Abstract: A control device for a sample separation apparatus, the sample separation apparatus including a first separation unit and a second separation unit downstream of the first separation unit and supplied with the fluidic sample after treatment by the first separation unit. A control device is configured for controlling the first separation unit to execute a primary separation sequence within a time interval for separating the fluidic sample into fractions, and for controlling the second separation unit to execute secondary separation sequences within the time interval for further separating the separated fractions into sub-fractions, wherein the secondary separation sequences form part of a common sample separation method defined by a common specification of the sample separation involving a set of parameters, and adjusting, over a progress of the primary separation sequence, at least one parameter according to which at least one of the plurality of secondary separation sequences is executed.

Abstract: A fluid pump for a fluid separation device for separating a fluid includes a fluid inlet being supplyable with fluid at an inlet pressure (pI), and a fluid conducting mechanism configured for conducting the fluid supplied to the fluid inlet towards a connected fluidic path, in which the fluid conducting mechanism is controllable so that, regardless of a value of the inlet pressure (pI), the fluid is continuously conducted away from the fluid inlet with a definable flow rate (FT).

Abstract: A method for controlling movement of a piston in a metering device is described. The method comprises supplying a fluid by actuating the metering device's piston, wherein compression or expansion of the fluid causes corresponding temperature variations. The method further comprises superposing a corrective movement onto the piston movement, with the corrective movement at least partly compensating for at least one of thermal expansion and contraction of the fluid induced by the temperature variations. In one embodiment, the corrective movement imposed onto the piston movement comprises two components: a reduction (74) of the compression jump (73), and a subsequent increase (75) of the piston's forward displacement rate (71) during a period (76) of time (72).

Abstract: A method for controlling operation of a pump unit, where the pump unit includes a primary piston pump having a primary piston and a secondary piston pump having a secondary piston. The primary piston pump is fluidically connected with the secondary piston pump. The primary piston pump includes an inlet valve and an outlet valve, and the pump unit operates periodically according to a pump cycle. The method includes determining a fluid pressure of fluid dispensed by the pump unit, and performing a closed loop control of a position of the primary piston in dependence on the fluid pressure of the fluid dispensed by the pump unit during a first time interval of the pump cycle.

Abstract: A method for metering two or more liquids in controlled proportions in a liquid supply system and for supplying a resultant mixture, in which the liquid supply system includes a plurality of solvent supply lines, a proportioning valve interposed between the solvent supply lines and an inlet of a pumping unit, the method includes drawing in a first liquid into the pumping unit via a first solvent supply line; determining one or more switching points of time for switching between different solvent supply lines, the switching points of time being determined in a way that at said switching points of time, the liquid supplied to the pumping unit is in a predefined pressure range; switching from the first solvent supply line to a second solvent supply line at one of said switching points of time; drawing in a second liquid into the pumping unit via the second solvent supply line.

Abstract: A method for controlling operation of a pump unit, where the pump unit includes a primary piston pump having a primary piston and a secondary piston pump having a secondary piston. The primary piston pump is fluidically connected with the secondary piston pump. The primary piston pump includes an inlet valve and an outlet valve, and the pump unit operates periodically according to a pump cycle. The method includes determining a fluid pressure of fluid dispensed by the pump unit, and performing a closed loop control of a position of the primary piston in dependence on the fluid pressure of the fluid dispensed by the pump unit during a first time interval of the pump cycle.

Abstract: A liquid chromatography device (200) being controllable for executing a chromatographic method (402) defined by a set of target parameters and by a corresponding target sequence of operation procedures, the device comprising a method execution unit (202) configured for executing the chromatographic method (402) by applying the set of target parameters and by running the corresponding target sequence of operation procedures within the liquid chromatography device (200), a determining unit (204) configured for determining a deviation of an actual result of the chromatographic method (402) from an expected target result, wherein the expected target result of the chromatographic method (402) represents a desired behavior of the liquid chromatography device (200) and wherein the actual result of the chromatographic method (402) is obtained by executing the chromatographic method (402) and represents an actual behavior of the liquid chromatography device (200), and an adjusting unit (206) configured for adjusting a

Abstract: An apparatus (200) for deriving an operation mode from a first fluidic device to a second fluidic device, wherein the first fluidic device has a first target operation mode (300) representing a desired behavior of the first fluidic device and has a first real operation mode (304) representing the actual behavior of the first fluidic device, wherein the second fluidic device has a second target operation mode (312) representing a desired behavior of the second fluidic device and has a second real operation mode (314) representing the actual behavior of the second fluidic device, the apparatus (200) comprising a first determining unit (202) adapted for determining the first real operation mode (304) based on the first target operation mode (300) and based on a preknown parameterization (302) of the first fluidic device, and a second determining unit (204) adapted for determining the second target operation mode (312) based on the determined first real operation mode (304) and based on a preknown parameterizatio

Abstract: A mixer for mixing a fluid having a property varying along a flow direction of the fluid includes an inlet configured for receiving an inlet flow, an outlet configured for providing an outlet flow, and a plurality of flow channels coupled between the inlet and the outlet. The mixer also includes a flow distributor for distributing the inlet flow into the plurality of flow channels so that each flow channel receives a partial flow from the inlet flow, and a flow combiner for combining the partial flows from the plurality of flow channels to the outlet flow. Each flow channel has a first flow section having a hydraulic resistance substantially representing a hydraulic resistance of the flow channel. One or more of the flow channels each have a second flow section coupled in series with the first flow section of the respective flow channel.

