Abstract: The present disclosure provides methods and composition for treating multi-drug resistant cancers, in particular, breast cancers, via administration to a subject the composition including a peptide having a sequence complementary to a highly conserved motif present in substantially all integrins responsible for an integrin-mediated attachment-independent chemoresistance to one or more chemotherapeutic agents. The binding of the sequence of the peptide to the highly conserved motif will enhance accumulation of the chemotherapeutic agents in the tumor-initiating cells and in turn restores the function of the chemotherapeutic agents in the tumor-initiating cells.

Abstract: A system for filtering a gas-solids mixture, comprises: a housing; a separating body dividing the housing in a raw gas chamber and a clean gas chamber, the raw gas chamber being accessible via an inlet for the gas-solids mixture and the clean gas chamber comprising an outlet for discharging a cleaned gas; a number of filter elements suspended from the separating body; lower ends of the filter elements being connected to a support grid, the support grid comprising a number of arms; one or more cleaning elements provided on the arms of the support grid for cleaning thereof.

Abstract: A triazole bridged flavonoid dimer compound library was efficiently constructed via the cycloaddition reaction of a series of flavonoid-containing azides (Az 1-15) and alkynes (Ac 1-17). These triazole bridged flavonoid dimers and their precursor alkyne- and azide-containing flavonoids were screened for their ability to modulate multidrug resistance (MDR) in P-gp-overexpressed cell line (LCC6MDR), MRP1-overexpressed cell line (2008/MRP1) and BCRP-overexpressed cell line (HEK293/R2 and MCF7-MX100). Generally, they displayed very promising MDR reversal activity against P-gp-, MRP1- and BCRP-mediated drug resistance. Moreover, they showed different levels of selectivity for various transporters. Overall, they can be divided into mono-selective, dual-selective and multi-selective modulators for the P-gp, MRP1 and BCRP transporters.

Abstract: A system for filtering a gas-solids mixture, comprises: a housing a separating body dividing the housing in a raw gas chamber and a clean gas chamber, the raw gas chamber being accessible via an inlet for the gas-solids mixture and the clean gas chamber comprising an outlet for discharging a cleaned gas; a number of filter elements suspended from the separating body; lower ends of the filter elements being connected to a support grid the support grid comprising a number of arms; one or more cleaning elements provided on the arms of the support grid for cleaning thereof.

Abstract: The present invention relates to novel series of amine-containing flavonoids and compositions containing the compounds, as well as the synthesis and the use of the same. The invention also relates to methods of treatment and prevention of diseases, in particular, parasitic infections including Leishmaniasis, comprising administration of the compounds.

Abstract: A pressing device includes a pressing device switch configured to cover a garage door switch. The garage door switch operates a garage door opener connected to the garage door switch. An actuator is coupled to the pressing device switch. An indicator outputs a combination of an audio and video signal. The pressing device receives a garage door control command and generates a warning signal to the indicator. The indicator outputs the combination of the audio and video signal in response to receiving the warning signal, and generates a trigger signal to the actuator. The actuator physically presses on the garage door switch in response to receiving the trigger signal.

Abstract: The present invention relates to novel series of amine-containing flavonoids and compositions containing the compounds, as well as the synthesis and the use of the same. The invention also relates to methods of treatment and prevention of diseases, in particular, parasitic infections including Leishmaniasis, comprising administration of the compounds.

Abstract: A triazole bridged flavonoid dimer compound library was efficiently constructed via the cycloaddition reaction of a series of flavonoid-containing azides (Az 1-15) and alkynes (Ac 1-17). These triazole bridged flavonoid dimers and their precursor alkyne- and azide-containing flavonoids were screened for their ability to modulate multidrug resistance (MDR) in P-gp-overexpressed cell line (LCC6MDR), MRP1-overexpressed cell line (2008/MRP1) and BCRP-overexpressed cell line (HEK293/R2 and MCF7-MX100). Generally, they displayed very promising MDR reversal activity against P-gp-, MRP1- and BCRP-mediated drug resistance. Moreover, they showed different levels of selectivity for various transporters. Overall, they can be divided into mono-selective, dual-selective and multi-selective modulators for the P-gp, MRP1 and BCRP transporters.

Abstract: A triazole bridged flavonoid dimer compound library was efficiently constructed via the cycloaddition reaction of a series of flavonoid-containing azides (Az 1-15) and alkynes (Ac 1-17). These triazole bridged flavonoid dimers and their precursor alkyne- and azide-containing flavonoids were screened for their ability to modulate multidrug resistance (MDR) in P-gp-overexpressed cell line (LCC6MDR), MRP1-overexpressed cell line (2008/MRP1) and BCRP-overexpressed cell line (HEK293/R2 and MCF7-MX100). Generally, they displayed very promising MDR reversal activity against P-gp-, MRP1- and BCRP-mediated drug resistance. Moreover, they showed different levels of selectivity for various transporters. Overall, they can be divided into mono-selective, dual-selective and multi-selective modulators for the P-gp, MRP1 and BCRP transporters.

Abstract: The present invention relates to novel series of amine-containing flavonoids and compositions containing the compounds, as well as the synthesis and the use of the same. The invention also relates to methods of treatment and prevention of diseases, in particular, parasitic infections including Leishmaniasis, comprising administration of the compounds.

Abstract: A nailer includes a housing, a handle connecting the housing, a combustion chamber and a cylinder inside the housing, a piston whose rear end is inside the cylinder, a cage covering the exterior front end of the cylinder with the front end abutting on that of the cylinder, and a pin guide component that separately connects the nailer and further includes a nose piece, a guide sleeve whose lower end links the pin guide, an adjusting threaded rod whose front end connects the upper end of the guide sleeve and rear end links the upper end of the rear sleeve, a knob, a rear sleeve inserted into the adjusting threaded rod and fixed between the upper end of the guide sleeve and that of the rear sleeve, and a piston guide. The nailer boasts capability of pin guide replacement, quick troubleshooting and regulation of the nail driving depth.

Abstract: The present invention relates to novel series of amine-containing flavonoids and compositions containing the compounds, as well as the synthesis and the use of the same. The invention also relates to methods of treatment and prevention of diseases, in particular, parasitic infections including Leishmaniasis, comprising administration of the compounds.

Abstract: A refill system is disclosed. The refill system having a container structure, having a wall with a refill opening, and a sealing structure, wherein the sealing structure is held by the container structure movably along the wall with the refill opening and is movable between a first position, which closes the refill opening, and a second position, which opens the refill opening.