Patents by Inventor Koichi Araki
Koichi Araki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20140370059Abstract: It is disclosed herein that treatment of a subject with an mTOR inhibitor enhances antigen-specific T cell immune responses. Thus, provided herein is a method of enhancing an antigen-specific T cell response in a subject by administering to the subject a therapeutically effective amount of an mTOR inhibitor. The antigen can be any antigen, such as an antigen from a pathogen or a vaccine, or a tumor antigen. In some embodiments, the method further comprises administering to the subject a vaccine, such as a virus vaccine or a cancer vaccine. The mTOR inhibitor can be administered either before or after vaccination to enhance the quantity and quality of the T cell immune response and immunological memory. In some examples, the mTOR inhibitor is rapamycin or a rapamycin analog.Type: ApplicationFiled: August 25, 2014Publication date: December 18, 2014Inventors: Rafi R. Ahmed, Christian P. Larsen, Koichi Araki
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Patent number: 8840899Abstract: It is disclosed herein that treatment of a subject with an mTOR inhibitor enhances antigen-specific T cell immune responses. Thus, provided herein is a method of enhancing an antigen-specific T cell response in a subject by administering to the subject a therapeutically effective amount of an mTOR inhibitor. The antigen can be any antigen, such as an antigen from a pathogen or a vaccine, or a tumor antigen. In some embodiments, the method further comprises administering to the subject a vaccine, such as a virus vaccine or a cancer vaccine. The mTOR inhibitor can be administered either before or after vaccination to enhance the quantity and quality of the T cell immune response and immunological memory. In some examples, the mTOR inhibitor is rapamycin or a rapamycin analog.Type: GrantFiled: August 5, 2009Date of Patent: September 23, 2014Assignee: Emory UniversityInventors: Rafi Ahmed, Christian P. Larsen, Koichi Araki
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Patent number: 8822691Abstract: To provide novel carboxamides which exhibit an excellent pesticidal activity as pesticides. Carboxamides represented by the following Formula (I) and use thereof as pesticides and an animal parasite control agent: wherein each substituent is as defined in the specification.Type: GrantFiled: July 10, 2010Date of Patent: September 2, 2014Assignee: Bayer CropScience AGInventors: Jun Mihara, Koichi Araki, Takuma Mori, Tetsuya Murata, Yasushi Yoneta, Eiichi Shimojo, Teruyuki Ichihara, Masashi Ataka, Katsuhiko Shibuya, Ulrich Görgens
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Patent number: 8785647Abstract: The invention is directed to arylpyrrolidines compounds which exhibit excellent insecticidal efficacy and which may be used as in the agrochemical field or in the vield of veterinary medicine. The compounds are represented by formula (I): wherein the respective substituents are defined in the specification.Type: GrantFiled: March 14, 2013Date of Patent: July 22, 2014Assignee: Bayer Intellectual Property GmbHInventors: Ulrich Görgens, Jun Mihara, Tetsuya Murata, Daiei Yamazaki, Yasushi Yoneta, Koichi Araki, Norio Sasaki, Kei Domon, Mamoru Hatazawa, Eiichi Shimojo, Teruyuki Ichihara, Masashi Ataka, Katsuhiko Shibuya
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Patent number: 8658798Abstract: Triazolylpyridine ketones expressed by the following formula (I) and use thereof as herbicides.Type: GrantFiled: July 24, 2008Date of Patent: February 25, 2014Assignee: Bayer Cropscience AGInventors: Andreas Van Almsick, Shinichi Narabu, Yoshitaka Sato, Kei Domon, Koichi Araki, Shinichi Shirakura, Seiji Ukawa, Teruyuki Ichihara, Chieko Ueno
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Publication number: 20140046069Abstract: Arylpyrrolidines of Formula (I): wherein each substituent is as defined in the specification, and use thereof as pesticides and animal paracite-controlling agents.Type: ApplicationFiled: September 13, 2011Publication date: February 13, 2014Applicant: BAYER INTELLECTUAL PROPERTY GMBHInventors: Jun Mihara, Mamoru Hatazawa, Daiei Yamazaki, Hidetoshi Kishikawa, Kei Domon, Hidekazu Watanabe, Norio Sasaki, Tetsuya Murata, Koichi Araki, Eiichi Shimojo, Teruyuki Ichihara, Tadashi Ishikawa, Katsuhiko Shibuya, Ulrich Goergens, Peter Bruechner, Reiner Fischer, Johannes-Rudolf Jansen, Tobias Kapferer, Simon Maechling, Michael Maue, Arnd Voerste
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Publication number: 20130310408Abstract: The invention is directed to arylpyrrolidines compounds which exhibit excellent insecticidal efficacy and which may be used as in the agrochemical field or in the vield of veterinary medicine. The compounds are represented by formula (I): wherein the respective substituents are defined in the specification.Type: ApplicationFiled: March 14, 2013Publication date: November 21, 2013Applicant: Bayer Intellectual Property GmbHInventors: Ulrich GÖRGENS, Jun MIHARA, Tetsuya MURATA, Daiei YAMAZAKI, Yasushi YONETA, Koichi ARAKI, Norio SASAKI, Kei DOMON, Mamoru HATAZAWA, Eiichi SHIMOJO, Teruyuki ICHIHARA, Masashi ATAKA, Katsuhiko SHIBUYA