Abstract: A fluidic device for providing fluidic connections is described. The fluidic device comprises a fluid conduit and a planar coupling member with a fluid port, the fluid port being fluidically connected with the fluid conduit. A contour of the planar coupling member is in a predefined relationship with the fluid port's position.

Abstract: A method for controlling operation of a pump unit, where the pump unit includes a primary piston pump having a primary piston and a secondary piston pump having a secondary piston. The primary piston pump is fluidically connected with the secondary piston pump. The primary piston pump includes an inlet valve and an outlet valve, and the pump unit operates periodically according to a pump cycle. The method includes determining a fluid pressure of fluid dispensed by the pump unit, and performing a closed loop control of a position of the primary piston in dependence on the fluid pressure of the fluid dispensed by the pump unit during a first time interval of the pump cycle.

Abstract: In a high performance liquid chromatography system, wherein a mobile phase is driven through a stationary phase for separating compounds of a sample fluid comprised in the mobile phase, a flow rate of the mobile phase is controlled in dependence on a variation in a control value in the system.

Abstract: A supply flow path for supplying a solvent is described. The supply flow path includes metering devices each with a piston, the metering devices being adapted for metering the solvent through separate source paths feeding the supply flow path. The supply flow path further includes a control unit adapted for controlling the metering devices' piston movement in accordance with solvent pressure, wherein a variation of the solvent pressure gives rise to a corresponding variation of a solvent volume contained in the supply flow path or a part thereof. The control unit is adapted for compensating for the variation of the solvent volume by corresponding movements or forward or backward displacements of the pistons.

Abstract: A leakage detection system is described, with the leakage detection system comprising a fluid chamber (8) containing a first fluid, and a sealing element (12) located between the fluid chamber and a second fluid chamber (15), said sealing element (12) being adapted for sealing the first fluid in the fluid chamber (8), and the second fluid chamber (15) being located adjacent the sealing element and containing a second fluid. The leakage detection system further comprises a detection unit (19) in fluid connection with the second fluid chamber, said detection unit being adapted for detecting leakage by evaluating a property of the second fluid, with said property being affected by first fluid leaking into the second fluid.

Abstract: A contactless detection cell (1) for detecting an electrical property of one or more sample compounds in a flow path is described. The contactless detection cell (1) comprises a transmitter electrode (3) adapted for capacitively coupling an AC current into a detection channel (4) of the flow path, and a receiver electrode (5) adapted for receiving the AC current that has been coupled into the detection channel (4). An inner cross-section (IDDET) in at least a section of the detection channel is different than an inner cross-section (IDSEP) of the flow path (2) towards the detection channel (4).

Abstract: A fluidic system has a flow source adapted for delivering a fluid, a plurality of flow channels, each being adapted for providing a fluid separation and being arranged downstream of the flow source, a flow meter adapted for determining a fluid flow in at least one of the flow channels and being arranged downstream of the at least one of the flow channels, and a control unit adapted for controlling the fluid flow in the at least one of the flow channels in response to the determined fluid flow.

Abstract: An apparatus for determining an operation mode of a device, wherein the device is capable of adjusting a physical condition at a source position to correspondingly influence a physical condition at a destination position, the apparatus comprising a determining unit adapted for determining the operation mode by defining a time dependency of the physical condition at the source position so that a target time-dependency of the physical condition is obtained for the destination position, the target time-dependency representing a resultant variation of the physical condition over time.

Abstract: A column device comprises a stationary phase having a plurality of particles adapted for interacting with a mobile phase in order to separate different compounds of a sample fluid dissolved in the mobile phase, a housing for at least partly housing the stationary phase, and a separator separating sections of the stationary phase and being force-coupled with the housing.

Abstract: A pumping apparatus for delivering liquid at high pressure at which compressibility of the liquid becomes noticeable. The pumping apparatus comprises a first actuator for actuating a first reciprocation piston for pumping at least a part of the fluid, a second actuator for actuating a second reciprocation piston for pumping at least a part of the fluid, and a main drive coupled to the first actuator and to the second actuator. A phase shifter is provided for varying a phase relationship between reciprocating motions of the first piston and the second piston.

Abstract: A method for controlling movement of a piston in a metering device is described. The method comprises supplying a fluid by actuating the metering device's piston, wherein compression or expansion of the fluid causes corresponding temperature variations. The method further comprises superposing a corrective movement onto the piston movement, with the corrective movement at least partly compensating for at least one of thermal expansion and contraction of the fluid induced by the temperature variations. In one embodiment, the corrective movement imposed onto the piston movement comprises two components: a reduction (74) of the compression jump (73), and a subsequent increase (75) of the piston's forward displacement rate (71) during a period (76) of time (72).