Abstract: Provided are a compound having a 1,2,3,4-tetrahydronaphthalene moiety or pharmaceutically acceptable salt thereof, of Formula 1 a pharmaceutical composition comprising the same and a use thereof, where the compound having a 1,2,3,4-tetrahydronaphthalene moiety or pharmaceutically acceptable salt thereof has an inhibitory activity against glucosylceramide synthase (GCS), and therefore can be usefully applied for preventing or treating various diseases associated with GCS, such as Gaucher disease, Fabry disease, Tay-Sachs disease, Parkinson's disease, etc.

Abstract: A cabin cooling/heating system for a vehicle includes: a heat pump system configured to generate a cold refrigerant and a hot refrigerant; an air conditioning device configured to receive the cold or hot refrigerant from the heat pump system, generate cold or warm air by using the cold or hot refrigerant, and blow the cold or warm air to a front cabin of the vehicle; a floor heat exchanger configured to receive the cold or hot refrigerant from the air conditioning device and cool or heat a cabin floor of a rear cabin of the vehicle by circulating the cold or hot refrigerant; and a line switching valve module configured to send the cold or hot refrigerant to the floor heat exchanger or send the cold or hot refrigerant to the heat pump system.

Abstract: A cabin cooling/heating system for a vehicle includes: a heat pump system to provide cold or hot water by circulating a refrigerant; an air conditioning device fluidly connected to the heat pump system, configured to receive the cold or hot water from the heat pump system, provide cold or warm air by exchanging heat between inside or outside air of the vehicle and the cold or hot water, and blow the cold air or the warm air to the front cabin; a floor heat exchanger to receive the cold or hot water from the air conditioning device, and configured to cool or heat a cabin floor by circulating the cold or hot water through the cabin floor; and a line switching valve module configured to send the cold or hot water to the floor heat exchanger or return the cold or hot water back to the heat pump system.

Abstract: The present disclosure to an electrolyte membrane containing a polyfluorene-based ionomer, and more particularly, to an electrolyte membrane containing a polyfluorene-based ionomer which has a fluorene main chain composed of only a carbon-carbon bond and a side chain composed of a perfluorosulfonic acid group. The electrolyte membrane containing the polyfluorene-based ionomer has high proton conductivity, excellent chemical durability, excellent mechanical property, and excellent volume stability.

Abstract: Provided is a stator applied to a motor. The stator of the present disclosure may reduce a production cost and simultaneously minimize a motor failure occurring due to corrosion by using an inexpensive steel ball bearing, which is enabled by reducing a magnitude of an shaft voltage that causes the corrosion rather than using a structure (for example, a ceramic bearing or an SGR bearing) for avoiding the corrosion.

Abstract: Provided is an organic electroluminescence device including a first electrode, an organic layer on the first electrode, and a second electrode on the organic layer, wherein the organic layer includes a polycyclic compound represented by Formula 1. The organic electroluminescence device including a polycyclic compound represented by Formula 1 thereby exhibits high luminous efficiency.

Abstract: Provided are a compound having an inhibitory activity against glucosylceramide synthase (GCS), i.e., compounds having a 2,3-dihydro-1H-indene, 1,2,3,4-tetrahydronaphthalene, or chromane moiety, or pharmaceutically acceptable salt thereof, a process for the preparation thereof, a pharmaceutical composition comprising the same and a use thereof, wherein the compound or pharmaceutically acceptable salt thereof has an inhibitory activity against glucosylceramide synthase (GCS), and exhibits the effects of alleviating symptoms in the central nervous system as well as in the peripheral nervous system, through excellent blood-brain barrier permeability, and therefore, the compound or pharmaceutically acceptable salt thereof can be usefully applied for preventing or treating various diseases associated with GCS, such as Gaucher disease, Fabry disease, Tay-Sachs disease, Parkinson's disease, etc.

Abstract: Provided is a vector library for yeast two-hybrid screening of a deubiquitinating enzyme that binds to a target protein and a method for identifying a deubiquitinating enzyme binding to a target protein using the same. Further provided is a method for screening an agent having anti-cancer activity targeting the deubiquitinating enzyme USP1, USP7, USP12, or USP49 identified by the identifying method.

Abstract: A light emitting device that includes a first electrode, a second electrode oppositely disposed to the first electrode, and an emission layer between the first electrode and the second electrode is provided.

Abstract: The present invention provides a vector library for yeast two-hybrid screening of a deubiquitinating enzyme that binds to a target protein and a method for identifying a deubiquitinating enzyme binding to a target protein using the same. Also, the present invention provides a method for screening an agent having anti-cancer activity targeting the deubiquitinating enzyme USP1, USP7, USP12, or USP49 identified by said identifying method.

