Abstract: The present invention relates to a method for fabrication of a three-dimensional lung organoid comprising human stem cell-derived alveolar macrophages. Specifically, a lung organoid is fabricated by co-culturing cells not expressing the definitive endoderm marker CRCX4 according to a fabrication method of the present disclosure. The lung organoid comprises type 1 and type 2 alveolar epithelial cells as well as alveolar macrophages and realizes infectious or inflammatory responses unlike conventional lung organoids that contain no immune cells and as such, can be advantageously used in studying mechanisms of related lung diseases, excavating biomarkers, developing therapeutic agents, and so on.

Abstract: The present invention provides a composition for adjusting biological tissue size and a method for adjusting the size of biological tissue using the said composition. The composition for adjusting the size of biological tissue according to the present invention can adjust the size of biological tissue according to the specifications of a microscope and the needs of a researcher, and can be used as a mounting solution to easily acquire an image of the biological tissue. Therefore, the composition can be usefully used to reveal the causes of and find treatment methods for various disorders.

Abstract: The present invention relates to a botulinum toxin pharmaceutical composition comprising tannic acid as an active ingredient. The botulinum toxin pharmaceutical composition comprising tannic acid provided in one aspect of the present invention improves the activity of the botulinum neurotoxin itself, allows the botulinum neurotoxin to stay in the injected place, and prevents the botulinum neurotoxin from spreading to the blood due to the properties of tannic acid. Therefore, the composition of the present invention has an effect of minimizing the side effects of the conventional Botox caused by the spread of the botulinum neurotoxin.

Abstract: The present invention relates to a composition for immunostaining cleared large tissues and a method for immunostaining cleared large biological tissues using the same. The composition for immunostaining cleared large tissues increases antibody permeability in cleared biological tissues, in particular, large biological tissues having a thickness of 3 mm or more, to allow antibodies to penetrate deep into thick tissues, thereby overcoming immunostaining problems associated with limited permeation of antibodies in existing methods, reduces the time required for immunostaining large tissues, thereby enabling simple and rapid three-dimensional bioimaging with high resolution for large biological tissues, and may be beneficially used, through structure images, for identifying the causes of various diseases, developing new treatment methods, and predicting the efficacy and toxicity of drugs.

Abstract: An apparatus for observing image of living tissue having a first cover slip and a second cover slip; and one or more chambers interposed between the first cover slip and the second cover slip and having a cavity therein; in order to observe a living tissue loaded in the cavity of the chamber above is provided. The apparatus for observing image of living tissue of the present invention can be easily prepared with a simple process and a low cost, and facilitates the observation of images of living tissues on both sides, so that an entire image of a huge living tissue at the level of several hundred micrometers can be obtained by using a tissue transparency technique, which is a distinguished advantage of the apparatus of the invention. In the apparatus of the invention, the outer wall part forming the chamber is strongly bound so that the leakage of the mounting solution and the bubble generation can be prevented, indicating the damage of the living tissue can also be prevented.

Abstract: The clarity method for biotissue using a biotissue clearing agent including CHAPS of the present invention enables fast tissue clarity without denaturation.

Abstract: The present invention relates to a water degradable film comprising hyaluronic acid or a salt thereof and polyphenol compounds. The film of the present invention can transcribe nanofilms in the form of CNT (carbon nanotube), graphene and magnetic particles to various places. The film of the present invention can be dissolved by an aqueous solution or body fluid, and can be effectively used in the medical field since it is non-toxic and biocompatible. The film of the present invention can also be effectively used as a transcript that does not degrade the quality and performance of the device because no residue remains in the electronic device and the existing photolithography process.

Abstract: Disclosed are a composition for clearing spheroids, a method for clearing spheroids using same, and a kit comprising same. The composition for clearing spheroids can clear the spheroids in a convenient and rapid manner and thus may be usefully used for imaging of spheroids and in identifying the causes of various diseases, treating the diseases, and predicting the therapeutic effects and toxicity of drugs. In addition, the composition may be used in combination with various medical devices, and in particular, can be prepared as a kit and usefully used as an in vitro medical diagnostic device.

Abstract: An apparatus for observing image of living tissue having a first cover slip and a second cover slip; and one or more chambers interposed between the first cover slip and the second cover slip and having a cavity therein; in order to observe a living tissue loaded in the cavity of the chamber above is provided. The apparatus for observing image of living tissue of the present invention can be easily prepared with a simple process and a low cost, and facilitates the observation of images of living tissues on both sides, so that an entire image of a huge living tissue at the level of several hundred micrometers can be obtained by using a tissue transparency technique, which is a distinguished advantage of the apparatus of the invention. In the apparatus of the invention, the outer wall part forming the chamber is strongly bound so that the leakage of the mounting solution and the bubble generation can be prevented, indicating the damage of the living tissue can also be prevented.

Abstract: The clarity method for biotissue using a biotissue clearing agent including CHAPS of the present invention enables fast tissue clarity without denaturation.

