Abstract: Disclosed is a sample dispatcher configured for individually introducing a plurality of portions of one or more sample fluids into a flow of a mobile phase of a separation system configured for separating compounds of the sample fluids. The separation system comprises a mobile phase drive configured for driving the mobile phase through a separation unit configured for separating compounds of the sample fluids in the mobile phase. The sample dispatcher comprises a plurality of sample reservoirs, each configured for receiving and temporarily storing a respective sample fluid portion or at least a part thereof. The sample dispatcher is configured for selectively coupling one of the plurality of sample reservoirs between the mobile phase drive and the separation unit, and further for coupling at least two of the plurality of sample reservoirs in parallel between the mobile phase drive and the separation unit.

Abstract: A pump unit comprises a primary piston pump, a secondary piston pump, and a flow path adapted for fluidically connecting in series the primary piston pump and the secondary piston pump. The pump unit's duty cycle comprises a delivery-and-fill phase, in which the primary piston pump supplies a flow of liquid to the secondary piston pump, and during the delivery-and-fill phase, the flow of liquid supplied by the primary piston pump is partly used for filling up the secondary piston pump and partly used for maintaining another flow of liquid dispensed across the secondary piston pump. The flow path comprises a heat exchanger, wherein liquid supplied by the primary piston pump passes through the heat exchanger before being supplied to the secondary piston pump.

Abstract: A fluid supply system (150) adapted for metering two or more fluids in controlled proportions and for supplying a resultant mixture, the fluid supply system (150) comprising a plurality of solvent supply lines (104 to 107), each fluidically connected with a fluid source (100 to 103) providing a respective fluid, a pumping unit (110) comprising a reciprocating element (115) adapted for intaking fluid supplied at an inlet of the pumping unit (110) and for supplying the pressurized fluid at an outlet of the pumping unit (110), wherein the pumping unit (110) is adapted for taking in fluids from selected solvent supply lines (104 to 107) and for supplying a pressurized mixture of the fluids at its outlet, a proportioning valve (108) interposed between the solvent supply lines (104 to 107) and the inlet of the pumping unit (110), the proportioning valve (108) adapted for modulating solvent composition by sequentially coupling selected ones of the solvent supply lines (104 to 107) with the inlet of the pumping unit

Abstract: A fluid supply system configured for supplying fluids includes a fluid packet supply unit configured for controlling supply of a sequence of fluid packets. The fluid packets include a packet of first fluid and a packet of second fluid, wherein the first fluid and the second fluid are media being prone to a phase separation upon direct interaction between the packet of first fluid and the packet of second fluid. The fluid supply system further includes a phase separation inhibiting unit configured for inhibiting phase separation by inserting an intermediate fluid packet between the packet of first fluid and the packet of second fluid.

Abstract: In a method for processing successive fluidic sample portions provided by a sample source, sample reception volumes are filled successively temporarily with at least a respective one of the sample sections, and the sample sections are emptied successively out of the sample reception volumes in such a way, that, while emptying, it is avoided to bring two respective ones of the sample sections, which have not left the sample source directly adjacent to one another, in contact with one another.

Abstract: A sample separation apparatus for separating a liquid sample includes a first separation unit for separating the sample, a first fluid drive for conducting the sample to be separated through the first separation unit, a second separation unit, arranged downstream of the first separation unit, for further separating the sample, a second fluid drive for at least partially conducting the sample through the second separation unit, and a fluidic valve having interfaces fluidically coupled to the first and second fluid drives and being switchable for performing the separation of the sample. The apparatus is configured for adjusting a pressure at a predefined position to a predefined value, wherein the predefined position is in a fluidic path between an outlet of the first separation unit and an inlet of the second separation unit or in fluid communication with this fluidic path.

Abstract: A secondary stage sample separation device for separating at least a portion of a fluidic sample includes a fluidic interface configured for forming a detachable fluidic coupling between a primary stage sample separation device and the secondary separation device so that the fluidic sample separated by the primary stage sample separation device is fluidically supplyable to the secondary stage sample separation device via the fluidic interface for further separation, wherein the secondary stage sample separation device is further configured for separating at least a portion of the supplied fluidic sample independent of a flow rate of the fluidic sample supplied from the primary stage sample separation device at the fluidic interface.

Abstract: A secondary stage sample separation device for separating at least a portion of a fluidic sample includes a fluidic interface configured for forming a fluidic coupling between a primary stage sample separation device and the secondary separation device, so that the fluidic sample separated by the primary stage sample separation device is fluidically suppliable to the secondary stage sample separation device via the fluidic interface for further separation, and a pressure reduction mechanism configured for reducing pressure at the fluidic interface at least in the event of an overpressure or of an excessive pressure increase.

Abstract: A device for determining a leakage of fluid in a piston pump, wherein the piston pump comprises a piston arranged in such a manner that it can reciprocate in a piston chamber for delivering fluid, wherein the device comprises a control unit for controlling the piston in such a manner that the piston executes two piston chamber evacuation processes with different evacuation times, in each case for at least partial evacuating of fluid located in the piston chamber, and a determination unit for determining the leakage based on a comparison of fluid quantities evacuated from the piston chamber in the two piston chamber evacuation processes.

Abstract: In a high performance liquid chromatography system, wherein a mobile phase is driven through a stationary phase for separating compounds of a sample fluid comprised in the mobile phase, a flow rate of the mobile phase is controlled in dependence on a variation in a control value in the system.

