Abstract: The present disclosure provides methods for treating one or more of cognitive deficits or cognitive impairments associated with or caused by mild brain injuries, chemotherapy treatment, chemotherapy medication, post-chemotherapy cognitive impairment (PCCI), chemo brain, and other disorders arising from cognitive dysfunction in a subject by administering to the subject an effective amount of a composition comprising ghrelin or a ghrelin variant.

Abstract: A virtual computing environment service may receive a request from a customer to provision a virtual computing environment and join the virtual computing environment to a managed directory. The virtual computing environment service may provision the virtual computing environment and uses a set of administrator credentials from the customer and a set of credentials corresponding to the environment to access the managed directory and request joining of the environment to the managed directory. In response, the managed directory may create a computer account corresponding to the environment and which enables the environment to be used to access the managed directory. The virtual computing environment service may then enable the customer to specify one or more users that may utilize the virtual computing environment to access the managed directory.

Abstract: The present invention relates to heterocyclic compounds of the general formula (I) their pharmaceutically acceptable salts, pharmaceutically acceptable solvates, enantiomers, diastereomers, and polymorphs. The invention also relates to processes for the preparation of the compounds of invention, pharmaceutical compositions containing the compounds and their use as selective Bruton's Tyrosine Kinase (BTK) inhibitors.

Abstract: The present disclosure provides methods for treating mild brain injury and other neurological disorders in a subject in need thereof, comprising administering to the subject an effective amount of a compound comprising a ghrelin or ghrelin variant. This invention provides for methods for treating a mild brain injury or concussion in a patient wherein said method comprises administering to the subject in need thereof suffering from said mild brain injury or concussion an effective amount of a ghrelin variant or a composition comprising a ghrelin variant so as to treat said mild brain injury or concussion.

Abstract: The present disclosure provides methods for treating traumatic brain injury and other neurological disorders in a subject in need thereof, comprising administering to the subject an effective amount of a composition comprising ghrelin or a ghrelin variant. This invention provides for methods for treating a severe or moderate traumatic brain injury in a patient wherein said method comprises administering to the subject suffering from said severe or moderate traumatic brain injury a therapeutic effective amount of ghrelin or a ghrelin variant or a composition comprising ghrelin or a ghrelin variant so as to treat said severe or moderate traumatic brain injury.

Abstract: A customer of a computing resource service provider may utilize a set of credentials to request creation of an identity pool within a managed directory service. Accordingly, the managed directory service may create the identity pool. Instead of having the customer create a separate account within this identity pool, the managed directory service may create a shadow administrator account within the identity pool, which may be used to manage other users and resources in the identity pool within the managed directory service. The managed directory service further exposes an application programming interface command that may be used to obtain a set of credentials for accessing the shadow administrator account. The customer may use this command to receive the set of credentials and access the shadow administrator account. Accordingly, the customer can manage users and resources in the identity pool within the managed directory service.

Abstract: A customer of a computing resource service provider may utilize a set of credentials to request creation of an identity pool within a managed directory service. Accordingly, the managed directory service may create the identity pool. Instead of having the customer create a separate account within this identity pool, the managed directory service may create a shadow administrator account within the identity pool, which may be used to manage other users and resources in the identity pool within the managed directory service. The managed directory service further exposes an application programming interface command that may be used to obtain a set of credentials for accessing the shadow administrator account. The customer may use this command to receive the set of credentials and access the shadow administrator account. Accordingly, the customer can manage users and resources in the identity pool within the managed directory service.

Abstract: A virtual computing environment service may receive a request from a customer to provision a virtual computing environment and join the virtual computing environment to a managed directory. The virtual computing environment service may provision the virtual computing environment and uses a set of administrator credentials from the customer and a set of credentials corresponding to the environment to access the managed directory and request joining of the environment to the managed directory. In response, the managed directory may create a computer account corresponding to the environment and which enables the environment to be used to access the managed directory. The virtual computing environment service may then enable the customer to specify one or more users that may utilize the virtual computing environment to access the managed directory.

Abstract: The present disclosure provides methods for treating a neurodegenerative condition or situation in a subject in need thereof, comprising administering to the subject an effective amount of a compound comprising ghrelin or a ghrelin variant.

Abstract: A system that includes a resource monitor and a resource consumer. The resource monitor keeps a state of resources that are available for consumption. For instance, the resources may be processing nodes in a distributed environment. The state of the resources kept by the resource monitor includes an estimated health score along a health score range for each of the resources being monitored. The resource monitor reports the resulting estimated health scores. The resource consumer uses at least some of the reported estimated health scores in order to determine which of the resources to consume. A higher estimated health score for a resource may result in the resource being more readily consumed. A lower estimated health score for a resource may result in consumption of the resource being more likely avoided.