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Publication number: 20130296168Abstract: Triazolylpyridine ketones expressed by the following formula (1) and use thereof as herbicides.Type: ApplicationFiled: May 22, 2013Publication date: November 7, 2013Inventors: Andreas Van Almsick, Shinichi Narabu, Yoshitaka Sato, Kei Domon, Koichi Araki, Shinichi Shirakura, Seiji Ukawa, Teruyuki Ichihara, Chieko Ueno
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Patent number: 8450483Abstract: The invention is directed to arylpyrrolidines compounds which exhibit excellent insecticidal efficacy and which may be used as in the agrochemical field or in the field of veterinary medicine. The compounds are represented by formula (I): wherein the respective substituents are defined in the specification.Type: GrantFiled: October 14, 2009Date of Patent: May 28, 2013Assignee: Bayer Cropscience AGInventors: Ulrich Görgens, Jun Mihara, Tetsuya Murata, Daiei Yamazaki, Yasushi Yoneta, Koichi Araki, Norio Sasaki, Kei Domon, Mamoru Hatazawa, Eiichi Shimojo, Teruyuki Ichihara, Masashi Ataka, Katsuhiko Shibuya
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Publication number: 20120277185Abstract: To provide novel carboxamides which exhibit an excellent pesticidal activity as pesticides. Carboxamides represented by the following Formula (I) and use thereof as pesticides and an animal parasite control agent: wherein each substituent is as defined in the specification.Type: ApplicationFiled: July 10, 2010Publication date: November 1, 2012Applicant: BAYER CROPSCIENDE AGInventors: Jun Mihara, Koichi Araki, Takuma Mori, Tetsuya Murata, Yasushi Yoneta, Eiichi Shimojo, Teruyuki Ichihara, Masashi Ataka, Katsuhiko Shibuya, Ulrich Görgens
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Publication number: 20120214851Abstract: The invention relates to a composition comprising at least one aminobenzamide compound or a salt thereof for controlling animal parasites, veterinary pharmaceutical compositions comprising at least one aminobenzamide of formula (I) for preventing infection with diseases transmitted through parasites, its use for the preparation of a veterinary pharmaceutical for controlling animal parasites, and a method for preventing infection with diseases transmitted through parasites.Type: ApplicationFiled: April 26, 2012Publication date: August 23, 2012Applicant: BAYER CROPSCIENCE AGInventors: Ulrich GÖRGENS, Akihiki YANAGI, Kazue YANAGI, Keisuke YANAGI, Kasumi YANAGI, Katsuaki WADA, Tetsuya MURATA, Yukiyoshi WATANABE, Jun MIHARA, Koichi ARAKI
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Publication number: 20120149910Abstract: The object of the present invention is to provide novel carboxamides which exhibit an excellent pesticidal activity as pesticides. Disclosed are the carboxamides represented by the following Formula (I): wherein each substituent is as defined in the specification, and use thereof as pesticides and animal parasite controlling agents.Type: ApplicationFiled: August 3, 2010Publication date: June 14, 2012Applicant: Bayer CropScience AGInventors: Jun Mihara, Koichi Araki, Takuma Mori, Tetsuya Murata, Yasushi Yoneta, Yukiyoshi Watanabe, Eiichi Shimojo, Teruyuki Ichihara, Masashi Ataka, Katsuhiko Shibuya, Ulrich Gorgens
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Publication number: 20120129854Abstract: The invention is directed to arylpyrrolidines compounds which exhibit excellent insecticidal efficacy and which may be used as in the agrochemical field or in the yield of veterinary medicine. The compounds are represented by formula (I): wherein the respective substituents are defined in the specification.Type: ApplicationFiled: April 27, 2010Publication date: May 24, 2012Applicant: Bayer CropScience AGInventors: Jun Mihara, Tetsuya Murata, Daiei Yamazaki, Yasushi Yoneta, Koichi Araki, Norio Sasaki, Kei Domon, Mamoru Hatazawa, Eiichi Shimojo, Teruyuki Ichihara, Masashi Ataka, Katsuhiko Shibuya, Ulrich Görgens
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Publication number: 20120029202Abstract: The present invention relates to a process for the manufacturing of 5-substituted 3-aryl-3-(trifluoromethyl)-3,4-dihydro-2H-pyrroles of formula (I) which comprises the following steps: (i) reacting a compound of formula (II) with a isonitrile compound of formula (III) in the presence of a metal catalyst to obtain compounds of formula (IV) (ii) isomerizing compounds of formula (IV) to obtain compounds of formula (V) and (iii) reacting the dihydropyrrole compound of formula (V) under acidic conditions, to obtain the compounds of formula (I), wherein X, n, Z, Y, and T are as defined in the description.Type: ApplicationFiled: May 11, 2011Publication date: February 2, 2012Applicant: Bayer CropScience AGInventors: Koichi ARAKI, Jun Mihara, Norio Sasaki, Peter Bruechner, Kei Domon, Johannes-Rudolf Jansen, Norbert Lui