Abstract: Provided are a compound having a chromane, isochromane, thiochromane, or tetrahydroquinoline moiety or pharmaceutically acceptable salt thereof, a process for the preparation thereof, a pharmaceutical composition comprising the same and a use thereof, wherein the compound having a chromane, isochromane, thiochromane, or tetrahydroquinoline moiety or pharmaceutically acceptable salt thereof has an inhibitory activity against glucosylceramide synthase (GCS), and therefore can be usefully applied for preventing or treating various diseases associated with GCS, such as Gaucher disease, Fabry disease, Tay-Sachs disease, Parkinson's disease, etc.

Abstract: Provided are a compound having a 2,3-dihydro-1H-indene or 2,3-dihydrobenzofuran moiety or pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the same and a use thereof, where the compound having a 2,3-dihydro-1H-indene or 2,3-dihydrobenzofuran moiety or pharmaceutically acceptable salt thereof has an inhibitory activity against glucosylceramide synthase (GCS), and therefore can be usefully applied for preventing or treating various diseases associated with GCS, such as Gaucher disease, Fabry disease, Tay-Sachs disease, Parkinson's disease, etc.

Abstract: Provided are a compound having a 1,2,3,4-tetrahydronaphthalene moiety or pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the same and a use thereof, where the compound having a 1,2,3,4-tetrahydronaphthalene moiety or pharmaceutically acceptable salt thereof has an inhibitory activity against glucosylceramide synthase (GCS), and therefore can be usefully applied for preventing or treating various diseases associated with GCS, such as Gaucher disease, Fabry disease, Tay-Sachs disease, Parkinson's disease, etc.

Abstract: The present invention relates to a novel polymer and an organic electronic device using same. In the polymer according to the present invention, a cyclic electron-donor, including thiophene, selenophene, or a combination thereof, is introduced into a central skeleton having an A-D-A structure including an electron-donor and electron-acceptor unit. Thus, the polymer has not only excellent chemical and thermal stability, but also good crystallinity. Moreover, intermolecular stacking is possible, and thus charge mobility can be maximized.

Abstract: An electronic device module includes: a substrate; a sealing portion disposed on a first surface of the substrate; an exothermic device disposed on the first surface of the substrate and embedded in the sealing portion; and a heat radiating portion at least partially embedded in the sealing portion. A lower surface of the heat radiating portion is bonded to one surface of the exothermic device. A side surface of the heat radiating portion is curved and is entirely in contact with the sealing portion. A plurality of grooves are disposed in the side surface of the heat radiating portion.

Abstract: The present invention provides a compound selected from the group consisting of a compound of formula (I), pharmaceutically acceptable salts, esters, prodrugs, hydrates, solvates and isomers thereof; a use of the compound for the treatment, relief or prevention of diseases caused by abnormal or uncontrolled activation of protein kinase, and a use of the compound for the manufacture of a medicament for the treatment, relief or prevention of the diseases; a pharmaceutical composition comprising the compound as an active ingredient; and a method for the treatment, relief or prevention of the diseases using the compound. The inventive compound is useful for the treatment, relief or prevention of diseases caused by abnormal or uncontrolled activation of protein kinase.

Abstract: Provided are a heterocyclic compound represented by Formula 1 below, and an organic electroluminescence device including the same in an emission layer. In Formula 1, X is a direct linkage or CR2R3, Z1 to Z8 are each independently CR4 or N, at least two of Z1, Z3, Z6 and Z8 are each independently CR5, and R5 is represented by Formula 2 or Formula 3 below.

Abstract: The present disclosure to an electrolyte membrane containing a polyfluorene-based ionomer, and more particularly, to an electrolyte membrane containing a polyfluorene-based ionomer which has a fluorene main chain composed of only a carbon-carbon bond and a side chain composed of a perfluorosulfonic acid group. The electrolyte membrane containing the polyfluorene-based ionomer has high proton conductivity, excellent chemical durability, excellent mechanical property, and excellent volume stability.

Abstract: An electronic device module includes: a substrate; a sealing portion disposed on a first surface of the substrate; an exothermic device disposed on the first surface of the substrate and embedded in the sealing portion; and a heat radiating portion at least partially embedded in the sealing portion. A lower surface of the heat radiating portion is bonded to one surface of the exothermic device. A side surface of the heat radiating portion is curved and is entirely in contact with the sealing portion. A plurality of grooves are disposed in the side surface of the heat radiating portion.

Abstract: Provided is an organic electroluminescence device including a first electrode, an organic layer on the first electrode, and a second electrode on the organic layer, wherein the organic layer includes a polycyclic compound represented by Formula 1. The organic electroluminescence device including a polycyclic compound represented by Formula 1 thereby exhibits high luminous efficiency.