Abstract: A virtual computing environment service may receive a request from a customer to provision a virtual computing environment and join the virtual computing environment to a managed directory. The virtual computing environment service may provision the virtual computing environment and uses a set of administrator credentials from the customer and a set of credentials corresponding to the environment to access the managed directory and request joining of the environment to the managed directory. In response, the managed directory may create a computer account corresponding to the environment and which enables the environment to be used to access the managed directory. The virtual computing environment service may then enable the customer to specify one or more users that may utilize the virtual computing environment to access the managed directory.

Abstract: The present invention relates to heterocyclic compounds of the general formula (I) their pharmaceutically acceptable salts, pharmaceutically acceptable solvates, enantiomers, diastereomers, and polymorphs. The invention also relates to processes for the preparation of the compounds of invention, pharmaceutical compositions containing the compounds and their use as selective Bruton's Tyrosine Kinase (BTK) inhibitors.

Abstract: A user may utilize a set of credentials to access, through a managed directory service, one or more services provided by a computing resource service provider. The managed directory service may be configured to identify one or more policies applicable to the user. These policies may define the level of access to the one or more services provided by the computing resource service provider. Based at least in part on these policies, the managed directory service may transmit a request to an identity management system to obtain a set of temporary credentials that may be used to enable the user to access the one or more services. Accordingly, the managed directory service may be configured to enable the user, based at least in part on the policies and the set of temporary credentials, to access an interface, which can be used to access the one or more services.

Abstract: Features are disclosed for facilitating management of network directories of multiple organizations by a centralized directory management system. Various applications can access the directories of the organizations via the directory management system according to the permissions that the applications have been granted by the respective organizations. Organizations may maintain directories on-premises or off-premises, and the applications can access the directories via the directory management system regardless of the physical location of the directories. Additionally, the applications may be hosted by a computing service provider that also hosts or otherwise manages the directory management service, or the applications can be hosted by third-party servers separate from the directory management system and the organizations.

Abstract: A customer utilizes an interface provided by a virtual computer system service to provision a virtual machine instance and join this instance to a directory. The interface may have previously obtained the domain name and the Internet Protocol addresses for one or more directories available to the customer for joining the virtual machine instance. The virtual computer system service may communicate with a managed directory service to obtain a set of temporary credentials that may be used to transmit a request to the directory to allow joining of the virtual machine instance. Upon provisioning of the instance, an agent operating within the instance may be configured to obtain the domain name and Internet Protocol addresses for the directory to establish a connection with the directory. The agent may also be configured to obtain the set of temporary credentials to transmit a request to the directory for joining of the instance.

Abstract: A user may utilize a set of credentials to access, through a managed directory service, one or more services provided by a computing resource service provider. The managed directory service may be configured to identify one or more policies applicable to the user. These policies may define the level of access to the one or more services provided by the computing resource service provider. Based at least in part on these policies, the managed directory service may transmit a request to an identity management system to obtain a set of temporary credentials that may be used to enable the user to access the one or more services. Accordingly, the managed directory service may be configured to enable the user, based at least in part on the policies and the set of temporary credentials, to access an interface, which can be used to access the one or more services.

Abstract: Techniques for connecting computer system entities to remotely extended local computer system resources are described herein. A computer system entity that requests access to a local computer system resource has that request fulfilled by a managed directory service which receives the request and connects the computer system entity to the local computer system resource. While connected, the managed directory service extends the local computer system resource to a corresponding extended remote computer system resource, receives commands to perform operations on the local or extended remote computer system resources and, if the computer system entity is authorized to perform the operations on the appropriate computer system resource, the managed directory service performs the operations on the appropriate computer system resource.

Abstract: A customer of a computing resource service provider may utilize a set of credentials to request creation of an identity pool within a managed directory service. Accordingly, the managed directory service may create the identity pool. Instead of having the customer create a separate account within this identity pool, the managed directory service may create a shadow administrator account within the identity pool, which may be used to manage other users and resources in the identity pool within the managed directory service. The managed directory service further exposes an application programming interface command that may be used to obtain a set of credentials for accessing the shadow administrator account. The customer may use this command to receive the set of credentials and access the shadow administrator account. Accordingly, the customer can manage users and resources in the identity pool within the managed directory service.

Abstract: Techniques for connection computer system entities to local computer system resources are described herein. A computer system entity that requests access to a local computer system resource has that request fulfilled by a managed directory service which receives the request and connects the computer system entity to the local computer system resource. While connected, the managed directory service receives commands to perform operations on the local computer system resource and, if the computer system entity is authorized to perform the operations on the local computer system resource, the managed directory service performs the operation on the local computer system resource.

Abstract: Techniques for connecting computer system entities to remote computer system resources are described herein. A computer system entity that requests access to a remote computer system resource has that request fulfilled by a managed directory service which receives the request and connects the computer system entity to the remote computer system resource. While connected, the managed directory service receives commands to perform operations on the remote computer system resource and, if the computer system entity is authorized to perform the operations on the remote computer system resource, the managed directory service performs the operation on the remote computer system resource.