Abstract: Provided is a fiber containing a composition obtained by mixing a compound having at least a ring structure containing one carbodiimide group, the first nitrogen and second nitrogen thereof being linked together through a linking group, with a polymer compound having an acidic group. Also provided is a fiber structure made thereof. A fiber and a fiber structure, which have improved hydrolysis resistance and from which no free isocyanate compounds are produced, can be provided.

Abstract: The present disclosure relates to a microneedle array having a pin frog shape which is coated with a drug composition comprising a drug and an additive and having Vickers hardness of about 3 or more is applied to a microneedle array. The microneedle array coated with the drug composition according to the present invention can be used in the field in which the drug is required to be administered with high quantitative performance even when the drug is contained at low content.

Abstract: The present invention relates to a microneedle and a microneedle array. More specifically, it relates to a microneedle and a microneedle array capable of injecting a drug into the surface layer or horny layer of the skin easily, safely and efficiently.

Abstract: A microneedle and a microneedle array, which have both aspects of safety and easiness to use and can administer a predetermined dose of a medical agent without causing a pain by smoothly running into the skin surface layer of a patient, includes a frustum and a forward end portion thereon, the forward end portion having a forward end apex angle in the range of 15 to 60° and a forward end diameter in the range of 1 to 20 ?m and satisfying the expression H/D?5, where H is a total height of the microneedle, and D is a diameter of a bottom surface of the frustum).

Abstract: The present invention provides a microneedle array which makes it possible to quantitatively and accurately inject a drug into the skin. The present inventors have found that when a microneedle array is coated with a drug composition comprising a drug and an additive which has a Vickers hardness of about 3 or more, the removal of the drug can be avoided, and the drug can be surely inserted into the skin along with the microneedle array. As a result, the microneedle array coated with the drug composition of the present invention can be used in the fields in which the drug is required to be administrated with high quantitative performance even when the drug is contained in small amounts, e.g., the administration of a vaccine, and the scope of application of the microneedle array can be extended.

Abstract: The present invention relates to a microneedle and a microneedle array. More specifically, it relates to a microneedle and a microneedle array capable of injecting a drug into the surface layer or horny layer of the skin easily, safely and efficiently.

Abstract: There are provided a resin composition including a polylactic acid which (i) includes a poly-L-lactic acid (component B-1) and a poly-D-lactic acid (component B-4), (ii) has a weight ratio of the component B-1 to the component B-4 (component B-1/component B-4) of 10/90 to 90/10, and (iii) shows a proportion of melt peaks at 195° C. or higher to all melt peaks in a temperature rising process in measurement by a differential scanning calorimeter (DSC) of at least 20%; a molded article of the resin composition; and methods for producing the resin composition and the molded article.

Abstract: A method for producing a composition including polylactic acid and having excellent heat stability, especially moist heat stability, and a molded article thereof. The composition includes 100 parts by weight of a resin component (component A) which is composed of 5 to 100 wt % of polylactic acid (component A-?) and 95 to 0 wt % of a thermoplastic resin (component A-?), 0.001 to 5 parts by weight of a phosphono-fatty acid ester (component B), 0.01 to 5 parts by weight of a phosphate metal salt (component C), 0.001 to 2 parts by weight of at least one antioxidant (component D) selected from the group consisting of a phosphite-based compound, a phosphonite-based compound, a hindered phenol-based compound and a thioether-based compound, and 0.001 to 10 parts by weight of an end-sealing agent (component E).

Abstract: Provided are a microneedle and a microneedle array which have both aspects of safety and easiness to use and can administer a predetermined dose of a medical agent without causing a pain by smoothly running into the skin surface layer of a patient, the microneedle comprising a frustum and a forward end portion thereon, having a forward end apex angle in the range of 15 to 60° and a forward end diameter in the range of 1 to 20 ?m and satisfying the following expression (1), H/D?5??(1) (H: Height of the whole, D: Diameter of bottom surface of the frustum).

Abstract: A composition which comprises polylactide and has excellent heat stability, color and hydrolytic resistance. The composition comprises (i) polylactide, (ii) a metal catalyst and (iii) a hypophosphorous acid-based deactivator or a metaphosphoric acid-based deactivator.

Abstract: There are provided a resin composition including a polylactic acid which (i) includes a poly-L-lactic acid (component B-1) and a poly-D-lactic acid (component B-4), (ii) has a weight ratio of the component B-1 to the component B-4 (component B-1/component B-4) of 10/90 to 90/10, and (iii) shows a proportion of melt peaks at 195° C. or higher to all melt peaks in a temperature rising process in measurement by a differential scanning calorimeter (DSC) of at least 20%; a molded article of the resin composition; and methods for producing the resin composition and the molded article.

