under vacuum. The compositions and methods may be employed in the preparation of vaccine medicaments.

Abstract: A solid-state battery and methods of making the same are disclosed. The battery includes a plurality of cells and first and second terminals on opposite sides/edges of the battery. Each cell includes a cathode current collector (CCC), a cathode thereon, a solid-state electrolyte, an anode current collector (ACC), a moat in the cathode and the electrolyte and around the ACC, a barrier/insulation film, a via/opening in the barrier/insulation film exposing the ACC, and a conductive redistribution layer in the via/opening, in the moat, on the barrier/insulation film, and on a first sidewall of each cell. The barrier/insulation film encapsulates the CCC, the cathode, the solid-state electrolyte and the ACC. One terminal is electrically connected to each ACC through the redistribution layer, and the other is electrically connected to each cathode or CCC.

Abstract: A method for asset routing including receiving a digital asset, determining a set of print partners for the digital asset, determining a set of candidate batches for the digital asset, selecting a print partner for the digital asset, optionally determining a print partner for an unmatched digital asset, and routing the digital asset to the print partner.

Abstract: Devices and methods provided for joint arthroscopy contemplate and enable the provision of patient specific instruments (PSI). The devices and anatomical features of a patient are rendered adjustable by the provision of conforming surfaces and support elements to account for and enable repositioning of the anatomical features during surgery. Where the joint arthroscopy involves shoulder arthroplasty, a PSI system includes at least one shoulder PSI operable to be positioned on a bone in a shoulder in the patient. The at least one shoulder PSI allow for the transfer of preoperative planning to intra-operative procedures. The at least one shoulder PSI may be virtually designed as a model based on scan data of the bone in the shoulder of the patient. The at least one shoulder PSI may be fabricated based on the virtually-designed at least one shoulder PSI model.

Abstract: A system for and a method of regulating the data interconnections between applications running on an infrastructure are provided. The system/method records access permission data into metadata embedded in the source code of each such application that regulates the data that can be received or transmitted by that application. In addition to regulating the receipt or transmission of data, the metadata can serve to provide instruction to firewalls and other regulating systems in order to configure those systems to allow the applications to receive and transmit data for which permissions have been recorded.

Abstract: A core-shell microneedle system and a method of manufacturing the microneedle system provides a pulsatile drug delivery system which is programmed to release drugs/vaccines at predictable times using biodegradable polymers and with controllable dosages. This microneedle system can be fully embedded into the skin and then release drugs/vaccines as sharp bursts in a timely manner, similar to multiple bolus injections.

Abstract: A core-shell microneedle system and a method of manufacturing the microneedle system provides a pulsatile drug delivery system which is programmed to release drugs/vaccines at predictable times using biodegradable polymers and with controllable dosages. This microneedle system can be fully embedded into the skin and then release drugs/vaccines as sharp bursts in a timely manner, similar to multiple bolus injections.

Abstract: Devices and methods provided for joint arthroscopy contemplate and enable the provision of patient specific instruments (PSI). The devices and anatomical features of a patient are rendered adjustable by the provision of guide elements and feature to account for and enable repositioning of the anatomical features during surgery. Where the joint arthroscopy involves ankle arthroplasty, a PSI system includes a tibial PSI operable to be coupled to a tibia and a talar PSI operable to be coupled to a talus. Pins pass through the tibial PSI into the tibia and through the talar PSI into the talus. The tibia and talus are aligned based on the tibial PSI, the talar PSI, the pins, and optionally a connection guide operable to receive, or be coupled to, the pins. The tibial PSI and the talar PSI allow for the transfer of pre-operative planning to intra-operative procedures.

Abstract: A method for asset routing including receiving a digital asset, determining a set of print partners for the digital asset, determining a set of candidate batches for the digital asset, selecting a print partner for the digital asset, optionally determining a print partner for an unmatched digital asset, and routing the digital asset to the print partner.

Abstract: Methods, systems, and computer-readable media for automatically detecting root causes of anomalies occurring in information technology (IT) systems are disclosed. In some embodiments, data of a service graph depicting dependencies between nodes or services of the IT infrastructure is traversed to determine propagation patterns of anomaly symptoms/alarms through the IT infrastructure. Also, a causal inference model is used to determine probabilities that an observed propagation pattern corresponds to a stored propagation pattern, wherein a close correspondence indicates that the current anomaly is likely caused by a similar root cause as a past anomaly that caused the stored propagation pattern.