Patents by Inventor Klaus Stockhaus

Klaus Stockhaus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 14-hydroxy-N-(2-methoxyethyl)-7,8-dihydromorphine and -norisomorphine, processes for the preparation thereof and the use thereof as pharmaceutical compositions
    Patent number: 5240933
    Abstract: The present invention relates to 14-hydroxy-N-(2-methoxyethyl)-7,8-dihydromorphine and -norisomorphine, processes for preparing them and their use as pharmaceutical compositions.
    Type: Grant
    Filed: September 25, 1992
    Date of Patent: August 31, 1993
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Herbert Merz, Ingrid Wiedemann, Helmut Ensinger, Klaus Stockhaus, Matthias Grauert
  • N-(3-trifluoromethyl-phenyl)-N'-propargyl-piperazine and salts thereof useful as analgesics
    Patent number: 4699910
    Abstract: The compound of the formula ##STR1## and non-toxic, pharmacologically acceptable acid addition salts thereof. The compound as well as its salts are useful as analgesics.
    Type: Grant
    Filed: November 22, 1985
    Date of Patent: October 13, 1987
    Assignee: Boehringer Ingelheim KG
    Inventors: Rolf Banholzer, Herbert Merz, Klaus Stockhaus, Hans M. Jennewein
  • Analgesic 1-acetonyl-2-(phenylimino)-imidazolidines and salts thereof
    Patent number: 4588736
    Abstract: Compounds of the formula ##STR1## wherein X, Y and Z are each independently hydrogen, halogen, lower alkyl, halo(lower alkyl), lower alkoxy, halo(lower alkoxy), (lower alkyl)thio or halo(lower alkyl)thio, orY and Z, together with each other, are lower alkylenedioxy;and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as analgesics.
    Type: Grant
    Filed: May 21, 1984
    Date of Patent: May 13, 1986
    Assignee: Boehringer Ingelheim KG
    Inventors: Franz Esser, Herbert Koppe, Wolfgang Abele, Klaus Stockhaus
  • Bradycardiac or analgesic 2-(N-(thienyl-2-methyl)-N-(2-fluoro-6-methyl-phenyl)-amino)-2-imidazolin e and salts thereof
    Patent number: 4478844
    Abstract: Compounds of the formula ##STR1## wherein R is bromine or trifluoromethyl, and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as bradycardiacs, analgesics and locomotion inhibitors.
    Type: Grant
    Filed: October 6, 1982
    Date of Patent: October 23, 1984
    Assignee: Boehringer Ingelheim KG
    Inventors: Helmut Stahle, Herbert Koppe, Werner Kummer, Walter Kobinger, Klaus Stockhaus
  • N-(2-methoxyethyl)-noroxymorphone and pharmaceutical compositions for relieving pain containing same
    Patent number: 4473573
    Abstract: The invention relates to N-(2-methoxyethyl)-noroxymorphone and pharmacologically acceptable acid addition salts thereof. These compounds are analgesically effective and can be used for controlling pain.
    Type: Grant
    Filed: May 17, 1983
    Date of Patent: September 25, 1984
    Assignee: Boehringer Ingelheim KG
    Inventors: Herbert Merz, Adolf Langbein, Klaus Stockhaus
  • Imidazo[1,2-a]imidazoles in the treatment of pain, hypertonia and coronary diseases
    Patent number: 4454149
    Abstract: This invention relates to substituted imidazo[1,2-a]imidazoles and non-toxic, pharmaceutically acceptable salts thereof. These compounds are useful in relieving pain and in treating hypertonia and coronary diseases.
    Type: Grant
    Filed: June 17, 1982
    Date of Patent: June 12, 1984
    Assignee: Boehringer Ingelheim KG
    Inventors: Helmut Stahle, Herbert Koppe, Werner Kummer, Klaus Stockhaus, Wolfgang Hoefke, Wolfram Gaida
  • Substituted imidazo[1,2-a]pyrimidines and pharmaceutical compositions containing them
    Patent number: 4438118
    Abstract: This invention relates to substituted imidazo[1,2-a]pyrimidines and non-toxic, pharmaceutically acceptable salts thereof. These compounds are useful in relieving pain and in treating hypertonia and coronary diseases.