Abstract: It is an object of the present invention to provide polylactic acid containing a stereocomplex crystal and having excellent moldability, a high molecular weight, high crystallinity and a high melting point and a process for manufacturing the same. It is another object of the present invention to provide a composition comprising the polylactic acid and a molded product of the polylactic acid. The present invention is characterized from polylactic acid having a weight average molecular weight of 80,000 to 500,000 and a melting peak at 195° C. or higher which accounts for 80% or more of the total of melting peaks in the temperature elevation step when measured by a differential scanning calorimeter (DSC) and a process for manufacturing the same.

Abstract: It is an object of the present invention to provide a composition which contains polylactic acid and has excellent heat stability, mechanical strength and color. The composition contains 0.001 to 0.1 part by weight of a metal catalyst and 0.001 to 0.5 part by weight of a phosphono-fatty acid ester based on 100 parts by weight of polylactic acid.

Abstract: Provided is a fiber containing a composition obtained by mixing a compound having at least a ring structure containing one carbodiimide group, the first nitrogen and second nitrogen thereof being linked together through a linking group, with a polymer compound having an acidic group. Also provided is a fiber structure made thereof. A fiber and a fiber structure, which have improved hydrolysis resistance and from which no free isocyanate compounds are produced, can be provided.

Abstract: It is an object of the present invention to produce a polylactic acid having a high molecular weight such as a weight average molecular weight (Mw) of more than 100,000 from which only a stereocomplex crystal is grown even by repeating melting and crystallization. The present invention is a process of producing a polylactic acid, including the steps of: (i) obtaining a solid by kneading together poly(L-lactic acid) and poly(D-lactic acid) at a temperature of 160 to 225° C. and crystallizing the kneaded product; and (ii) melt kneading the obtained solid.

Abstract: A composition comprising polylactic acid and having excellent heat stability, especially moist heat stability, and a molded article thereof. The composition comprises 100 parts by weight of a resin component (component A) which is composed of 5 to 100 wt % of polylactic acid (component A-?) and 95 to 0 wt % of a thermoplastic resin (component A-?), 0.001 to 5 parts by weight of a phosphono-fatty acid ester (component B), 0.01 to 5 parts by weight of a phosphate metal salt (component C), 0.001 to 2 parts by weight of at least one antioxidant (component D) selected from the group consisting of a phosphite-based compound, a phosphonite-based compound, a hindered phenol-based compound and a thioether-based compound, and 0.001 to 10 parts by weight of an end-sealing agent (component E).

Abstract: To provide a resin composition having high heat resistance with a high melting point and excellent melt stability and hydrolysis resistance, a molded article of the resin composition and a method of manufacturing the resin composition; the resin composition comprises an aromatic polyester (component A) having a butylene terephthalate skeleton as the main constituent unit and polylactic acid (component B) having a melting point of 190° C. or higher.

Abstract: A flame retardant resin composition which has high flame retardancy and excellent physical properties and comprises a resin obtained from a plant-derived raw material and a molded article thereof. The flame retardant resin composition comprises: (A) 100 parts by weight of a resin component (component A) which contains at least 50 wt % of a resin (component A-1) obtained from a plant-derived raw material; and (B) 1 to 100 parts by weight of an organic phosphorus compound (component B) represented by the following formula (1).

Abstract: Provided is a button obtained by using a biomass material. The button has a heat deformation temperature of 160° C. or more, and high quality as follows; excellent in heat resistance, high in strength, excellent in dyeing properties, and also capable of having transparency to semi-transparency and/or glossiness.

Abstract: A resin composition comprising an aromatic polyester having a butylene terephthalate skeleton as the main constituent unit (component A), polylactic acid comprising poly(L-lactic acid) and poly(D-lactic acid) (component B), and a modifier (component C), wherein the resin composition has (i) a crystal melting peak of stereocomplex-phase polylactic acid at 190° C. or higher in differential scanning calorimeter measurement, (ii) a biomass ratio of not less than 50%, (iii) a notched Izod impact strength of 4 to 15 kJ/m2 and (iv) a flexural modulus of 2.5 to 6 GPa. The resin composition provides a molded article having excellent impact resistance and stiffness. The resin composition has a biomass ratio of not less than 50%. The resin composition has a low moisture absorptivity, hydrolysis resistance and high-speed moldability. The resin composition provides a molded article having excellent heat resistance.