Abstract: A data path root cause analysis application (“application”) identifies a node in a computing fabric as a root cause of failure in a data path. Based on detecting a failure in the data path, the application performs a reverse traversal starting at the last node in the data path. At each node in the reverse traversal, the application sends modified packets through the data path with custom headers comprising flags to exit the data path at the current node. When modified packets successfully exit the data path at a current node in the reverse traversal, the application identifies a previous node as the root cause of failure. The node identified as a root cause of failure is then remediated to allow further communication of packets through the data path.

Abstract: An expansion device for a prosthetic implant comprises a first balloon and a second balloon arranged radially outward of the first balloon. The expansion device can be configured to expand from an uninflated state to a first inflated state for stabilizing the prosthetic implant, and from the first inflated state to a second inflated state for radially expanding the prosthetic implant. In the first inflated state, the first balloon and the second balloon can each have radially enlarged distal end portions and radially enlarged proximal end portions relative to their respective center portions. In the second inflation state, a center portion of the second balloon radially expands radially beyond the expandable distal and proximal end portions of the first balloon while a center portion of the first balloon remains radially smaller than the expandable distal and proximal end portions of the first balloon.

Abstract: A method of implanting a prosthetic heart valve includes advancing a distal end portion of a catheter shaft through a patient's vasculature. The distal end portion of the catheter shaft includes an expansion device. A prosthetic heart valve is mounted on the expansion device with the expansion device and the prosthetic heart valve in a compressed configuration. The method further includes positioning the distal end portion of the catheter shaft and the prosthetic heart valve to an implantation location and expanding the prosthetic heart valve and the expansion device to an expanded configuration. The expansion device includes a main body and a plurality of projections extending radially from the main body. The projections are spaced apart relative to each such that there are grooves extending between adjacent projections providing perfusion passageways between the expansion device and the prosthetic heart valve when the expansion device is in the expanded configuration.

Abstract: Disclosed is a computer-implemented method of training a likelihood-based computational model for determining the position of an image representation of an annotated anatomical structure in a two-dimensional x-ray image, wherein the method encompasses inputting medical DRRs together with annotation to a machine learning algorithm to train the algorithm, i.e. to generate adapted learnable parameters of the machine learning model. The annotations may be derived from metadata associated with the DRRs or may be included in atlas data which is matched with the DRRs to establish a relation between the annotations included in the atlas data and the DRRs. The thus generated machine learning algorithm may then be used to analyse clinical or synthesized DRRs so as to appropriately add annotations to those DRRs and/or identify the position of an anatomical structure in those DRRs.

Abstract: Disclosed is a computer-implemented method of training a likelihood-based computational model for determining the position of an image representation of an annotated anatomical structure in a two-dimensional x-ray image, wherein the method encompasses inputting medical DRRs together with annotation to a machine learning algorithm to train the algorithm, i.e. to generate adapted leamable parameters of the machine learning model. The annotations may be derived from metadata associated with the DRRs or may be included in atlas data which is matched with the DRRs to establish a relation between the annotations included in the atlas data and the DRRs. The thus generated machine learning algorithm may then be used to analyse clinical or synthesized DRRs so as to appropriately add annotations to those DRRs and/or identify the position of an anatomical structure in those DRRs.

Abstract: The present invention relates to methods for reducing low molecular weight species of recombinantly-produced proteins. In particular, methods of reducing the formation of low molecular weight species produced by a host cell during the cell culture process through pH control of the production cell culture are disclosed. Also disclosed are methods for reducing or eliminating the generation of alternative splice variants by a host cell during production of a recombinant protein.

Abstract: A method of implanting a prosthetic heart valve includes advancing a distal end portion of a catheter shaft through a patient's vasculature. The distal end portion of the catheter shaft includes an expansion device. A prosthetic heart valve is mounted on the expansion device with the expansion device and the prosthetic heart valve in a compressed configuration. The method further includes positioning the distal end portion of the catheter shaft and the prosthetic heart valve to an implantation location and expanding the prosthetic heart valve and the expansion device to an expanded configuration. The expansion device includes a main body and a plurality of projections extending radially from the main body. The projections are spaced apart relative to each such that there are grooves extending between adjacent projections providing perfusion passageways between the expansion device and the prosthetic heart valve when the expansion device is in the expanded configuration.

Abstract: A method of implanting a prosthetic heart valve includes advancing a distal end portion of a catheter shaft through a patient's vasculature. The distal end portion of the catheter shaft includes an expansion device. A prosthetic heart valve is mounted on the expansion device with the expansion device and the prosthetic heart valve in a compressed configuration. The method further includes positioning the distal end portion of the catheter shaft and the prosthetic heart valve to an implantation location, and expanding the prosthetic heart valve and the expansion device from the compressed configuration to an expanded configuration. The expansion device includes an inner expandable member and a plurality of outer expandable members. The outer expandable members are distributed such that there are gaps providing perfusion passageways between the expansion device and the prosthetic heart valve when the expansion device is in the expanded configuration.

Abstract: Disclosed is a computer-implemented method of training a likelihood-based computational model for determining the position of an image representation of an annotated anatomical structure in a two-dimensional x-ray image, wherein the method encompasses inputting medical DRRs together with annotation to a machine learning algorithm to train the algorithm, i.e. to generate adapted leamable parameters of the machine learning model. The annotations may be derived from metadata associated with the DRRs or may be included in atlas data which is matched with the DRRs to establish a relation between the annotations included in the atlas data and the DRRs. The thus generated machine learning algorithm may then be used to analyse clinical or synthesized DRRs so as to appropriately add annotations to those DRRs and/or identify the position of an anatomical structure in those DRRs.