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Publication number: 20110237800Abstract: Triazolylpyridine ketones expressed by the following formula (I) and use thereof as herbicides.Type: ApplicationFiled: July 24, 2008Publication date: September 29, 2011Applicant: BAYER CROPSCIENCE AGInventors: Van Almsick Andreas, Shinichi Narabu, Yoshitaka Sato, Kei Domon, Koichi Araki, Shinichi Shirakura, Seiji Ukawa, Teruyuki Ichihara, Ueno Chieko
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Patent number: 8008484Abstract: Compounds of the formula (I), wherein Z represents C—R7 or N, and R5 represents alkyl that may be optionally substituted, alkenyl, alkynyl, cycloalkyl or alkoxycarbonylamino, are useful as agricultural and horticultural fungicides.Type: GrantFiled: July 21, 2005Date of Patent: August 30, 2011Assignee: Bayer CropScience AGInventors: Koichi Araki, Sachio Kudo, Yoshitaka Sato, Masahito Ito, Takuya Gomibuchi, Yasuo Araki, Tetsuya Inuta, Keiji Endo, Shinichi Shirakura, Shin Nakamura
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Publication number: 20110129496Abstract: It is disclosed herein that treatment of a subject with an mTOR inhibitor enhances antigen-specific T cell immune responses. Thus, provided herein is a method of enhancing an antigen-specific T cell response in a subject by administering to the subject a therapeutically effective amount of an mTOR inhibitor. The antigen can be any antigen, such as an antigen from a pathogen or a vaccine, or a tumor antigen. In some embodiments, the method further comprises administering to the subject a vaccine, such as a virus vaccine or a cancer vaccine. The mTOR inhibitor can be administered either before or after vaccination to enhance the quantity and quality of the T cell immune response and immunological memory. In some examples, the mTOR inhibitor is rapamycin or a rapamycin analog.Type: ApplicationFiled: August 5, 2009Publication date: June 2, 2011Applicant: EMORY UNIVERSITYInventors: Rafi Ahmed, Christian P. Larsen, Koichi Araki
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Publication number: 20110071141Abstract: Condensed-ring aryl compounds of formula (I) and use of the same as a agrochemical for controlling noxious organisms wherein (X)mQ, A, R1, (Y)n and the grouping —W1—W2—W3—W4— are as defined herein.Type: ApplicationFiled: March 13, 2009Publication date: March 24, 2011Inventors: Tetsuya Murata, Yasushi Yoneta, Jun Mihara, Kei Domon, Mamoru Hatazawa, Koichi Araki, Eiichi Shimojo, Katsuhiko Shibuya, Teruyuki Ichihara, Ulrich Görgens, Arnd Voerste, Angela Becker, Eva-Maria Franken, Klaus-Helmut Müller
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Publication number: 20110009457Abstract: The invention relates to a composition comprising at least one aminobenzamide compound or a salt thereof for controlling animal parasites, veterinary pharmaceutical compositions comprising at least one aminobenzamide of formula (I) for preventing infection with diseases transmitted through parasites, its use for the preparation of a veterinary pharmaceutical for controlling animal parasites, and a method for preventing infection with diseases transmitted through parasites.Type: ApplicationFiled: December 9, 2008Publication date: January 13, 2011Applicant: BAYER CROPSCIENCE AGInventors: Ulrich Görgens, Katsuaki Wada, Yukiyoshi Watanabe, Jun Mihara, Koichi Araki
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Publication number: 20100323896Abstract: Herbicidal compositions comprising containing sulfonanilides of the formula (I) wherein R1 represents hydrogen, fluorine, chlorine, C1-4 alkyl, C1-4 alkoxy, C3-6 cycloalkyl-C1-4 alkyloxy or C1-4 haloalkoxy, R2 represents hydrogen, fluorine or chlorine, R3 represents hydrogen or fluorine, R4 represents hydrogen or C1-4 alkyl which may be optionally C1-4 alkoxy-substituted, C3-6 alkenyl or C3-6 alkynyl, R5 represents hydrogen, R6 represents hydroxy, fluorine or chlorine, or R5 and R6 may form, together with the carbon to which they are bonded, C?O, and X represents CH or N, provided that the following cases are excluded: (i) R1 represents hydrogen, fluorine or chlorine, R2 represents hydrogen, R3 represents hydrogen, R4 represents hydrogen, R5 represents hydrogen, and R6 represents hydroxy, (ii) R1 represents hydrogen, fluorine or chlorine, R2 represents hydrogen, R3 represents hydrogen, R4 represents hydrogen, and R5 and R6 form C?O together with the carbon to which they are bonded, (iii) R1 represents C1-Type: ApplicationFiled: August 25, 2010Publication date: December 23, 2010Applicant: Bayer CropScience AGInventors: Koichi Araki, Yoshitaka Sato, Takuya Gomibuchi, Keiji Endo, Shinichi Shirakura, Shin Nakamura, Christopher Rosinger, Dieter Feucht