Patents by Inventor Klaus Muller

Klaus Muller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 10-substituted 1,8-dihydroxy-9 (10H) anthracenone pharmaceuticals
    Patent number: 5844004
    Abstract: Therapeutic compositions comprising 1,8-dihyroxy-9(10H) anthracenones substituted at position 10 thereof with phenylalkylidene or arylacyl blocking moieties, said compounds having substantial therapeutic activity and minimal inflammatory effect.
    Type: Grant
    Filed: March 27, 1997
    Date of Patent: December 1, 1998
    Assignee: Teva Pharmaceutical Industries, Ltd.
    Inventors: Klaus Muller, Wolfgang Wiegrebe, Dieter Gurster, Susanne Peters, nee Piwek
  • Tetrahydronaphthalene compounds
    Patent number: 5837807
    Abstract: This invention is directed to tetrahydronaphthalene compounds of the formula ##STR1## wherein R.sup.1 is hydrogen, bromine, cyano, formyl, hydroxy, lower alkyl, lower alkenyl, lower alkynyl, lower alkoxy, aryloxy, lower aralkoxy or aryl; R.sup.2 is an amino acid residue or a chain of 2 to 20 amino acid residues wherein reactive moieties in the side chains of the amino acid residue(s) is/are protected or unprotected, and wherein the amino group of the N-terminal amino acid is a free or protected amino group; A.sup.1, A.sup.2, A.sup.3 and A.sup.4 each are .alpha.-amino acid residues wherein A.sup.1 and A.sup.2 are in the L configuration and A.sup.3 and A.sup.4 are in the D configuration when the .alpha.-C atom of said .alpha.-amino acid residue is asymmetric; X is oxygen or sulphur; Y is a residue of the formula ##STR2## n is 0 or 1; R.sup.3 is hydrogen or lower alkyl; R.sup.
    Type: Grant
    Filed: February 27, 1996
    Date of Patent: November 17, 1998
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Christine Abrecht, Alfred Grieder, Klaus Muller, Daniel Obrecht
  • Tri- and tetracyclic compounds
    Patent number: 5811389
    Abstract: There are described compounds of the formula ##STR1## Wherein the variables have been defined herein. The compounds are useful as research tools in the determination of biologically active peptides sequences and also potentially suitable as medicaments, some of them being useful in the prevention or control of the formation of blood platelet thrombi, and some compounds are useful as intermediates.
    Type: Grant
    Filed: June 24, 1996
    Date of Patent: September 22, 1998
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Wilhelm Bannwarth, Fernand Gerber, Alfred Grieder, Andreas Knierzinger, Klaus Muller, Daniel Obrecht, Arnold Trzeciak
  • Tri-and tetracyclic compounds
    Patent number: 5811548
    Abstract: There are described compounds of the formula ##STR1## Wherein the variables have been defined herein. The compounds are useful as research tools in the determination of biologically active peptides sequences and also potentially suitable as medicaments, some of them being useful in the prevention or control of the formation of blood platelet thrombi, and some compounds are useful as intermediates.
    Type: Grant
    Filed: June 24, 1996
    Date of Patent: September 22, 1998
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Wilhelm Bannwarth, Fernand Gerber, Alfred Grieder, Andreas Knierzinger, Klaus Muller, Daniel Obrecht, Arnold Trzeciak
  • Guanidine derivatives
    Patent number: 5763436
    Abstract: Compounds of the formula ##STR1## wherein L, M, R, T and X are set forth in the description, as well as hydrates or solvates thereof, which inhibit thrombin-induced platelet aggregation and clotting of fibrinogen in plasma, are described. The compounds of formula I are prepared by amidination or, depending on whether L is NH or O, by amide formation or esterification.
    Type: Grant
    Filed: September 17, 1996
    Date of Patent: June 9, 1998
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jean Ackermann, David Banner, Klaus Gubernator, Paul Hadvary, Kurt Hilpert, Klaus Muller, Ludvik Labler, Gerard Schmid, Thomas B. Tschopp, Hans Peter Wessel, Beat Wirz
  • Venting device for vehicle fuel tanks
    Patent number: 5740842
    Abstract: A fuel tank arrangement for a motor vehicle. The arrangement includes a fuel tank containing fuel therein and having a gas space disposed above the fuel, and a venting device connected to the fuel tank. The venting device includes an activated charcoal filter and a venting conduit connecting the gas space to the activated charcoal filter for establishing gas communication therebetween. A stop valve is disposed in the venting conduit and is adapted to open gas communication between the gas space and the activated charcoal filter during refueling. Moreover, a fuel separator is disposed in the venting conduit for separating fuel from a gas flow through the venting conduit thereby yielding separated fuel.
    Type: Grant
    Filed: February 16, 1996
    Date of Patent: April 21, 1998
    Assignees: Walter Alfmeier GmbH + Co. Prazisions-Baugruppenelemente, Mercedes Benz AG
    Inventors: Josef Maier, Dieter Simon, Wolfgang Liebhart, Thomas Theuer, Klaus Muller, Rolf Walter, Dieter Scheurenbrandt, Manfred Weil, Wolfgang Freiwald, Gerhard Kiermaier
  • Arrangement for operating a consumer in a motor vehicle
    Patent number: 5723958
    Abstract: An arrangement for driving a consumer in a vehicle is suggested. The arrangement has at least two switch elements for influencing the current flow through the consumer. For each switch element, the current flowing through this switch element is monitored and evaluated for detecting a short circuit.
