Abstract: Specific phenylalanine derivatives and analogues thereof have an antagonistic activity to ?4 integrin. They are used as therapeutic agents for various diseases concerning ?4 integrin.

Abstract: Crystals of isopropyl ester of N-(2,6-dichlorobenzoyl)-4-[6-(methylamino)methyl-1-methyl-2,4-dioxo-1,4-dihydroquinazoline-3(2H)-yl]-L-phenylalanine hydrochloride: are useful as ?4 integrin inhibitors.

Abstract: A method for preparing a phenylalanine derivative having a quinazoline-dione ring represented by the following formula (1) or a pharmaceutically acceptable salt thereof, comprising the following steps (a), (b) and (c): (a) reacting an acyl phenylalanine derivative represented by the following formula (2): with a carbonyl group-introducing reagent and a specific anthranilic acid derivative to thus form the corresponding carboxy-asymmetric urea derivative; (b) converting the carboxy-asymmetric urea derivative into the corresponding quinazoline-dione derivative in the presence of a carboxyl group-activating agent: (c) if desired, substituting an N-alkyl group for the hydrogen atom bonded to the nitrogen atom present in the quinazoline-dione ring of the quinazoline-dione derivative using an N-alkylation agent and then deprotecting the resulting product, when the substituent R3? which is a group corresponding to R3 is protected.

Abstract: The present invention releates to a method for preparing a phenylalanine compound having a quinazoline-dione ring represented by the following formula (1) or a pharmaceutically acceptable salt thereof: where R1-R4 are defined herein. The method involves reacting a specified acyl phenylalanine compound with a carbonyl group-introducing reagent and a specified anthranilic acid compound to form a carboxy-asymmetric urea compound which is converted to a quinazoline-dione compound in the presence of a carboxyl group-activating agent.

Abstract: A magnetostrictive torque sensor comprising: a magnetostrictive film provided on a ferromagnetic shaft; a bias magnetization device which applies a bias magnetic field to the shaft to magnetize the shaft; and a detection device which detects a change in magnetism of the magnetostrictive film, wherein: a torque acting on the shaft calculated based on the detection results of the detection device; and the bias magnetization device applies a bias magnetic field to the shaft at a predetermined timing.

Abstract: Crystals of isopropyl ester of N-(2,6-dichlorobenzoyl)-4-[6-(methylamino)methyl-1-methyl-2,4-dioxo-1,4-dihydroquinazoline-3(2H)-yl]-L-phenylalanine hydrochloride are useful as ?4 integrin inhibitors.

Abstract: Crystals of isopropyl ester of N-(2,6-dichlorobenzoyl)-4-[6-(methylamino)methyl-1-methyl-2,4-dioxo-1,4-dihydroquinazoline-3(2H)-yl]-L-phenylalanine hydrochloride are useful as ?4 integrin inhibitors.

Abstract: A method for preparing a phenylalanine derivative having a quinazoline-dione ring represented by the following formula (1) or a pharmaceutically acceptable salt thereof, comprising the following steps (a), (b) and (c): (a) reacting an acyl phenylalanine derivative represented by the following formula (2): with a carbonyl group-introducing reagent and a specific anthranilic acid derivative to thus form the corresponding carboxy-asymmetric urea derivative; (b) converting the carboxy-asymmetric urea derivative into the corresponding quinazoline-dione derivative in the presence of a carboxyl group-activating agent: (c) if desired, substituting an N-alkyl group for the hydrogen atom bonded to the nitrogen atom present in the quinazoline-dione ring of the quinazoline-dione derivative using an N-alkylation agent and then deprotecting the resulting product, when the substituent R3? which is a group corresponding to R3 is protected.

Abstract: A magnetostrictive torque sensor comprising: a magnetostrictive film provided on a ferromagnetic shaft; a bias magnetization device which applies a bias magnetic field to the shaft to magnetize the shaft; and a detection device which detects a change in magnetism of the magnetostrictive film, wherein: a torque acting on the shaft calculated based on the detection results of the detection device; and the bias magnetization device applies a bias magnetic field to the shaft at a predetermined timing.