Abstract: A fluid processing device (10) for processing fluid, wherein the fluid processing device (10) comprises a first fluid drive unit (20) configured for driving a first fluid along a first flow path (85), a second fluid drive unit (20?) configured for driving a second fluid along a second flow path (86), and a fluidic switch (90) fluidically coupled to the first flow path (85) and to the second flow path (86) and configured for being switchable for transferring first fluid from the first flow path (85) into the second flow path (86) without interruption of fluid flow along at least one of the first flow path (85) and the second flow path (86).

Abstract: An apparatus for deriving an operation mode from a first fluidic device to a second fluidic device, wherein the first fluidic device has a first target operation mode representing a desired behavior of the first fluidic device and has a first real operation mode representing the actual behavior of the first fluidic device, wherein the second fluidic device has a second target operation mode representing a desired behavior of the second fluidic device and has a second real operation mode representing the actual behavior of the second fluidic device, the apparatus comprising a first determining unit configured for determining the first real operation mode based on the first target operation mode and based on a preknown parameterization of the first fluidic device, and a second determining unit configured for determining the second target operation mode based on the determined first real operation mode and based on a preknown parameterization of the second fluidic device.

Abstract: A sample separation apparatus includes a metering device for metering a predefined amount of fluidic sample to be separated by a sample separation apparatus, a metering path for fluidically coupling the metering device and a sample source providing fluidic sample to be metered, and a control device. The control device is configured for controlling operation of the metering device for at least partially compensating for a deviation between a target value to be metered and an actual value of an amount of fluidic sample that is metered, the deviation resulting from a thermally induced volume change in the sample separation apparatus.

Abstract: A fluid supply system configured for metering two or more fluids in controlled proportions, including a plurality of solvent supply lines, a pumping unit configured for taking in fluids from selected solvent supply lines and for supplying a pressurized mixture, a proportioning valve configured for modulating solvent composition by sequentially coupling selected ones of the solvent supply lines with the inlet of the pumping unit, a sensor configured for sensing process information in the fluid supply system, an analysis entity configured for analyzing the process information for determining reciprocating element related information at a beginning of fluid intake, and a control unit configured for switching the proportioning valve to sequentially couple selected ones of the solvent supply lines to the inlet of the pumping unit at one or more switching points based on the given metering scheme and based on the reciprocating element related information.

Abstract: An apparatus (200) for deriving an operation mode from a first fluidic device to a second fluidic device, wherein the first fluidic device has a first target operation mode (300) representing a desired behavior of the first fluidic device and has a first real operation mode (304) representing the actual behavior of the first fluidic device, wherein the second fluidic device has a second target operation mode (312) representing a desired behavior of the second fluidic device and has a second real operation mode (314) representing the actual behavior of the second fluidic device, the apparatus (200) comprising a first determining unit (202) adapted for determining the first real operation mode (304) based on the first target operation mode (300) and based on a preknown parameterization (302) of the first fluidic device, and a second determining unit (204) adapted for determining the second target operation mode (312) based on the determined first real operation mode (304) and based on a preknown parameterizatio

Abstract: A liquid chromatography analysis unit configured for executing a predefined liquid chromatography analysis task, wherein the liquid chromatography analysis unit comprises a sample insertion compartment configured for inserting a fluidic sample to be separated, wherein the fluidic sample is to be separated when executing the liquid chromatography analysis task, a solvent accommodation section accommodating a predefined volume of at least one predefined solvent required for executing the liquid chromatography analysis task, and a sample separation unit configured for separating the fluidic sample inserted into the sample insertion compartment upon applying a solvent and sample drive force for driving the solvent and the fluidic sample through the sample separation unit.

Abstract: A base station for separating a fluidic sample by liquid chromatography in cooperation with a liquid chromatography analysis unit configured for executing a predefined liquid chromatography analysis task, wherein the base station comprises an analysis unit coupling section configured for removably coupling the liquid chromatography analysis unit to the base station, and an analysis task identification unit configured for identifying the predefined liquid chromatography analysis task of the liquid chromatography analysis unit coupled to the analysis unit coupling section, so that the fluidic sample is separable by executing the identified predefined liquid chromatography analysis task in cooperation between the base station and the liquid chromatography analysis unit.

Abstract: A method and a system for introducing a sample into a mobile phase of a chromatography system is provided. The method includes initially directing the mobile phase directly into a separation unit of the chromatography system, bypassing a sample loop, the mobile phase including a combined solvent, metered from a pressurized first solvent and a second solvent; loading the sample into the sample loop, while the mobile phase continues to be directed directly into the separation unit; pressurizing the sample in the sample loop with the pressurized first solvent, while the mobile phase continues to be directed directly into the separation unit; and switching the sample loop into the mobile phase, thereby introducing the pressurized sample to the separation unit.

Abstract: A method for controlling operation of a pump unit, where the pump unit includes a primary piston pump having a primary piston and a secondary piston pump having a secondary piston. The primary piston pump is fluidically connected with the secondary piston pump. The primary piston pump includes an inlet valve and an outlet valve, and the pump unit operates periodically according to a pump cycle. The method includes determining a fluid pressure of fluid dispensed by the pump unit, and performing a closed loop control of a position of the primary piston in dependence on the fluid pressure of the fluid dispensed by the pump unit during a first time interval of the pump cycle.

Abstract: In a fluid separation device, fluid supplied to a fluid inlet conduit at an inlet flow rate is split such that a first part of the fluid flows into a first outlet conduit and into a pump at a first flow rate, and a second part of the fluid flows from the fluid inlet conduit into a second outlet conduit at a second flow rate. The second flow rate is controlled by controlling the pump such that, regardless of inlet pressure in the fluid inlet conduit, the first part of the fluid is continuously conducted away from the fluid inlet conduit at a defined value of the first flow rate. The second flow rate is defined based on the defined value of the first flow rate.