    Type: Grant
    Filed: March 4, 1996
    Date of Patent: March 3, 1998
    Assignee: Robert Bosch GmbH
    Inventors: Leonhard Boll, Klaus Muller
  • Sliding element and process for producing the same
    Patent number: 5712049
    Abstract: A sliding element has a bearing metallic layer made of aluminum or an aluminum alloy which bears on its side facing the sliding surface a galvanically produced tin layer bonded to the bearing metallic layer by a very thin alkaline, halogen-free layer of zinc, copper, nickel and iron immersion deposited on the bearing metallic layer. To produce such sliding element, a highly-alkaline immersion bath is used containing salts of zinc, nickel, copper and iron mainly cyanide-based. After the immersion treatment, the sliding element blank is rinsed with considerably carbonic acid-free deionized water. During a first tinning step, the sliding element is treated in a bath at a temperature between 20.degree. and 26.degree. C. with a current intensity from 2 to 3 amperes/dm.sup.2 and for a duration of exposure of at least one minute.
    Type: Grant
    Filed: July 27, 1995
    Date of Patent: January 27, 1998
    Assignee: Glyco-Metall-Werke Glyco B.V. & Co. KG
    Inventors: Hans-Ulrich Huhn, Klaus Muller
  • Apparatus for controlling a power control element of a drive unit of a motor vehicle
    Patent number: 5712550
    Abstract: An arrangement for driving a power control element of a drive unit of a motor vehicle is proposed and the arrangement has a full-bridge output stage. A direct-current motor is arranged in the bridge diagonal and the current through the direct-current motor is limited to at least one preadjusted value in that the clocked drive signals are interrupted when the preadjusted value is exceeded.
    Type: Grant
    Filed: February 15, 1996
    Date of Patent: January 27, 1998
    Assignee: Robert Bosch GmbH
    Inventors: Leonhard Boll, Thomas Zeller, Klaus Muller
  • 10-thio-substituted 1,8-dihydroxy-9 (10H) -anthracenone pharmaceuticals
    Patent number: 5705533
    Abstract: 10-thio-substituted 1,8-dihydroxy-9(10H) anthracenones, therapeutic compositions containing at least one of the 10-thio-substituted 1,8-dihydroxy-9(10H) anthracenones of the invention and methods of treating inflammatory conditions are provided.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 6, 1998
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Klaus Muller, Hsu-Shan Huang, Wolfgang Wiegrebe
  • 10-substituted 1,8-dihydroxy-9 (10H) anthracenone pharmaceuticals
    Patent number: 5661187
    Abstract: Therapeutic compositions comprising 1,8-dihyroxy-9(10H) anthracenones substituted at position 10 thereof with phenylalkylidene or arylacyl blocking moieties, said compounds having substantial therapeutic activity and minimal inflammatory effect.
    Type: Grant
    Filed: March 7, 1995
    Date of Patent: August 26, 1997
    Assignee: Teva Pharmaceutical Industries, Ltd.
    Inventors: Klaus Muller, Wolfgang Wiegrebe, Dieter Gurster, Susanne Peters, nee Piwek
  • Tetrahydronaphthalene derivatives
    Patent number: 5644024
    Abstract: The present invention is concerned with tetrahydronaphthalene derivatives which are mimics of domains of peptides or proteins which can interact with other proteins or with DNA or RNA through .alpha.-helical conformation, said tetrahydronaphthalene derivatives having the formulae: ##STR1## are valuable aids in the determination of biologically active peptide sequences and are accordingly so-called "research tools". They are, however, also potentially suitable as medicaments.
    Type: Grant
    Filed: August 17, 1994
    Date of Patent: July 1, 1997
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Christine Abrecht, Klaus Muller, Daniel Obrecht, Arnold Trzeciak
  • Method for producing granulated sodium percarbonate
    Patent number: 5560896
    Abstract: Sodium percarbonate is produced by means of fluidized bed granulation. The process includes spraying an aqueous sodium carbonate solution and a hydrogen peroxide solution onto nuclei in a fluidized bed and evaporating the water. In the process of the invention, it is not necessary to use a phosphorus-containing crystallization inhibitor in order to avoid cloggings and incrustations in and on the nozzle. This is accomplished by spraying the solutions through separate channels in a single ternary atomizer nozzle, to provide external mixing of the solutions with respect to the nozzle.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: October 1, 1996
    Assignee: Degussa Aktiengesellschaft
    Inventors: Martin Bewersdorf, Claas-Jurgen Klasen, Petra Look-Herber, Birgit Bertsch-Frank, Thomas Lieser, Klaus Muller
  • Guanidine derivatives
    Patent number: 5532232
    Abstract: Compounds of the formula ##STR1## wherein L, M, R, T and X are set forth in the description, as well as hydrates or solvates thereof, which inhibit thrombin-induced platelet aggregation and clotting of fibrinogen in plasma, are described. The compounds of formula I are prepared by amidination or, depending on whether L is NH or O, by amide formation or esterification.