Abstract: An electronic device and a method for controlling the electronic device are provided. The method includes acquiring an image comprising a guide member positioned in an area at which a display device is to be installed; displaying the acquired image; analyzing a background area of the acquired image, the background area being positioned within the guide member in the acquired image; and acquiring information about a background image that is to be displayed in the background area of the acquired image.

Abstract: A display device is disclosed. The display device includes a display including a backlight comprising a plurality of light sources and a display panel and configured to display a background image including a preset object, a sensor disposed at an outer part of the display and configured to sense an external lighting environment and a processor configured to determine a direction of a lighting based on the sensed lighting environment, to display a shadow object for the preset object at a position corresponding to the determined lighting direction, and to adjust a brightness of a light source corresponding to a position of the shadow object from among the plurality of light sources based on the sensed lighting environment.

Abstract: The present invention provides a composition for adjusting biological tissue size and a method for adjusting the size of biological tissue using the said composition. The composition for adjusting the size of biological tissue according to the present invention can adjust the size of biological tissue according to the specifications of a microscope and the needs of a researcher, and can be used as a mounting solution to easily acquire an image of the biological tissue. Therefore, the composition can be usefully used to reveal the causes of and find treatment methods for various disorders.

Abstract: The present invention relates to a heart targeting agent comprising tannic acid, in which the agent aids a heart disease therapeutic drug to be delivered to the heart and bind to the cardiac myocardium by inducing tannylation of the drug so as to make heart targeting and accumulation of the drug possible. Unlike the conventional invasive method used for the traditional drugs to be able to target the heart, the agent of the present invention can help a drug to target the heart with high efficiency just via non-invasive intravenous administration.

Abstract: A display device is disclosed. The display device includes a display including a backlight comprising a plurality of light sources and a display panel and configured to display a background image including a preset object, a sensor disposed at an outer part of the display and configured to sense an external lighting environment and a processor configured to determine a direction of a lighting based on the sensed lighting environment, to display a shadow object for the preset object at a position corresponding to the determined lighting direction, and to adjust a brightness of a light source corresponding to a position of the shadow object from among the plurality of light sources based on the sensed lighting environment.

Abstract: A display apparatus is disclosed. The display apparatus includes a voice collecting unit which collects a user's voice; a first communication unit which transmits the user's voice to a first server, and receives text information corresponding to the user's voice from the first server; a second communication unit which transmits the received text information to a second server, and receives response information corresponding to the text information; an output unit which outputs a response message corresponding to the user's voice based on the response information; and a control unit which controls the output unit to output a response message differentiated from a response message corresponding to a previously collected user's voice, when a user's voice having a same utterance intention is re-collected.

Abstract: A display device is disclosed. The display device includes a display including a backlight comprising a plurality of light sources and a display panel and configured to display a background image including a preset object, a sensor disposed at an outer part of the display and configured to sense an external lighting environment and a processor configured to determine a direction of a lighting based on the sensed lighting environment, to display a shadow object for the preset object at a position corresponding to the determined lighting direction, and to adjust a brightness of a light source corresponding to a position of the shadow object from among the plurality of light sources based on the sensed lighting environment.

Abstract: The present invention relates to a composition for clearing biotissue and a clarity method for biotissue using the same. The composition for clearing biotissue and the clarity method for biotissue using the same of the present invention do not need a high price electrophoresis apparatus and expensive solutions, and can not only be applied to various biotissues including brain, liver, lung, kidney, intestine, heart, muscle, and blood vessel, without damaging any of them but also prevent bubble formation, color change, and dark sediment; improve the clarity of biotissues; and help antibody-staining of the cleared tissues. Therefore, it is useful to identify the reason of various diseases through structural imaging of biotissue and to establish a treatment method.

Abstract: A display apparatus, an electronic device, an interactive system, and controlling methods thereof are provided. The display apparatus includes: a storage unit which stores peripheral device control information in which a remote control signal for controlling a peripheral device of the display apparatus matches with a control signal corresponding to a user voice; a voice collector which the user voice; a communicator which transmits the collected user voice to the display apparatus and receives the control signal corresponding to the user voice from the display apparatus; an infrared ray (IR) transmitter which transmits the remote control signal for controlling the peripheral device; and a controller which, if the control signal is received from the display apparatus, controls the IR transmitter to transmit a remote control signal corresponding to the received control signal among remote control signals stored in the storage unit, to the peripheral device.

Abstract: A display apparatus, an electronic device, an interactive system, and controlling methods thereof are provided. The display apparatus includes: a storage unit which stores peripheral device control information in which a remote control signal for controlling a peripheral device of the display apparatus matches with a control signal corresponding to a user voice; a voice collector which the user voice; a communicator which transmits the collected user voice to the display apparatus and receives the control signal corresponding to the user voice from the display apparatus; an infrared ray (IR) transmitter which transmits the remote control signal for controlling the peripheral device; and a controller which, if the control signal is received from the display apparatus, controls the IR transmitter to transmit a remote control signal corresponding to the received control signal among remote control signals stored in the storage unit, to the peripheral device.