Abstract: Azole compounds represented by formula I: wherein ring A is isoxazole and the like, R1 is a substituted or unsubstituted aryl group and the like, R2 is a hydrogen atom and the like, and R3 is a substituted or unsubstituted alkyl group and the like, and pharmaceutically acceptable salts thereof inhibit the physiological activity of lysophosphatidic acid (LPA), and are useful as for the prophylaxis or treatment of diseases in which inhibition of the physiological activity of LPA is useful for the prophylaxis or treatment thereof, such as diseases involving the LPA receptor.

Abstract: A muffler includes a shell main that is formed in a cylinder with two openings opposite to each other being apart from each other in an axial direction of the shell main body by rolling a flat plate to have an overlapped portion overlapping an inner end portion and a shell portion, and a pair of end plates that are partially inserted in the openings of the shell main body and fixed to the shell main body. The inner end portion is formed with two cut-off portions at opening-side edges of the inner end portion, respectively, to avoid interference between the inner end portion and the end plates when the end plates are inserted into the openings of the shell main body.

Abstract: Azole compounds represented by formula I: wherein ring A is isoxazole and the like, R1 is a substituted or unsubstituted aryl group and the like, R2 is a hydrogen atom and the like, and R3 is a substituted or unsubstituted alkyl group and the like, and pharmaceutically acceptable salts thereof inhibit the physiological activity of lysophosphatidic acid (LPA), and are useful as for the prophylaxis or treatment of diseases in which inhibition of the physiological activity of LPA is useful for the prophylaxis or treatment thereof, such as diseases involving the LPA receptor.

Abstract: A Ni-containing plating film includes a lower plating film and an upper plating film laminated on lower plating film. The lower plating film is formed by plating with no saccharin sodium added to a plating bath, and the upper plating film is formed by plating with saccharin sodium added to a plating bath. In the upper plating film, a NiS layer exists at a position below the film surface.

Abstract: The present invention provides a more effective gastrointestinal function promoter. The present invention also provides a method for the prophylaxis or improvement of functional gastrointestinal disorders, a method for appetite regulation and the like. The present invention also provides a method for screening for a substance capable of promoting a gastrointestinal function. The present invention provides a gastrointestinal function promoter containing a T1R agonist as an active ingredient and a method for the prophylaxis or improvement of functional gastrointestinal disorders, a method for appetite regulation and the like by administering a T1R agonist. The present invention also provides a method of screening for a substance capable of promoting a gastrointestinal function which method uses a cell expressing T1R receptor.

Abstract: A semiconductor device packaged in a non-hermetic package includes a semiconductor substrate; a wiring metal film on the semiconductor substrate; a plating power supply film on the wiring metal film; an Au plated portion on the plating power supply film; a metal film covering the Au plated portion; and an insulating protective film covering the metal film. The metal film is a material having corrosion resistance properties such that a potential-pH diagram of the metal material predominantly includes a corrosion-free region and a passive region and either does not include a corrosion region or includes a very small corrosion region, the potential-pH diagram showing the effects of electrical potential and pH on corrosion of the metal material.

Abstract: The present invention discloses crystals of phenylalanine derivatives which have a specific structural formula, and particularly crystals which are easy to be used; crystals excellent in preservation stability, humidity resistance or solubility; and crystals which can be manufactured on the industrial scale. The present invention also discloses the production method thereof and use thereof, and particularly the use thereof as an active ingredient of pharmaceutical compositions.

Abstract: Specific phenylalanine derivatives and analogues thereof have an antagonistic activity to ?4 integrin. They are used as therapeutic agents for various diseases concerning ?4 integrin.

Abstract: Specific phenylalanine derivatives and analogues thereof have an antagonistic activity to ?4 integrin. They are used as therapeutic agents for various diseases concerning ?4 integrin.

Abstract: A platinum temperature sensor incorporating an evaporation-suppressing layer containing platinum in the vicinity of the platinum thin-film resistor of the sensor. The evaporation-suppressing layer is preferably positioned between the platinum resistor and a porous layer that is formed close to the platinum resistor and in contact with the evaporation-suppressing layer.

Abstract: A suction unit for use in an electric vacuum cleaner and an electric vacuum cleaner includes a floor nozzle and a mini nozzle detachably secured to the floor nozzle. When a suction head of the mini nozzle is secured to the floor nozzle, an air communication is provided therebetween. Further, the mini nozzle is provided with an ion generating unit.