    Type: Grant
    Filed: November 22, 1994
    Date of Patent: July 2, 1996
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jean Ackermann, David Banner, Klaus Gubernator, Paul Hadvary, Kurt Hilpert, Klaus Muller, Ludvik Labler, Gerard Schmid, Thomas B. Tschopp, Hans P. Wessel, Beat Wirz
  • Stabilized diesel engine oil
    Patent number: 5523007
    Abstract: A lubricant oil composition comprising a diesel engine lubricating oil and, as antioxidant, a compound of formula I ##STR1## wherein R.sup.1 and R.sup.2 are each independently of the other C.sub.1 -C.sub.12 alkyland X is ##STR2## or --CH.sub.2 --S--R and R is a straight chain or branched alkyl radical of the formula --C.sub.n H.sub.2n+1, wherein n is an integer from 8 to 22.
    Type: Grant
    Filed: February 23, 1995
    Date of Patent: June 4, 1996
    Assignee: Ciba-Geigy Corporation
    Inventors: Ulrich Kristen, Klaus Muller, Michael Rasberger
  • Process for cleaning hollow fibers
    Patent number: 5470474
    Abstract: The invention relates to a process for removing a lumen filler and/or undesired auxiliary processing agents from hollow fibers or hollow fiber membranes by extraction with supercritical gases. The invention likewise relates to the hollow fibers or hollow fiber membranes freed of a lumen filler and/or undesired auxiliary processing agents by this process.
    Type: Grant
    Filed: March 25, 1994
    Date of Patent: November 28, 1995
    Assignee: Akzo Nobel NV
    Inventors: Wolfgang Ansorge, Ralf Hornscheidt, Andreas Jungheim, Klaus Muller
  • Electromagnetic valve housing containing throttle and check valve which permit armature stroke adjustment
    Patent number: 5425575
    Abstract: A valve whose valve stroke must be adjusted is provided with a throttle bore. The valve has a guide tube open on the bottom with a press-fit in a valve body through whose through bore the valve closing member of an armature received in a guide tube is accessible for engagement by a scanner pin of a measuring tool. After adjustment of the valve stroke, a throttle insert is introduced into the throttle bore of the valve body, using a double-lipped cuff. While an inner lip seals off the throttle insert in the valve body, an outer lip of the cuff, in cooperation with a housing receives the valve and takes on the function of a check valve. The valve is suitable for anti-lock and/or traction-control systems of motor vehicle brake systems.
    Type: Grant
    Filed: March 30, 1994
    Date of Patent: June 20, 1995
    Assignee: Robert Bosch GmbH
    Inventors: Klaus Schmidt, Werner Wilde, Norbert Alaze, Kurt Herzog, Klaus Muller, Friedrich Megerle, Dietmar Baumann
  • 10-substituted 1,8-dihydroxy-9(10H) anthracenone pharmaceuticals
    Patent number: 5426197
    Abstract: Therapeutic compositions comprising 1,8-dihyroxy-9(10H) anthracenones substituted at position 10 thereof with phenylalkylidene or arylacyl blocking moieties, said compounds having substantial therapeutic activity and minimal inflammatory effect.
    Type: Grant
    Filed: July 19, 1993
    Date of Patent: June 20, 1995
    Assignee: Teva Pharmaceutical Industries, Ltd.
    Inventors: Klaus Muller, Wolfgang Wiegrebe, Dieter Gurster, Susanne Peters, nee Piwek
  • Guanidine derivatives
    Patent number: 5393760
    Abstract: Compounds of the formula ##STR1## wherein L, M, R, T and X are set forth in the description, as well as hydrates or solvates thereof, which inhibit thrombin-induced platelet aggregation and clotting of fibrinogen in plasma, are described. The compounds of formula I are prepared by amidination or, depending on whether L is NH or O, by amide formation or esterification.
    Type: Grant
    Filed: June 15, 1993
    Date of Patent: February 28, 1995
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jean Ackermann, David Banner, Klaus Gubernator, Paul Hadvary, Kurt Hilpert, Klaus Muller, Ludvik Labler, Gerard Schmid, Thomas B. Tschopp, Hans P. Wessel, Beat Wirz
  • Flanking peptides of calcitonin and processes for their manufacture
    Patent number: 5354843
    Abstract: Peptides of formula I ##STR1## in which R is hydrogen or acetyl and X is an amino acid sequence of formula -Ser-Leu-Asp-Ser-Pro-Arg-Ser- (Ia) or of formula -Arg-Ile-Ile-Ala-Gln- (Ib), and salts of such compounds, can be used for the treatment of diseases involving bone degeneration.
    Type: Grant
    Filed: August 23, 1989
    Date of Patent: October 11, 1994
    Assignee: Ciba-Geigy Corporation
    Inventors: Hans Rink, Klaus Muller