Abstract: A method of implanting a prosthetic heart valve includes advancing a distal end portion of a catheter shaft through a patient's vasculature. The distal end portion of the catheter shaft includes an expansion device. A prosthetic heart valve is mounted on the expansion device with the expansion device and the prosthetic heart valve in a compressed configuration. The method further includes positioning the distal end portion of the catheter shaft and the prosthetic heart valve to an implantation location, and expanding the prosthetic heart valve and the expansion device from the compressed configuration to an expanded configuration. The expansion device includes an inner expandable member and a plurality of outer expandable members. The outer expandable members are distributed such that there are gaps providing perfusion passageways between the expansion device and the prosthetic heart valve when the expansion device is in the expanded configuration.

Abstract: A delivery system for stabilizing a catheter shaft across an aortic arch can include one or more stabilizing members configured to fix or stabilize the position of the catheter relative to the aortic arch of a patient.

Abstract: A safety switching device for an automated installation includes a power supply unit for providing at least one operating voltage for the device. The power supply unit receives an input voltage via a feed line and provides a defined output voltage on an output side. Electrical supply to the power supply unit is interrupted if an instantaneous output voltage is higher than the defined output voltage. The interruption is achieved by first and second switching elements arranged in series and connecting the input of the power supply unit to ground, and by an interrupter element in the feed line. The interrupter element triggers when both the first and the second switching elements are in a closed, low-impedance state.

Abstract: A safety switching apparatus for switching on or off a technical installation has a failsafe control/evaluation unit with an input for receiving an input signal. The failsafe control/evaluation unit is designed to process the input signal in order to produce an output signal for switching on or off the technical installation at a defined output signal time. The failsafe control/evaluation unit has a first output for transmitting the output signal to an electromechanical switch. The electromechanical switch has an operating contact for switching a load circuit of the technical installation and has a positively guided auxiliary contact in an auxiliary contact current path. The auxiliary contact can be used to carry a current for checking the switching position of the operating contact. A switching element is arranged in the auxiliary contact current path.

Abstract: A safety switching device for the failsafe shutdown of an electrical load has at least one input circuit for receiving an input signal from a signaling device which signals a safety-related state, an evaluation and control unit for evaluating the input signal, and at least one output circuit for outputting an output signal. The safety switching device further has at least one switching element for interrupting a current supply path to the load in dependence on the input signal. The input circuit and the output circuit are joined at a device connector so that the device connector can selectively be used as an input for receiving the input signal or as an output for outputting the output signal. The input circuit has a test switch which is coupled to the evaluation and control unit which is designed for selectively suppressing the input signal using the test switch.

Abstract: A delivery system for stabilizing a catheter shaft across an aortic arch can include one or more stabilizing members configured to fix or stabilize the position of the catheter relative to the aortic arch of a patient.

Abstract: A safety switching device for an automated installation includes a power supply unit for providing at least one operating voltage for the device. The power supply unit receives an input voltage via a feed line and provides a defined output voltage on an output side. Electrical supply to the power supply unit is interrupted if an instantaneous output voltage is higher than the defined output voltage. The interruption is achieved by first and second switching elements arranged in series and connecting the input of the power supply unit to ground, and by an interrupter element in the feed line. The interrupter element triggers when both the first and the second switching elements are in a closed, low-impedance state.

Abstract: A safety switching apparatus for switching on or off a technical installation has a failsafe control/evaluation unit with an input for receiving an input signal. The failsafe control/evaluation unit is designed to process the input signal in order to produce an output signal for switching on or off the technical installation at a defined output signal time. The failsafe control/evaluation unit has a first output for transmitting the output signal to an electromechanical switch. The electromechanical switch has an operating contact for switching a load circuit of the technical installation and has a positively guided auxiliary contact in an auxiliary contact current path. The auxiliary contact can be used to carry a current for checking the switching position of the operating contact. A switching element is arranged in the auxiliary contact current path.

Abstract: A safety switching device for the failsafe shutdown of an electrical load has at least one input circuit for receiving an input signal from a signaling device which signals a safety-related state, an evaluation and control unit for evaluating the input signal, and at least one output circuit for outputting an output signal. The safety switching device further has at least one switching element for interrupting a current supply path to the load in dependence on the input signal. The input circuit and the output circuit are joined at a device connector so that the device connector can selectively be used as an input for receiving the input signal or as an output for outputting the output signal. The input circuit has a test switch which is coupled to the evaluation and control unit which is designed for selectively suppressing the input signal using the test switch.

Abstract: A delivery system for stabilizing a catheter shaft across an aortic arch can include one or more stabilizing members configured to fix or stabilize the position of the catheter relative to the aortic arch of a patient.

Abstract: A non-volatile memory chip package is prepared for surface mounting to a substrate in a solder reflow process by programming erased blocks to higher threshold voltage levels, to improve data retention for blocks which are preloaded with content, such as by an electronic device manufacturer. Following the surface mounting, the previously-erased blocks are returned to the erased state. The threshold voltage of storage elements of the preloaded blocks can change during the surface mounting process due to a global charge effect phenomenon. The effect is most prominent for higher state storage elements which are surrounded by erased blocks, in a chip for which the wafer backside was thinned and polished. The erased blocks can be programmed using a single program pulse without performing a verify operation, as a wide threshold voltage distribution is acceptable.