Abstract: As an antitumor drug which is excellent in terms of antitumor effect and safety and has an excellent therapeutic effect, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-HER2 antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-(CH2)n2-C(?O)— wherein the anti-HER2 antibody is connected to the terminal L1, and the antitumor compound is connected to the carbonyl group of the —(CH2)n2-C(?O)— moiety with the nitrogen atom of the amino group at position 1 as the connecting position.

Abstract: A semiconductor device formed in a single semiconductor integrated circuit, the semiconductor device including: a transmission signal circuit block; a reception signal circuit block; a signal processing circuit block; and at least one of a charging control circuit block or a monitoring circuit block.

Abstract: A light 2 for reflected light that emits visible light for reflected light onto a front side of a veneer 6, a light 32 for invisible light that emits near-infrared light for transmitted light onto a back side of the veneer 6, and an image processing device 1 that detects defects of the veneer 6 by analyzing a captured image generated by a line sensor camera 4 are provided. Defects of the veneer 6 are discriminated on the basis of a set of shading and shapes in an infrared-transmitted-light image based on the transmitted light, and colors in a visible-light image based on the reflected light. Consequently, even if a defect has a small color difference from a normal part in the visible-light image, difference of shading between the defective part and the normal part appears in the infrared-transmitted-light image, and a defect that is difficult to detect by seeing only a color difference in a visible-light image can be relatively easily detected.

Abstract: The present invention provides an immunity-inducing agent comprising, as an active component, a polynucleotide/peptide conjugate in which a single-chain polynucleotide or polynucleotide derivative comprising a CpG motif, and an antigenic peptide are bound via a spacer, wherein the spacer is covalently bound at one end thereof to the polynucleotide or polynucleotide derivative and covalently bound at the other end thereof to the antigenic peptide, as well as a pharmaceutical composition comprising said immunity-inducing agent.

Abstract: A program display control unit performs a display process of displaying first time-series data corresponding to a specified time specified by a display time specification unit, on a first sequence program stored in a first device, which is displayed in a second display section, and another display process of displaying second time-series data acquired from a second device of multiple devices, corresponding to the specified time specified by the display time specification unit, on a second sequence program stored in the second device, which is displayed in a third display section.

Abstract: This aircraft inspection support device includes a first imaging unit configured to capture a measurement information image displayed on a measurement instrument-side display unit of a specific measurement instrument associated with a model of an aircraft or an inspection target of an aircraft component, the measurement instrument-side display unit being configured to display measurement information on the inspection target, and an operator-side display unit configured to display the measurement information image so as to be visible to an inspection operator who is performing an inspection operation near the inspection target.

Abstract: As an antitumor drug which is excellent in terms of antitumor effect and safety and has an excellent therapeutic effect, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-HER2 antibody via a linker having a structure represented by the formula: L1-L2-LP-NH—(CH2)n1-La-Lb-Lc or -L1-L2-LP- wherein the anti-HER2 antibody is connected to the terminal L1, and the antitumor compound is connected to the terminal Lc or LP with the nitrogen atom of the amino group at position 1 as the connecting position.

Abstract: A program display control unit performs a display process of displaying first time-series data corresponding to a specified time specified by a display time specification unit, on a first sequence program stored in a first device, which is displayed in a second display section, and another display process of displaying second time-series data acquired from a second device of multiple devices, corresponding to the specified time specified by the display time specification unit, on a second sequence program stored in the second device, which is displayed in a third display section.

Abstract: An information processing device includes a communication processing unit that performs communication with an external device according to an instruction from application software, and a trace processing unit that executes a first information trace process when a first predetermined condition is satisfied and executes a second information trace process when a second predetermined condition is satisfied. The first information trace process includes obtaining, from an operating system, environmental information that is information about an operating environment of the application software and writing the environmental information to an environmental information log file.

Abstract: As an antitumor drug which is excellent in terms of antitumor effect and safety, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-Lb-Lc- wherein the antibody is connected to the terminal of L1, and the antitumor compound is connected to the terminal of Lc with the nitrogen atom of the amino group at position 1 as a connecting position.

Abstract: A workpiece for a fuel injection component is made of a steel having compositions, by mass %, of C: 0.08 to 0.16%, Si: 0.10 to 0.30%, Mn: 1.00 to 2.00%, S: 0.005 to 0.030%, Cu: 0.01 to 0.30%, Ni: 0.40 to 1.50%, Cr: 0.50 to 1.50%, Mo: 0.30 to 0.70%, V: 0.10 to 0.40%, s-Al: 0.001 to 0.100%, and Fe and unavoidable impurities as remaining components. After heating the workpiece to a temperature of 950° C. or more and 1350° C. or less, the workpiece is subjected to a hot forging, and thereafter cooled at an average cooling rate of 0.1° C./sec. or more in a temperature range from 800° C. to 500° C., and at the average cooling rate of 0.02° C./sec. or more and 10° C./sec. or less in the subsequent temperature range from 500° C. to 300° C. to set an area ratio of a bainite structure after hot forging to 85% or more.

