Patents by Inventor Kiyotoshi Sekiguchi

Kiyotoshi Sekiguchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-EDA monoclonal antibody and a method for diagnosis of disease associated with the EDA region of fibronectin
    Patent number: 5571679
    Abstract: The invention provides an anti-EDA monoclonal antibody which recognizes an amino acid sequence portion in the EDA region of fibronectin (FN). The antibody of the invention has specific reactivity against EDA, in particular EDA-FN. By utilizing it, a simple and easy, high-sensitivity and high-precision immunoassay method for EDA-FN as well as a screening or diagnostic technique for EDA-FN-associated inflammatory and other diseases can be established.
    Type: Grant
    Filed: September 22, 1993
    Date of Patent: November 5, 1996
    Assignee: Otsuka Pharmaceutical Factory, Inc.
    Inventors: Kiyotoshi Sekiguchi, Kaneji Asakawa, Eiji Sakashita, Kazuo Hino, Sadahito Shin, Tetsuya Tachikawa, Hisanobu Hirano
  • Artificial antibody
    Patent number: 5475100
    Abstract: This invention provides an antibody having antigen binding activity and which has a heavy chain constant region into which has been introduced an RGDS amino acid sequence giving the antibody affinity for cells, including macrophages. The antibody exhibits artificial cell adhesive activity which is the newly expressed activity that results from insertion of the RGDS amino acid sequence. This antibody having artificial cell adhesive activity can accelerate the phagocytosis of macrophages, and can activate other effector cells. Therefore, this antibody contributes to the self-defense mechanism.
    Type: Grant
    Filed: August 19, 1993
    Date of Patent: December 12, 1995
    Assignees: Fujita Health University, Takara Shuzo Co., Ltd.
    Inventors: Kimikazu Hashino, Fusao Kimizuka, Ikunoshin Kato, Yoshikazu Kurosawa, Koiti Titani, Kiyotoshi Sekiguchi