Abstract: A MEMS device is disclosed. In an embodiment a MEMS device includes a substrate having an active region and at least one integrated electrical and mechanical connection element configured to electrically and mechanically mount the MEMS device to a carrier, wherein the connection element comprises a stress-reducing structure.

Abstract: The present invention relates to multispecific antibodies, methods for their production, pharmaceutical compositions containing said antibodies and uses thereof.

Abstract: Herein is reported a method for the generation of multispecific antibodies by a half-antibody exchange reaction between two 2/3-IgGs destabilized in one half by asymmetric perturbing mutations fostering the generation of correctly assemble full length bispecific antibodies. The method can be performed in the absence of reducing agents and does not require hinge region disulfide bonds in the starting 2/3-IgGs.

Abstract: Herein is reported a method for the generation of multispecific antibodies directly on the cell-surface at the site of action by a half-antibody exchange reaction between two 2/3-IgGs or two 2/3-BiFabs destabilized in one half by asymmetric perturbing mutations fostering the generation of correctly assembled full length bi- or multi-specific antibodies. The method is performed in the absence hinge region disulfide bonds in the starting 2/3-IgGs or 2/3-BiFabs.

Abstract: The present invention relates to multispecific antibodies, methods for their production, pharmaceutical compositions containing said antibodies and uses thereof.

Abstract: Herein is reported a conjugate of a haptenylated polypeptide toxin and an anti-hapten antibody, wherein a disulfide bond is formed between a cysteine residue either before or after the lysine residue that is used for hapten-conjugation and a cysteine residue in the CDR2 of the antibody, whereby the CDR2 is determined according to Kabat.

Abstract: A MEMS device is disclosed. In an embodiment a MEMS device includes a substrate having an active region and at least one integrated electrical and mechanical connection element configured to electrically and mechanically mount the MEMS device to a carrier, wherein the connection element comprises a stress-reducing structure.

Abstract: The present invention relates to multispecific antibodies, methods for their production, pharmaceutical compositions containing said antibodies and uses thereof.

Abstract: Herein is reported a conjugate of a haptenylated polypeptide toxin and an anti-hapten antibody, wherein a disulfide bond is formed between a cysteine residue either before or after the lysine residue that is used for hapten-conjugation and a cysteine residue in the CDR2 of the antibody, whereby the CDR2 is determined according to Kabat.

Abstract: A stabilizer for a lower link of a three-point hitch of a tractor, includes a first stabilizer element and a second stabilizer element, which is supported so it can move with spring action relative to the first stabilizer element along a common longitudinal axis. A first limiting member is connected with the first stabilizer element, which in a closed position forms a first stop which interacts with the second stabilizer element to limit compression movement between the two stabilizer elements. A second limiting member between the two stabilizer elements forms a second stop to limit the compression movement relative to a corresponding end stop of the stabilizer when the first limiting member is brought into an opened position.

Abstract: A method for controlling medical examinations by means of a patient communication system and includes connecting a patient device to a clinic server unit, and exchanging examination information between the patient device and the clinic server unit. The exchange of examination information can include a retrieval of examination information from the clinic server unit by means of the patient device, a retrieval of a calendar entry, and a retrieval of patient information.

Abstract: A stabilizer for a lower link of a three-point hitch of a tractor, includes a first stabilizer element and a second stabilizer element, which is supported so it can move with spring action relative to the first stabilizer element along a common longitudinal axis. A first limiting member is connected with the first stabilizer element, which in a closed position forms a first stop which interacts with the second stabilizer element to limit compression movement between the two stabilizer elements. A second limiting member between the two stabilizer elements forms a second stop to limit the compression movement relative to a corresponding end stop of the stabilizer when the first limiting member is brought into an opened position.

Abstract: A method to plan at least one examination of an examination subject with at least one medical imaging apparatus by means of a planning unit, includes the following steps. The planning unit is connected with the at least one medical imaging apparatus. At least one input parameter of a database of the planning unit and at least one input parameter of a database of a subset of the at least one medical imaging apparatus are detected. The database of the planning unit and the database of the subset of the at least one medical imaging apparatus are filtered depending on the at least one detected input parameter. At least one item of output information is determined that includes a selection from medical imaging apparatuses available for the examination of the examination subject.

Abstract: A tractor includes a vehicle coupler which couples with a trailer brake coupler to connect it to a pressure source for the trailer brake system. The pressure source is driven by a controllable drive unit, and an electronic control unit controls the activation of the drive unit. The vehicle coupler includes a first sensor which is connected to the control unit and which senses when the trailer coupler is coupled to the vehicle coupler. The control unit controls the activation of the drive unit in response to the sensor in order to prevent the pressure source from being driven unnecessarily.

Abstract: In a finding system, a control system and a computer-implemented method to assess medical images, within the scope of a finding workflow a control module can be activated via which the user can enter control data at the finding system. The control data are automatically converted into control commands, which are transmitted to the acquisition system for execution. The acquisition system is expanded by an expansion module in order to transmit process data and status data to the finding system.

Abstract: A tractor includes a vehicle coupler which couples with a trailer brake coupler to connect it to a pressure source for the trailer brake system. The pressure source is driven by a controllable drive unit, and an electronic control unit controls the activation of the drive unit. The vehicle coupler includes a first sensor which is connected to the control unit and which senses when the trailer coupler is coupled to the vehicle coupler. The control unit controls the activation of the drive unit in response to the sensor in order to prevent the pressure source from being driven unnecessarily.

Abstract: A system and method may generate a radiological request by which to conduct a radiological procedure that employs a series of procedural steps to acquire internal images of a patient. Each step may have a corresponding protocol item which affects image quality and the time required to complete the step. A database may be maintained that includes protocol items and patient characteristic data. A rule-based algorithm may accept patient characteristic data as input. Based upon one or more patient characteristics, an overall protocol by which to conduct the radiological procedure may be determined. The tailored protocol may include steps that are selected, omitted, and/or altered based upon a patient characteristic. The patient characteristics may be medical restrictions, such as age, pregnancy, allergies, artificial joints, or other limitations. As a result, the protocol items may be automatically selected based upon patient specific characteristics, and/or an anatomical structure to be examined.

Abstract: In a method for planning an examination of an examination subject in a magnetic resonance system, the planning of the examination ensues based on a composite overview image that is composed of at least two individual images. A first part of the overview image is acquired and the first part of the overview image is made available to operating personnel of the magnetic resonance system for planning further measurements. A second part of the overview image is acquired and the first part and the second part of the overview image are combined. The combined image of the first part and second part of the overview image is made available for planning further measurements. The first part of the overview image is made available to operating personnel no later than before making the overview image available.

Abstract: In a method and device for planning an examination of an examination subject in an imaging diagnosis device, a reference image is selected, and an image of the examination subject is to be made that corresponds to the reference image. A workflow protocol is determined with which the reference image was generated. The acquisition of all required images of the examination subject is planned using this workflow protocol. The workflow protocol is executed for creation of an image of the examination subject that corresponds to the reference image.

Abstract: A method for detection and classification of imperfections in components is proposed having the following stages: Irradiation of pulsed ultrasonic waves from electrical emission pulses on several points of the surface of the component to be examined, reception of the reflected ultrasonic waves at several points of the surface for generating multiple electrical reception signals, analysis and evaluation of the electrical reception signals in terms of their amplitude information with reference to the positions of the points of the irradiated ultrasonic waves and the detected reflected sound waves for generating a three-dimensional spatial distribution of the scattering properties of the component.