    Type: Grant
    Filed: June 17, 1982
    Date of Patent: March 20, 1984
    Assignee: Boehringer Ingelheim KG
    Inventors: Helmut Stahle, Herbert Koppe, Werner Kummer, Klaus Stockhaus, Wolfram Gaida, Wolfgang Hoefke
  • Analgesic 2-(2-alkoxy-ethyl)-2'-hydroxy-6,7-benzomorphans and salts thereof
    Patent number: 4293556
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is methyl, ethyl or propyl;R.sub.2 is hydrogen, methyl or ethyl; andR.sub.3 is ##STR2## where R.sub.4 is hydrogen or methyl,R.sub.5 is methyl, ethyl or propyl, andn is 1 or 2,and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as the salts are useful as analgesics.
    Type: Grant
    Filed: May 28, 1980
    Date of Patent: October 6, 1981
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Herbert Merz, Klaus Stockhaus
  • Quaternary derivatives of noroxymorphone which relieve intestinal immobility
    Patent number: 4176186
    Abstract: Compounds of the formula ##STR1## wherein R is allyl or a related radical such as chloroallyl, cyclopropyl-methyl or propargyl, andX is the anion of an acid, especially a chloride, bromide, iodide or methylsulfate anion;the compounds prevent or relieve the intestinal mobility inhibiting side-effects of narcotic analgesics without interfering with the analgesic activity of the latter.
    Type: Grant
    Filed: July 28, 1978
    Date of Patent: November 27, 1979
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Leon I. Goldberg, Herbert Merz, Klaus Stockhaus
  • Analgesic and morphine antagonistic 2'-hydroxy-2-(5-isoxazolyl-methyl)-6,7-benzomorphans and salts thereof
    Patent number: 4133888
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is methyl, ethyl or propyl; and R.sub.2 is hydrogen, methyl or ethyl; and non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as analgesics and morphine antagonists.
    Type: Grant
    Filed: April 12, 1978
    Date of Patent: January 9, 1979
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Herbert Merz, Klaus Stockhaus
  • N-Tetrahydrofurfuryl-noroxymorphones, their salts, and analgesic compositions and methods employing them
    Patent number: 4100288
    Abstract: Diastereoisomers of the compound of the formula ##STR1## and non-toxic, pharmacologically acceptable acid addition salts thereof; the isomers as well as their salts are useful as analgesics and morphine-antagonists.
    Type: Grant
    Filed: August 13, 1976
    Date of Patent: July 11, 1978
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Herbert Merz, Gerhard Walther, Adolf Langbein, Klaus Stockhaus, Helmut Wick
  • 2-[N-phenyl-N-(cycloalkyl-methyl)-amino]-2-imidazolines and salts thereof
    Patent number: 4100292
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3, which may be identical or different from each other, are each hydrogen, fluorine, chlorine, bromine, methyl, ethyl, methoxy, hydroxyl, trifluoromethyl or cyano; andR.sub.4 is (cycloalkyl of 3 to 6 carbon atoms)-methyl; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as analgesics.
    Type: Grant
    Filed: August 12, 1977
    Date of Patent: July 11, 1978
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Helmut Stahle, Herbert Koppe, Werner Kummer, Klaus Stockhaus, Wolfgang Hoefke, Franz Josef Kohn
  • Analgesically useful 2-tetrahydrofurfuryl-5-lower alkyl-2-oxy-6,7-benzomorphans and salts thereof
    Patent number: 4087532
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is methyl, ethyl or propyl,R.sub.2 is hydrogen, methyl or ethyl,R.sub.3 is hydrogen or methyl, andR.sub.4 is hydrogen, alkyl of 1 to 4 carbon atoms or alkanoyl of 2 to 5 carbon atoms,And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as the salts are useful as analgesics.
    Type: Grant
    Filed: April 2, 1976
    Date of Patent: May 2, 1978
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Herbert Merz, Adolf Langbein, Gerhard Walther, Klaus Stockhaus
  • Pharmaceutical compositions containing an N-(furyl-methyl)-2'-hydroxy-5,9,9-trimethyl benzomorphan and method of use
    Patent number: 4069328
    Abstract: Pharmaceutical compositions containing as an active ingredient compounds of the formula ##STR1## wherein R is hydrogen or methyl, or a non-toxic, pharmacologically acceptable acid addition salt thereof; and a method of using the same as morphine-antagonists and analgesics.