Abstract: An information processing device includes a communication processing unit that performs communication with an external device according to an instruction from application software, and a trace processing unit that executes a first information trace process when a first predetermined condition is satisfied and executes a second information trace process when a second predetermined condition is satisfied. The first information trace process includes obtaining, from an operating system, environmental information that is information about an operating environment of the application software and writing the environmental information to an environmental information log file.

Abstract: As an antitumor drug which is excellent in terms of antitumor effect and safety and has an excellent therapeutic effect, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-HER2 antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-(CH2)n2-C(?O)— wherein the anti-HER2 antibody is connected to the terminal L1, and the antitumor compound is connected to the carbonyl group of the —(CH2)n2-C(?O)— moiety with the nitrogen atom of the amino group at position 1 as the connecting position.

Abstract: As an antitumor drug which is excellent in terms of antitumor effect and safety, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an antibody via a linker having a structure represented by the following formula: -L1-L2-LF-NH—(CH2)n1-La-Lb-Lc- wherein the antibody is connected to the terminal of L1, and the antitumor compound is connected to the terminal of Lc with the nitrogen atom of the amino group at position 1 as a connecting position.

Abstract: A control device of an automatic transmission controls an automatic transmission 1 comprising a transmission mechanism 3 including a plurality of engagement elements, and a hydraulic oil supply device 4 supplying hydraulic oil to the transmission mechanism The control device of the automatic transmission comprises an engagement element control part 41 configured to use the hydraulic oil supply device to make the plurality of engagement elements change between an engaged state and a disengaged state; and a deceleration degree calculating part 42 configured to calculate a target deceleration degree of a vehicle in which the automatic transmission is provided. The engagement element control part is configured to make the engagement element in the disengaged state engage so that the vehicle decelerates if the target deceleration degree is equal to or more than a predetermined value when an increase in temperature of hydraulic oil in the automatic transmission is demanded.

Abstract: A workpiece for a fuel injection component is made of a steel having compositions, by mass %, of C: 0.08 to 0.16%, Si: 0.10 to 0.30%, Mn: 1.00 to 2.00%, S: 0.005 to 0.030%, Cu: 0.01 to 0.30%, Ni: 0.40 to 1.50%, Cr: 0.50 to 1.50%, Mo: 0.30 to 0.70%, V: 0.10 to 0.40%, s-Al: 0.001 to 0.100%, and Fe and unavoidable impurities as remaining components. After heating the workpiece to a temperature of 950° C. or more and 1350° C. or less, the workpiece is subjected to a hot forging, and thereafter cooled at an average cooling rate of 0.1° C./sec. or more in a temperature range from 800° C. to 500° C., and at the average cooling rate of 0.02° C./sec. or more and 10° C./sec. or less in the subsequent temperature range from 500° C. to 300° C. to set an area ratio of a bainite structure after hot forging to 85% or more.

Abstract: A control device of an automatic transmission controls an automatic transmission 1 comprising a transmission mechanism 3 including a plurality of engagement elements, and a hydraulic oil supply device 4 supplying hydraulic oil to the transmission mechanism The control device of the automatic transmission comprises an engagement element control part 41 configured to use the hydraulic oil supply device to make the plurality of engagement elements change between an engaged state and a disengaged state; and a deceleration degree calculating part 42 configured to calculate a target deceleration degree of a vehicle in which the automatic transmission is provided. The engagement element control part is configured to make the engagement element in the disengaged state engage so that the vehicle decelerates if the target deceleration degree is equal to or more than a predetermined value when an increase in temperature of hydraulic oil in the automatic transmission is demanded.

Abstract: A lithium ion secondary battery includes a positive electrode, a negative electrode, and an electrolyte. The negative electrode has a negative electrode current collector and a negative electrode active material layer provided on the negative electrode current collector. The negative electrode current collector satisfies: (D2/D1)?0.968 ??(1), D2?21.947*(X/100)?24.643 ??(2), 110?X?125 ??(3), and where D1 is a first displacement amount in a first piercing test at a first piercing speed of 0.1 mm/min or more; D2 is a second displacement amount in a second piercing test at a second piercing speed of less than 0.1 mm/min; and X is an expansion coefficient (%) of the negative electrode active material layer.

Abstract: A semiconductor device formed in a single semiconductor integrated circuit, the semiconductor device including: a transmission signal circuit block; a reception signal circuit block; a signal processing circuit block; and at least one of a charging control circuit block or a monitoring circuit block.

Abstract: As an antitumor drug which is excellent in terms of antitumor effect and safety and has an excellent therapeutic effect, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-HER2 antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-(CH2)n2-C(?O)— wherein the anti-HER2 antibody is connected to the terminal L1, and the antitumor compound is connected to the carbonyl group of the —(CH2)n2-C(?O)— moiety with the nitrogen atom of the amino group at position 1 as the connecting position.