    Type: Grant
    Filed: October 15, 1976
    Date of Patent: January 17, 1978
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Adolf Langbein, Herbert Merz, Gerhard Walther, Klaus Stockhaus
  • Pharmaceutical compositions containing an N-[(methoxymethyl-furyl)-methyl]- 6
    Patent number: 4038397
    Abstract: Pharmaceutical compositions containing as an active ingredient a compound of the formula ##STR1## wherein R.sub.1 is methyl, ethyl or propyl, R.sub.2 is hydrogen, methyl or ethyl,R.sub.3 is hydrogen or methyl,R.sub.4 is ##STR2## R.sub.5 is hydrogen, methyl or acetyl, or a non-toxic, pharmacologically acceptable acid addition salt thereof; and a method of using the same as analgesics.
    Type: Grant
    Filed: June 25, 1976
    Date of Patent: July 26, 1977
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Herbert Merz, Adolf Langbein, Gerard Walther, Klaus Stockhaus
  • 2-(N-thienylmethyl-phenylamino)-imidazolines-(2) and salts thereof
    Patent number: 4036972
    Abstract: Compounds of the formula ##STR1## wherein R, R.sub.1 and R.sub.2 are each hydrogen, fluorine, chlorine, bromine, methoxy or trifluoromethyl, but other than all hydrogen at the same time, andR.sub.3 is hydrogen, methyl or ethyl,And non-toxic, pharmaceutically acceptable acid addition salts thereof; the compounds as well as their salts are useful as analgesics and hypotensives.
    Type: Grant
    Filed: August 25, 1975
    Date of Patent: July 19, 1977
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Helmut Stahle, Herbert Koppe, Werner Kummer, Klaus Stockhaus
  • Propargyl-substituted 2-phenylamino-2-imidazolines and salts thereof
    Patent number: 4025607
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3, which may be identical to or different from each other, are each hydrogen, fluorine, chlorine, bromine, methyl, ethyl, methoxy or trifluoromethyl, andR.sub.4 and R.sub.5 are each hydrogen or propargyl, but other than both hydrogen or both propargyl at the same time,And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as the salts are useful as analgesics and hypotensives.
    Type: Grant
    Filed: May 17, 1976
    Date of Patent: May 24, 1977
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Helmut Stahle, Herbert Koppe, Werner Kummer, Klaus Stockhaus, Wolfgang Hoefke, Franz Josef Kuhn
  • N-(furyl-methyl)-2-hydroxy-5,9,9-trimethyl-benzomorphans and salts thereof
    Patent number: 4010164
    Abstract: Compounds of the formula ##STR1## wherein R is hydrogen or methyl, and non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as morphine-antagonists and analgesics.
    Type: Grant
    Filed: July 28, 1975
    Date of Patent: March 1, 1977
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Adolf Langbein, Herbert Merz, Gerhard Walther, Klaus Stockhaus
  • Pharmaceutical compositions containing an N-(furyl-methyl)-7.alpha.-acyl-6,14-(endoetheno or endoethano)-tetrahydro-nororipavine or -northebaine and method of use
    Patent number: 4004010
    Abstract: Pharmaceutical compositions containing as an active ingredient a compound of the formula ##STR1## wherein R is hydrogen, methyl or acetyl,R.sub.1 is methyl, phenyl or hydrogen,Z is --CH=CH-- or --CH.sub.2 --CH.sub.2 --, andR.sub.3 is hydrogen or methyl,And non-toxic, pharmacologically acceptable acid addition salts thereof; and a method using the same as analgesics and antitussives.
    Type: Grant
    Filed: October 30, 1975
    Date of Patent: January 18, 1977
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Adolf Langbein, Herbert Merz, Gerhard Walther, Klaus Stockhaus
  • Pharmaceutical compositions containing a 2-(heteroaryl-methyl)-5,9.beta.-dialkyl-6,7-benzomorphan and method of use
    Patent number: 3998960
    Abstract: Pharmaceutical compositions containing as an active ingredient a compound of the formula ##STR1## wherein R is hydrogen, methyl or acetyl,R.sub.1 and R.sub.2, which may be identical to or different from each other, are each alkyl of 1 to 3 carbon atoms,R.sub.3 is hydrogen or methyl, andY is oxygen or sulfur,Or a non-toxic, pharmacologically acceptable acid addition salt thereof; and a method of using the same as analgesics, antitussives and opiate-antagonists.
    Type: Grant
    Filed: October 30, 1975
    Date of Patent: December 21, 1976
    Assignee: Boehringer Ingelheim GmbH
    Inventors: Herbert Merz, Adolf Langbein, Klaus Stockhaus, Helmut Wick